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1. 发明专利

JP2004233105A Dna micro array manufacturing method 有权
公开(公告)号：JP2004233105A
公开(公告)日：2004-08-19
申请号：JP2003019434
申请日：2003-01-28
申请人： Micro Diagnostic Kk , Shinya Watanabe , マイクロダイアグノスティック株式会社 , 慎哉渡辺
发明人： WATANABE SHINYA , IMAI JUNICHI
IPC分类号： G01N33/53 , C12N15/09 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a DNA micro array manufacturing method for detecting the gene expression level of an DNA micro array with high efficiency.
SOLUTION: In the DNA micro array manufacturing method in which DNA is immobilized in a plurality of spots on a surface of a support, and subjected to chemical modification by using succinic anhydride solution, the mixed solution with succinic anhydride dissolved therein is formed by mixing aprotic polar solvent of 0.1-75 part by volume and alcohol of 0-90 part by volume in solution of succinic anhydride solution of 100 part by volume with succinic anhydride dissolved in succinic anhydride dissolving solvent. The aprotic polar solvent is preferably DMSO, and, more preferably, mixed solvent with methanol added thereto.
COPYRIGHT: (C)2004,JPO&NCIPI

2. 发明专利

AU5668801A Method of constructing polynucleotide microarray, apparatus for the constructionand polynucleotide microarray 未知
公开(公告)号：AU5668801A
公开(公告)日：2001-11-20
申请号：AU5668801
申请日：2001-05-10
申请人： KYOWA HAKKO KOGYO KK , NIPPON LASER AND ELECTRONICS L , SHINYA WATANABE
发明人： WATANABE SHINYA
IPC分类号： B01J19/00 , C07H21/00 , C07H21/04 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N33/52 , G01N33/543 , G01N33/53 , G01N33/566
摘要： An object of the present invention is to provide a method for preparing a polynucleotide microarray which enables fixation of a sufficient amount of polynucleotides onto the support and can provide signals having uniform and sufficient intensity within a spot area, even when the polynucleotides are synthetic oligo polynucleotides which have a short chain length and are known to be difficult to be fixed by electrostatic binding. The present invention provides a method for preparing a polynucleotide microarray, wherein a solution for dissolving polynucleotides which is used to fix the polynucleotides onto a support contains substantially no anionic electrolyte, and is a solution of water or mixture of water and an organic solvent; and when the solution is a mixture of water and an organic solvent, the content of the organic solvent in the solution is less than 50 volume %.

3. 发明专利

JP2003125751A SLIDE GLASS HYBRIDIZATION CHAMBER 审中-公开
公开(公告)号：JP2003125751A
公开(公告)日：2003-05-07
申请号：JP2001323412
申请日：2001-10-22
申请人： WATANABE SHINYA , MICRO DIAGNOSTIC KK
发明人： WATANABE SHINYA
IPC分类号： G01N33/53 , B01L3/00 , B24B7/24 , C12M1/00 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a slide glass hybridization chamber excellent in thermal homogeneity, having high airtightness and easy to handle. SOLUTION: This slide glass hybridization chamber composed of aluminum comprises a lower chamber 100 which has a ditch 2 for storage of the slide glass for hybridization chamber and an elastic packing 8 inserted into a ditch 6 for fixing the packing formed along the outer periphery of the slide glass storage ditch, and an upper lid 110 having a stopper fixing ditch 14 formed along its periphery on the upper side.

4. 发明专利

JP2002065259A METHOD FOR LABELING NUCLEIC ACID AND KIT THEREFOR 失效
公开(公告)号：JP2002065259A
公开(公告)日：2002-03-05
申请号：JP2000254172
申请日：2000-08-24
申请人： WATANABE SHINYA , MICRO DIAGNOSTIC KK , NIPPON GENE CO LTD
发明人： WATANABE SHINYA , IMAI JUNICHI , HONGO KUNIHIRO
IPC分类号： G01N33/50 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/532 , G01N33/58 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a method for labeling a nucleic acid, enabling the intake efficiency of a labeling substance into a 1st chain cDNA to be significantly improved in synthesizing the 1st chain cDNA from mRNA by reverse transcriptase reaction, and to provide a kit to be used for the method. SOLUTION: This method for labeling a nucleic acid comprises the following practice: in synthesizing a 1st chain cDNA from a specified mRNA by reverse transcriptase reaction in a solution containing deoxyribonucleotide triphosphate as the substrate, a primer is used; wherein the primer is such that a labeling substance consisting of a sequence of plural unit labeling substance molecules is previously bound to the 5' end of a random nucleotide oligomer composed of four kinds of nucleotides and having a length corresponding to 4-45 nucleotides.

5. 发明专利

JP2012075341A Marker for detecting gastrointestinal stromal tumor 审中-公开
标题翻译：用于检测胃肠道结构肿瘤的标记
公开(公告)号：JP2012075341A
公开(公告)日：2012-04-19
申请号：JP2010220877
申请日：2010-09-30
申请人： Shinya Watanabe , 慎哉渡邉
发明人： WATANABE SHINYA , ITO EMI , IMAI JUNICHI , IWADATE MANABU , FUJITA TEIZO , SAKAI YUKA
IPC分类号： C12N15/09 , A61K31/7088 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/47 , C12Q1/68 , G01N33/53 , G01N33/574 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a marker for detecting GIST (gastrointestinal stromal tumor), to provide a method for detecting or diagnosing the GIST using the marker, and to further provide a kit for detecting or diagnosing the GIST.SOLUTION: Cathepsin L1 gene having a low expression level in gastric cancer or a normal tissue of the stomach, on the other hand, raising the expression level in the GIST and a polypeptide encoded by the gene are used as the marker for detecting the GIST. The marker for detecting the GIST can be detected, and the detection or diagnosis of the GIST can quickly and surely be carried out by using a detecting probe for the GIST marker gene and an antibody against the polypeptide encoded by the gene.
摘要翻译：要解决的问题：提供用于检测GIST（胃肠道间质瘤）的标记物，提供使用标记物检测或诊断GIST的方法，并进一步提供用于检测或诊断GIST的试剂盒。解决方案：另一方面，在胃癌或胃正常组织中具有低表达水平的组织蛋白酶L1基因，提高GIST中的表达水平和由该基因编码的多肽被用作检测的标记物 GIST。可以检测GIST的检测标记，通过使用GIST标记基因的检测探针和针对该基因编码的多肽的抗体，可以快速，可靠地进行GIST的检测或诊断。版权所有（C）2012，JPO＆INPIT

6. 发明专利

JP2007078634A Electromagnetic field distribution simulation device and method 有权
标题翻译：电磁场分布仿真器件及方法
公开(公告)号：JP2007078634A
公开(公告)日：2007-03-29
申请号：JP2005270287
申请日：2005-09-16
申请人： Daiwa Can Co Ltd , Osamu Hashimoto , Shinya Watanabe , 大和製罐株式会社 , 橋本修 , 慎也渡邊
发明人： HASHIMOTO OSAMU , WATANABE SHINYA , TAKATOMI TETSUYA , IJUIN TAICHI , NAKAMURA KOJI
IPC分类号： G01R29/08 , G06F17/11 , G06F19/00
摘要： PROBLEM TO BE SOLVED: To simulate electromagnetic field distribution in an environment accompanied by lost dielectric or lost magnetic substance at high accuracy and low calculation cost. SOLUTION: A parameter such as a boundary condition is input by an input section 11. An electromagnetic field equation is divided into an advective term and a non-advective term and is processed by applying a segregation-by-time method. A CIP method and characteristic curve method are applied to the advective term of the electromagnetic field equation and numerical solution of the mean value of time variation is obtained by an advective term processing section 13. A non-advective term processing section 14 substitutes the numerical solution of the advective term processing section 13 for a discrete equation of a secondary central difference method, and obtains numerical solution advanced by one time step. The time step is repeated until it becomes a desired time. When it becomes the desired time, a numerical analysis result is displayed or printed using an output section 15. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：在高精度和低计算成本的情况下模拟伴有电介质或磁性物质损失的环境中的电磁场分布。解决方案：诸如边界条件的参数由输入部分11输入。电磁场方程被分为平流项和非平流项，并且通过应用隔离方法进行处理。电磁场方程的平流项应用CIP方法和特征曲线法，平流项处理部分13获得时间变化平均值的数值解。非平流项处理部分14代替数值解对于二次中心差分方法的离散方程的平流项处理部分13，并获得一次提前的数值解。重复时间步骤，直到它变成期望的时间。当成为期望的时间时，使用输出部分15显示或打印数字分析结果。版权所有：（C）2007，JPO＆INPIT

7. 发明专利

JP2004074759A Super calendar 审中-公开
标题翻译：超级日历
公开(公告)号：JP2004074759A
公开(公告)日：2004-03-11
申请号：JP2002280045
申请日：2002-08-21
申请人： Watanabe Harumi , Watanabe Jiyuri , Watanabe Naho , Shinya Watanabe , Watanabe Taro , 渡辺太朗 , 渡辺奈帆 , 渡辺晴美 , 渡辺樹里 , 渡辺眞也
发明人： WATANABE SHINYA
IPC分类号： B42D5/04
摘要： PROBLEM TO BE SOLVED: To provide a calendar which gives width to the time axis in a calendar in addition to the relevant month, enabling a plurality of dates in a plurality of months to be confirmed in a moment.
SOLUTION: In this calendar, display columns of months and dates other than the relevant month are provided in margins for the display columns of the calendar month and days.
COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：为了提供除了相关月份之外的在日历中给出时间轴的宽度的日历，使得能够在一段时间内确认多个月的多个日期。
解决方案：在该日历中，显示相关月份以外的月份和日期列，以日历月份和日期的显示列的边距提供。版权所有（C）2004，JPO

8. 发明专利

JP2012085555A Marker for diagnosing breast cancer 审中-公开
标题翻译：用于诊断乳腺癌的标记
公开(公告)号：JP2012085555A
公开(公告)日：2012-05-10
申请号：JP2010233482
申请日：2010-10-18
申请人： Shinya Watanabe , 慎哉渡邉
发明人： WATANABE SHINYA , ITO EMI , IMAI JUNICHI , OTAKE TORU , FUJITA TEIZO , SAKAI YUKA
IPC分类号： C12N15/09 , C12Q1/68 , G01N33/574 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a marker for detecting triple negative breast cancer; to provide a method for detecting or diagnosing the triple negative breast cancer with the marker; and to provide a kit for detecting or diagnosing the triple negative breast cancer.SOLUTION: MMP7 gene which is low in expression level in Luminal A, Luminal B and HER2 diseases among the sub-types of breast cancer, and rises the expression level in the triple negative breast cancer on the other hand, and a polypeptide encoded by the gene are used as markers for detecting the triple negative breast cancer. A probe for detecting the triple negative breast cancer marker gene and an antibody for the polypeptide encoded by the gene are used. Thus, the marker for detecting the triple negative breast cancer can be detected, and the triple negative breast cancer can quickly and surely be detected or diagnosed.
摘要翻译：要解决的问题：提供检测三阴性乳腺癌的标记物; 提供用该标记检测或诊断三阴性乳腺癌的方法; 并提供用于检测或诊断三阴性乳腺癌的试剂盒。解决方案：在乳腺癌亚型中Luminal A，Luminal B和HER2疾病的表达水平低的MMP7基因和三阴性乳腺癌的表达水平升高，另一方面，多肽由该基因编码用作检测三阴性乳腺癌的标记物。使用检测三阴性乳腺癌标记基因的探针和由该基因编码的多肽的抗体。因此，可以检测出三重阴性乳腺癌的检测标记，能够快速，可靠地检测或诊断三阴性乳腺癌。版权所有（C）2012，JPO＆INPIT

9. 发明专利

JP2007080177A Temperature distribution simulation device and method 有权
标题翻译：温度分布模拟装置及方法
公开(公告)号：JP2007080177A
公开(公告)日：2007-03-29
申请号：JP2005270288
申请日：2005-09-16
申请人： Daiwa Can Co Ltd , Osamu Hashimoto , Shinya Watanabe , 大和製罐株式会社 , 橋本修 , 慎也渡邊
发明人： HASHIMOTO OSAMU , WATANABE SHINYA , TAKATOMI TETSUYA , IJUIN TAICHI , NAKAMURA KOJI
IPC分类号： G06F17/50
摘要： PROBLEM TO BE SOLVED: To simulate a radio wave absorber and the temperature distribution of its periphery by taking into consideration heat radiation. SOLUTION: An FDTD method processing part 13 calculates the absorption electric power distribution per unit volume in a steady state of an electromagnetic field by using an FDTD method. Next, an MR method processing part 14 determines a self-absorption rate αs of the heat radiation and a rate (a READ value) Rd of absorbing from the other wall surface element by using a Monte Carlo read method. A SIMPLE method processing part 15 also determines an analytical value of a speed field and a pressure field by continuously solving an equation of continuity and an equation of motion by using a SIMPLE method. Radiation energy and absorption energy in the respective wall surface elements are finally calculated by using the αs and the Rd determined by a Monte Carlo read method. These energy quantity is substituted in an equation of energy together with absorption electric power provided by the FDTD method, and an analytical value of a temperature field is determined. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：通过考虑热辐射来模拟无线电波吸收体及其周边的温度分布。解决方案：FDTD方法处理部分13通过使用FDTD方法计算电磁场的稳定状态下的每单位体积的吸收功率分布。接下来，MR方法处理部分14通过使用蒙特卡罗读取方法确定热辐射的自吸收率αs和从另一壁表面元件吸收的速率（READ值）Rd。 SIMPLE方法处理部分15还通过使用SIMPLE方法连续求解连续性方程和运动方程式来确定速度场和压力场的分析值。最终通过使用通过蒙特卡洛读取方法确定的αs和Rd来计算相应壁表面元件中的辐射能和吸收能。这些能量在能量方程式中与FDTD方法提供的吸收电力代替，并且确定温度场的分析值。版权所有（C）2007，JPO＆INPIT

10. 发明专利

JP2012088221A Diagnosis method of gist 审中-公开
标题翻译： GIST诊断方法
公开(公告)号：JP2012088221A
公开(公告)日：2012-05-10
申请号：JP2010236257
申请日：2010-10-21
申请人： Shinya Watanabe , 慎哉渡邉
发明人： WATANABE SHINYA , ITO EMI , IMAI JUNICHI , IWADATE MANABU , FUJITA TEIZO , SAKAI YUKA
IPC分类号： G01N33/53 , A61K39/395 , A61P35/00 , C07K14/705 , C07K16/28 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a marker for detecting a Gastrointestinal stromal tumor (GIST), a method for detecting or diagnosing the GIST by using the marker, and a kit for detecting or diagnosing the GIST.SOLUTION: In the method for detecting the GIST, an LY6H gene which has a low expression level in a gastric cancer and a gastric normal tissue, and on the other hand, a raised expression level in the GIST and a polypeptide encoded by the LY6H gene are used as a marker for detection. By using a probe for detecting the marker gene and an antibody against the polypeptide encoded by the marker gene, the detection or diagnosis of the GIST is conducted rapidly and reliably.
摘要翻译：要解决的问题：提供用于检测胃肠道间质瘤（GIST）的标记物，通过使用标记物检测或诊断GIST的方法，以及用于检测或诊断GIST的试剂盒。解决方案：在检测GIST的方法中，在胃癌和胃正常组织中具有低表达水平的LY6H基因，另一方面，GIST中提高的表达水平和由 LY6H基因用作检测标记。通过使用用于检测标记基因的探针和针对由标记基因编码的多肽的抗体，快速且可靠地进行GIST的检测或诊断。版权所有（C）2012，JPO＆INPIT

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