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1. 发明申请

US20140093947A1 NUCLEIC ACID AMPLIFICATION APPARATUS AND NUCLEIC ACID ANALYSIS APPARATUS 有权
标题翻译：核酸扩增装置和核酸分析装置
公开(公告)号：US20140093947A1
公开(公告)日：2014-04-03
申请号：US14123824
申请日：2012-05-31
申请人： Kohshi Maeda , Chie Sugiyama , Yoshiyuki Shoji , Masato Ishizawa , Minoru Sano
发明人： Kohshi Maeda , Chie Sugiyama , Yoshiyuki Shoji , Masato Ishizawa , Minoru Sano
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L2200/148 , B01L2300/024 , B01L2300/0829 , B01L2300/1822
摘要： According to a conventional technique, when a calibrated temperature measuring probe is used for correcting the temperature absolute values of individually temperature-controllable thermal control blocks, a temperature difference of a maximum of 0.5° C. remains between the thermal control blocks. According to the present invention, the melting temperature of a temperature calibration sample housed in a reaction vessel corresponding to each of the temperature control blocks is measured as a measured melting temperature. The measured melting temperature corresponding to each of the thermal control blocks and the reference melting temperature of the temperature calibration sample are compared, and the temperature absolute value of each of the thermal control blocks is corrected based on respective difference values.
摘要翻译：根据常规技术，当使用校准的温度测量探针来校正单独的温度可控热控制块的温度绝对值时，在热控制块之间保留最大值为0.5℃的温差。根据本发明，测量容纳在对应于每个温度控制块的反应容器中的温度校准样品的熔融温度作为测量的熔融温度。比较对应于每个热控制块的测量的熔化温度和温度校准样品的参考熔融温度，并且基于各自的差值来校正每个热控制块的温度绝对值。

2. 发明授权

US09211541B2 Nucleic acid amplification apparatus and nucleic acid analysis apparatus 有权
标题翻译：核酸扩增仪和核酸分析仪
公开(公告)号：US09211541B2
公开(公告)日：2015-12-15
申请号：US14123824
申请日：2012-05-31
申请人： Kohshi Maeda , Chie Sugiyama , Yoshiyuki Shoji , Masato Ishizawa , Minoru Sano
发明人： Kohshi Maeda , Chie Sugiyama , Yoshiyuki Shoji , Masato Ishizawa , Minoru Sano
IPC分类号： C12M3/00 , B01L7/00
CPC分类号： B01L7/52 , B01L2200/148 , B01L2300/024 , B01L2300/0829 , B01L2300/1822
摘要： According to a conventional technique, when a calibrated temperature measuring probe is used for correcting the temperature absolute values of individually temperature-controllable thermal control blocks, a temperature difference of a maximum of 0.5° C. remains between the thermal control blocks. According to the present invention, the melting temperature of a temperature calibration sample housed in a reaction vessel corresponding to each of the temperature control blocks is measured as a measured melting temperature. The measured melting temperature corresponding to each of the thermal control blocks and the reference melting temperature of the temperature calibration sample are compared, and the temperature absolute value of each of the thermal control blocks is corrected based on respective difference values.
摘要翻译：根据常规技术，当使用校准的温度测量探针来校正单独的温度可控热控制块的温度绝对值时，在热控制块之间保留最大值为0.5℃的温差。根据本发明，测量容纳在对应于每个温度控制块的反应容器中的温度校准样品的熔融温度作为测量的熔融温度。比较对应于每个热控制块的测量的熔化温度和温度校准样品的参考熔融温度，并且基于各自的差值来校正每个热控制块的温度绝对值。

3. 发明授权

US08574891B2 Nucleic acid analyzer, automatic analyzer, and analysis method 有权
标题翻译：核酸分析仪，自动分析仪和分析方法
公开(公告)号：US08574891B2
公开(公告)日：2013-11-05
申请号：US13000579
申请日：2009-06-17
申请人： Kohshi Maeda , Masato Ishizawa , Minoru Sano , Hironori Kaji
发明人： Kohshi Maeda , Masato Ishizawa , Minoru Sano , Hironori Kaji
IPC分类号： C12M1/34 , C12M3/00 , C12M1/00 , C12Q1/68 , G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： G01N35/025 , G01N2035/0463 , G01N2035/103
摘要： This invention relates to a nucleic acid analyzer comprising: reaction containers capable of containing nucleic-acid-containing samples and reagents; an incubation mechanism capable of controlling temperatures of reaction containers set at different levels; an analysis mechanism for analyzing the samples contained in the reaction containers; and a transport mechanism for transporting a reaction container. In accordance with the assay technique to be performed on a nucleic-acid-containing sample, the transport mechanism transports a reaction container to a given incubation mechanism in a given order. The reaction container subjected to the process of sample preparation is transported to the analysis mechanism at a given time and the sample is analyzed.
摘要翻译：本发明涉及一种核酸分析仪，其包括：能够含有含有核酸的样品和试剂的反应容器; 能够控制设置在不同水平的反应容器的温度的孵育机构; 用于分析包含在反应容器中的样品的分析机构; 以及用于输送反应容器的输送机构。根据对含核酸样品进行的测定技术，转运机制以给定的顺序将反应容器输送到给定的培养机制。将经过样品制备过程的反应容器在给定时间运送到分析机构，并分析样品。

4. 发明申请

US20110294131A1 ANALYZER, AND CONTROL METHOD FOR ROTATION OF DISC 审中-公开
标题翻译：分析仪和旋转盘的控制方法
公开(公告)号：US20110294131A1
公开(公告)日：2011-12-01
申请号：US13147106
申请日：2009-12-14
申请人： Kohshi Maeda , Takehiko Hosoiri , Minoru Sano , Masato Ishizawa
发明人： Kohshi Maeda , Takehiko Hosoiri , Minoru Sano , Masato Ishizawa
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N35/025
摘要： The present invention has an object to provide an automatic analyzer using a disc, which treats samples with different pretreatment times or samples with different measurement times requested at random with high throughput. The present invention relates to performing adjustment rotation, rotation returning to origin, and measurement rotation in specimen analysis using a disc having a plurality of sample positions on a circumference. The adjustment rotation is an operation for placing a desired sample position in a particular position for introducing a sample into the disc or discarding the sample. The rotation returning to origin is an operation for placing an origin of the disc in a particular position. The measurement rotation is an operation for rotating the disc at a predetermined speed for measuring a plurality of samples held by the disc.
摘要翻译：本发明的目的是提供一种使用盘的自动分析器，其以不同的预处理时间处理样品或以高生产量随机请求不同测量时间的样品。本发明涉及使用在圆周上具有多个样本位置的盘来进行样本分析中的调整旋转，原点返回和测量旋转。调整旋转是将期望的样品位置放置在用于将样品引入盘或者丢弃样品的特定位置的操作。返回到原点的旋转是将盘的原点放置在特定位置的操作。测量旋转是用于以预定速度旋转盘的操作，用于测量由盘保持的多个样本。

5. 发明授权

US10512915B2 Nucleic acid amplifier and nucleic acid inspection device employing the same 有权
公开(公告)号：US10512915B2
公开(公告)日：2019-12-24
申请号：US13696444
申请日：2011-04-28
申请人： Minoru Sano , Yoshiyuki Shoji , Masato Ishizawa , Kimikazu Sugiyama
发明人： Minoru Sano , Yoshiyuki Shoji , Masato Ishizawa , Kimikazu Sugiyama
IPC分类号： B01L7/00
摘要： A nucleic acid amplifier comprises a holder 3 which is provided with a plurality of temperature control blocks 10 each designed to hold at least one reaction vessel 105 storing a reaction solution. The temperature of the reaction solution in each reaction vessel 105 is controlled individually by using temperature control devices 14 and 15 arranged in each of the temperature control blocks 10. The temperature that is set in each temperature control block 10 and the timing for temperature changes are controlled independently of the temperatures of other temperature control blocks 10. This configuration makes it possible to provide a nucleic acid amplifier and a nucleic acid inspection device (employing the nucleic acid amplifier) capable of processing multiple types of samples differing in the protocol in parallel (parallel processing) and starting a process for a different sample even when there is a process in execution.

6. 发明申请

US20130224753A1 GENETIC TESTING METHOD AND TESTING APPARATUS 有权
标题翻译：遗传测试方法和测试装置
公开(公告)号：US20130224753A1
公开(公告)日：2013-08-29
申请号：US13883612
申请日：2011-11-04
申请人： Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
发明人： Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , C12Q1/686 , G01N35/00623 , G01N2035/00346 , G01N2035/00366 , G01N2035/009
摘要： A genetic testing method and an apparatus therefor are provided, in which temperatures of a plurality of reaction tubes are independently controlled using a thermostat, a temperature detecting device, and a heating and cooling device provided on each of the reaction tubes, the reaction tubes each accommodate an amplification liquid and a component necessary for amplification, temperature is controlled at individual positions to hold the reaction tubes and at a predetermined temperature set at the individual positions according to an analysis and testing protocol predetermined at individual positions of the reaction tubes, a controlled temperature value is monitored in a reaction tube unit and a corrected value of controlled temperature is computed and stored on a reaction tube unit, a temperature of the reaction tube is controlled based on the computed value, and light emission of the amplification liquid accommodated in the reaction tube is measured.
摘要翻译：提供了一种基因检测方法及其装置，其中使用在每个反应管上设置的恒温器，温度检测装置和加热和冷却装置独立地控制多个反应管的温度，每个反应管适应放大液体和扩增所需的成分，根据在反应管的各个位置预先确定的分析和测试方案，在各个位置控制温度以保持反应管并在设定在各个位置的预定温度，受控的在反应管单元中监测温度值，并计算控制温度的校正值并将其存储在反应管单元上，基于计算值控制反应管的温度，并将容纳在该反应管中的扩增液的发光测量反应管。

7. 发明申请

US20130130229A1 Method for Detecting Nucleic Acid Amplification in Sample and Device Therefor 有权
标题翻译：检测样品及其装置中核酸扩增的方法
公开(公告)号：US20130130229A1
公开(公告)日：2013-05-23
申请号：US13810954
申请日：2011-07-04
申请人： Kimikazu Sugiyama , Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
发明人： Kimikazu Sugiyama , Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
IPC分类号： C12Q3/00
CPC分类号： C12Q3/00 , B01L7/52 , G01N35/0092 , G01N35/026 , G01N35/04
摘要： A device for detecting nucleic acid amplification in a sample, comprising: a loading unit (thermoregulation unit) which is provided with a plurality of holes for loading reaction containers and capable of arbitrarily controlling a measurement unit for measuring samples in the containers that are loaded in the holes. The loading unit and the measurement unit, which are placed opposite to each other, can be operated independently from each other. In a transfer operation, the operation speeds of the thermoregulation unit and measurement unit are controlled so that the sum of these speeds amounts to an arbitrary constant value.
摘要翻译：一种用于检测样品中核酸扩增的装置，包括：加载单元（温度调节单元），其设置有用于装载反应容器的多个孔，并且能够任意地控制用于测量装载在容器中的样品的测量单元孔。彼此相对放置的装载单元和测量单元可以彼此独立地操作。在传送操作中，控制温度调节单元和测量单元的操作速度，使得这些速度之和等于任意的常数值。

8. 发明申请

US20130078712A1 Nucleic Acid Amplifier and Nucleic Acid Inspection Device Employing the Same 审中-公开
标题翻译：使用它的核酸放大器和核酸检测装置
公开(公告)号：US20130078712A1
公开(公告)日：2013-03-28
申请号：US13696444
申请日：2011-04-28
申请人： Minoru Sano , Yoshiyuki Shoji , Masato Ishizawa , Kimikazu Sugiyama
发明人： Minoru Sano , Yoshiyuki Shoji , Masato Ishizawa , Kimikazu Sugiyama
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L3/5082 , B01L7/525 , B01L7/5255 , B01L2300/1822 , G01N35/025 , G01N2035/00366
摘要： A nucleic acid amplifier comprises a holder 3 which is provided with a plurality of temperature control blocks 10 each designed to hold at least one reaction vessel 105 storing a reaction solution. The temperature of the reaction solution in each reaction vessel 105 is controlled individually by using temperature control devices 14 and 15 arranged in each of the temperature control blocks 10. The temperature that is set in each temperature control block 10 and the timing for temperature changes are controlled independently of the temperatures of other temperature control blocks 10. This configuration makes it possible to provide a nucleic acid amplifier and a nucleic acid inspection device (employing the nucleic acid amplifier) capable of processing multiple types of samples differing in the protocol in parallel (parallel processing) and starting a process for a different sample even when there is a process in execution.
摘要翻译：核酸放大器包括具有多个温度控制块10的保持器3，每个温度控制块被设计成保持至少一个存储反应溶液的反应容器105。通过使用布置在每个温度控制块10中的温度控制装置14和15，分别控制每个反应容器105中的反应溶液的温度。每个温度控制块10中设置的温度和温度变化的时间是独立于其它温度控制块10的温度进行控制。这种配置使得可以提供能够并行处理方案不同的多种类型样品的核酸放大器和核酸检查装置（使用核酸放大器）并行处理），并且即使在执行过程中也启动不同样本的处理。

9. 发明授权

US09714455B2 Method for detecting nucleic acid amplification in sample and device therefor 有权
公开(公告)号：US09714455B2
公开(公告)日：2017-07-25
申请号：US13810954
申请日：2011-07-04
申请人： Kimikazu Sugiyama , Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
发明人： Kimikazu Sugiyama , Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
IPC分类号： C12Q1/68 , B01L7/00 , C12Q3/00 , G01N35/02 , G01N35/04 , G01N35/00
CPC分类号： C12Q3/00 , B01L7/52 , G01N35/0092 , G01N35/026 , G01N35/04
摘要： A device for detecting nucleic acid amplification in a sample, comprising: a loading unit (thermoregulation unit) which is provided with a plurality of holes for loading reaction containers and capable of arbitrarily controlling a measurement unit for measuring samples in the containers that are loaded in the holes. The loading unit and the measurement unit, which are placed opposite to each other, can be operated independently from each other. In a transfer operation, the operation speeds of the thermoregulation unit and measurement unit are controlled so that the sum of these speeds amounts to an arbitrary constant value.

10. 发明授权

US09440235B2 Genetic testing method and testing apparatus 有权
标题翻译：遗传检测方法及检测仪器
公开(公告)号：US09440235B2
公开(公告)日：2016-09-13
申请号：US13883612
申请日：2011-11-04
申请人： Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
发明人： Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
IPC分类号： B01L7/00 , C12Q1/68 , G01N35/00
CPC分类号： B01L7/52 , C12Q1/686 , G01N35/00623 , G01N2035/00346 , G01N2035/00366 , G01N2035/009
摘要： A genetic testing method and an apparatus therefor are provided, in which temperatures of a plurality of reaction tubes are independently controlled using a thermostat, a temperature detecting device, and a heating and cooling device provided on each of the reaction tubes, the reaction tubes each accommodate an amplification liquid and a component necessary for amplification, temperature is controlled at individual positions to hold the reaction tubes and at a predetermined temperature set at the individual positions according to an analysis and testing protocol predetermined at individual positions of the reaction tubes, a controlled temperature value is monitored in a reaction tube unit and a corrected value of controlled temperature is computed and stored on a reaction tube unit, a temperature of the reaction tube is controlled based on the computed value, and light emission of the amplification liquid accommodated in the reaction tube is measured.
摘要翻译：提供了一种基因检测方法及其装置，其中使用在每个反应管上设置的恒温器，温度检测装置和加热和冷却装置独立地控制多个反应管的温度，每个反应管适应放大液体和扩增所需的成分，根据在反应管的各个位置预先确定的分析和测试方案，在各个位置控制温度以保持反应管并在设定在各个位置的预定温度，受控的在反应管单元中监测温度值，并计算控制温度的校正值并将其存储在反应管单元上，基于计算值控制反应管的温度，并将容纳在该反应管中的扩增液的发光测量反应管。

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