专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06391939B1 Collagenic material useful in particular for preventing post-operative adhesions 有权
公开(公告)号：US06391939B1
公开(公告)日：2002-05-21
申请号：US09355842
申请日：1999-08-05
申请人： Jean-Louis Tayot , Michel Tardy , Philippe Gravagna
发明人： Jean-Louis Tayot , Michel Tardy , Philippe Gravagna
IPC分类号： A61L3100
摘要： The present invention relates to a biocompatible collagenous material which is non-toxic and biodegradable in less than one month, preferably in less than one week. This material comprises collagen and at least one hydrophilic macromolecular additive which is chemically non-reactive towards the collagen, with the collagen having at least partially lost its helical structure and being crosslinked. The invention also relates to a process for obtaining such a material. The collagenous material according to the invention is used, in particular, for preventing post-operative adhesions.

2. 发明授权

US6165488A Adhesive composition with macromolecular polyaldehyde base and method for cross-linking collagen 失效
标题翻译：胶体组合物与大分子多醛基和交联胶原蛋白的方法
公开(公告)号：US6165488A
公开(公告)日：2000-12-26
申请号：US91050
申请日：1998-06-08
申请人： Michel Tardy , Herve Volckmann , Jerome Tiollier , Philippe Gravagna , Jean-Louis Tayot
发明人： Michel Tardy , Herve Volckmann , Jerome Tiollier , Philippe Gravagna , Jean-Louis Tayot
IPC分类号： A61L24/00 , A61L24/04 , A61L24/08 , C08H1/06 , C09J103/10 , C09J189/06 , A61F2/02
CPC分类号： A61L24/08 , A61L24/0042 , A61L24/043 , A61L24/046 , C08H1/06 , C08L2666/02 , C09J189/06 , C08L1/04 , C08L89/06 , C08L61/00
摘要： A biocompatible, bioresorbable and nontoxic adhesive composition for surgical and/or therapeutic use, especially for the bonding of biological tissues to one another or to an implanted biomaterial, is provided which comprises at least one biodegradable macromolecular polyaldehyde of natural origin in aqueous solution and a collagen-based component dissolved in aqueous medium. A process for preparing this composition is also provided wherein these aqueous components are mixed together (e.g., at neutral, physiological pH) to give a gel which is rapidly applied to tissues and/or biomaterial to achieve binding. The present invention is advantageous in that it provides biodegradable macromolecular polyaldehydes with adhesive properties and the ability to be extremely well tolerated by the recipient while retaining their adhesive properties during their retention in the body. The invention thus makes it possible to rapidly bind biological tissues to one another or to implanted biological material without tissue lesions in a manner which also retains the quality and the mechanical strength of the adhesion.
摘要翻译： PCT No.PCT / FR97 / 01787第 371日期1998年6月8日第 102（e）日期1998年6月8日PCT 1997年10月7日提交PCT公布。第WO98 / 15299号公报日期1998年04月16日提供了用于手术和/或治疗用途的生物相容性，生物可再吸收和无毒性粘合剂组合物，特别是用于将生物组织彼此粘附或植入的生物材料结合，其包含至少一种天然来源的可生物降解的大分子多醛水溶液和溶于水性介质中的基于胶原的组分。还提供了一种制备该组合物的方法，其中将这些水性成分混合在一起（例如，在中性，生理pH），得到快速施用于组织和/或生物材料以实现结合的凝胶。本发明的优点在于它提供具有粘合性质的生物可降解的大分子多醛，并且其能够在接受者中保持极好的耐受性，同时保持其在体内的粘合性能。因此，本发明使得可以以同样保持粘附的质量和机械强度的方式将生物组织彼此快速结合或植入生物材料而无组织损伤。

3. 发明授权

US5618551A Biocompatible bioresorbable and non-toxic adhesive composition for surgical use 失效
标题翻译：生物相容性生物可吸收和无毒的外用胶粘剂组合物
公开(公告)号：US5618551A
公开(公告)日：1997-04-08
申请号：US376185
申请日：1995-01-20
申请人： Michel Tardy , J er ome Tiollier , Jean-Louis Tayot
发明人： Michel Tardy , J er ome Tiollier , Jean-Louis Tayot
IPC分类号： A61L24/00 , A61L24/10 , C08H1/06 , A61L25/00
CPC分类号： C08H1/06 , A61L24/102 , A61L24/104
摘要： The invention relates to a biocompatible, bioresorbable and non-toxic adhesive composition for surgical use, for the bonding, in particular, of biological tissues to one another or in an implanted biomaterial, characterized in that it comprises a reactive acidic solution of non-crosslinked and potentially crosslinkable collagen or gelatin modified by oxidative cleavage, at a concentration which is preferably between approximately 5 and 30 by weight. It also relates to reactive acidic solutions and powders based on non-crosslinked collagen or gelatin modified by oxidative cleavage which are used as intermediate products in the preparation of the above-mentioned composition, and to the process for their preparation. It also relates to adhesive kits which comprise, on the one hand, the above-mentioned reactive acidic solution and, on the other hand, a neutralizing solution and which are intended for extemporaneous mixing. Finally it relates to a method of application of the adhesive, composition according to the invention. The invention is particularly useful in the areas of adhesion, haemostasis, leaktightness with respect to liquids or gases, cicatrization, filling, avoiding adhesion in surgery, embolization, as a local system for release of medicamentary active principles, etc.
摘要翻译：本发明涉及用于外科用途的生物相容性，生物可再吸收和无毒性粘合剂组合物，用于将生物组织彼此或植入的生物材料结合，特别是其包含非交联的反应性酸性溶液和通过氧化切割改性的潜在可交联的胶原或明胶，其浓度优选在约5至30重量比之间。它还涉及基于非交联胶原或通过氧化裂解改性的明胶的反应性酸性溶液和粉末，其用作上述组合物的制备中的中间产物及其制备方法。它还涉及粘合剂试剂盒，其一方面包含上述反应性酸性溶液，另一方面包含中和溶液，其用于临时混合。最后，本发明涉及粘合剂，根据本发明的组合物的应用方法。本发明在粘合，止血，相对于液体或气体的密封性，瘢痕形成，填充，避免手术中的粘连，栓塞，作为释放药物活性成分的局部系统等方面特别有用。

4. 发明授权

US4673734A Porous mineral support coated with an aminated polysaccharide polymer 失效
标题翻译：涂有胺化多糖聚合物的多孔矿物载体
公开(公告)号：US4673734A
公开(公告)日：1987-06-16
申请号：US714525
申请日：1985-03-21
申请人： Jean-Louis Tayot , Michel Tardy
发明人： Jean-Louis Tayot , Michel Tardy
IPC分类号： B01J20/281 , A61K35/30 , A61K47/48 , B01J20/10 , B01J20/32 , B01J41/08 , B01J41/14 , B01J41/16 , C07K1/18 , C07K14/76 , C07K14/765 , C07K16/00 , C07K16/06 , C07K17/14 , C08B37/00 , C08J5/20 , C08K3/36 , C08K5/06 , C08K5/1515 , C08K5/16 , C08K13/02 , C08L1/26 , C08L3/00 , C08L5/12 , C12N11/10 , C12N11/14 , G01N30/88 , B01J20/26 , B01J20/22 , B01D15/08
CPC分类号： B01J20/3204 , A61K35/30 , B01J20/06 , B01J20/28019 , B01J20/28057 , B01J20/286 , B01J20/3092 , B01J20/3274 , B01J20/3425 , B01J20/3475 , C07K1/18 , C07K14/765 , C07K16/065 , C08B37/00 , C12N11/10 , C12N11/14 , B01J2220/54 , B01J2220/58 , Y10S530/83
摘要： A porous mineral support such as a porous mineral oxide coated with an aminated polysaccharide polymer has cationic characteristics and is capable of reversibly fixing thereto biological macromolecules. This material is employed in the separation and purification of said biologic maromolecules.
摘要翻译：涂覆有胺化多糖聚合物的多孔矿物氧化物等多孔矿物载体具有阳离子特性，能够可逆地固定生物大分子。该材料用于分离和纯化所述生物大分子。

5. 发明授权

US4931546A Process for the treatment of collagen, notably for facilitating its cross-linking, and the collagen obtained by the application of the said process 失效
标题翻译：用于治疗胶原的方法，特别是用于促进其交联，以及通过应用所述方法获得的胶原
公开(公告)号：US4931546A
公开(公告)日：1990-06-05
申请号：US72368
申请日：1987-07-13
申请人： Michel Tardy , Jean-Louis Tayot
发明人： Michel Tardy , Jean-Louis Tayot
IPC分类号： A61L27/00 , A61F2/00 , A61L27/24 , C07K1/107 , C07K1/113 , C07K1/14 , C07K14/78 , C08H1/00 , C08H1/06 , C12N9/96 , C12N11/02
CPC分类号： A61L27/24 , C08H1/06 , C12N11/02 , C12N9/96 , A61F2310/00365
摘要： Collagen is submitted to a controlled oxidation by treatment with a solution of periodic acid or of a periodate, notably of sodium. Application to gels, implants, lenses, films, spheres, etc., of collagen.
摘要翻译：通过用高碘酸或高碘酸盐，特别是钠的溶液处理，将胶原蛋白进行受控氧化。适用于胶原蛋白的凝胶，植入物，镜片，胶片，球体等。

6. 发明授权

US5234991A Porous mineral support coated with an aminated polysaccharide polymer 失效
标题翻译：涂有胺化多糖聚合物的多孔矿物载体
公开(公告)号：US5234991A
公开(公告)日：1993-08-10
申请号：US26856
申请日：1987-03-17
申请人： Jean-Louis Tayot , Michel Tardy
发明人： Jean-Louis Tayot , Michel Tardy
IPC分类号： A61K35/30 , A61K47/48 , B01J20/32 , C07K1/18 , C07K14/765 , C07K16/06 , C08B37/00 , C12N11/14
CPC分类号： A61K35/30 , B01J20/06 , B01J20/103 , B01J20/28047 , B01J20/28059 , B01J20/28078 , B01J20/28097 , B01J20/286 , B01J20/291 , B01J20/3092 , B01J20/3204 , B01J20/3274 , B01J20/328 , B01J20/3282 , C07K1/18 , C07K14/765 , C07K16/065 , C08B37/00 , C12N11/14 , B01J2220/4825 , B01J2220/54 , B01J2220/58
摘要： A porous mineral support such as a porous mineral oxide coated with an aminated polysaccharide polymer has cationic characteristics and is capable of reversibly fixing thereto biological macromolecules. This material is employed in the separation and purification of said biologic macromolecules.
摘要翻译：涂覆有胺化多糖聚合物的多孔矿物氧化物等多孔矿物载体具有阳离子特性，能够可逆地固定生物大分子。该材料用于分离和纯化所述生物大分子。

7. 发明授权

US5201745A Visceral surgery patch 失效
标题翻译：内脏手术补片
公开(公告)号：US5201745A
公开(公告)日：1993-04-13
申请号：US746199
申请日：1991-08-15
申请人： Jean-Louis Tayot , Jacques Marescaux , Henri Dumas , Michel Tardy
发明人： Jean-Louis Tayot , Jacques Marescaux , Henri Dumas , Michel Tardy
IPC分类号： A61F2/00 , A61L31/10 , A61L31/12
CPC分类号： A61L31/10 , A61F2/0063 , A61L31/129 , A61L31/148
摘要： A patch for visceral surgery is made from a biomaterial consisting of two layers of collagen superimposed and closely combined, namely a porous adhesive layer of fibrous collagen and a film of collagen and/or gelatin.
摘要翻译：用于内脏手术的贴片由叠加并紧密组合的两层胶原组成的生物材料制成，即纤维胶原的多孔粘合剂层和胶原和/或明胶膜。

8. 发明授权

US4675384A Fractionation/purification of plasma by ion exchange chromatography 失效
标题翻译：通过离子交换色谱法分级/纯化血浆
公开(公告)号：US4675384A
公开(公告)日：1987-06-23
申请号：US595823
申请日：1984-04-02
申请人： Adrien Dromard , Michel Exertier , Claude Rollin , Jean-Louis Tayot , Michel Tardy
发明人： Adrien Dromard , Michel Exertier , Claude Rollin , Jean-Louis Tayot , Michel Tardy
IPC分类号： A61K39/395 , A61K35/14 , A61K35/16 , A61K38/00 , A61K38/16 , B01J39/16 , B01J47/00 , C07K1/18 , C07K14/435 , C07K14/76 , C07K14/765 , C07K16/00 , C07K16/06 , A61K37/02 , B01D15/06
CPC分类号： C07K16/065 , B01J39/165 , B01J47/003 , C07K14/765 , A61K38/00
摘要： The plasma proteins contained in a plasma solution thereof are chromatographically fractioned, e.g., to obtain a high purity therapeutic grade albumin product, by successively contacting said plasma solution with at least one anion exchanger and at least one cation exchanger in fixed bed chromatography columns, the contact and exchange medium of chromatography therein also comprising a plurality of at least partially hydrophobic support particulates and a plurality of hydrophilic ion exchanger support particulates.
摘要翻译：通过将固定床色谱柱中的至少一个阴离子交换剂和至少一个阳离子交换剂连续接触，将其血浆溶液中含有的血浆蛋白进行色谱分级，例如获得高纯度治疗级白蛋白产物，其中还含有多个至少部分疏水的载体颗粒和多个亲水离子交换剂支持微粒的色谱的接触和交换介质。

9. 发明授权

US4308254A Material able to fix reversibly biologial macromolecules, its preparation and its application 失效
标题翻译：能够修复可逆生物大分子的材料及其制备及其应用
公开(公告)号：US4308254A
公开(公告)日：1981-12-29
申请号：US944121
申请日：1978-09-19
申请人： Jean-Louis Tayot , Michel Tardy
发明人： Jean-Louis Tayot , Michel Tardy
IPC分类号： C04B41/83 , A61K38/16 , A61K39/395 , B01J20/281 , B01J20/32 , B01J41/16 , C07G15/00 , C07H15/10 , C07H21/00 , C07K1/18 , C07K1/22 , C07K14/195 , C07K14/28 , C07K14/41 , C07K14/575 , C07K14/76 , C07K14/765 , C07K16/00 , C07K16/06 , C07K17/02 , C12N9/68 , C12N11/14 , G01N30/88 , G01N33/548 , G01N33/551 , A61K37/04 , A61K39/00 , A61K39/106 , A61K39/12
CPC分类号： C07H15/10 , B01J20/103 , B01J20/262 , B01J20/265 , B01J20/267 , B01J20/28057 , B01J20/28078 , B01J20/286 , B01J20/3092 , B01J20/3204 , B01J20/3246 , B01J20/3248 , B01J20/3251 , B01J20/3253 , B01J20/3272 , B01J20/328 , B01J20/3282 , B01J20/3425 , B01J20/3475 , C07K1/18 , C07K14/28 , C07K14/765 , C07K16/065 , C12N9/6435 , C12Y304/21007 , B01J2220/54 , B01J2220/58
摘要： A process for preparing a porous solid material for use in a chromatography column and which is capable of fixing reversibly biological macromolecules comprises coating a porous inorganic support with a polysaccharide polymer having .alpha.-glycol groups which undergo oxidative scission, subjecting the polysaccharide polymer to an oxidative scission reaction, reacting the resulting oxidized polysaccharide polymer with an amino molecule or macromolecule having the formula R'--NH.sub.2 to produce a polysacchride polymer having the formula R.sub.4 --CH.dbd.N--R' and reducing the imine bond in said immediately above defined polysaccharide polymer to a stable amine bond.
摘要翻译：制备用于色谱柱并能够固定可逆生物大分子的多孔固体材料的方法包括用具有经历氧化断裂的α-二醇基团的多糖聚合物涂覆多孔无机载体，使多糖聚合物经受氧化使所得到的氧化多糖聚合物与具有式R'-NH 2的氨基分子或大分子反应，以产生具有式R4-CH = NR'的多糖聚合物，并将所述立即定义的多糖聚合物中的亚胺键还原成稳定的胺键。

10. 发明授权

US5436135A New preparation of placenta collagen, their extraction method and their applications 失效
标题翻译：胎盘胶原蛋白的新制备及其提取方法及应用
公开(公告)号：US5436135A
公开(公告)日：1995-07-25
申请号：US638022
申请日：1991-01-07
申请人： Jean-Louis Tayot , Michel Tardy
发明人： Jean-Louis Tayot , Michel Tardy
IPC分类号： A61L27/36 , C08H1/06 , C07K14/78
CPC分类号： A61L27/3604 , A61L27/3683 , C08H1/06 , A61L2430/40
摘要： Human or animal placenta is subjected to moderate enzymatic digestion, in particular with pepsin at an acid pH, then, after separation of the residual tissue the impurities are separated at a moderately acid pH, the collagen is precipitated at a neutral pH, redissolved and the residual impurities precipitated at an acid pH. The collagen obtained can be brought back to a neutral pH and dried in the form of fibres. Completely transparent, physiological and hemocompatible gels and solutions can be prepared. Applications for the fabrication of contact lenses and implants.
摘要翻译：对人或动物胎盘进行适度的酶消化，特别是在酸性pH下用胃蛋白酶消化，然后在残留组织分离后，在中等酸性pH下分离杂质，胶原蛋白在中性pH下沉淀，再溶解，残余杂质在酸性pH下沉淀。所获得的胶原可以恢复到中性pH并以纤维的形式干燥。可以制备完全透明的生理和血液相容性凝胶和溶液。用于制造隐形眼镜和植入物的应用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式