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1. 发明授权

US6165488A Adhesive composition with macromolecular polyaldehyde base and method for cross-linking collagen 失效
标题翻译：胶体组合物与大分子多醛基和交联胶原蛋白的方法
公开(公告)号：US6165488A
公开(公告)日：2000-12-26
申请号：US91050
申请日：1998-06-08
申请人： Michel Tardy , Herve Volckmann , Jerome Tiollier , Philippe Gravagna , Jean-Louis Tayot
发明人： Michel Tardy , Herve Volckmann , Jerome Tiollier , Philippe Gravagna , Jean-Louis Tayot
IPC分类号： A61L24/00 , A61L24/04 , A61L24/08 , C08H1/06 , C09J103/10 , C09J189/06 , A61F2/02
CPC分类号： A61L24/08 , A61L24/0042 , A61L24/043 , A61L24/046 , C08H1/06 , C08L2666/02 , C09J189/06 , C08L1/04 , C08L89/06 , C08L61/00
摘要： A biocompatible, bioresorbable and nontoxic adhesive composition for surgical and/or therapeutic use, especially for the bonding of biological tissues to one another or to an implanted biomaterial, is provided which comprises at least one biodegradable macromolecular polyaldehyde of natural origin in aqueous solution and a collagen-based component dissolved in aqueous medium. A process for preparing this composition is also provided wherein these aqueous components are mixed together (e.g., at neutral, physiological pH) to give a gel which is rapidly applied to tissues and/or biomaterial to achieve binding. The present invention is advantageous in that it provides biodegradable macromolecular polyaldehydes with adhesive properties and the ability to be extremely well tolerated by the recipient while retaining their adhesive properties during their retention in the body. The invention thus makes it possible to rapidly bind biological tissues to one another or to implanted biological material without tissue lesions in a manner which also retains the quality and the mechanical strength of the adhesion.
摘要翻译： PCT No.PCT / FR97 / 01787第 371日期1998年6月8日第 102（e）日期1998年6月8日PCT 1997年10月7日提交PCT公布。第WO98 / 15299号公报日期1998年04月16日提供了用于手术和/或治疗用途的生物相容性，生物可再吸收和无毒性粘合剂组合物，特别是用于将生物组织彼此粘附或植入的生物材料结合，其包含至少一种天然来源的可生物降解的大分子多醛水溶液和溶于水性介质中的基于胶原的组分。还提供了一种制备该组合物的方法，其中将这些水性成分混合在一起（例如，在中性，生理pH），得到快速施用于组织和/或生物材料以实现结合的凝胶。本发明的优点在于它提供具有粘合性质的生物可降解的大分子多醛，并且其能够在接受者中保持极好的耐受性，同时保持其在体内的粘合性能。因此，本发明使得可以以同样保持粘附的质量和机械强度的方式将生物组织彼此快速结合或植入生物材料而无组织损伤。

2. 发明授权

US06391939B1 Collagenic material useful in particular for preventing post-operative adhesions 有权
公开(公告)号：US06391939B1
公开(公告)日：2002-05-21
申请号：US09355842
申请日：1999-08-05
申请人： Jean-Louis Tayot , Michel Tardy , Philippe Gravagna
发明人： Jean-Louis Tayot , Michel Tardy , Philippe Gravagna
IPC分类号： A61L3100
摘要： The present invention relates to a biocompatible collagenous material which is non-toxic and biodegradable in less than one month, preferably in less than one week. This material comprises collagen and at least one hydrophilic macromolecular additive which is chemically non-reactive towards the collagen, with the collagen having at least partially lost its helical structure and being crosslinked. The invention also relates to a process for obtaining such a material. The collagenous material according to the invention is used, in particular, for preventing post-operative adhesions.

3. 发明授权

US06706684B1 Method for preparing a collagen material with controlled in vivo degradation 有权
标题翻译：用于制备具有受控体内降解的胶原材料的方法
公开(公告)号：US06706684B1
公开(公告)日：2004-03-16
申请号：US09856858
申请日：2001-05-29
申请人： Yves Bayon , Philippe Gravagna , Jean-Louis Tayot
发明人： Yves Bayon , Philippe Gravagna , Jean-Louis Tayot
IPC分类号： A61K3800
CPC分类号： C08H1/06 , A61L15/325 , A61L27/24 , A61L27/48 , A61L27/54 , A61L31/044 , A61L31/129 , A61L31/16 , C08L89/06
摘要： The invention concerns a method for preparing a non-toxic, sterile, biocompatible, crosslinked collagen material with controlled in vivo biodegradation speed. It consists in subjecting a collagen constituent, either to beta radiation, or to gamma radiation. The collagen material obtained is biodegradable in a few days depending on the type of irradiation used.
摘要翻译：本发明涉及制备具有受控的体内生物降解速度的无毒的，无菌的，生物相容的，交联的胶原材料的方法。它包括对胶原蛋白成分进行β辐射或γ辐射。获得的胶原材料在几天内是可生物降解的，这取决于所使用的照射类型。

4. 发明授权

US5618551A Biocompatible bioresorbable and non-toxic adhesive composition for surgical use 失效
标题翻译：生物相容性生物可吸收和无毒的外用胶粘剂组合物
公开(公告)号：US5618551A
公开(公告)日：1997-04-08
申请号：US376185
申请日：1995-01-20
申请人： Michel Tardy , J er ome Tiollier , Jean-Louis Tayot
发明人： Michel Tardy , J er ome Tiollier , Jean-Louis Tayot
IPC分类号： A61L24/00 , A61L24/10 , C08H1/06 , A61L25/00
CPC分类号： C08H1/06 , A61L24/102 , A61L24/104
摘要： The invention relates to a biocompatible, bioresorbable and non-toxic adhesive composition for surgical use, for the bonding, in particular, of biological tissues to one another or in an implanted biomaterial, characterized in that it comprises a reactive acidic solution of non-crosslinked and potentially crosslinkable collagen or gelatin modified by oxidative cleavage, at a concentration which is preferably between approximately 5 and 30 by weight. It also relates to reactive acidic solutions and powders based on non-crosslinked collagen or gelatin modified by oxidative cleavage which are used as intermediate products in the preparation of the above-mentioned composition, and to the process for their preparation. It also relates to adhesive kits which comprise, on the one hand, the above-mentioned reactive acidic solution and, on the other hand, a neutralizing solution and which are intended for extemporaneous mixing. Finally it relates to a method of application of the adhesive, composition according to the invention. The invention is particularly useful in the areas of adhesion, haemostasis, leaktightness with respect to liquids or gases, cicatrization, filling, avoiding adhesion in surgery, embolization, as a local system for release of medicamentary active principles, etc.
摘要翻译：本发明涉及用于外科用途的生物相容性，生物可再吸收和无毒性粘合剂组合物，用于将生物组织彼此或植入的生物材料结合，特别是其包含非交联的反应性酸性溶液和通过氧化切割改性的潜在可交联的胶原或明胶，其浓度优选在约5至30重量比之间。它还涉及基于非交联胶原或通过氧化裂解改性的明胶的反应性酸性溶液和粉末，其用作上述组合物的制备中的中间产物及其制备方法。它还涉及粘合剂试剂盒，其一方面包含上述反应性酸性溶液，另一方面包含中和溶液，其用于临时混合。最后，本发明涉及粘合剂，根据本发明的组合物的应用方法。本发明在粘合，止血，相对于液体或气体的密封性，瘢痕形成，填充，避免手术中的粘连，栓塞，作为释放药物活性成分的局部系统等方面特别有用。

5. 发明授权

US4673734A Porous mineral support coated with an aminated polysaccharide polymer 失效
标题翻译：涂有胺化多糖聚合物的多孔矿物载体
公开(公告)号：US4673734A
公开(公告)日：1987-06-16
申请号：US714525
申请日：1985-03-21
申请人： Jean-Louis Tayot , Michel Tardy
发明人： Jean-Louis Tayot , Michel Tardy
IPC分类号： B01J20/281 , A61K35/30 , A61K47/48 , B01J20/10 , B01J20/32 , B01J41/08 , B01J41/14 , B01J41/16 , C07K1/18 , C07K14/76 , C07K14/765 , C07K16/00 , C07K16/06 , C07K17/14 , C08B37/00 , C08J5/20 , C08K3/36 , C08K5/06 , C08K5/1515 , C08K5/16 , C08K13/02 , C08L1/26 , C08L3/00 , C08L5/12 , C12N11/10 , C12N11/14 , G01N30/88 , B01J20/26 , B01J20/22 , B01D15/08
CPC分类号： B01J20/3204 , A61K35/30 , B01J20/06 , B01J20/28019 , B01J20/28057 , B01J20/286 , B01J20/3092 , B01J20/3274 , B01J20/3425 , B01J20/3475 , C07K1/18 , C07K14/765 , C07K16/065 , C08B37/00 , C12N11/10 , C12N11/14 , B01J2220/54 , B01J2220/58 , Y10S530/83
摘要： A porous mineral support such as a porous mineral oxide coated with an aminated polysaccharide polymer has cationic characteristics and is capable of reversibly fixing thereto biological macromolecules. This material is employed in the separation and purification of said biologic maromolecules.
摘要翻译：涂覆有胺化多糖聚合物的多孔矿物氧化物等多孔矿物载体具有阳离子特性，能够可逆地固定生物大分子。该材料用于分离和纯化所述生物大分子。

6. 再颁专利

USRE39172E1 Method for preparing two-layer bicomposite collagen material for preventing post-operative adhesions 有权
标题翻译：制备双层双层复合胶原材料以防止手术后粘连的方法
公开(公告)号：USRE39172E1
公开(公告)日：2006-07-11
申请号：US10761055
申请日：1999-09-16
申请人： Yves Bayon , Philippe Gravagna , Jean-Louis Tayot
发明人： Yves Bayon , Philippe Gravagna , Jean-Louis Tayot
IPC分类号： A61L15/16 , C12N11/02 , C12M5/06 , C12M5/08 , C08H1/00
CPC分类号： A61L15/325 , A61L31/044
摘要： A bicomposite material based on collagen is prepared which has two closely bound layers and is biocompatible, non-toxic, hemostatic and biodegradable in less than a month, and can be used in surgery to achieve hemostasis and prevent post-surgical adhesion. To prepare the material, a solution of collagen or gelatin, which may contain glycerine and a hydrophilic additive such as polyethylene glycol or a polysaccharide, is poured onto an inert support to form a layer 30 μm to less than 100 μm thick. Then a polymeric porous fibrous layer is applied during gelling of the collagen or gelatin, and the resultant material is dried. The polymeric porous fibrous layer may be made of collagen or a polysaccharide, and have a density of not more than 75 mg/cm2, a pore size from 30 μm to 300 μm and a thickness of 0.2 cm to 1.5 cm.
摘要翻译：制备基于胶原的双组分材料，其具有两个紧密结合的层，并且在不到一个月的时间内具有生物相容性，无毒性，止血性和生物降解性，并且可用于手术以实现止血并防止手术后粘连。为了制备材料，将可能含有甘油和亲水性添加剂如聚乙二醇或多糖的胶原蛋白或明胶溶液倒入惰性支持体中以形成30μm至小于100μm厚的层。然后在胶原或明胶的胶凝过程中施加聚合物多孔纤维层，并将所得材料干燥。聚合物多孔纤维层可以由胶原或多糖制成，并且具有不大于75mg / cm 2的密度，30μm至300μm的孔径和0.2cm的厚度至1.5厘米。

7. 发明授权

US06730299B1 Adhesive protein foam for surgical and/or therapeutic uses 失效
标题翻译：用于手术和/或治疗用途的粘合蛋白泡沫
公开(公告)号：US06730299B1
公开(公告)日：2004-05-04
申请号：US09787543
申请日：2001-03-20
申请人： Jean-Louis Tayot , Yves Bayon , Philippe Gravagna , Michel Marie Dubois
发明人： Jean-Louis Tayot , Yves Bayon , Philippe Gravagna , Michel Marie Dubois
IPC分类号： A61K3851
CPC分类号： C09J189/00 , A61L15/32 , A61L15/425 , A61L24/0036 , A61L24/043 , A61L24/10 , A61L26/0028 , A61L26/0052 , A61L26/0085 , C08J9/122 , C08J2207/02 , C08L89/06
摘要： A biocompatible fluid adhesive protein foam, which is bioresorbable and nontoxic, for surgical and/or therapeutic use, in particular for protecting/cicatrizing tissue wounds and for attaching biological tissues to each other or to an implanted biomaterial. The biocompatible fluid adhesive protein foam includes a biocompatible fluid adhesive protein matrix, which is bioresorbable and nontoxic, containing a biocompatible and nontoxic gas or mixture of gases. Further, a process and a kit for preparing such a foam are provided.
摘要翻译：用于手术和/或治疗用途的生物相容性流体粘合蛋白泡沫，其是生物可再吸收和无毒的，特别是用于保护/瘢痕组织伤口并将生物组织连接到植入的生物材料。生物相容性流体粘合蛋白泡沫包括生物相容性流体粘合蛋白基质，其是生物可再吸收和无毒的，含有生物相容性和无毒气体或气体混合物。此外，提供了制备这种泡沫的方法和试剂盒。

8. 发明授权

US06451032B1 Composite prosthesis for preventing post-surgical adhesions and method for obtaining same 有权
标题翻译：用于预防手术后粘连的复合假体及其获得方法
公开(公告)号：US06451032B1
公开(公告)日：2002-09-17
申请号：US09463313
申请日：2000-01-24
申请人： François Régis Ory , Michel Therin , Philippe Gravagna , Jean-Louis Tayot
发明人： François Régis Ory , Michel Therin , Philippe Gravagna , Jean-Louis Tayot
IPC分类号： A61B1704
CPC分类号： A61L31/10 , A61L31/129 , D04B21/10 , D10B2403/0112 , D10B2403/0213 , D10B2509/08 , C08L89/06 , A61B90/00 , A61L31/148 , A61L31/146 , A61L31/145 , C08L67/00 , C08L71/02 , C08L5/00
摘要： The composite prosthesis comprises a prosthetic fabric having a three-dimensional structure separating two surfaces, one of which is open to post-surgical cell colonization. The composite prosthesis further comprises at least one film of a collagenous material linked to the other surface of the prosthetic fabric. The composite prosthesis may be used to prevent post-surgical adhesion.
摘要翻译：复合假体包括具有分离两个表面的三维结构的假体织物，其中一个表面对手术后细胞定植开放。所述复合假体还包括至少一层与所述假体织物的另一表面连接的胶原材料的膜。复合假体可用于防止手术后粘连。

9. 发明授权

US06605066B1 Device for forming and delivering a mixture 有权
标题翻译：用于形成和输送混合物的装置
公开(公告)号：US06605066B1
公开(公告)日：2003-08-12
申请号：US09554577
申请日：2000-08-29
申请人： Philippe Gravagna , Jean-Louis Tayot
发明人： Philippe Gravagna , Jean-Louis Tayot
IPC分类号： A61M500
CPC分类号： A61B17/00491 , A61B2017/00004 , A61B2017/00084 , A61B2017/00495 , A61M2205/3653
摘要： A device for the formation and delivery of a mixture, notably a surgical adhesive, consisting of a receptacle adapted for easy handling by the surgeon, and including the means of receiving two syringe barrels containing the constituents of the mixture, the means of simultaneously expelling the contents, the means of maintaining the contents of syringe containing the first constituent, at a predetermined temperature setting which is higher than body temperature, and a mixer simultaneously receiving the contents of the two syringes, and the mixer also being used for cooling.
摘要翻译：用于形成和输送混合物的装置，特别是手术粘合剂，其由适于外科医生容易处理的容器组成，并且包括容纳包含混合物成分的两个注射器筒的装置，同时排出内容物，将含有第一成分的注射器的内容物保持在比体温高的预定温度设定的装置以及同时接收两个注射器的内容物的混合器，并且混合器也用于冷却。

10. 发明授权

US5234991A Porous mineral support coated with an aminated polysaccharide polymer 失效
标题翻译：涂有胺化多糖聚合物的多孔矿物载体
公开(公告)号：US5234991A
公开(公告)日：1993-08-10
申请号：US26856
申请日：1987-03-17
申请人： Jean-Louis Tayot , Michel Tardy
发明人： Jean-Louis Tayot , Michel Tardy
IPC分类号： A61K35/30 , A61K47/48 , B01J20/32 , C07K1/18 , C07K14/765 , C07K16/06 , C08B37/00 , C12N11/14
CPC分类号： A61K35/30 , B01J20/06 , B01J20/103 , B01J20/28047 , B01J20/28059 , B01J20/28078 , B01J20/28097 , B01J20/286 , B01J20/291 , B01J20/3092 , B01J20/3204 , B01J20/3274 , B01J20/328 , B01J20/3282 , C07K1/18 , C07K14/765 , C07K16/065 , C08B37/00 , C12N11/14 , B01J2220/4825 , B01J2220/54 , B01J2220/58
摘要： A porous mineral support such as a porous mineral oxide coated with an aminated polysaccharide polymer has cationic characteristics and is capable of reversibly fixing thereto biological macromolecules. This material is employed in the separation and purification of said biologic macromolecules.
摘要翻译：涂覆有胺化多糖聚合物的多孔矿物氧化物等多孔矿物载体具有阳离子特性，能够可逆地固定生物大分子。该材料用于分离和纯化所述生物大分子。

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