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1. 发明授权

US4680307A Carbacyclin analogs 失效
标题翻译： Carbacyclin类似物
公开(公告)号：US4680307A
公开(公告)日：1987-07-14
申请号：US574125
申请日：1984-01-26
申请人： Masami Muraoka , Toshio Nakamura , Akihiko Sugie , Keiichi Ono , Michihiro Yamamoto
发明人： Masami Muraoka , Toshio Nakamura , Akihiko Sugie , Keiichi Ono , Michihiro Yamamoto
IPC分类号： C07C69/708 , A61K31/16 , A61K31/19 , A61K31/215 , A61K31/557 , A61P43/00 , C07C33/14 , C07C51/00 , C07C59/125 , C07C59/46 , C07C59/62 , C07C59/72 , C07C67/00 , C07C69/73 , C07C231/00 , C07C231/02 , C07C231/12 , C07C235/06 , C07C235/16 , C07C405/00 , C07D307/20 , C07D309/12 , A61K31/185 , A61K31/235 , A61K31/35 , C07C69/734 , C07C69/78 , C07D315/00
CPC分类号： C07C405/0083 , C07C309/00 , C07C33/14 , Y10S514/925
摘要： A compound of the formula: ##STR1## wherein X.sup.1 is a free or an esterified carboxyl group, or a group of the formula: ##STR2## (R.sup.a and R.sup.b are each independently a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.3 -C.sub.7 cycloalkyl group, a benzyl group, a phenyl group, a phenyl group substituted with a halogen atom or a C.sub.1 -C.sub.4 alkyl group, or, when taken together with the adjacent nitrogen atom to which they are attached, they represent a 5 to 7 membered saturated heterocyclic group, Y.sup.1 is a group of the formula: ##STR3## (R.sup.6 is a hydrogen atom or C.sub.1 -C.sub.4 alkyl group), ##STR4## (R.sup.6 is as defined above), ##STR5## R.sup.1 is a hydrogen atom, a hydroxyl group or a protected hydroxyl group, R.sup.2 is a hydrogen atom or R.sup.1 and R.sup.2, when taken together, mean a shingle linkage to from a double bond between the carbon atoms which they are linked, R.sup.3 is a hydroxyl group or a protected hydroxyl group, R.sup.4 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, R.sup.5 is a hydrogen atom, a C.sub.1 -C.sub.12 alkyl group, a C.sub.2 -C.sub.12 alkenyl group, a C.sub.2 -C.sub.12 alkynyl group, a C.sub.3 -C.sub.10 cycloalkyl group, a C.sub.4 -C.sub.10 cycloalkenyl group, a hydroxy C.sub.1 -C.sub.12 alkyl group, a C.sub.3 -C.sub.10 heterocyclic group, a phenyl group optionally substituted with a halogen atom; a hydroxyl group, a C.sub.1 -C.sub.4 alkyl group, a trifluoromethyl group, or a C.sub.1 -C.sub.4 alkyl group or a formula: A-B (A is a C.sub.1 -C.sub.7 alkylene chain and B is a C.sub.3 -C.sub.10 cycloalkyl group, a C.sub.4 -C.sub.10 cycloalkenyl group, a C.sub.1 -C.sub.12 alkoxy group, a C.sub.3 -C.sub.10 cycloalkoxy group, a C.sub.4 -C.sub.10 cycloalkenyloxy group, a C.sub.3 -C.sub.10 heterocyclic group, or a phenyl or phenoxy group optionally substituted with a halogen atom, a hydroxy group, a C.sub.1 -C.sub.4 alkyl group, a trifluoromethyl group or a C.sub.1 -C.sub.4 alkoxy group); or a non-toxic pharmaceutically acceptable salt thereof. Said compound have strong anti-ulcerous action or antithrombotic action, and are useful in treatment of ulcer or thrombosis.
摘要翻译：下式的化合物，其中X 1是游离的或酯化的羧基，或下式的基团：（R a和R b各自独立地是氢原子，C 1 -C 4烷基，C 3 -C 7环烷基，苄基，苯基，被卤素原子或C1-C4烷基取代的苯基，或者当与它们所连接的相邻氮原子一起时，它们表示5〜 7元饱和杂环基，Y 1是下式的基团：R 6是氢原子或C 1 -C 4烷基，R 6如上所定义，R 1是氢原子，羟基或被保护的羟基，R2是氢原子或R1和R2，当它们一起表示与它们所连接的碳原子之间的双键的键合键，R3是羟基或被保护的羟基，R4是氢原子或C1-C4烷基，R5是氢原子，C1-C12烷基，C2-C12烯基，C2-C12烷基辛基，C3-C10环烷基，C4-C10环烯基，羟基C1-C12烷基，C3-C10杂环基，任选被卤素原子取代的苯基; 羟基，C1-C4烷基，三氟甲基或C1-C4烷基或式：AB（A是C1-C7亚烷基链，B是C3-C10环烷基，C4-C10 环烯基，C1-C12烷氧基，C3-C10环烷氧基，C4-C10环烯基氧基，C3-C10杂环基或任选被卤素原子取代的苯基或苯氧基，羟基，C1 -C4烷基，三氟甲基或C1-C4烷氧基）; 或其无毒的药学上可接受的盐。所述化合物具有强的抗溃疡作用或抗血栓形成作用，可用于治疗溃疡或血栓形成。

2. 发明授权

US08642626B2 Ethinyl-pyrazole derivative 失效
标题翻译：乙烯基 - 吡唑衍生物
公开(公告)号：US08642626B2
公开(公告)日：2014-02-04
申请号：US13812437
申请日：2011-07-29
申请人： Toshio Nakamura , Kazunari Sakagami , Kazuhide Konishi , Kanako Yamamoto , Seiji Masuda , Yohei Matsuda , Kumiko Okada , Tsuyoshi Shibata , Hiroshi Ohta , Akito Yasuhara , Hiroshi Kawamoto
发明人： Toshio Nakamura , Kazunari Sakagami , Kazuhide Konishi , Kanako Yamamoto , Seiji Masuda , Yohei Matsuda , Kumiko Okada , Tsuyoshi Shibata , Hiroshi Ohta , Akito Yasuhara , Hiroshi Kawamoto
IPC分类号： A61K31/4439 , A61K31/415 , C07D231/12 , C07D231/20 , C07D231/38 , C07D403/06 , C07D401/06
CPC分类号： C07D231/12 , C07D231/14 , C07D231/20 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D413/04
摘要： Provided is a novel compound represented by formula [I] or a pharmaceutically acceptable salt thereof having antagonistic activity against group II metabolism-type glutamic acid (m-Glu) receptors. The compound or pharmaceutically acceptable salt thereof is useful as a prophylactic or therapeutic agent for diseases such as new mood disorders (depressive and bipolar disorders), anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, and acute stress disorder), schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, drug dependence, convulsions, tremors, pain, sleep disorders, and the like.
摘要翻译：本发明提供由式[I]表示的新化合物或其对II类代谢型谷氨酸（m-Glu）受体具有拮抗作用的药学上可接受的盐。化合物或其药学上可接受的盐可用作疾病的预防或治疗剂，例如新的情绪障碍（抑郁和双相性精神障碍），焦虑症（广泛性焦虑症，惊恐障碍，强迫症，社会焦虑症，创伤性应激障碍，特异性恐惧症和急性应激障碍），精神分裂症，阿尔茨海默病，认知功能障碍，痴呆，药物依赖，惊厥，震颤，疼痛，睡眠障碍等。

3. 发明申请

US20130137865A1 HETEROARYL-PYRAZOLE DERIVATIVE 审中-公开
标题翻译：异丙基吡唑衍生物
公开(公告)号：US20130137865A1
公开(公告)日：2013-05-30
申请号：US13814869
申请日：2011-08-11
申请人： Toshio Nakamura , Kazunari Sakagami , Kazuhide Konishi , Kanako Yamamoto , Seiji Masuda , Yohei Matsuda , Kumiko Okada , Tsuyoshi Shibata , Hiroshi Ohta , Akito Yasuhara , Hiroshi Kawamoto , Hideaki Amada , Hiroki Urabe , Rie Nishikawa , Shuhei Kashiwa ASHIWA
发明人： Toshio Nakamura , Kazunari Sakagami , Kazuhide Konishi , Kanako Yamamoto , Seiji Masuda , Yohei Matsuda , Kumiko Okada , Tsuyoshi Shibata , Hiroshi Ohta , Akito Yasuhara , Hiroshi Kawamoto , Hideaki Amada , Hiroki Urabe , Rie Nishikawa , Shuhei Kashiwa ASHIWA
IPC分类号： C07D413/14 , C07D413/04 , C07D403/04 , C07D231/38
CPC分类号： C07D413/14 , C07D231/38 , C07D403/04 , C07D403/14 , C07D413/04
摘要： A compound represented by formula [I] and a pharmaceutically accepted salt of said compound are a novel compound and a pharmaceutically accepted salt thereof which exert antagonistic activity against group II metabotropic glutamate (mGlu) receptors, and are effective as a novel preventive or therapeutic agent for disorders such as mood disorders (depressive disorder, bipolar disorder, etc.), anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, a specific phobic disorder, acute stress disorder, etc.), schizophrenia, Alzheimer's disease, cognitive impairment, dementia, drug dependence, convulsions, shivering, pain, sleep disorders, and the like.
摘要翻译：由式[I]表示的化合物和所述化合物的药学上可接受的盐是对II族代谢型谷氨酸（mGlu）受体具有拮抗作用的新化合物及其药学上可接受的盐，并且作为新的预防或治疗剂是有效的用于诸如情绪障碍（抑郁障碍，双相情感障碍等），焦虑障碍（广泛性焦虑症，恐慌症，强迫症，社会焦虑症，创伤后应激障碍，特异性恐怖症，急性应激障碍等），精神分裂症，阿尔茨海默病，认知障碍，痴呆，药物依赖，抽搐，发抖，疼痛，睡眠障碍等。

4. 发明授权

US08376934B2 Multijoint manipulator and endoscope system having the same 有权
标题翻译：具有相同的多节点机械手和内窥镜系统
公开(公告)号：US08376934B2
公开(公告)日：2013-02-19
申请号：US13092702
申请日：2011-04-22
申请人： Kazuhiko Takahashi , Toshio Nakamura
发明人： Kazuhiko Takahashi , Toshio Nakamura
IPC分类号： A61B1/00 , A61B1/04 , G06F3/033
CPC分类号： B25J9/06 , A61B1/00147 , A61B1/0052 , A61B1/0055 , A61B5/065 , A61B34/30 , A61B34/37 , A61B2034/2059 , A61B2034/306 , A61B2090/064
摘要： A multijoint manipulator apparatus includes a tubular-member, linear-motion-transmission-members, a drive-unit, a position-detector, a tension-detector, an operation-unit, and a movement-degree-calculation-unit. The linear-members are inserted in the tubular-member, one end and the other end of each of the linear-members being fixed to the vicinity of a joint of the tubular-member and the drive-unit, respectively. The drive-unit moves the linear-members. The position-detector and the tension-detector detect positions and tension of the linear-members, respectively. A desired position/posture of a point of interest is input to the operation-unit. The calculation-unit calculates a current position/posture of the point, a weighting factor serving to give priority to and move the linear-members the tension of which is relatively low among the linear-members, and movement degrees of the linear-members to move the point to the desired position/posture, and causes the drive-unit to pull the linear-members.
摘要翻译：多关节机械手装置包括管状构件，直线运动传递构件，驱动单元，位置检测器，张力检测器，操作单元和移动程度计算单元。线性构件插入管状构件中，每个线性构件的一端和另一端分别固定在管状构件和驱动单元的接头附近。驱动单元移动线性元件。位置检测器和张力检测器分别检测线性元件的位置和张力。将感兴趣点的期望位置/姿势输入到操作单元。计算单元计算点的当前位置/姿势，用于优先使线性构件中的线性构件的张力相对较低的直线构件的加权系数和线性构件的移动度向将点移动到期望的位置/姿势，并且使驱动单元拉动线性构件。

5. 发明授权

US08282543B2 Surgical instrument and endoscope surgical system having surgical instrument 有权
标题翻译：手术器械和内窥镜手术系统具有手术器械
公开(公告)号：US08282543B2
公开(公告)日：2012-10-09
申请号：US12573201
申请日：2009-10-05
申请人： Tsutomu Ishiguro , Toshio Nakamura , Jun Hasegawa
发明人： Tsutomu Ishiguro , Toshio Nakamura , Jun Hasegawa
IPC分类号： A61B1/00
CPC分类号： A61B17/29 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B34/70 , A61B34/71 , A61B34/74 , A61B2017/003 , A61B2017/00318 , A61B2017/0034 , A61B2017/00398 , A61B2017/2927 , A61B2017/2939 , A61B2017/320072 , A61B2018/1425 , A61B2018/1475 , A61B2034/742
摘要： A surgical instrument having a surgical unit which operates on an operating portion in a body cavity, an accommodation portion capable of accommodating the surgical unit. The surgical instrument having movement manipulation mechanism connected to the surgical unit for moving the surgical unit to a position at which the surgical unit is accommodated in the accommodation portion and to a position at which the surgical unit is exposed from the accommodation portion along the inside of the accommodation portion.
摘要翻译：一种具有在体腔内的操作部分上操作的手术单元的手术器械，能够容纳外科单元的容纳部分。该外科器具具有连接到外科单元的移动操作机构，用于将手术单元移动到手术单元容纳在容纳部分中的位置，以及外科单元沿着容纳部分沿着内窥镜住宿部分。

6. 发明申请

US20090291940A1 AMINOPYRROLIDINE COMPOUND 失效
标题翻译：氨基吡啶化合物
公开(公告)号：US20090291940A1
公开(公告)日：2009-11-26
申请号：US12296082
申请日：2007-03-30
申请人： Taketoshi Okubo , Toshihito Kumagai , Takaaki Ishii , Toshio Nakamura , Kumi Abe , Yuri Amada , Tomoko Ishizaka , Xiang-Min Sun , Yoshinori Sekiguchi , Shigetada Sasako , Takanori Shimizu , Takayuki Nagatsuka
发明人： Taketoshi Okubo , Toshihito Kumagai , Takaaki Ishii , Toshio Nakamura , Kumi Abe , Yuri Amada , Tomoko Ishizaka , Xiang-Min Sun , Yoshinori Sekiguchi , Shigetada Sasako , Takanori Shimizu , Takayuki Nagatsuka
IPC分类号： A61K31/553 , A61K31/541 , A61K31/5377 , A61K31/497 , A61K31/517 , A61K31/4709 , C07D417/14 , C07D413/14 , C07D403/14 , C07D401/14
CPC分类号： C07D401/12
摘要： Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for mode disorder such as depression, anxiety disorder, anorexia, cachexia, pain and drug dependence, whose action relies on the MC4 receptor antagonistic effect.
摘要翻译：公开了由式[I]表示的氨基吡咯烷化合物或其药学上可接受的盐。化合物或盐可用作模式障碍如抑郁症，焦虑障碍，厌食症，恶病质，疼痛和药物依赖性的预防/治疗剂，其作用依赖于MC4受体拮抗作用。

7. 发明申请

US20090227834A1 ENERGY SURGICAL DEVICE 审中-公开
标题翻译：能量手术器械
公开(公告)号：US20090227834A1
公开(公告)日：2009-09-10
申请号：US12400917
申请日：2009-03-10
申请人： Koji Nakamoto , Toshio Nakamura , Kazuhiko Takahashi , Michifumi Yoshie
发明人： Koji Nakamoto , Toshio Nakamura , Kazuhiko Takahashi , Michifumi Yoshie
IPC分类号： A61B18/14 , A61B1/012
CPC分类号： A61B18/148 , A61B18/1402 , A61B18/1492 , A61B34/30 , A61B2018/00595 , A61B2018/00642 , A61B2018/00982 , A61B2018/1412 , A61B2090/064 , A61B2090/065
摘要： An energy surgical device is provided with a treatment section which treats a subject, an energy supply section which supplies energy to the treatment section, a state-change detecting section which detects a state change of the treatment section, an energy instruction input section which inputs an instruction for the energy supply, and a regulation section which regulates the energy supply by the energy supply section based on the input of the energy supply instruction through the energy instruction input section and a result of detection in the state-change detecting section.
摘要翻译：能量手术装置具有处理对象的治疗部，向治疗部供给能量的能量供给部，检测治疗部的状态变化的状态变化检测部，能够进行输入的能量指示输入部能量供给指令，以及调节部，其基于通过能量指示输入部的能量供给指示的输入和状态变化检测部的检测结果来调节能量供给部的能量供给。

8. 发明申请

US20060204158A1 Method of manufacturing cage for roller bearing and cage for roller bearing 有权
标题翻译：滚子轴承和滚子轴承保持架的制造方法
公开(公告)号：US20060204158A1
公开(公告)日：2006-09-14
申请号：US10567568
申请日：2004-08-06
申请人： Kazuto Kobayashi , Toshio Nakamura , Keiichi Horino , Yoshiro Ide
发明人： Kazuto Kobayashi , Toshio Nakamura , Keiichi Horino , Yoshiro Ide
IPC分类号： F16C33/52
CPC分类号： F16C33/4682 , B21D53/12 , F16C19/38 , F16C23/086 , F16C33/543 , Y10T29/49686 , Y10T29/49687 , Y10T29/49691
摘要： A method of manufacturing a retainer for a roller bearing made of a metal plate and has a tubular main portion, pockets formed in the main portion intermittently concerning a circumferential direction and capable of retaining rollers rollably, and an outwardly oriented flange-like collar portion. An annular intermediate material is formed by die cutting the metal plate, and after a second intermediate material is formed by forming through holes in the intermediate material intermittently, a portion of the second intermediate material excluding a radially outer end portion is plastically deformed into a tubular shape. The portion plastically deformed tubular shape is formed as the main portion, a portion corresponding to the radially outer end portion of the second intermediate material is formed as the collar portion or a collar portion element for forming the collar portion, and portions corresponding to the through holes are formed as the pockets.
摘要翻译：一种制造用于由金属板制成的滚子轴承的保持器的方法，并且具有管状主体部分，在主体部分中间歇地形成有围绕圆周方向并且能够滚动地保持辊的口袋和向外定向的凸缘状套环部分。通过对金属板进行模切而形成环状的中间材料，在间歇地形成中间材料的贯通孔而形成第二中间材料之后，除了径向外端部以外的部分第二中间材料塑性地变形为管状形状。形成塑性变形管状的部分形成为主要部分，对应于第二中间材料的径向外端部的部分形成为套环部分或用于形成套环部分的套环部分元件，以及对应于贯穿孔形成为袋。

9. 发明授权

US06476056B2 Heterocycle substituted aryloxyaniline derivatives and their use as MDR ligands 失效
标题翻译：杂环取代的芳氧基苯胺衍生物及其作为MDR配体的用途
公开(公告)号：US06476056B2
公开(公告)日：2002-11-05
申请号：US09922807
申请日：2001-08-07
申请人： Atsuro Nakazato , Taketoshi Okubo , Toshio Nakamura , Shigeyuki Chaki , Kazuyuki Tomisawa , Masashi Nagamine , Kenji Yamamoto , Koichiro Harada , Masanori Yoshida
发明人： Atsuro Nakazato , Taketoshi Okubo , Toshio Nakamura , Shigeyuki Chaki , Kazuyuki Tomisawa , Masashi Nagamine , Kenji Yamamoto , Koichiro Harada , Masanori Yoshida
IPC分类号： A61K3144
CPC分类号： C07D213/40 , C07C233/25 , C07C233/33 , C07C233/54 , C07C235/38 , C07C235/78 , C07C237/30 , C07C247/10 , C07C275/32 , C07C311/27 , C07C311/29 , C07C311/46 , C07C323/20 , C07C323/41 , C07C323/60 , C07D213/643 , C07D213/65 , C07D213/68
摘要： An aryloxyaniline derivative represented by the formula: wherein Ar1 and Ar2 are the same or different, and are each a substituted or unsubstituted phenyl group, a substituted or unsubstituted pyridyl group or a naphthyl group, provided that Ar1 and Ar2 are not both phenyl or both naphthyl and are not phenyl and naphthyl, R1 is a hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 10 carbon atoms, an alkoxy group having 1 to 10 carbon atoms, a substituted or unsubstituted phenyl group or a group of the formula: —NR2(R3) (wherein R2 and R3 are the same or different, and are each a hydrogen atom or an alkyl group having 1 to 10 carbon atoms, X1 is a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a phenoxy group, a halogen atom, a trifluoromethyl group, a carbamoyl group or an aminosulfonyl group, Y1 is a branched or unbranched alkylene group having 1 to 6 carbon atoms or a single bond; and pharmaceutically acceptable salts thereof.
摘要翻译：由下式表示的芳氧基苯胺衍生物：其中Ar1和Ar2相同或不同，并且各自为取代或未取代的苯基，取代或未取代的吡啶基或萘基，条件是Ar 1和Ar 2不同时为苯基或两者萘基，不是苯基和萘基，R1是氢原子，取代或未取代的碳原子数1〜10的烷基，碳原子数1〜10的烷氧基，取代或未取代的苯基或下式的基团： -NR2（R3）（其中R2和R3相同或不同，并且各自为氢原子或具有1-10个碳原子的烷基，X 1为氢原子，具有1至5个碳原子的烷基，具有1至5个碳原子的烷氧基，苯氧基，卤素原子，三氟甲基，氨基甲酰基或氨基磺酰基，Y1是具有1至6个碳原子或单键的支链或非支链亚烷基; 可以接受的盐。

10. 发明授权

US6151388A Communication charge management system 有权
标题翻译：通信费用管理系统
公开(公告)号：US6151388A
公开(公告)日：2000-11-21
申请号：US136363
申请日：1998-08-19
申请人： Toshio Nakamura
发明人： Toshio Nakamura
IPC分类号： H04M3/42 , H04M15/00 , H04M15/02 , H04M15/28 , H04Q3/58
CPC分类号： H04M15/745 , H04M15/00 , H04M15/44 , H04M15/765 , H04M15/7652 , H04M2215/0104 , H04M2215/0108 , H04M2215/724 , H04M2215/7245
摘要： A communication charge management system includes one or more master telephone sets serving as managing telephone sets, one or more slave telephone sets serving as telephone sets managed by the master telephone sets, and a charge informing unit. The charge informing unit informs the master telephone set of the communication charge in communication of the slave telephone set.
摘要翻译：通信费用管理系统包括用作管理电话机的一个或多个主电话机，用作由主电话机管理的电话机的一个或多个从属电话机和充电通知单元。收费通知单元通知主电话机通信从站电话机的通信费用。

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