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1. 发明授权

US06326010B1 Plastic vessel containing an albumin preparation 有权
标题翻译：含有白蛋白制剂的塑料容器
公开(公告)号：US06326010B1
公开(公告)日：2001-12-04
申请号：US09695215
申请日：2000-10-25
申请人： Minoru Sano , Yoshihisa Hama , Toshiya Kai , Masakazu Mameta
发明人： Minoru Sano , Yoshihisa Hama , Toshiya Kai , Masakazu Mameta
IPC分类号： A61J105
摘要： To provide a plastic vessel containing an albumin preparation which completely restrains formation of thermally denatured albumin, a plastic molded member in a cylindrical shape is extruded in a molten state into opened dies, one end of which is closed in the dies, and a vessel is molded by blowing a compressed gas into the molded member in the dies or by bringing inner portions of the dies into a vacuum state. While the vessel is still disposed in the dies, an albumin preparation is introduced from an opening portion into an inner portion of the vessel and, therefore, the albumin preparation can be filled into the vessel in a sterilized state without being brought into contact with the atmosphere. Then, an opening portion of the vessel filled with the albumin preparation is hermetically sealed at an internal temperature of the opening portion of about 40 to 70° C. Thus formation of thermally denatured albumin can be completely restrained.
摘要翻译：为了提供一种含有完全抑制热变性白蛋白形成的白蛋白制剂的塑料容器，将具有圆筒形状的塑料成型体以熔融状态挤出成开模，其一端在模具中封闭，容器为通过将压缩气体吹入模具中的模制构件中或通过使模具的内部部分成为真空状态来模制。当容器仍然设置在模具中时，白蛋白制剂从开口部分引入容器的内部，因此白蛋白制剂可以在灭菌状态下填充到容器中而不与其接触大气层。然后，填充有白蛋白制剂的容器的开口部分在约40-70℃的开口部分的内部温度下气密密封。因此可以完全抑制热变性白蛋白的形成。

2. 发明授权

US06197936B1 Method for producing a plastic vessel containing an albumin preparation 有权
标题翻译：含有白蛋白制剂的塑料容器的制造方法
公开(公告)号：US06197936B1
公开(公告)日：2001-03-06
申请号：US09400000
申请日：1999-10-20
申请人： Minoru Sano , Yoshihisa Hama , Toshiya Kai , Masakazu Mameta
发明人： Minoru Sano , Yoshihisa Hama , Toshiya Kai , Masakazu Mameta
IPC分类号： A61J105
CPC分类号： A61J1/05 , A61J1/14 , A61M2207/00 , B29C49/04 , B65B3/022
摘要： To provide a plastic vessel containing an albumin preparation which completely restrains formation of thermally denatured albumin, a plastic molded member in a cylindrical shape is extruded in a molten state into opened dies, one end of which is closed in the dies, and a vessel is molded by blowing a compressed gas into the molded member in the dies or by bringing inner portions of the dies into a vacuum state. While the vessel is still disposed in the dies, an albumin preparation is introduced from an opening portion into an inner portion of the vessel and, therefore, the albumin preparation can be filled into the vessel in a sterilized state without being brought into contact with the atmosphere. Then, an opening portion of the vessel filled with the albumin preparation is hermetically sealed at an internal temperature of the opening portion of about 40° to 70° C. Thus formation of thermally denatured albumin can be completely restrained. A METHOD FOR PRODUCING A PLASTIC VESSEL CONTAINING AN ALBUMIN PREPARATION
摘要翻译：为了提供一种含有完全抑制热变性白蛋白形成的白蛋白制剂的塑料容器，将具有圆筒形状的塑料成型体以熔融状态挤出成开模，其一端在模具中封闭，容器为通过将压缩气体吹入模具中的模制构件中或通过使模具的内部部分成为真空状态来模制。当容器仍然设置在模具中时，白蛋白制剂从开口部分引入容器的内部，因此白蛋白制剂可以在灭菌状态下填充到容器中而不与其接触大气层。然后，将填充有白蛋白制剂的容器的开口部分在约40℃至70℃的开口部分的内部温度下气密密封。因此可以完全抑制热变性白蛋白的形成。一种生产含有铝制品的塑料容器的方法

3. 发明授权

US06475206B1 Liquid container 失效
标题翻译：液体容器
公开(公告)号：US06475206B1
公开(公告)日：2002-11-05
申请号：US09719105
申请日：2000-12-08
申请人： Yoshihisa Hama , Masakazu Mameta , Takamitsu Okawara
发明人： Yoshihisa Hama , Masakazu Mameta , Takamitsu Okawara
IPC分类号： A61B1900
CPC分类号： A61J1/2089 , A61J1/06 , A61J1/14 , A61J1/201
摘要： There is provided a liquid container capable of transferring liquids germ free in a simple manner within a short period of time and with inconsiderable solution remaining after transfer. The liquid container includes a vessel main body 1, a mouth portion 11 of which is closed by an easily breakable closing member 12, and a hollow needle member 2 crowned pivotably on the mouth portion 11 of the container main body 1. The closing member 12 is provided with a flat knob portion 121. A knob-containing portion 22 of the hollow needle member 2 is provided with a protrusion 24 for joining the knob portion 121 when the hollow needle member 2 is pivoted.
摘要翻译：提供了能够在短时间内以简单的方式输送无菌液体并且在转移后残留的溶液不足的液体容器。液体容器包括容器主体1，其口部11由容易断开的封闭构件12封闭，空心针构件2可枢转地顶盖在容器主体1的口部11上。封闭构件12 设置有扁平的按钮部分121.中空针状构件2的按钮容纳部分22设置有当空心针构件2枢转时用于接合旋钮部分121的突起24。

4. 发明授权

US09408982B2 Safety syringe preventing the needle storage mechanism from being operated before use 有权
标题翻译：防止针存储机构在使用前被操作的安全注射器
公开(公告)号：US09408982B2
公开(公告)日：2016-08-09
申请号：US11991807
申请日：2006-09-12
申请人： Minoru Sano , Yoshihisa Hama
发明人： Minoru Sano , Yoshihisa Hama
IPC分类号： A61M5/32 , A61M5/315 , A61M5/50
CPC分类号： A61M5/322 , A61M5/31501 , A61M5/31505 , A61M2005/31506 , A61M2005/31508 , A61M2005/3231 , A61M2005/5073
摘要： To provide a syringe with a needle storage mechanism in which the needle storage mechanism is not activated before use. A safety syringe including an injection barrel 1 having a connecting portion 11 at the distal end and an opening at the proximal end thereof, a needle assembly B having an injection needle 5 and a needle base 6 fixed to the proximal end of the injection needle 5 and being connected to the connecting portion 11, a gasket 2 provided liquid-tightly and slidably in the injection barrel, a plunger 3 being connected to the proximal end of the gasket 2 and joining means 21 provided at the distal portion of the gasket 2 or the plunger 3, and joined means 61 provided at the proximal portion of the needle base 6, wherein a joint preventing means 90 which prevents the joining means 21 and the joined means 61 from being joined unintentionally before use, and allows joining to each other when in use is provided.
摘要翻译：为注射器提供针存储机构，其中针存储机构在使用前未被激活。一种安全注射器，包括具有在远端的连接部分11和其近端的开口的注射筒1，具有注射针5的针组件B和固定到注射针5的近端的针座6 并且连接到连接部分11，在注射筒中液密地且可滑动地设置的垫圈2，连接到垫圈2的近端的柱塞3和设置在垫圈2的远端部分处的接合装置21或柱塞3和设置在针座6的近端部分处的接合装置61，其中防止接合装置21和接合装置61在使用前意外接合的接合防止装置90，并且允许接合装置在使用中提供。

5. 发明授权

US07998120B2 Prefilled syringe and production method for a barrel thereof 有权
标题翻译：预充注射器及其桶的生产方法
公开(公告)号：US07998120B2
公开(公告)日：2011-08-16
申请号：US10762530
申请日：2004-01-23
申请人： Minoru Sano , Yoshihisa Hama
发明人： Minoru Sano , Yoshihisa Hama
IPC分类号： A61M5/00 , A61M5/31
CPC分类号： B29C45/1603 , A61M5/3129 , B29C45/1642 , B29K2023/00 , B29K2023/086 , B29K2995/0067 , B29L2031/7544
摘要： A prefilled syringe composed of a barrel having a luer tip at one end and an open proximal end, the barrel having at least a three layer structure of an innermost layer, an outermost layer, both made of a polyolefin resin, and an intermediate layer made of a resin with a barrier property and sandwiched by the innermost layer and the outermost layer. The barrel is produced through the sequential steps of: (a) injecting a specific amount of a polyolefin resin inside a cavity; (b) injecting a specific amount of a resin excelling in barrier property; (c) injecting a specific amount of the polyolefin resin again; and (d) separating the luer tip surface and an injection unit by pushing off a valve pin provided inside a valve gate or an inner nozzle of the injection unit, which injects the resin excelling in barrier property, toward the direction of the luer tip surface as desired.
摘要翻译：一种预充式注射器，由具有在一端的鲁棒末端和开放的近端的筒体组成，所述筒体具有至少三层结构的最内层，最外层，均由聚烯烃树脂制成，中间层由的具有阻挡性的树脂，并被最内层和最外层夹在中间。通过以下顺序生产桶：（a）在空腔内注入特定量的聚烯烃树脂; （b）注入特定量的阻隔性优异的树脂; （c）再次注入特定量的聚烯烃树脂; 以及（d）通过将设置在注射单元的阀门或注射单元的内部喷嘴内的阀销推向鲁尔末端面的方向，从而分离鲁尔末端面和注射单元如预期的。

6. 发明申请

US20100312197A1 Saftey Syringe 有权
标题翻译： Saftey注射器
公开(公告)号：US20100312197A1
公开(公告)日：2010-12-09
申请号：US11991807
申请日：2006-09-12
申请人： Minoru Sano , Yoshihisa Hama
发明人： Minoru Sano , Yoshihisa Hama
IPC分类号： A61M5/315 , A61M5/34
CPC分类号： A61M5/322 , A61M5/31501 , A61M5/31505 , A61M2005/31506 , A61M2005/31508 , A61M2005/3231 , A61M2005/5073
摘要： To provide a syringe with a needle storage mechanism in which the needle storage mechanism is not activated before use. A safety syringe including an injection barrel 1 having a connecting portion 11 at the distal end and an opening at the proximal end thereof, a needle assembly B having an injection needle 5 and a needle base 6 fixed to the proximal end of the injection needle 5 and being connected to the connecting portion 11, a gasket 2 provided liquid-tightly and slidably in the injection barrel, a plunger 3 being connected to the proximal end of the gasket 2 and joining means 21 provided at the distal portion of the gasket 2 or the plunger 3, and joined means 61 provided at the proximal portion of the needle base 6, wherein a joint preventing means 90 which prevents the joining means 21 and the joined means 61 from being joined unintentionally before use, and allows joining to each other when in use is provided.
摘要翻译：为注射器提供针存储机构，其中针存储机构在使用前未被激活。一种安全注射器，包括具有在远端的连接部分11和其近端的开口的注射筒1，具有注射针5的针组件B和固定到注射针5的近端的针座6 并且连接到连接部分11，在注射筒中液密地且可滑动地设置的垫圈2，连接到垫圈2的近端的柱塞3和设置在垫圈2的远端部分处的接合装置21或柱塞3和设置在针座6的近端部分处的接合装置61，其中防止接合装置21和接合装置61在使用前意外接合的接合防止装置90，并且允许接合装置在使用中提供。

7. 发明授权

US4666394A Apparatus for thermally fixing the formed thermoplastic products 失效
标题翻译：用于热固定所形成的热塑性产品的装置
公开(公告)号：US4666394A
公开(公告)日：1987-05-19
申请号：US699153
申请日：1985-02-06
申请人： Sukeyoshi Wakamiya , Naokazu Takeuchi , Yoshihisa Hama , Tatsu Akashi , Tatsuo Shimura
发明人： Sukeyoshi Wakamiya , Naokazu Takeuchi , Yoshihisa Hama , Tatsu Akashi , Tatsuo Shimura
IPC分类号： B29C51/04 , B29C51/10 , B29C51/42 , B29C71/02 , B29C51/18
CPC分类号： B29C51/04 , B29C51/10 , B29C51/42 , B29C71/02 , Y10S264/901
摘要： A process and apparatus for pneumatic-pressure forming or vacuum/pneumatic-pressure forming a web of thermoplastic material into a matrix form of containers and having the thus-formed plastic product processed with a thermal fixation operation, which comprises in combination the steps of holding a forming mold at a thermal fixing temperature for the plastic to be formed so as to have the matrix of containers thermally fixed through a temperature range characteristic of the plastic; and cooling-off thus-formed plastic containers, while maintaining the interior of the formed plastic containers at such a pressure level that the formed plastic containers are no longer subjected to any risk of deformation after the forming mold is removed, and after having been removed from the engagement with the forming mold.
摘要翻译：一种用于气压成形或真空/气压加压成型为容器的矩阵形式并具有用热固定操作处理的如此形成的塑料制品的热塑性材料网的方法和装置，其包括以下步骤：在热定形温度下形成塑料的成形模具，以使容器的基体在塑料特性的温度范围内热固定; 并冷却如此形成的塑料容器，同时将成形的塑料容器的内部保持在这样的压力水平，使得成形的塑料容器在成形模具被移除之后不再经受变形的风险，并且在被去除之后从与成型模具的接合。

8. 发明申请

US20050016893A1 PTP for visually handicapped person 有权
标题翻译：视力障碍者的PTP
公开(公告)号：US20050016893A1
公开(公告)日：2005-01-27
申请号：US10886049
申请日：2004-07-08
申请人： Sachiko Nakagawa , Yoshihisa Hama , Yasuhiro Tsukamasa , Susumu Kimura , Takafumi Araki
发明人： Sachiko Nakagawa , Yoshihisa Hama , Yasuhiro Tsukamasa , Susumu Kimura , Takafumi Araki
IPC分类号： B65D83/04 , A61F9/08 , A61J1/03 , A61J1/14 , B65D75/32 , B65D75/34
CPC分类号： B65D75/327 , B65D2203/00 , B65D2575/3227 , Y10S116/17
摘要： A PTP constructed so that when the PTP is divided into a section having one or a plurality of pocket portions, a person can discriminate between the top, bottom, right and left sides of this section in the planar direction and a visually handicapped person can correctly identify the direction of medicament identifying means provided on the section. The PTP includes a flexible sheet having a pocket portion containing a tablet T, and a metal foil adhered to the flexible sheet to hermetically seal the pocket portion containing the tablet T, and the PTP is dividable into sections including a plurality of pocket portions by a dividing line. An unevenness serving as medicament identifying means is provided on a top surface of a pocket portion, and arcs are respectively formed on the dividing line on the sides so that the shapes of all the divided sections become the same.
摘要翻译： PTP被构造成使得当PTP被分成具有一个或多个口袋部分的部分时，人可以在平面方向上区分该部分的顶部，底部，左侧和右侧，并且视觉障碍的人可以正确地区分识别在该部分上提供的药物识别装置的方向。 PTP包括具有包含片剂T的口袋部分的柔性片材和粘附到柔性片材上的金属箔以气密地密封包含片剂T的口袋部分，并且PTP可分割成包括多个袋部分的部分分界线。在袋部的上表面设置有用作药剂识别装置的凹凸，并且在两侧的分割线上分别形成弧，使得所有分割部的形状变得相同。

9. 发明授权

US4535901A Blow-molded multi-ply vessel 失效
标题翻译：吹塑多层容器
公开(公告)号：US4535901A
公开(公告)日：1985-08-20
申请号：US341425
申请日：1982-01-21
申请人： Tadashi Okudaira , Akio Tsuboi , Yoshihisa Hama , Mamoru Hara
发明人： Tadashi Okudaira , Akio Tsuboi , Yoshihisa Hama , Mamoru Hara
IPC分类号： B29C45/16 , B29C49/22 , B65D1/02 , B65D23/00 , B32B27/00
CPC分类号： B32B1/02 , B29C45/1646 , B29C49/221 , B32B27/08 , B32B27/20 , B32B27/28 , B32B27/30 , B32B27/34 , B32B27/36 , B65D1/0215 , B29B2911/1402 , B29B2911/14026 , B29B2911/14066 , B29B2911/14073 , B29B2911/1408 , B29B2911/14093 , B29B2911/14113 , B29B2911/1412 , B29B2911/14146 , B29B2911/14593 , B29B2911/14646 , B29B2911/14653 , B29B2911/14713 , B29C2045/1648 , B29K2077/00 , B29K2105/253 , Y10T428/1352 , Y10T428/1383
摘要： A blow-molded multi-ply vessel having excellent physical properties and good appearance which comprises two or more kinds of thermoplastic resins, at least one of which is a thermoplastic polyester resin, said vessel having a multi-ply structure of three or more layers at least at the thin wall part of the body thereof and a single layer structure at least at the open end of the mouth part thereof, and at least the thin wall part of the body being biaxially orientated. The vessel is produced by sequently and alternatively injecting two or more kinds of molten thermoplastic resins into one mold with shifting injection timing from a molding machine having plural injection cylinders with one mold closing operation to form a multi-ply parison and then blow-molding the parison at an orientating temperature.
摘要翻译：一种具有优异的物理性能和良好外观的吹塑多层容器，其包含两种或更多种热塑性树脂，其中至少一种是热塑性聚酯树脂，所述容器具有三层或更多层的多层结构至少在其本体的薄壁部分处至少在其口部的开口端处具有单层结构，并且至少该主体的薄壁部分被双向定向。该容器是通过随机地和替代地将两种或更多种熔融热塑性树脂注射到一个模具中，从具有多个注射缸的成型机以一个模具关闭操作移动喷射正时，形成多层型坯，然后吹塑成型型坯在定向温度。

10. 发明授权

US4358491A Process for producing a hollow vessel having a frosted glass-like surface 失效
标题翻译：具有磨砂玻璃状表面的中空容器的制造方法
公开(公告)号：US4358491A
公开(公告)日：1982-11-09
申请号：US937699
申请日：1978-08-29
申请人： Akiho Ota , Masanori Nishikawa , Masao Hattori , Akio Tsuboi , Yoshihisa Hama , Tadashi Okudaira , Shigeharu Sugihara
发明人： Akiho Ota , Masanori Nishikawa , Masao Hattori , Akio Tsuboi , Yoshihisa Hama , Tadashi Okudaira , Shigeharu Sugihara
IPC分类号： B29B11/08 , B29B11/10 , B29C49/00 , B29C49/04 , B29C49/06 , B29C49/12 , B29C49/24 , B29C49/64 , B29C49/68 , B29C65/00 , B29K67/00 , B29L23/00 , B65D23/00 , B29C17/07
CPC分类号： B29C49/0005 , B29C49/0073 , B29C49/6445 , B29B2911/1402 , B29B2911/14026 , B29B2911/14033 , B29B2911/1404 , B29B2911/14106 , B29B2911/14133 , B29B2911/1416 , B29B2911/14593 , B29B2911/14666 , B29B2911/14693 , B29B2911/14713 , B29B2911/14726 , B29K2067/00 , B29K2995/004 , Y10S264/907 , Y10T428/1352
摘要： A process for producing a hollow vessel having a frosted glass-like surface which comprises molding a crystalline thermoplastic polyester copolymer comprising units of ethylene terephthalate as the main component into a transparent parison, crystallizing at least the surface layer portion of the parison and then subjecting it to blow molding.
摘要翻译：一种制造具有磨砂玻璃状表面的中空容器的方法，包括将包含对苯二甲酸乙二醇酯单元作为主要成分的结晶性热塑性聚酯共聚物成型为透明型坯，至少将型坯的表层部分结晶，然后使其吹塑成型。

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