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1. 发明申请

US20090054350A1 PROCESS FOR THE STERILE CONCENTRATION OF COLLAGEN PREPARATIONS, AND COLLAGEN PREPARATIONS OBTAINED 审中-公开
标题翻译：胶原蛋白制剂的无菌浓缩方法和获得的胶原蛋白制剂
公开(公告)号：US20090054350A1
公开(公告)日：2009-02-26
申请号：US12194100
申请日：2008-08-19
申请人： Jean-Louis Tayot , Florent Sapin
发明人： Jean-Louis Tayot , Florent Sapin
IPC分类号： A61K38/39
CPC分类号： C07K14/78
摘要： The invention relates to a process for the preparation of sterile collagen, especially injectable collagen, comprising the steps of preparing a purified acidic collagen solution, filtering that solution through a filter or a sterile membrane, precipitating the filtered solution in the form of a suspension, and concentrating the collagen suspension, in which process the suspension is placed in an elongate supple tubular filter constituting a porous filtering wall, permeable to the liquid but not permeable to the collagen fibres, and is concentrated by the slow passage of the liquid through the wall, without any pressure other than gravity, in order to prevent the filtering wall from becoming clogged by the collagen fibres, optionally with absorption of the liquid by an absorbent layer covering the wall or forming part of that wall, and the subsequent flowing-away and/or evaporation of the liquid via the face of the layer remote from the wall, and collagen preparations obtained.
摘要翻译：本发明涉及一种制备无菌胶原蛋白，特别是可注射胶原蛋白的方法，包括以下步骤：制备纯化的酸性胶原溶液，通过过滤器或无菌膜过滤该溶液，以悬浮液的形式沉淀过滤的溶液，并且将胶原悬浮液浓缩，在该过程中，将悬浮液放置在构成多孔过滤壁的细长的柔性管状过滤器中，该液体可透过液体但不能透过胶原纤维，并且通过液体缓慢通过壁，除了重力之外没有任何压力，以防止过滤壁被胶原纤维阻塞，任选地通过覆盖该壁或形成该壁的一部分的吸收层吸收液体，随后流出和 /或通过远离壁的层的表面蒸发液体和获得的胶原蛋白制剂。

2. 发明授权

US5618551A Biocompatible bioresorbable and non-toxic adhesive composition for surgical use 失效
标题翻译：生物相容性生物可吸收和无毒的外用胶粘剂组合物
公开(公告)号：US5618551A
公开(公告)日：1997-04-08
申请号：US376185
申请日：1995-01-20
申请人： Michel Tardy , J er ome Tiollier , Jean-Louis Tayot
发明人： Michel Tardy , J er ome Tiollier , Jean-Louis Tayot
IPC分类号： A61L24/00 , A61L24/10 , C08H1/06 , A61L25/00
CPC分类号： C08H1/06 , A61L24/102 , A61L24/104
摘要： The invention relates to a biocompatible, bioresorbable and non-toxic adhesive composition for surgical use, for the bonding, in particular, of biological tissues to one another or in an implanted biomaterial, characterized in that it comprises a reactive acidic solution of non-crosslinked and potentially crosslinkable collagen or gelatin modified by oxidative cleavage, at a concentration which is preferably between approximately 5 and 30 by weight. It also relates to reactive acidic solutions and powders based on non-crosslinked collagen or gelatin modified by oxidative cleavage which are used as intermediate products in the preparation of the above-mentioned composition, and to the process for their preparation. It also relates to adhesive kits which comprise, on the one hand, the above-mentioned reactive acidic solution and, on the other hand, a neutralizing solution and which are intended for extemporaneous mixing. Finally it relates to a method of application of the adhesive, composition according to the invention. The invention is particularly useful in the areas of adhesion, haemostasis, leaktightness with respect to liquids or gases, cicatrization, filling, avoiding adhesion in surgery, embolization, as a local system for release of medicamentary active principles, etc.
摘要翻译：本发明涉及用于外科用途的生物相容性，生物可再吸收和无毒性粘合剂组合物，用于将生物组织彼此或植入的生物材料结合，特别是其包含非交联的反应性酸性溶液和通过氧化切割改性的潜在可交联的胶原或明胶，其浓度优选在约5至30重量比之间。它还涉及基于非交联胶原或通过氧化裂解改性的明胶的反应性酸性溶液和粉末，其用作上述组合物的制备中的中间产物及其制备方法。它还涉及粘合剂试剂盒，其一方面包含上述反应性酸性溶液，另一方面包含中和溶液，其用于临时混合。最后，本发明涉及粘合剂，根据本发明的组合物的应用方法。本发明在粘合，止血，相对于液体或气体的密封性，瘢痕形成，填充，避免手术中的粘连，栓塞，作为释放药物活性成分的局部系统等方面特别有用。

3. 发明授权

US4673734A Porous mineral support coated with an aminated polysaccharide polymer 失效
标题翻译：涂有胺化多糖聚合物的多孔矿物载体
公开(公告)号：US4673734A
公开(公告)日：1987-06-16
申请号：US714525
申请日：1985-03-21
申请人： Jean-Louis Tayot , Michel Tardy
发明人： Jean-Louis Tayot , Michel Tardy
IPC分类号： B01J20/281 , A61K35/30 , A61K47/48 , B01J20/10 , B01J20/32 , B01J41/08 , B01J41/14 , B01J41/16 , C07K1/18 , C07K14/76 , C07K14/765 , C07K16/00 , C07K16/06 , C07K17/14 , C08B37/00 , C08J5/20 , C08K3/36 , C08K5/06 , C08K5/1515 , C08K5/16 , C08K13/02 , C08L1/26 , C08L3/00 , C08L5/12 , C12N11/10 , C12N11/14 , G01N30/88 , B01J20/26 , B01J20/22 , B01D15/08
CPC分类号： B01J20/3204 , A61K35/30 , B01J20/06 , B01J20/28019 , B01J20/28057 , B01J20/286 , B01J20/3092 , B01J20/3274 , B01J20/3425 , B01J20/3475 , C07K1/18 , C07K14/765 , C07K16/065 , C08B37/00 , C12N11/10 , C12N11/14 , B01J2220/54 , B01J2220/58 , Y10S530/83
摘要： A porous mineral support such as a porous mineral oxide coated with an aminated polysaccharide polymer has cationic characteristics and is capable of reversibly fixing thereto biological macromolecules. This material is employed in the separation and purification of said biologic maromolecules.
摘要翻译：涂覆有胺化多糖聚合物的多孔矿物氧化物等多孔矿物载体具有阳离子特性，能够可逆地固定生物大分子。该材料用于分离和纯化所述生物大分子。

4. 发明授权

US4347244A Ganglioside containing compositions for treating diarrhea 失效
标题翻译：含神经节苷脂的含有治疗腹泻的组合物
公开(公告)号：US4347244A
公开(公告)日：1982-08-31
申请号：US217114
申请日：1980-11-13
申请人： Marie-Claude Mynard , Jean-Louis Tayot
发明人： Marie-Claude Mynard , Jean-Louis Tayot
IPC分类号： C07G99/00 , A61K9/00 , A61K9/14 , A61K9/16 , A61K35/30 , A61K38/00 , A61K47/48 , C07H15/10 , A61K31/70
CPC分类号： A61K9/143 , A61K35/30 , A61K47/48853 , A61K9/1676 , Y10S514/867
摘要： The invention is concerned with a medium onto which is fixed a ganglioside or ganglioside derivative having an affinity for the toxins produced by the bacteria responsible for diarrheas and in particular for the cholera toxin.
摘要翻译： PCT No.PCT / FR80 / 00037 Sec。 371日期：1980年11月13日 102（e）1980年11月13日PCT PCT。出版物WO80 / 01875 1980年9月18日。本发明涉及一种固定有对由负责腹泻的细菌产生的毒素，特别是霍乱毒素具有亲和力的神经节苷脂或神经节苷脂衍生物的培养基。

5. 发明授权

US4303638A Cholera vaccine 失效
标题翻译：霍乱疫苗
公开(公告)号：US4303638A
公开(公告)日：1981-12-01
申请号：US944122
申请日：1978-09-19
申请人： Jean-Louis Tayot , Marie-Claude Mynard
发明人： Jean-Louis Tayot , Marie-Claude Mynard
IPC分类号： A61K9/00 , A61K9/32 , A61K9/50 , A61K35/30 , A61K39/106 , C07H15/10 , A61K9/58
CPC分类号： A61K39/107 , A61K2039/515 , A61K2039/6006 , A61K2039/6087 , A61K2039/622
摘要： A particulate material for inducing immunity to cholera toxin comprises support particles provided with a first coating of a ganglioside having affinity for cholera toxin and a second coating of cholera toxin attached to said ganglioside coating. This particulate material can be used as an orally or parenterally administered medicine for humans to induce an immunity response to cholera toxin.
摘要翻译：用于诱导对霍乱毒素免疫的颗粒材料包括提供有与霍乱毒素具有亲和力的神经节苷脂的第一包衣和附着于所述神经节苷脂包衣的霍乱毒素的第二包衣的载体颗粒。这种颗粒物质可以作为口服或胃肠外给药的药物用于诱导针对霍乱毒素的免疫应答。

6. 发明授权

US06706684B1 Method for preparing a collagen material with controlled in vivo degradation 有权
标题翻译：用于制备具有受控体内降解的胶原材料的方法
公开(公告)号：US06706684B1
公开(公告)日：2004-03-16
申请号：US09856858
申请日：2001-05-29
申请人： Yves Bayon , Philippe Gravagna , Jean-Louis Tayot
发明人： Yves Bayon , Philippe Gravagna , Jean-Louis Tayot
IPC分类号： A61K3800
CPC分类号： C08H1/06 , A61L15/325 , A61L27/24 , A61L27/48 , A61L27/54 , A61L31/044 , A61L31/129 , A61L31/16 , C08L89/06
摘要： The invention concerns a method for preparing a non-toxic, sterile, biocompatible, crosslinked collagen material with controlled in vivo biodegradation speed. It consists in subjecting a collagen constituent, either to beta radiation, or to gamma radiation. The collagen material obtained is biodegradable in a few days depending on the type of irradiation used.
摘要翻译：本发明涉及制备具有受控的体内生物降解速度的无毒的，无菌的，生物相容的，交联的胶原材料的方法。它包括对胶原蛋白成分进行β辐射或γ辐射。获得的胶原材料在几天内是可生物降解的，这取决于所使用的照射类型。

7. 发明授权

US5654290A Polyunsaturated fatty acid based drugs 失效
标题翻译：多不饱和脂肪酸类药物
公开(公告)号：US5654290A
公开(公告)日：1997-08-05
申请号：US256825
申请日：1994-09-21
申请人： Yves Bayon , Martine Croset , Michel Lagarde , Jean Lecerf , Frank Thies , Jean-Louis Tayot , Veronique Chirouze
发明人： Yves Bayon , Martine Croset , Michel Lagarde , Jean Lecerf , Frank Thies , Jean-Louis Tayot , Veronique Chirouze
IPC分类号： A61K38/00 , A61K31/195 , A61K31/23 , A61K31/685 , A61P9/08 , A61P9/10 , A61P13/02 , A61P15/00 , C07F9/10 , C11B11/00 , C11C3/00
CPC分类号： A61K31/23
摘要： Drug compositions comprised of therapeutically effective amounts of at least one compound selected from the group consisting of:DHA esterified in the form of lysophosphatidyl-choline (lyso-PCDHA) in position sn-2;DHA-phosphatidylcholines (PCDHAs) in which DHA is esterified in position sn-2 and which have an acyl group of [very short length] 2 to 6 carbon atoms in position sn-1;and triglycerides in which DHA is esterified in position sn-2 and which have acyl groups of [very short length] 2 to 6 carbon atoms in positions sn-1 and sn-3.
摘要翻译： PCT No.PCT / FR93 / 01158 Sec。 371日期1994年9月21日 102（e）1994年9月21日PCT 1993年11月24日PCT公布。公开号WO94 / 12170 日期1994年6月9日由治疗有效量的至少一种选自以下的化合物组成的药物组合物：在位置sn-2中以溶血磷脂酰胆碱（溶血磷脂酰胆碱）的形式酯化的DHA; DHA在位置sn-2中被酯化并且具有位置sn-1具有2至6个[非常短的长度] 2至6个碳原子的酰基的DHA-磷脂酰胆碱（PCDHA）和其中DHA在位置sn-2被酯化并且在sn-1和sn-3位具有[具有短长度] 2至6个碳原子的酰基的甘油三酯。

8. 发明授权

US5234991A Porous mineral support coated with an aminated polysaccharide polymer 失效
标题翻译：涂有胺化多糖聚合物的多孔矿物载体
公开(公告)号：US5234991A
公开(公告)日：1993-08-10
申请号：US26856
申请日：1987-03-17
申请人： Jean-Louis Tayot , Michel Tardy
发明人： Jean-Louis Tayot , Michel Tardy
IPC分类号： A61K35/30 , A61K47/48 , B01J20/32 , C07K1/18 , C07K14/765 , C07K16/06 , C08B37/00 , C12N11/14
CPC分类号： A61K35/30 , B01J20/06 , B01J20/103 , B01J20/28047 , B01J20/28059 , B01J20/28078 , B01J20/28097 , B01J20/286 , B01J20/291 , B01J20/3092 , B01J20/3204 , B01J20/3274 , B01J20/328 , B01J20/3282 , C07K1/18 , C07K14/765 , C07K16/065 , C08B37/00 , C12N11/14 , B01J2220/4825 , B01J2220/54 , B01J2220/58
摘要： A porous mineral support such as a porous mineral oxide coated with an aminated polysaccharide polymer has cationic characteristics and is capable of reversibly fixing thereto biological macromolecules. This material is employed in the separation and purification of said biologic macromolecules.
摘要翻译：涂覆有胺化多糖聚合物的多孔矿物氧化物等多孔矿物载体具有阳离子特性，能够可逆地固定生物大分子。该材料用于分离和纯化所述生物大分子。

9. 发明授权

US5201745A Visceral surgery patch 失效
标题翻译：内脏手术补片
公开(公告)号：US5201745A
公开(公告)日：1993-04-13
申请号：US746199
申请日：1991-08-15
申请人： Jean-Louis Tayot , Jacques Marescaux , Henri Dumas , Michel Tardy
发明人： Jean-Louis Tayot , Jacques Marescaux , Henri Dumas , Michel Tardy
IPC分类号： A61F2/00 , A61L31/10 , A61L31/12
CPC分类号： A61L31/10 , A61F2/0063 , A61L31/129 , A61L31/148
摘要： A patch for visceral surgery is made from a biomaterial consisting of two layers of collagen superimposed and closely combined, namely a porous adhesive layer of fibrous collagen and a film of collagen and/or gelatin.
摘要翻译：用于内脏手术的贴片由叠加并紧密组合的两层胶原组成的生物材料制成，即纤维胶原的多孔粘合剂层和胶原和/或明胶膜。

10. 发明授权

US4675384A Fractionation/purification of plasma by ion exchange chromatography 失效
标题翻译：通过离子交换色谱法分级/纯化血浆
公开(公告)号：US4675384A
公开(公告)日：1987-06-23
申请号：US595823
申请日：1984-04-02
申请人： Adrien Dromard , Michel Exertier , Claude Rollin , Jean-Louis Tayot , Michel Tardy
发明人： Adrien Dromard , Michel Exertier , Claude Rollin , Jean-Louis Tayot , Michel Tardy
IPC分类号： A61K39/395 , A61K35/14 , A61K35/16 , A61K38/00 , A61K38/16 , B01J39/16 , B01J47/00 , C07K1/18 , C07K14/435 , C07K14/76 , C07K14/765 , C07K16/00 , C07K16/06 , A61K37/02 , B01D15/06
CPC分类号： C07K16/065 , B01J39/165 , B01J47/003 , C07K14/765 , A61K38/00
摘要： The plasma proteins contained in a plasma solution thereof are chromatographically fractioned, e.g., to obtain a high purity therapeutic grade albumin product, by successively contacting said plasma solution with at least one anion exchanger and at least one cation exchanger in fixed bed chromatography columns, the contact and exchange medium of chromatography therein also comprising a plurality of at least partially hydrophobic support particulates and a plurality of hydrophilic ion exchanger support particulates.
摘要翻译：通过将固定床色谱柱中的至少一个阴离子交换剂和至少一个阳离子交换剂连续接触，将其血浆溶液中含有的血浆蛋白进行色谱分级，例如获得高纯度治疗级白蛋白产物，其中还含有多个至少部分疏水的载体颗粒和多个亲水离子交换剂支持微粒的色谱的接触和交换介质。

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