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1. 发明申请

US20100312197A1 Saftey Syringe 有权
标题翻译： Saftey注射器
公开(公告)号：US20100312197A1
公开(公告)日：2010-12-09
申请号：US11991807
申请日：2006-09-12
申请人： Minoru Sano , Yoshihisa Hama
发明人： Minoru Sano , Yoshihisa Hama
IPC分类号： A61M5/315 , A61M5/34
CPC分类号： A61M5/322 , A61M5/31501 , A61M5/31505 , A61M2005/31506 , A61M2005/31508 , A61M2005/3231 , A61M2005/5073
摘要： To provide a syringe with a needle storage mechanism in which the needle storage mechanism is not activated before use. A safety syringe including an injection barrel 1 having a connecting portion 11 at the distal end and an opening at the proximal end thereof, a needle assembly B having an injection needle 5 and a needle base 6 fixed to the proximal end of the injection needle 5 and being connected to the connecting portion 11, a gasket 2 provided liquid-tightly and slidably in the injection barrel, a plunger 3 being connected to the proximal end of the gasket 2 and joining means 21 provided at the distal portion of the gasket 2 or the plunger 3, and joined means 61 provided at the proximal portion of the needle base 6, wherein a joint preventing means 90 which prevents the joining means 21 and the joined means 61 from being joined unintentionally before use, and allows joining to each other when in use is provided.
摘要翻译：为注射器提供针存储机构，其中针存储机构在使用前未被激活。一种安全注射器，包括具有在远端的连接部分11和其近端的开口的注射筒1，具有注射针5的针组件B和固定到注射针5的近端的针座6 并且连接到连接部分11，在注射筒中液密地且可滑动地设置的垫圈2，连接到垫圈2的近端的柱塞3和设置在垫圈2的远端部分处的接合装置21或柱塞3和设置在针座6的近端部分处的接合装置61，其中防止接合装置21和接合装置61在使用前意外接合的接合防止装置90，并且允许接合装置在使用中提供。

2. 发明授权

US06197936B1 Method for producing a plastic vessel containing an albumin preparation 有权
标题翻译：含有白蛋白制剂的塑料容器的制造方法
公开(公告)号：US06197936B1
公开(公告)日：2001-03-06
申请号：US09400000
申请日：1999-10-20
申请人： Minoru Sano , Yoshihisa Hama , Toshiya Kai , Masakazu Mameta
发明人： Minoru Sano , Yoshihisa Hama , Toshiya Kai , Masakazu Mameta
IPC分类号： A61J105
CPC分类号： A61J1/05 , A61J1/14 , A61M2207/00 , B29C49/04 , B65B3/022
摘要： To provide a plastic vessel containing an albumin preparation which completely restrains formation of thermally denatured albumin, a plastic molded member in a cylindrical shape is extruded in a molten state into opened dies, one end of which is closed in the dies, and a vessel is molded by blowing a compressed gas into the molded member in the dies or by bringing inner portions of the dies into a vacuum state. While the vessel is still disposed in the dies, an albumin preparation is introduced from an opening portion into an inner portion of the vessel and, therefore, the albumin preparation can be filled into the vessel in a sterilized state without being brought into contact with the atmosphere. Then, an opening portion of the vessel filled with the albumin preparation is hermetically sealed at an internal temperature of the opening portion of about 40° to 70° C. Thus formation of thermally denatured albumin can be completely restrained. A METHOD FOR PRODUCING A PLASTIC VESSEL CONTAINING AN ALBUMIN PREPARATION
摘要翻译：为了提供一种含有完全抑制热变性白蛋白形成的白蛋白制剂的塑料容器，将具有圆筒形状的塑料成型体以熔融状态挤出成开模，其一端在模具中封闭，容器为通过将压缩气体吹入模具中的模制构件中或通过使模具的内部部分成为真空状态来模制。当容器仍然设置在模具中时，白蛋白制剂从开口部分引入容器的内部，因此白蛋白制剂可以在灭菌状态下填充到容器中而不与其接触大气层。然后，将填充有白蛋白制剂的容器的开口部分在约40℃至70℃的开口部分的内部温度下气密密封。因此可以完全抑制热变性白蛋白的形成。一种生产含有铝制品的塑料容器的方法

3. 发明授权

US09408982B2 Safety syringe preventing the needle storage mechanism from being operated before use 有权
标题翻译：防止针存储机构在使用前被操作的安全注射器
公开(公告)号：US09408982B2
公开(公告)日：2016-08-09
申请号：US11991807
申请日：2006-09-12
申请人： Minoru Sano , Yoshihisa Hama
发明人： Minoru Sano , Yoshihisa Hama
IPC分类号： A61M5/32 , A61M5/315 , A61M5/50
CPC分类号： A61M5/322 , A61M5/31501 , A61M5/31505 , A61M2005/31506 , A61M2005/31508 , A61M2005/3231 , A61M2005/5073
摘要： To provide a syringe with a needle storage mechanism in which the needle storage mechanism is not activated before use. A safety syringe including an injection barrel 1 having a connecting portion 11 at the distal end and an opening at the proximal end thereof, a needle assembly B having an injection needle 5 and a needle base 6 fixed to the proximal end of the injection needle 5 and being connected to the connecting portion 11, a gasket 2 provided liquid-tightly and slidably in the injection barrel, a plunger 3 being connected to the proximal end of the gasket 2 and joining means 21 provided at the distal portion of the gasket 2 or the plunger 3, and joined means 61 provided at the proximal portion of the needle base 6, wherein a joint preventing means 90 which prevents the joining means 21 and the joined means 61 from being joined unintentionally before use, and allows joining to each other when in use is provided.
摘要翻译：为注射器提供针存储机构，其中针存储机构在使用前未被激活。一种安全注射器，包括具有在远端的连接部分11和其近端的开口的注射筒1，具有注射针5的针组件B和固定到注射针5的近端的针座6 并且连接到连接部分11，在注射筒中液密地且可滑动地设置的垫圈2，连接到垫圈2的近端的柱塞3和设置在垫圈2的远端部分处的接合装置21或柱塞3和设置在针座6的近端部分处的接合装置61，其中防止接合装置21和接合装置61在使用前意外接合的接合防止装置90，并且允许接合装置在使用中提供。

4. 发明授权

US07998120B2 Prefilled syringe and production method for a barrel thereof 有权
标题翻译：预充注射器及其桶的生产方法
公开(公告)号：US07998120B2
公开(公告)日：2011-08-16
申请号：US10762530
申请日：2004-01-23
申请人： Minoru Sano , Yoshihisa Hama
发明人： Minoru Sano , Yoshihisa Hama
IPC分类号： A61M5/00 , A61M5/31
CPC分类号： B29C45/1603 , A61M5/3129 , B29C45/1642 , B29K2023/00 , B29K2023/086 , B29K2995/0067 , B29L2031/7544
摘要： A prefilled syringe composed of a barrel having a luer tip at one end and an open proximal end, the barrel having at least a three layer structure of an innermost layer, an outermost layer, both made of a polyolefin resin, and an intermediate layer made of a resin with a barrier property and sandwiched by the innermost layer and the outermost layer. The barrel is produced through the sequential steps of: (a) injecting a specific amount of a polyolefin resin inside a cavity; (b) injecting a specific amount of a resin excelling in barrier property; (c) injecting a specific amount of the polyolefin resin again; and (d) separating the luer tip surface and an injection unit by pushing off a valve pin provided inside a valve gate or an inner nozzle of the injection unit, which injects the resin excelling in barrier property, toward the direction of the luer tip surface as desired.
摘要翻译：一种预充式注射器，由具有在一端的鲁棒末端和开放的近端的筒体组成，所述筒体具有至少三层结构的最内层，最外层，均由聚烯烃树脂制成，中间层由的具有阻挡性的树脂，并被最内层和最外层夹在中间。通过以下顺序生产桶：（a）在空腔内注入特定量的聚烯烃树脂; （b）注入特定量的阻隔性优异的树脂; （c）再次注入特定量的聚烯烃树脂; 以及（d）通过将设置在注射单元的阀门或注射单元的内部喷嘴内的阀销推向鲁尔末端面的方向，从而分离鲁尔末端面和注射单元如预期的。

5. 发明授权

US06326010B1 Plastic vessel containing an albumin preparation 有权
标题翻译：含有白蛋白制剂的塑料容器
公开(公告)号：US06326010B1
公开(公告)日：2001-12-04
申请号：US09695215
申请日：2000-10-25
申请人： Minoru Sano , Yoshihisa Hama , Toshiya Kai , Masakazu Mameta
发明人： Minoru Sano , Yoshihisa Hama , Toshiya Kai , Masakazu Mameta
IPC分类号： A61J105
摘要： To provide a plastic vessel containing an albumin preparation which completely restrains formation of thermally denatured albumin, a plastic molded member in a cylindrical shape is extruded in a molten state into opened dies, one end of which is closed in the dies, and a vessel is molded by blowing a compressed gas into the molded member in the dies or by bringing inner portions of the dies into a vacuum state. While the vessel is still disposed in the dies, an albumin preparation is introduced from an opening portion into an inner portion of the vessel and, therefore, the albumin preparation can be filled into the vessel in a sterilized state without being brought into contact with the atmosphere. Then, an opening portion of the vessel filled with the albumin preparation is hermetically sealed at an internal temperature of the opening portion of about 40 to 70° C. Thus formation of thermally denatured albumin can be completely restrained.
摘要翻译：为了提供一种含有完全抑制热变性白蛋白形成的白蛋白制剂的塑料容器，将具有圆筒形状的塑料成型体以熔融状态挤出成开模，其一端在模具中封闭，容器为通过将压缩气体吹入模具中的模制构件中或通过使模具的内部部分成为真空状态来模制。当容器仍然设置在模具中时，白蛋白制剂从开口部分引入容器的内部，因此白蛋白制剂可以在灭菌状态下填充到容器中而不与其接触大气层。然后，填充有白蛋白制剂的容器的开口部分在约40-70℃的开口部分的内部温度下气密密封。因此可以完全抑制热变性白蛋白的形成。

6. 发明授权

US09714455B2 Method for detecting nucleic acid amplification in sample and device therefor 有权
公开(公告)号：US09714455B2
公开(公告)日：2017-07-25
申请号：US13810954
申请日：2011-07-04
申请人： Kimikazu Sugiyama , Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
发明人： Kimikazu Sugiyama , Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
IPC分类号： C12Q1/68 , B01L7/00 , C12Q3/00 , G01N35/02 , G01N35/04 , G01N35/00
CPC分类号： C12Q3/00 , B01L7/52 , G01N35/0092 , G01N35/026 , G01N35/04
摘要： A device for detecting nucleic acid amplification in a sample, comprising: a loading unit (thermoregulation unit) which is provided with a plurality of holes for loading reaction containers and capable of arbitrarily controlling a measurement unit for measuring samples in the containers that are loaded in the holes. The loading unit and the measurement unit, which are placed opposite to each other, can be operated independently from each other. In a transfer operation, the operation speeds of the thermoregulation unit and measurement unit are controlled so that the sum of these speeds amounts to an arbitrary constant value.

7. 发明授权

US09440235B2 Genetic testing method and testing apparatus 有权
标题翻译：遗传检测方法及检测仪器
公开(公告)号：US09440235B2
公开(公告)日：2016-09-13
申请号：US13883612
申请日：2011-11-04
申请人： Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
发明人： Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
IPC分类号： B01L7/00 , C12Q1/68 , G01N35/00
CPC分类号： B01L7/52 , C12Q1/686 , G01N35/00623 , G01N2035/00346 , G01N2035/00366 , G01N2035/009
摘要： A genetic testing method and an apparatus therefor are provided, in which temperatures of a plurality of reaction tubes are independently controlled using a thermostat, a temperature detecting device, and a heating and cooling device provided on each of the reaction tubes, the reaction tubes each accommodate an amplification liquid and a component necessary for amplification, temperature is controlled at individual positions to hold the reaction tubes and at a predetermined temperature set at the individual positions according to an analysis and testing protocol predetermined at individual positions of the reaction tubes, a controlled temperature value is monitored in a reaction tube unit and a corrected value of controlled temperature is computed and stored on a reaction tube unit, a temperature of the reaction tube is controlled based on the computed value, and light emission of the amplification liquid accommodated in the reaction tube is measured.
摘要翻译：提供了一种基因检测方法及其装置，其中使用在每个反应管上设置的恒温器，温度检测装置和加热和冷却装置独立地控制多个反应管的温度，每个反应管适应放大液体和扩增所需的成分，根据在反应管的各个位置预先确定的分析和测试方案，在各个位置控制温度以保持反应管并在设定在各个位置的预定温度，受控的在反应管单元中监测温度值，并计算控制温度的校正值并将其存储在反应管单元上，基于计算值控制反应管的温度，并将容纳在该反应管中的扩增液的发光测量反应管。

8. 发明授权

US09211541B2 Nucleic acid amplification apparatus and nucleic acid analysis apparatus 有权
标题翻译：核酸扩增仪和核酸分析仪
公开(公告)号：US09211541B2
公开(公告)日：2015-12-15
申请号：US14123824
申请日：2012-05-31
申请人： Kohshi Maeda , Chie Sugiyama , Yoshiyuki Shoji , Masato Ishizawa , Minoru Sano
发明人： Kohshi Maeda , Chie Sugiyama , Yoshiyuki Shoji , Masato Ishizawa , Minoru Sano
IPC分类号： C12M3/00 , B01L7/00
CPC分类号： B01L7/52 , B01L2200/148 , B01L2300/024 , B01L2300/0829 , B01L2300/1822
摘要： According to a conventional technique, when a calibrated temperature measuring probe is used for correcting the temperature absolute values of individually temperature-controllable thermal control blocks, a temperature difference of a maximum of 0.5° C. remains between the thermal control blocks. According to the present invention, the melting temperature of a temperature calibration sample housed in a reaction vessel corresponding to each of the temperature control blocks is measured as a measured melting temperature. The measured melting temperature corresponding to each of the thermal control blocks and the reference melting temperature of the temperature calibration sample are compared, and the temperature absolute value of each of the thermal control blocks is corrected based on respective difference values.
摘要翻译：根据常规技术，当使用校准的温度测量探针来校正单独的温度可控热控制块的温度绝对值时，在热控制块之间保留最大值为0.5℃的温差。根据本发明，测量容纳在对应于每个温度控制块的反应容器中的温度校准样品的熔融温度作为测量的熔融温度。比较对应于每个热控制块的测量的熔化温度和温度校准样品的参考熔融温度，并且基于各自的差值来校正每个热控制块的温度绝对值。

9. 发明申请

US20110294131A1 ANALYZER, AND CONTROL METHOD FOR ROTATION OF DISC 审中-公开
标题翻译：分析仪和旋转盘的控制方法
公开(公告)号：US20110294131A1
公开(公告)日：2011-12-01
申请号：US13147106
申请日：2009-12-14
申请人： Kohshi Maeda , Takehiko Hosoiri , Minoru Sano , Masato Ishizawa
发明人： Kohshi Maeda , Takehiko Hosoiri , Minoru Sano , Masato Ishizawa
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N35/025
摘要： The present invention has an object to provide an automatic analyzer using a disc, which treats samples with different pretreatment times or samples with different measurement times requested at random with high throughput. The present invention relates to performing adjustment rotation, rotation returning to origin, and measurement rotation in specimen analysis using a disc having a plurality of sample positions on a circumference. The adjustment rotation is an operation for placing a desired sample position in a particular position for introducing a sample into the disc or discarding the sample. The rotation returning to origin is an operation for placing an origin of the disc in a particular position. The measurement rotation is an operation for rotating the disc at a predetermined speed for measuring a plurality of samples held by the disc.
摘要翻译：本发明的目的是提供一种使用盘的自动分析器，其以不同的预处理时间处理样品或以高生产量随机请求不同测量时间的样品。本发明涉及使用在圆周上具有多个样本位置的盘来进行样本分析中的调整旋转，原点返回和测量旋转。调整旋转是将期望的样品位置放置在用于将样品引入盘或者丢弃样品的特定位置的操作。返回到原点的旋转是将盘的原点放置在特定位置的操作。测量旋转是用于以预定速度旋转盘的操作，用于测量由盘保持的多个样本。

10. 发明申请

US20110256532A1 ANALYZER 有权
标题翻译：分析仪
公开(公告)号：US20110256532A1
公开(公告)日：2011-10-20
申请号：US13142154
申请日：2009-12-10
申请人： Minoru Sano , Masato Ishizawa , Shuhei Yamamoto
发明人： Minoru Sano , Masato Ishizawa , Shuhei Yamamoto
IPC分类号： C12Q1/68 , C12M1/38 , C12M1/34
CPC分类号： C12Q1/68 , B01L7/52 , G01N21/0332 , G01N21/645 , G01N21/6452 , G01N35/025 , G01N2035/00366
摘要： An object of the present invention relates to providing a nucleic acid analyzer capable of testing a plurality of test items in parallel, and of obtaining high efficiency of specimen processing even if the test item or a measuring object is changed. The present invention relates to an analyzer including a carousel rotatable about a rotation axis, a plurality of reaction containers held along a circumferential edge of the carousel, and at least one detector having a light source for irradiating the reaction container with excitation light and a detection element for detecting fluorescence from a reaction liquid in the reaction container. The detector is removable. By attaching a desired detector, it is possible to perform fluorescence measurement in response to the test item. According to the present invention, it is possible to test a plurality of test items in parallel, and even if the test item or the measuring object is changed, the high efficiency of specimen processing can be obtained.
摘要翻译：本发明的目的是提供一种能够并行地测试多个测试项目的核酸分析仪，并且即使测试项目或测量对象改变也能获得高效率的样本处理。本发明涉及一种分析仪，其包括可围绕旋转轴线旋转的圆盘传送带，沿圆盘传送带的圆周边缘保持的多个反应容器，以及至少一个检测器，具有用于向反应容器照射激发光和检测的光源用于检测来自反应容器中的反应液体的荧光的元件。检测器是可拆卸的。通过附加所需的检测器，可以响应于测试项目执行荧光测量。根据本发明，可以并行地进行多个测试项目的测试，即使测试项目或测量对象发生变化，也能够获得高效的样本处理。

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