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1. 发明授权

US5066666A Aminoazole derivatives and their production and use 失效
标题翻译：氨基衍生物及其生产和使用
公开(公告)号：US5066666A
公开(公告)日：1991-11-19
申请号：US470731
申请日：1990-01-26
申请人： Yukinori Ozato , Nobuhiko Tamura , Hiroaki Masumori , Michihiro Yamamoto , Atsuyuki Kojima , Fumio Nishikaku , Yoshihiko Kimura
发明人： Yukinori Ozato , Nobuhiko Tamura , Hiroaki Masumori , Michihiro Yamamoto , Atsuyuki Kojima , Fumio Nishikaku , Yoshihiko Kimura
IPC分类号： A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/433 , A61P29/00 , A61P37/00 , A61P37/08 , C07D261/14 , C07D263/48 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/38 , C07D277/40 , C07D277/42 , C07D277/44 , C07D277/46 , C07D277/48 , C07D285/04 , C07D317/30 , C07D413/06 , C07D413/10 , C07D417/10
CPC分类号： C07D271/07 , C07D261/14 , C07D263/48 , C07D277/40 , C07D277/42 , C07D277/46 , C07D277/48 , C07D413/06 , C07D413/10
摘要： compound of the formula: ##STR1## wherein A is the group of the formula:Ar.sup.1 --D--Ar.sup.2 --wherein Ar.sup.1 is a phenyl or thienyl group which may be optionally substituted with at least one of the same or different halogen atom; Ar.sup.2 is a phenylene or thienylene group which may be optionally substituted with at least one of the same or different halogen atom; D is a divalent radical selected from the group consisting of >.dbd.N.dbd.OR.sup.4 [wherein R.sup.4 is a hydrogen atom or lower alkyl group], >C.dbd.O, ##STR2## >CHOH, >NH radical, or single bond, wherein R.sup.5 is a lower alkoxy or a phenyl group which may be optionally substituted with at least one of the same or different halogen atom; E is a methine group or a nitrogen atom; F is a vinylene group or an oxygen atom, ##STR3## wherein R.sup.6 is a lower alkoxy group; R.sup.7 is a lower alkyl group; R.sup.8 is a benzoyl group which may be optionally substituted with at least one of the same or different halogen atom,B is a divalent azole group;R.sup.1 is a hydrogen atom or a lower alkyl group;R.sup.2 is a hydrogen atom, lower alkyl aryl-lower alkyl, or the group of the formula:R.sup.9 --G-- wherein R.sup.9 is a hydrogen atom, lower alkyl, halo-lower alkyl, amino-lower alkyl, aryl or aryl-lower alkyl group or the group of the formula: ##STR4## wherein R.sup.10 is a hydrogen atom or lower alkyl group; R.sup.11 is a hydrogen atom, lower alkyl, lower alkenyl, lower cycloalkyl, aryl-lower alkyl, aryl or aroyl group; or the group of the formula: --NR.sup.10 R.sup.11 is a 5-, 6- or 7-membered saturated heterocyclic ring; or the group of the formula:R.sup.12 --O-- wherein R.sup.12 is a lower alkyl or polyhalo-lower alkyl group;G is a divalent group selected from the group consisting of >C.dbd.O, >C.dbd.S, >(C.dbd.O).sub.2 or >SO.sub.2 radical; or the group of the formula: --NR.sup.1 R.sup.2 is a 5-, 6- or 7-membered saturated heterocyclic ring:R.sup.3 is a hydrogen atom or lower alkyl group, or its acid addition salts, which is useful for immunomodulator.

2. 发明授权

US4914112A Aminoazole derivatives and their production and use 失效
标题翻译：氨基唑衍生物及其生产和使用
公开(公告)号：US4914112A
公开(公告)日：1990-04-03
申请号：US55079
申请日：1987-05-28
申请人： Yukinori Ozato , Nobuhiko Tamura , Hiroaki Masumori , Michihiro Yamamoto , Atsuyuki Kojima , Fumio Nishikaku , Yoshihiko Kimura
发明人： Yukinori Ozato , Nobuhiko Tamura , Hiroaki Masumori , Michihiro Yamamoto , Atsuyuki Kojima , Fumio Nishikaku , Yoshihiko Kimura
IPC分类号： A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/433 , A61P29/00 , A61P37/00 , A61P37/08 , C07D261/14 , C07D263/48 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/38 , C07D277/40 , C07D277/42 , C07D277/44 , C07D277/46 , C07D277/48 , C07D285/04 , C07D317/30 , C07D413/06 , C07D413/10 , C07D417/10
CPC分类号： C07D271/07 , C07D261/14 , C07D263/48 , C07D277/40 , C07D277/42 , C07D277/46 , C07D277/48 , C07D413/06 , C07D413/10
摘要： A compound of the formula: ##STR1## wherein A is the group of the formula:Ar.sup.1 --D--Ar.sup.2 --wherein Ar.sup.1 is a phenyl or thienyl group which may be optionally substituted with at least one of the same or different halogen atom; Ar.sup.2 is a phenylene or thienylene group which may be optionally substituted with at least one of the same or different halogen atom; D is a divalent radical selected from the group consisting of >C.dbd.N--OR.sup.4 [wherein R.sup.4 is a hydrogen atom or lower alkyl group], >C.dbd.O, ##STR2## >CHOH, >NH radical, or single bond, ##STR3## wherein R.sup.5 is a lower alkoxy or a phenyl group which may be optionally substituted with at least one of the same or different halogen atom; E is a methine group or a nitrogen atom; F is a vinylene group or an oxygen atom, ##STR4## wherein R.sup.6 is a lower alkoxy group; R.sup.7 is a lower alkyl group; R.sup.8 is a benzoyl group which may be optionally substituted with at least one of the same or different halogen atom, B is a divalent azole group; R.sup.1 is a hydrogen atom or a lower alkyl group; R.sup.2 is a hydrogen atom, lower alkyl, aryl-lower alkyl, or the group of the formula:R.sup.9 --G--wherein R.sup.9 is a hydrogen atom, lower alkyl, halo-lower alkyl, amino-lower alkyl, aryl or aryl-lower alkyl group or the group of the formula: ##STR5## wherein R.sup.10 is a hydrogen atom or lower alkoxy group; R.sup.11 is a hydrogen atom, lower alkyl, lower alkenyl, lower cycloalkyl, aryl-lower alkyl, aryl or aroyl group; or the group of the formula: --NR.sup.10 R.sup.11 is a 5-, 6- or 7-membered saturated heterocyclic ring; or the group of the formula:R.sup.12 --O--wherein R.sup.12 is a lower alkyl or polyhalo-lower alkyl group; G is a divalent group selected from the group consisting of >C.dbd.O, >C.dbd.S, >(C.dbd.O).sub.2 or >SO.sub.2 radical; or the group of the formula: --NR.sup.1 R.sup.2 is a 5-, 6- or 7-membered saturated heterocyclic ring: R.sup.3 is a hydrogen atom or lower alkyl group, or its acid addition salts, which is useful for immunomodulator.

3. 发明授权

US5180731A Aminoazole derivatives and their production and use 失效
公开(公告)号：US5180731A
公开(公告)日：1993-01-19
申请号：US732169
申请日：1991-07-18
申请人： Yukinori Ozato , Nobuhiko Tamura , Hiroaki Masumori , Michihiro Yamamoto , Atsuyuki Kojima , Fumio Nishikaku , Yoshihiko Kimura
发明人： Yukinori Ozato , Nobuhiko Tamura , Hiroaki Masumori , Michihiro Yamamoto , Atsuyuki Kojima , Fumio Nishikaku , Yoshihiko Kimura
IPC分类号： C07D261/14 , C07D263/48 , C07D271/06 , C07D271/07 , C07D277/38 , C07D277/40 , C07D277/42 , C07D277/46 , C07D277/48 , C07D413/06 , C07D413/10
CPC分类号： C07D271/07 , C07D261/14 , C07D263/48 , C07D277/40 , C07D277/42 , C07D277/46 , C07D277/48 , C07D413/06 , C07D413/10
摘要： A compound of the formula: ##STR1## wherein A is the group of the formula:Ar.sup.1 --D--Ar.sup.2 --wherein Ar.sup.1 is a phenyl or thienyl group which may be optionally substituted with at least one of the same or different halogen atom; Ar.sup.2 is a phenylene or thienylene group which may be optionally substituted with at least one of the same or different halogen atom; D is a divalent radical selected from the group consisting of >C.dbd.N--OR .sup.4 [wherein R.sup.4 is a hydrogen atom or lower alkyl group], >C.dbd.O, ##STR2## >CHOH, >NH radical, or single bond, ##STR3## wherein R.sup.5 is a lower alkoxy or phenyl group which may be optionally substituted with at least one of the same or different halogen atom; E is a methine group or a nitrogen atom; F is a vinylene group or an oxygen atom, ##STR4## wherein R.sup.6 is a lower alkoxy group; R.sup.7 is a lower alkyl group; R.sup.8 is a benzoyl group which may be optionally substituted with at least one of the same or different halogen atom, B is a divalent azole group; R.sup.1 is a hydrogen atom or a lower alkyl group; R.sup.2 is a hydrogen atom, lower alkyl, aryl-lower alkyl, or the group of the formula:R.sup.9 --G--wherein R.sup.9 is a hydrogen atom, lower alkyl, halo-lower alkyl, amino-lower alkyl, aryl or aryl-lower alkyl group or the group of the formula: ##STR5## wherein R.sup.10 is a hydrogen atom or lower alkyl group; R.sup.11 is a hydrogen atom, lower alkyl, lower alkenyl, lower cycloalkyl, aryl-lower alkyl, aryl or aroyl group; or the group of the formula: --NR.sup.10 R.sup.11 is a 5-, 6- or 7-membered saturated heterocyclic ring; or the group of the formula:R.sup.12 --O--wherein R.sup.12 is a lower alkyl or polyhalo-lower alkyl group; G is a divalent group selected from the group consisting of >C.dbd.O, >C.dbd.S, >(C.dbd.O).sub.2 or >SO.sub.2 radical; or the group of the formula: --NR.sup.1 R.sup.2 is a 5-, 6- or 7-membered saturated heterocyclic ring: R.sup.3 is a hydrogen atom or lower alkyl group, or its acid addition salts, which is useful for immunomodulator.

4. 发明授权

US5021435A Certain pyridyl-thiazolidin-4-one having anti-ulcer activity 失效
标题翻译：某些具有抗溃疡活性的吡啶基 - 噻唑烷-4-酮
公开(公告)号：US5021435A
公开(公告)日：1991-06-04
申请号：US297313
申请日：1989-01-17
申请人： Naruhito Masai , Masao Enomoto , Atsuyuki Kojima , Hiroaki Masumori , Nobuyuki Hara , Youichi Hara , Shigeaki Morooka
发明人： Naruhito Masai , Masao Enomoto , Atsuyuki Kojima , Hiroaki Masumori , Nobuyuki Hara , Youichi Hara , Shigeaki Morooka
IPC分类号： A61K31/44 , A61P1/04 , C07D417/04
CPC分类号： C07D417/04
摘要： A 2-pyridyl-thiazolidin-4-one derivative represented by the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each a hydrogen atom, an C.sub.1 -C.sub.20 alkyl group, an C.sub.2 -C.sub.20 alkenyl group, an C.sub.2 -C.sub.20 alkynyl group, an aryl group, a C.sub.3 -C.sub.8 cycloalkyl group or an aralkyl group which may have a substituent, R.sub.3 is a hydrogen atom, an C.sub.1 -C.sub.20 alkyl group, an C.sub.2 -C.sub.20 alkenyl group, an C.sub.2 -C.sub.20 alkynyl group, a C.sub.3 -C.sub.8 cycloalkyl group or an aralkyl group which may have a substituent, P is a pyridyl group or its N-substituted pyridinium salt which may have a substituent, said substituent being selected from the group consisting of halogen atom, cyano group, hydroxy group, amino group, lower alkyl group, lower alkoxy group, lower alkylamino group, halogenated lower alkyl group, acyl group, acyloxy group, acylthio group, acylamino group, carboxyl group, lower alkoxycarbonyl group, carbamoyl group, lower alkyl substituted carbamoyl group, heterocyclic group, and lower cycloalkyl group, and n represents an integer of 0, 1 or 2, or a pharmaceutically acceptable salts thereof and an anti-ulcer agent which contains, as an effective ingredient, said 2-pyridyl-thiazolidine-4-one derivative or a pharmaceutically acceptable salt thereof.

5. 发明授权

US4400393A Novel bicyclooctane compounds 失效
标题翻译：新型双环辛烷化合物
公开(公告)号：US4400393A
公开(公告)日：1983-08-23
申请号：US246938
申请日：1981-03-24
申请人： Shunsuke Sami , Akihiko Sugie , Keiichi Ono , Hajime Kawakami , Atsuyuki Kojima , Junki Katsube
发明人： Shunsuke Sami , Akihiko Sugie , Keiichi Ono , Hajime Kawakami , Atsuyuki Kojima , Junki Katsube
IPC分类号： C07C69/013 , A61K31/19 , A61K31/215 , A61P9/00 , A61P9/10 , C07C45/59 , C07C45/71 , C07C49/743 , C07C51/00 , C07C59/46 , C07C59/62 , C07C59/66 , C07C67/00 , C07C405/00 , C07D317/72 , C07F9/40 , C07C69/753
CPC分类号： C07F9/4018 , C07C405/0083 , C07C45/59 , C07C45/71 , C07C49/743 , C07C59/46 , C07C59/66 , C07D317/72 , Y02P20/55
摘要： A novel bicyclooctane derivative represented by the formula: ##STR1## wherein R.sub.1 is hydrogen or C.sub.1-4 alkyl, X is ethylene or vinylene, and Y.sub.1 and Y.sub.2 are independently hydrogen or a hydroxyl-protecting group, or a pharmaceutically acceptable salt of said compound in which R.sub.1 is hydrogen. Said compound and pharmaceutically acceptable salt are chemically stable, have platelet anti-aggregation activity without undesirable pharmacological actions and exhibit the duration of high biological activity.
摘要翻译：由下式表示的新型双环辛烷衍生物：其中R 1是氢或C 1-4烷基，X是亚乙基或亚乙烯基，Y 1和Y 2独立地是氢或羟基保护基，或所说化合物的药学上可接受的盐其中R1是氢。所述化合物和药学上可接受的盐是化学稳定的，具有没有不希望的药理作用的血小板抗聚集活性，并表现出高生物活性的持续时间。

6. 发明授权

US4103030A Novel cyclopropylmethylamine derivatives 失效
标题翻译：新型环丙基甲胺衍生物
公开(公告)号：US4103030A
公开(公告)日：1978-07-25
申请号：US635331
申请日：1975-11-26
申请人： Atsuyuki Kojima , Yoshito Kameno , Junki Katsube , Shigeho Inaba , Hisao Yamamoto
发明人： Atsuyuki Kojima , Yoshito Kameno , Junki Katsube , Shigeho Inaba , Hisao Yamamoto
IPC分类号： A61K31/13 , A61K31/135 , A01N9/20 , A01N9/24 , C07C91/16 , C07C91/28
摘要： Novel cyclopropylmethylamine compounds of the formula: ##STR1## wherein Ar.sup.1 represents a phenyl group having one or more substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy and trifluoromethyl, of which at least one is present at the o- or m-position, Ar.sup.2 represents an unsubstituted phenyl group or a phenyl group substituted with one or more substituents selected from the group consisting of halogen and C.sub.1 -C.sub.4 alkyl, R represents hydrogen, C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.4 hydroxyalkyl and R' represents C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.4 hydroxyalkyl, and their non-toxic salts, which possess various useful pharmacological activities and can be produced by reduction of the corresponding compounds of the formula: ##STR2## wherein Ar.sup.1, Ar.sup.2, R and R' are each as defined above or by condensation of the corresponding compounds of the formula: ##STR3## wherein Ar.sup.1 and Ar.sup.2 are each as defined above and X is a conventional leaving (removable) group with amines of the formula: ##STR4## wherein R and R' are each as defined above.
摘要翻译：新的下式的环丙基甲胺化合物：其中Ar 1表示具有一个或多个选自卤素，C 1 -C 4烷基，C 1 -C 4烷氧基和三氟甲基的取代基的苯基，其中至少一个存在于或位置，Ar 2表示未取代的苯基或被一个或多个选自卤素和C 1 -C 4烷基的取代基取代的苯基，R表示氢，C 1 -C 4烷基或C 2 -C 4羟烷基， R'表示C1-C4烷基或C2-C4羟基烷基及其无毒盐，它们具有各种有用的药理活性，可以通过还原相应的下式化合物来制备：其中Ar1，Ar2，R和 R'各自如上所定义，或通过下式的相应化合物的缩合：其中Ar 1和Ar 2各自如上所定义，X是具有下式的胺的常规离去（可除去）基团：其中 R和R'各自如上所定义。

7. 发明授权

US4418079A Conjugated ketone compounds in preventing platelet thrombosis 失效
标题翻译：共轭酮化合物预防血小板血栓形成
公开(公告)号：US4418079A
公开(公告)日：1983-11-29
申请号：US335522
申请日：1981-12-29
申请人： Atsuyuki Kojima , Tsunemasa Irie , Shuichi Harada , Yoshito Kameno , Junki Katsube , Hisao Yamamoto
发明人： Atsuyuki Kojima , Tsunemasa Irie , Shuichi Harada , Yoshito Kameno , Junki Katsube , Hisao Yamamoto
IPC分类号： C07C29/42 , C07D209/44 , C07D295/108 , C07D307/52 , C07D317/58 , C07D333/22 , A61K27/00 , A61K31/135 , A61K31/34 , A61K31/36 , A61K31/38 , A61K31/40 , A61K31/44 , A61K31/445
CPC分类号： C07D295/108 , C07C29/42 , C07D209/44 , C07D307/52 , C07D317/58 , C07D333/22
摘要： Conjugated ketone compounds of the formula: ##STR1## wherein Ar is naphthyl, furyl, thienyl, or phenyl optionally bearing one or more substituents selected from the group consisting of chlorine, bromine, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, trifluoromethyl and methylenedioxy, R.sub.1 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.5 alkenyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.7 -C.sub.8 aralkyl or adamantyl, R.sub.2 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.5 alkenyl or C.sub.3 -C.sub.6 cycloalkyl, or when R.sub.1 and R.sub.2 are taken together with the nitrogen atom to which they are attached, they form a heterocyclic amino group containing up to 8 carbon atoms, A is straight or branched C.sub.1 -C.sub.3 alkylene, N-[4-(p-chlorophenyl)-4-oxo-2-trans-butenyl]morpholine and N-[4-(p-methoxyphenyl)-4-oxo-2-trans-butenyl]piperidine being excluded, and their non-toxic salts, which are useful as blood platelet anti-aggregative agents.
摘要翻译：具有下式的共轭酮化合物：其中Ar是萘基，呋喃基，噻吩基或任选具有一个或多个选自氯，溴，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4 烷基硫基，三氟甲基和亚甲二氧基，R 1是C 1 -C 6烷基，C 3 -C 5烯基，C 3 -C 6环烷基，C 7 -C 8芳烷基或金刚烷基，R 2是C 1 -C 6烷基，C 3 -C 5链烯基或C 3 -C 6环烷基，并且R 2与它们所连接的氮原子一起形成含有至多8个碳原子的杂环氨基，A是直链或支链C1-C3亚烷基，N- [4-（对氯苯基）-4 - 氧代-2-反式 - 丁烯基]吗啉和N- [4-（对甲氧基苯基）-4-氧代-2-反式 - 丁烯基]哌啶，以及它们的无毒盐，其可用作血小板抗体聚集代理。

8. 发明授权

US4169146A Novel morpholine derivatives and treating depression therewith 失效
标题翻译：新型吗啉衍生物和治疗抑郁症
公开(公告)号：US4169146A
公开(公告)日：1979-09-25
申请号：US811944
申请日：1977-06-30
申请人： Junki Katsube , Atsuyuki Kojima , Makoto Sunagawa , Yoshinori Takashima , Yoshito Kameno , Hisao Yamamoto
发明人： Junki Katsube , Atsuyuki Kojima , Makoto Sunagawa , Yoshinori Takashima , Yoshito Kameno , Hisao Yamamoto
IPC分类号： C07D265/30 , C07D267/10 , A61K27/00
CPC分类号： C07D265/30 , C07D267/10
摘要： Novel morpholine compounds of the formula: ##STR1## wherein R.sub.1 represents hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.5 alkenyl, C.sub.3 -C.sub.5 alkynyl, aryl-(C.sub.1 -C.sub.4)alkyl, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.4)alkyl, polyhalo(C.sub.2 -C.sub.4) alkyl or hydroxy(C.sub.2 -C.sub.4)alkyl, A represents straight or branched C.sub.2 -C.sub.4 alkylene, B represents a divalent radical selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, ##STR2## --CH.sub.2 --O--, --CH.sub.2 --S--, --S-- and --O--, >D--E-- represents a trivalent radical selected from the group consisting of >CH--CH.sub.2 -- and >C.dbd.CH-- and C.sub.1 and C.sub.2 each represent 1,2-phenylene optionally substituted with one or more substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy, and their non-toxic salts, which are useful as antidepressants and can be produced by various methods.
摘要翻译：式中：R1代表氢或C1-C4烷基，R2代表氢，C1-C4烷基，C3-C5烯基，C3-C5炔基，芳基 - （C1-C4）烷基，（C3 -C 6）环烷基（C 1 -C 4）烷基，多卤代（C 2 -C 4）烷基或羟基（C 2 -C 4）烷基，A表示直链或支链C 2 -C 4亚烷基，B表示选自-CH 2 -CH 2 - ， - CH = CH-， -CH 2 -O-，-CH 2 -S-，-S-和-O-，> DE-表示选自下组的三价基团：CH-CH 2 - 和> C = CH-和C1和C2各自表示任选被一个或多个选自卤素，C 1 -C 4烷基和C 1 -C 4烷氧基的取代基取代的1,2-亚苯基及其无毒盐，其可用作抗抑郁药并且可以通过各种方法制备。

9. 发明授权

US5556860A Quinazolinone derivatives possessing calcium uptake inhibiting activity 失效
标题翻译：具有钙摄取抑制活性的喹唑啉酮衍生物
公开(公告)号：US5556860A
公开(公告)日：1996-09-17
申请号：US249212
申请日：1994-05-26
申请人： Masami Muraoka , Kazuki Matsui , Hirohiko Hasegawa , Atsuyuki Kojima
发明人： Masami Muraoka , Kazuki Matsui , Hirohiko Hasegawa , Atsuyuki Kojima
IPC分类号： A61K31/505 , A61K31/535 , C07D239/82 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/06 , C07D453/02 , C07D471/04 , C07D495/04 , A61K31/435 , C07D239/84
CPC分类号： C07D401/04 , A61K31/505 , A61K31/535 , C07D239/82 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/06 , C07D453/02 , C07D471/04 , C07D495/04
摘要： This invention is to provide quinazolinone derivatives, and their acid salts and quaternary ammonium salts, having an effect of preventing or treating diseases caused by calcium ion overload in cells, such as ischemic heart disease, ischemic cerebral disease and ischemic renal disease, and their usage. The quinazolinone derivatives are represented by the formula: ##STR1## typically, T represents an oxygen atom; Y represents a phenyl or cyclohexyl group; R.sup.1 represents a hydrogen or chlorine atom; R.sup.2 represents a hydrogen atom; ring W represents a benzene or pyridine ring; Z represents a group of the formula: ##STR2##
摘要翻译：本发明提供具有预防或治疗由缺血性心脏病，缺血性脑病和缺血性肾病等细胞中的钙离子过载引起的疾病的效果的喹唑啉酮衍生物及其酸式盐和季铵盐及其用途。喹唑啉酮衍生物由下式表示：（1）通常，T表示氧原子; Y表示苯基或环己基; R1表示氢或氯原子; R2表示氢原子; 环W表示苯或吡啶环; Z表示一组下列公式：

10. 发明授权

US4849434A Novel thiazolidin-4-one derivatives and acid addition salts therof 失效
标题翻译：新型噻唑烷-4-酮衍生物和酸加成盐
公开(公告)号：US4849434A
公开(公告)日：1989-07-18
申请号：US74873
申请日：1987-07-17
申请人： Masao Enomoto , Masami Muraoka , Keiichi Ono , Atsuyuki Kojima , Toshio Atsumi , Yoshihiro Komuro , Yuzuru Sanemitsu , Masato Mizutani
发明人： Masao Enomoto , Masami Muraoka , Keiichi Ono , Atsuyuki Kojima , Toshio Atsumi , Yoshihiro Komuro , Yuzuru Sanemitsu , Masato Mizutani
IPC分类号： A61K31/44 , A61P1/04 , A61P7/02 , A61P9/00 , A61P11/00 , A61P29/00 , C07D417/04
CPC分类号： C07D417/04
摘要： A novel 2-pyridylthiazolidin-4-one derivative represented by the general formula ##STR1## wherein Ar denotes an aryl group unsubstituted or substituted with a halogen atom or with a lower alkoxy group; X denotes a straight-chain or branched-chain lower alkylene group or a single bond; R denotes a hydrogen atom, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, acyloxy, di(lower alkyl) amino, hydroxyl or aryl group, or denotes an aryl group substituted with a lower alkoxy group; and Py denotes a pyridyl group, and the acid addition salt thereof, which have an excellent platelet activating factor antagonsm.

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