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1. 发明授权

US5962438A Estrogen derivative having carriers to bone 失效
标题翻译：雌激素衍生物具有载体至骨
公开(公告)号：US5962438A
公开(公告)日：1999-10-05
申请号：US945124
申请日：1997-10-17
申请人： Michihiro Yamamoto , Akira Sasaki , Takashi Katsumata , Naomi Tsushima , Hideyuki Harada
发明人： Michihiro Yamamoto , Akira Sasaki , Takashi Katsumata , Naomi Tsushima , Hideyuki Harada
IPC分类号： C07F9/38 , A61K31/675 , A61K31/66 , A61K31/665 , C07F9/6541
CPC分类号： C07F9/3869
摘要： A novel estrogen derivative represented by the formula: ##STR1## is useful for treating or preventing diseases caused by estrogen deficiency.
摘要翻译： PCT No.PCT / JP96 / 01054 Sec。 371日期1997年10月17日第 102（e）日期1997年10月17日PCT 1996年4月18日PCT PCT。出版物WO96 / 33158 日期1996年10月24日由式表示的新型雌激素衍生物可用于治疗或预防由雌激素缺乏引起的疾病。

2. 发明授权

US4618617A Novel 5-substituted 1,2,4,-oxadiazole derivatives and preparation thereof 失效
标题翻译：新型5-取代的1,2,4-恶二唑衍生物及其制备方法
公开(公告)号：US4618617A
公开(公告)日：1986-10-21
申请号：US469511
申请日：1983-02-24
申请人： Michihiro Yamamoto
发明人： Michihiro Yamamoto
IPC分类号： A61K31/44 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5377 , A61P25/04 , A61P29/00 , C07C259/12 , C07D271/06 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D471/04 , C07D491/04 , C07D491/044 , C07D491/052 , C07D521/00
CPC分类号： C07D271/06 , C07C259/12 , C07D231/12 , C07D233/56 , C07D249/08 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D471/04 , C07D491/04
摘要： This disclosure describes novel 5-substituted 1,2,4-oxadiazoles useful as pharmaceuticals such as anti-inflammatory and analgesic agents.
摘要翻译：本公开描述了用作药物如抗炎剂和止痛剂的新型5-取代的1,2,4-恶二唑。

3. 发明授权

US4079053A Benzodiazepine derivatives 失效
标题翻译：苯并二氮杂衍生物
公开(公告)号：US4079053A
公开(公告)日：1978-03-14
申请号：US710665
申请日：1976-08-02
申请人： Hisao Yamamoto , Shigeho Inaba , Toshiyuki Hirohashi , Michihiro Yamamoto , Kikuo Ishizumi , Mitsuhiro Akatsu , Isamu Maruyama , Kazuo Mori , Yoshiharu Kume , Takahiro Izumi
发明人： Hisao Yamamoto , Shigeho Inaba , Toshiyuki Hirohashi , Michihiro Yamamoto , Kikuo Ishizumi , Mitsuhiro Akatsu , Isamu Maruyama , Kazuo Mori , Yoshiharu Kume , Takahiro Izumi
IPC分类号： A61K31/55 , C07D243/24 , C07D401/04
CPC分类号： C07D243/24 , A61K31/55 , C07D243/26 , C07D243/28 , C07D243/30 , C07D243/36 , C07D401/04
摘要： Novel 1-substituted benzodiazepine derivatives and salt thereof having the formula, ##STR1## wherein R.sub.1 is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a lower alkoxy group or a trifluoromethyl group; R.sub.2 is a pyridyl group or a group of the formula ##STR2## wherein R.sub.5 and R.sub.6 represent individually a hydrogen atom, a halogen atom, a lower alkyl group or a trifluoromethyl group); R.sub.3 is a hydrogen atom or a lower alkyl group; R.sub.4 is a lower alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl group; m is 1 or 2; and n is an integer of 1 to 4, and a process for preparation thereof and pharmaceutical use of the same.The benzodiazepine derivatives are effective as tranquillizers, muscle-relaxants and hypnotics.
摘要翻译：新颖的1-取代苯并二氮杂衍生物及其盐，具有下式：其中R 1是氢原子，卤原子，硝基，氰基，低级烷氧基或三氟甲基; R2是吡啶基或式的基团，其中R5和R6分别表示氢原子，卤素原子，低级烷基或三氟甲基）。 R3是氢原子或低级烷基; R4是低级烷基，环烷基，环烷基烷基，芳基或芳烷基; m为1或2; n为1〜4的整数，其制备方法和药物用途。

4. 发明授权

US3953446A Process for preparing quinazolines 失效
标题翻译：制备喹唑啉的方法
公开(公告)号：US3953446A
公开(公告)日：1976-04-27
申请号：US494885
申请日：1974-08-05
申请人： Kikuo Ishizumi , Kazuo Mori , Michihiro Yamamoto , Masao Koshiba , Shigeho Inaba , Hisao Yamamoto
发明人： Kikuo Ishizumi , Kazuo Mori , Michihiro Yamamoto , Masao Koshiba , Shigeho Inaba , Hisao Yamamoto
IPC分类号： C07D239/82 , C07D209/10 , C07D209/42 , C07D401/06 , C07D405/06 , C07D409/06 , C07D405/04
CPC分类号： C07C247/00 , C07D209/42
摘要： Quinazoline derivatives which have anti-inflammatory, antiviral, uricosuric activities are prepared by reacting an indole-2-carbonylazide derivative with an oxidizing agent under mild conditions.
摘要翻译：具有抗炎，抗病毒，尿酸营养活性的喹唑啉衍生物通过在温和条件下使吲哚-2-羰基叠氮化物衍生物与氧化剂反应来制备。

5. 发明授权

US5066666A Aminoazole derivatives and their production and use 失效
标题翻译：氨基衍生物及其生产和使用
公开(公告)号：US5066666A
公开(公告)日：1991-11-19
申请号：US470731
申请日：1990-01-26
申请人： Yukinori Ozato , Nobuhiko Tamura , Hiroaki Masumori , Michihiro Yamamoto , Atsuyuki Kojima , Fumio Nishikaku , Yoshihiko Kimura
发明人： Yukinori Ozato , Nobuhiko Tamura , Hiroaki Masumori , Michihiro Yamamoto , Atsuyuki Kojima , Fumio Nishikaku , Yoshihiko Kimura
IPC分类号： A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/433 , A61P29/00 , A61P37/00 , A61P37/08 , C07D261/14 , C07D263/48 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/38 , C07D277/40 , C07D277/42 , C07D277/44 , C07D277/46 , C07D277/48 , C07D285/04 , C07D317/30 , C07D413/06 , C07D413/10 , C07D417/10
CPC分类号： C07D271/07 , C07D261/14 , C07D263/48 , C07D277/40 , C07D277/42 , C07D277/46 , C07D277/48 , C07D413/06 , C07D413/10
摘要： compound of the formula: ##STR1## wherein A is the group of the formula:Ar.sup.1 --D--Ar.sup.2 --wherein Ar.sup.1 is a phenyl or thienyl group which may be optionally substituted with at least one of the same or different halogen atom; Ar.sup.2 is a phenylene or thienylene group which may be optionally substituted with at least one of the same or different halogen atom; D is a divalent radical selected from the group consisting of >.dbd.N.dbd.OR.sup.4 [wherein R.sup.4 is a hydrogen atom or lower alkyl group], >C.dbd.O, ##STR2## >CHOH, >NH radical, or single bond, wherein R.sup.5 is a lower alkoxy or a phenyl group which may be optionally substituted with at least one of the same or different halogen atom; E is a methine group or a nitrogen atom; F is a vinylene group or an oxygen atom, ##STR3## wherein R.sup.6 is a lower alkoxy group; R.sup.7 is a lower alkyl group; R.sup.8 is a benzoyl group which may be optionally substituted with at least one of the same or different halogen atom,B is a divalent azole group;R.sup.1 is a hydrogen atom or a lower alkyl group;R.sup.2 is a hydrogen atom, lower alkyl aryl-lower alkyl, or the group of the formula:R.sup.9 --G-- wherein R.sup.9 is a hydrogen atom, lower alkyl, halo-lower alkyl, amino-lower alkyl, aryl or aryl-lower alkyl group or the group of the formula: ##STR4## wherein R.sup.10 is a hydrogen atom or lower alkyl group; R.sup.11 is a hydrogen atom, lower alkyl, lower alkenyl, lower cycloalkyl, aryl-lower alkyl, aryl or aroyl group; or the group of the formula: --NR.sup.10 R.sup.11 is a 5-, 6- or 7-membered saturated heterocyclic ring; or the group of the formula:R.sup.12 --O-- wherein R.sup.12 is a lower alkyl or polyhalo-lower alkyl group;G is a divalent group selected from the group consisting of >C.dbd.O, >C.dbd.S, >(C.dbd.O).sub.2 or >SO.sub.2 radical; or the group of the formula: --NR.sup.1 R.sup.2 is a 5-, 6- or 7-membered saturated heterocyclic ring:R.sup.3 is a hydrogen atom or lower alkyl group, or its acid addition salts, which is useful for immunomodulator.

6. 发明授权

US4387223A Process for preparing 2(1H)-quinazolinone derivatives 失效
标题翻译：制备2（1H） - 喹唑啉酮衍生物的方法
公开(公告)号：US4387223A
公开(公告)日：1983-06-07
申请号：US748145
申请日：1976-12-06
申请人： Michihiro Yamamoto , Shigenari Katayama , Masao Koshiba , Hisao Yamamoto
发明人： Michihiro Yamamoto , Shigenari Katayama , Masao Koshiba , Hisao Yamamoto
IPC分类号： C07D239/78 , C07D239/82 , C07D401/04 , C07D405/04 , C07D409/04 , C07D491/04 , C07D491/056 , C07D413/04 , C07D413/06
CPC分类号： C07D491/04 , C07D239/78 , C07D239/82
摘要： 2(1H)-Quinazolinone and quinazolinethione derivatives having excellent pharmacological activities are produced in high yield with high purity by heating the corresponding 3,4-dihydro-2(1H)-quinazolinone or quinazolinethione derivatives together with sulfur in an inert solvent.
摘要翻译：通过在惰性溶剂中与硫一起加热相应的3,4-二氢-2（1H） - 喹唑啉酮或喹唑啉硫酮衍生物，通过加热相应的3,4-二氢-2（1H） - 喹唑啉酮或喹唑啉硫酮衍生物，以高纯度产生具有优异药理活性的2（1H） - 喹唑啉酮和喹唑啉酮衍生物。

7. 发明授权

US4179560A Imidazo- and pyrimido[2,1-b]quinazolines and preparation thereof 失效
标题翻译：咪唑并嘧啶并[2,3-b]喹唑啉及其制备方法
公开(公告)号：US4179560A
公开(公告)日：1979-12-18
申请号：US553676
申请日：1975-02-27
申请人： Michihiro Yamamoto , Shigeaki Morooka , Masao Koshiba , Shigeho Inaba , Hisao Yamamoto
发明人： Michihiro Yamamoto , Shigeaki Morooka , Masao Koshiba , Shigeho Inaba , Hisao Yamamoto
IPC分类号： A61K31/505 , A61P7/10 , A61P9/12 , A61P25/24 , A61P25/26 , C07D487/04 , C07D491/147 , A61K31/395
CPC分类号： C07D487/04
摘要： Imidazo- and pyrimido[2,1-b]quinazolines of the formula, ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen, halogen, trifluoromethyl, nitro, C.sub.1-4 alkyl or C.sub.1-4 alkoxy, or R.sub.1 and R.sub.2 may together represent methylenedioxy; R.sub.3 is hydrogen, C.sub.1-4 alkyl, phenyl or substituted phenyl of the formula, ##STR2## (wherein R is halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy); R.sub.4 is hydrogen, C.sub.1-4 alkyl or aralkyl; and A is C.sub.2-3 alkylene wich may be optionally substituted by one or two C.sub.1-2 alkyl radicals, and pharmaceutically acceptable acid addition salts thereof, are prepared by reacting a compound of the formula, ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and A are as defined above; and X is oxygen or sulfur, with a halogenating agent at a temperature of about 30.degree. C. to about 180.degree. C. In the above imidaxo- and pyrimido[2,1-b]quinazolines, those having C.sub.1-4 alkyl, or ##STR4## as R.sub.3 are novel compounds and show antidepressant and/or antihypertensive activities.
摘要翻译：其中R 1和R 2独立地为氢，卤素，三氟甲基，硝基，C 1-4烷基或C 1-4烷氧基，或者R 1和R 2可以一起代表下式的咪唑并 - 嘧啶并[2,3-b]喹唑啉，亚甲二氧基; R 3是氢，C 1-4烷基，苯基或下式的取代的苯基，其中R是卤素，C 1-4烷基或C 1-4烷氧基; R4是氢，C1-4烷基或芳烷基; 并且A是可以任选被一个或两个C 1-2烷基取代的C 2-3亚烷基及其药学上可接受的酸加成盐，其通过使下式化合物，其中R1，R2，R3， R4和A如上所定义; 在上述酰胺基 - 和嘧啶并[2,1-b]喹唑啉中，具有C 1-4烷基的那些，或其中X是氧或硫，与卤化剂在约30℃至约180℃的温度下反应。作为R3是新化合物并显示抗抑郁药和/或抗高血压活性的图像。

8. 发明授权

US4002611A Preparation of benzodiazepines 失效
标题翻译：苯二氮卓类的制备
公开(公告)号：US4002611A
公开(公告)日：1977-01-11
申请号：US797663
申请日：1969-02-07
申请人： Hisao Yamamoto , Shigeho Inaba , Tadashi Okamoto , Toshiyuki Hirohashi , Kikuo Ishizumi , Michihiro Yamamoto , Isamu Maruyama , Kazuo Mori , Tsuyoshi Kobayashi
发明人： Hisao Yamamoto , Shigeho Inaba , Tadashi Okamoto , Toshiyuki Hirohashi , Kikuo Ishizumi , Michihiro Yamamoto , Isamu Maruyama , Kazuo Mori , Tsuyoshi Kobayashi
IPC分类号： C07D209/04 , C07D209/08 , C07D243/16
CPC分类号： C07D209/04 , C07D209/08
摘要： A 1-alkyl-1,2,4,5-tetrahydro-3H-1,4-benzodiazepine derivative is produced by contacting a 1-aminoethyl-indole derivative with a suitable oxidizing agent and then reducing the resulting 1-acyl-2,3-dihydro-1H-1,4-benzodiazepine derivative. The starting 1-aminoethyl-indole derivative is prepared by subjecting a 3-phenyl-indole derivative to cyanomethylation (or carbamoylemethylation) and then reducing the resulting 1-cyanomethyl- (or 1-carbamoylmethyl)-indole derivative. The 1-acyl-1,2,4,5-tetrahydro-3H-1,4-benzodiazepine derivative is useful as a tranquillizer, muscle-relaxant, etc.
摘要翻译： 1-烷基-1,2,4,5-四氢-3H-1,4-苯并二氮杂衍生物是通过使1-氨基乙基 - 吲哚衍生物与合适的氧化剂接触，然后将所得1-酰基-2 3-二氢-1H-1,4-苯并二氮杂衍生物。起始的1-氨基乙基 - 吲哚衍生物通过使3-苯基 - 吲哚衍生物进行氰甲基化（或氨甲酰甲基化）然后还原所得的1-氰基甲基 - （或1-氨基甲酰基甲基） - 吲哚衍生物来制备。 1-酰基-1,2,4,5-四氢-3H-1,4-苯并二氮杂衍生物可用作镇静剂，肌肉松弛剂等

9. 发明授权

US4914112A Aminoazole derivatives and their production and use 失效
标题翻译：氨基唑衍生物及其生产和使用
公开(公告)号：US4914112A
公开(公告)日：1990-04-03
申请号：US55079
申请日：1987-05-28
申请人： Yukinori Ozato , Nobuhiko Tamura , Hiroaki Masumori , Michihiro Yamamoto , Atsuyuki Kojima , Fumio Nishikaku , Yoshihiko Kimura
发明人： Yukinori Ozato , Nobuhiko Tamura , Hiroaki Masumori , Michihiro Yamamoto , Atsuyuki Kojima , Fumio Nishikaku , Yoshihiko Kimura
IPC分类号： A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/433 , A61P29/00 , A61P37/00 , A61P37/08 , C07D261/14 , C07D263/48 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/38 , C07D277/40 , C07D277/42 , C07D277/44 , C07D277/46 , C07D277/48 , C07D285/04 , C07D317/30 , C07D413/06 , C07D413/10 , C07D417/10
CPC分类号： C07D271/07 , C07D261/14 , C07D263/48 , C07D277/40 , C07D277/42 , C07D277/46 , C07D277/48 , C07D413/06 , C07D413/10
摘要： A compound of the formula: ##STR1## wherein A is the group of the formula:Ar.sup.1 --D--Ar.sup.2 --wherein Ar.sup.1 is a phenyl or thienyl group which may be optionally substituted with at least one of the same or different halogen atom; Ar.sup.2 is a phenylene or thienylene group which may be optionally substituted with at least one of the same or different halogen atom; D is a divalent radical selected from the group consisting of >C.dbd.N--OR.sup.4 [wherein R.sup.4 is a hydrogen atom or lower alkyl group], >C.dbd.O, ##STR2## >CHOH, >NH radical, or single bond, ##STR3## wherein R.sup.5 is a lower alkoxy or a phenyl group which may be optionally substituted with at least one of the same or different halogen atom; E is a methine group or a nitrogen atom; F is a vinylene group or an oxygen atom, ##STR4## wherein R.sup.6 is a lower alkoxy group; R.sup.7 is a lower alkyl group; R.sup.8 is a benzoyl group which may be optionally substituted with at least one of the same or different halogen atom, B is a divalent azole group; R.sup.1 is a hydrogen atom or a lower alkyl group; R.sup.2 is a hydrogen atom, lower alkyl, aryl-lower alkyl, or the group of the formula:R.sup.9 --G--wherein R.sup.9 is a hydrogen atom, lower alkyl, halo-lower alkyl, amino-lower alkyl, aryl or aryl-lower alkyl group or the group of the formula: ##STR5## wherein R.sup.10 is a hydrogen atom or lower alkoxy group; R.sup.11 is a hydrogen atom, lower alkyl, lower alkenyl, lower cycloalkyl, aryl-lower alkyl, aryl or aroyl group; or the group of the formula: --NR.sup.10 R.sup.11 is a 5-, 6- or 7-membered saturated heterocyclic ring; or the group of the formula:R.sup.12 --O--wherein R.sup.12 is a lower alkyl or polyhalo-lower alkyl group; G is a divalent group selected from the group consisting of >C.dbd.O, >C.dbd.S, >(C.dbd.O).sub.2 or >SO.sub.2 radical; or the group of the formula: --NR.sup.1 R.sup.2 is a 5-, 6- or 7-membered saturated heterocyclic ring: R.sup.3 is a hydrogen atom or lower alkyl group, or its acid addition salts, which is useful for immunomodulator.

10. 发明授权

US4680307A Carbacyclin analogs 失效
标题翻译： Carbacyclin类似物
公开(公告)号：US4680307A
公开(公告)日：1987-07-14
申请号：US574125
申请日：1984-01-26
申请人： Masami Muraoka , Toshio Nakamura , Akihiko Sugie , Keiichi Ono , Michihiro Yamamoto
发明人： Masami Muraoka , Toshio Nakamura , Akihiko Sugie , Keiichi Ono , Michihiro Yamamoto
IPC分类号： C07C69/708 , A61K31/16 , A61K31/19 , A61K31/215 , A61K31/557 , A61P43/00 , C07C33/14 , C07C51/00 , C07C59/125 , C07C59/46 , C07C59/62 , C07C59/72 , C07C67/00 , C07C69/73 , C07C231/00 , C07C231/02 , C07C231/12 , C07C235/06 , C07C235/16 , C07C405/00 , C07D307/20 , C07D309/12 , A61K31/185 , A61K31/235 , A61K31/35 , C07C69/734 , C07C69/78 , C07D315/00
CPC分类号： C07C405/0083 , C07C309/00 , C07C33/14 , Y10S514/925
摘要： A compound of the formula: ##STR1## wherein X.sup.1 is a free or an esterified carboxyl group, or a group of the formula: ##STR2## (R.sup.a and R.sup.b are each independently a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.3 -C.sub.7 cycloalkyl group, a benzyl group, a phenyl group, a phenyl group substituted with a halogen atom or a C.sub.1 -C.sub.4 alkyl group, or, when taken together with the adjacent nitrogen atom to which they are attached, they represent a 5 to 7 membered saturated heterocyclic group, Y.sup.1 is a group of the formula: ##STR3## (R.sup.6 is a hydrogen atom or C.sub.1 -C.sub.4 alkyl group), ##STR4## (R.sup.6 is as defined above), ##STR5## R.sup.1 is a hydrogen atom, a hydroxyl group or a protected hydroxyl group, R.sup.2 is a hydrogen atom or R.sup.1 and R.sup.2, when taken together, mean a shingle linkage to from a double bond between the carbon atoms which they are linked, R.sup.3 is a hydroxyl group or a protected hydroxyl group, R.sup.4 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, R.sup.5 is a hydrogen atom, a C.sub.1 -C.sub.12 alkyl group, a C.sub.2 -C.sub.12 alkenyl group, a C.sub.2 -C.sub.12 alkynyl group, a C.sub.3 -C.sub.10 cycloalkyl group, a C.sub.4 -C.sub.10 cycloalkenyl group, a hydroxy C.sub.1 -C.sub.12 alkyl group, a C.sub.3 -C.sub.10 heterocyclic group, a phenyl group optionally substituted with a halogen atom; a hydroxyl group, a C.sub.1 -C.sub.4 alkyl group, a trifluoromethyl group, or a C.sub.1 -C.sub.4 alkyl group or a formula: A-B (A is a C.sub.1 -C.sub.7 alkylene chain and B is a C.sub.3 -C.sub.10 cycloalkyl group, a C.sub.4 -C.sub.10 cycloalkenyl group, a C.sub.1 -C.sub.12 alkoxy group, a C.sub.3 -C.sub.10 cycloalkoxy group, a C.sub.4 -C.sub.10 cycloalkenyloxy group, a C.sub.3 -C.sub.10 heterocyclic group, or a phenyl or phenoxy group optionally substituted with a halogen atom, a hydroxy group, a C.sub.1 -C.sub.4 alkyl group, a trifluoromethyl group or a C.sub.1 -C.sub.4 alkoxy group); or a non-toxic pharmaceutically acceptable salt thereof. Said compound have strong anti-ulcerous action or antithrombotic action, and are useful in treatment of ulcer or thrombosis.
摘要翻译：下式的化合物，其中X 1是游离的或酯化的羧基，或下式的基团：（R a和R b各自独立地是氢原子，C 1 -C 4烷基，C 3 -C 7环烷基，苄基，苯基，被卤素原子或C1-C4烷基取代的苯基，或者当与它们所连接的相邻氮原子一起时，它们表示5〜 7元饱和杂环基，Y 1是下式的基团：R 6是氢原子或C 1 -C 4烷基，R 6如上所定义，R 1是氢原子，羟基或被保护的羟基，R2是氢原子或R1和R2，当它们一起表示与它们所连接的碳原子之间的双键的键合键，R3是羟基或被保护的羟基，R4是氢原子或C1-C4烷基，R5是氢原子，C1-C12烷基，C2-C12烯基，C2-C12烷基辛基，C3-C10环烷基，C4-C10环烯基，羟基C1-C12烷基，C3-C10杂环基，任选被卤素原子取代的苯基; 羟基，C1-C4烷基，三氟甲基或C1-C4烷基或式：AB（A是C1-C7亚烷基链，B是C3-C10环烷基，C4-C10 环烯基，C1-C12烷氧基，C3-C10环烷氧基，C4-C10环烯基氧基，C3-C10杂环基或任选被卤素原子取代的苯基或苯氧基，羟基，C1 -C4烷基，三氟甲基或C1-C4烷氧基）; 或其无毒的药学上可接受的盐。所述化合物具有强的抗溃疡作用或抗血栓形成作用，可用于治疗溃疡或血栓形成。

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