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1. 发明申请

US20120245505A1 INTRACAMERAL DEVICES FOR SUSTAINED DELIVERY 审中-公开
标题翻译：用于持续交付的内部设备
公开(公告)号：US20120245505A1
公开(公告)日：2012-09-27
申请号：US13511548
申请日：2010-12-14
申请人： Michael R. Robinson , Werhner C. Orilla , Zoran Novakovic , James A. Burke , Alazar N. Ghebremeskel , Lon T. Spada
发明人： Michael R. Robinson , Werhner C. Orilla , Zoran Novakovic , James A. Burke , Alazar N. Ghebremeskel , Lon T. Spada
IPC分类号： A61F9/00 , A61M1/00 , A61M35/00
CPC分类号： A61F9/0017 , A61F9/00781 , A61K9/0051 , A61K9/0092
摘要： Described herein are intracameral drug and/or therapeutic bioactive agent delivery devices comprising a substantially cylindrical structure for at least partial placement into the anterior chamber of an eye The intracameral delivery devices have a sustained release material associated with at least a portion of the device and at least one drug and/or therapeutic bioactive agent associated with said sustained release material.
摘要翻译：本文描述的是包括用于至少部分地放置到眼睛前房中的基本圆柱形结构的房内药物和/或治疗性生物活性剂递送装置。室内输送装置具有与装置的至少一部分相关联的持续释放材料，并且在与所述缓释材料相关的至少一种药物和/或治疗性生物活性剂。

2. 发明申请

US20100247606A1 INTRAOCULAR SUSTAINED RELEASE DRUG DELIVERY SYSTEMS AND METHODS FOR TREATING OCULAR CONDITIONS 审中-公开
标题翻译：内镜持续释放药物输送系统及治疗眼睛病症的方法
公开(公告)号：US20100247606A1
公开(公告)日：2010-09-30
申请号：US12411250
申请日：2009-03-25
申请人： Michael R. ROBINSON , James A. Burke , Hui Liu , Werhner C. Orilla , Lon T. Spada , Scott Whitcup , Alazar N. Ghebremskel , Patrick M. Hughes , Kun Xu , Marianne M. Do
发明人： Michael R. ROBINSON , James A. Burke , Hui Liu , Werhner C. Orilla , Lon T. Spada , Scott Whitcup , Alazar N. Ghebremskel , Patrick M. Hughes , Kun Xu , Marianne M. Do
IPC分类号： A61F2/00 , A61K31/215 , A61K31/165 , A61K9/14 , A61K31/4025 , A61K31/426 , A61K31/415 , A61K31/42
CPC分类号： A61K31/557 , A61K9/0051 , A61K9/1647 , A61K9/70 , A61K31/00 , A61K31/5575
摘要： Biocompatible, bioerodible sustained release implants and microspheres for intracameral or anterior vitreal placement include an anti-hypertensive agent and a biodegradable polymer effective to treat an ocular hypertensive condition (such as glaucoma) by relapsing therapeutic amount of the anti-hypertensive agent over a period of time between 10 days and 1 year.
摘要翻译：生物相容性，生物可蚀性缓释植入物和用于乳房内或玻璃体前置放置的微球包括抗高血压剂和可生物降解的聚合物，其通过在一段时间内复发治疗量的抗高血压药物而有效治疗眼高血压病症（如青光眼）时间在10天到1年之间。

3. 发明授权

US08969415B2 Intraocular drug delivery systems 有权
标题翻译：眼内药物输送系统
公开(公告)号：US08969415B2
公开(公告)日：2015-03-03
申请号：US11565917
申请日：2006-12-01
申请人： Michael R. Robinson , Wendy M. Blanda , Patrick M. Hughes , Guadalupe Ruiz , Werhner C. Orilla , Scott M. Whitcup , Devin F. Welty , Joan-En Lin , Lon T. Spada
发明人： Michael R. Robinson , Wendy M. Blanda , Patrick M. Hughes , Guadalupe Ruiz , Werhner C. Orilla , Scott M. Whitcup , Devin F. Welty , Joan-En Lin , Lon T. Spada
IPC分类号： A61K31/165 , A61F2/00 , A61K31/565 , A61F9/00 , A61K9/00 , A61K9/16 , A61K9/50 , A61K31/498 , A61K31/557 , A61K9/10
CPC分类号： A61K31/565 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K9/10 , A61K9/1635 , A61K9/1694 , A61K9/5031 , A61K31/498 , A61K31/557 , A61K47/34 , Y10S514/913
摘要： Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 10 days and one year or longer.
摘要翻译：尺寸适于植入眼部或部位的可生物降解植入物以及用于治疗眼部病症的方法。植入物以治疗有效量提供活性剂在10天至1年或更长时间内的延长释放。

4. 发明授权

US08529927B2 Alpha-2 agonist polymeric drug delivery systems 有权
标题翻译： α-2激动剂聚合物药物递送系统
公开(公告)号：US08529927B2
公开(公告)日：2013-09-10
申请号：US11394765
申请日：2006-03-31
申请人： James N. Chang , Lon T. Spada , Wendy M. Blanda , Werhner C. Orilla , James A. Burke , Patrick M. Hughes
发明人： James N. Chang , Lon T. Spada , Wendy M. Blanda , Werhner C. Orilla , James A. Burke , Patrick M. Hughes
IPC分类号： A61K9/00 , A61K31/415 , A61K31/417 , A61K31/498 , A01N43/50
CPC分类号： A61K9/0051 , A61K31/498 , A61L27/18 , A61L27/26 , A61L27/54 , A61L27/58 , A61L2300/604 , A61L2430/16 , Y02A50/401 , C08L67/04
摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, including reduction of an elevated intraocular pressure.
摘要翻译：生物相容性眼内植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。植入物可以放置在眼睛中以治疗一种或多种眼部病症，例如眼睛血管病变或青光眼，包括降低眼内压升高。

5. 发明申请

US20090004245A1 Use of an iris simulated layer to allow aesthetic appearance drug loaded contact lens 审中-公开
标题翻译：使用虹膜模拟层，使美容外观加载隐形眼镜
公开(公告)号：US20090004245A1
公开(公告)日：2009-01-01
申请号：US11823865
申请日：2007-06-28
申请人： Werhner C. Orilla , Michael R. Robinson , James A. Burke
发明人： Werhner C. Orilla , Michael R. Robinson , James A. Burke
IPC分类号： A61K9/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： A drug delivery device includes a contact lens along with a drug delivery zone disposed above an applied axis of the lens. A colored layer is disposed over the drug delivery zone in order to mark a color of the drug delivery zone.
摘要翻译：药物输送装置包括接触透镜以及设置在透镜的施加轴线上方的药物输送区域。为了标记药物递送区域的颜色，将着色层设置在药物递送区域上方。

6. 发明授权

US09039761B2 Ocular implant delivery assemblies with distal caps 有权
标题翻译：具有远端帽的眼部植入物输送组件
公开(公告)号：US09039761B2
公开(公告)日：2015-05-26
申请号：US11552630
申请日：2006-10-25
申请人： John T. Trogden , Robert T. Lyons , James N. Chang , Michael R. Robinson , Werhner C. Orilla
发明人： John T. Trogden , Robert T. Lyons , James N. Chang , Michael R. Robinson , Werhner C. Orilla
IPC分类号： A61F2/16 , A61F9/00 , A61K9/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： Ocular implant delivery assemblies are provided which include a cannula having a lumen extending therethrough, a proximal end, a proximal end opening, a distal end, a distal end opening, and a lumen extending through the cannula. A cap is provided having a closed distal end, being in contact with the outer wall of the cannula, and covering the distal end and the distal end opening of the cannula, the cap being structured to allow the distal end and the distal end opening of the cannula to pass through the cap as the cannula is passed into an eye. An ocular implant is located in the lumen. The implant may be sealed in the cannula without the addition of a liquid carrier or it may be contained in a liquid carrier medium in the cannula. The implant may be made up of a number of microparticles having different compositions or different forms. The assembly also includes a sleeve located on the proximal end of the cannula and suitable for coupling the assembly to a syringe containing a pushing gel.
摘要翻译：提供了眼部植入物递送组件，其包括具有延伸穿过其中的内腔的套管，近端，近端开口，远端，远端开口和延伸穿过套管的内腔。提供具有封闭的远端的盖，其与套管的外壁接触并且覆盖套管的远端和远端开口，帽被构造成允许远端和远端开口当套管穿过眼睛时，套管穿过帽子。眼内植入物位于内腔中。植入物可以密封在套管中而不加入液体载体，或者其可以包含在插管中的液体载体介质中。植入物可以由具有不同组成或不同形式的许多微粒组成。组件还包括位于套管的近端上的套筒，并且适于将组件耦合到包含推动凝胶的注射器。

7. 发明申请

US20080033351A1 OCULAR IMPLANT DELIVERY ASSEMBLIES WITH DISTAL CAPS 有权
标题翻译： OCULAR IMPLANT交付组件与远端CAPS
公开(公告)号：US20080033351A1
公开(公告)日：2008-02-07
申请号：US11552630
申请日：2006-10-25
申请人： John T. Trogden , Robert T. Lyons , James N. Chang , Michael R. Robinson , Werhner C. Orilla
发明人： John T. Trogden , Robert T. Lyons , James N. Chang , Michael R. Robinson , Werhner C. Orilla
IPC分类号： A61M31/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： Ocular implant delivery assemblies are provided which include a cannula having a lumen extending therethrough, a proximal end, a proximal end opening, a distal end, a distal end opening, and a lumen extending through the cannula. A cap is provided having a closed distal end, being in contact with the outer wall of the cannula, and covering the distal end and the distal end opening of the cannula, the cap being structured to allow the distal end and the distal end opening of the cannula to pass through the cap as the cannula is passed into an eye. An ocular implant is located in the lumen. The implant may be sealed in the cannula without the addition of a liquid carrier or it may be contained in a liquid carrier medium in the cannula. The implant may be made up of a number of microparticles having different compositions or different forms. The assembly also includes a sleeve located on the proximal end of the cannula and suitable for coupling the assembly to a syringe containing a pushing gel.
摘要翻译：提供了眼部植入物递送组件，其包括具有延伸穿过其中的内腔的套管，近端，近端开口，远端，远端开口和延伸穿过套管的内腔。提供具有封闭的远端的盖，其与套管的外壁接触并且覆盖套管的远端和远端开口，帽被构造成允许远端和远端开口当套管穿过眼睛时，套管穿过帽子。眼内植入物位于内腔中。植入物可以密封在套管中而不加入液体载体，或者其可以包含在插管中的液体载体介质中。植入物可以由具有不同组成或不同形式的许多微粒组成。组件还包括位于套管的近端上的套筒，并且适于将组件耦合到包含推动凝胶的注射器。

8. 发明申请

US20080131484A1 INTRAOCULAR DRUG DELIVERY SYSTEMS 有权
标题翻译：内分泌药物输送系统
公开(公告)号：US20080131484A1
公开(公告)日：2008-06-05
申请号：US11565917
申请日：2006-12-01
申请人： Michael R. Robinson , Wendy M. Blanda , Patrick M. Hughes , Guadalupe Ruiz , Werhner C. Orilla , Scott M. Whitcup
发明人： Michael R. Robinson , Wendy M. Blanda , Patrick M. Hughes , Guadalupe Ruiz , Werhner C. Orilla , Scott M. Whitcup
IPC分类号： A61K9/00 , A61K31/56 , A61F9/00 , A61K31/498 , A61P27/02 , A61K31/565 , A61K31/495
CPC分类号： A61K31/565 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K9/10 , A61K9/1635 , A61K9/1694 , A61K9/5031 , A61K31/498 , A61K31/557 , A61K47/34 , Y10S514/913
摘要： Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 10 days and one year or longer.
摘要翻译：尺寸适于植入眼部或部位的可生物降解植入物以及用于治疗眼部病症的方法。植入物以治疗有效量提供活性剂在10天至1年或更长时间内的延长释放。

9. 发明申请

US20090004244A1 Iris design as a drug depot for zonal drug delivery by contact lens 审中-公开
标题翻译：虹膜设计为隐形眼镜带状药物递送的药物库
公开(公告)号：US20090004244A1
公开(公告)日：2009-01-01
申请号：US11823471
申请日：2007-06-27
申请人： Werhner C. Orilla , James A. Burke
发明人： Werhner C. Orilla , James A. Burke
IPC分类号： G02C7/04
CPC分类号： G02C7/046
摘要： A contact lens providing zonal drug delivery includes a lens body having an optical axis and an opaque simulated iris pattern applied to the lens body, about the optical axis, with the pattern including an ophthalmic drug.
摘要翻译：提供区域药物递送的隐形眼镜包括透镜体，其具有围绕光轴施加到透镜体的光轴和不透明的模拟虹膜图案，图案包括眼科药物。

10. 发明授权

US08353862B2 Drug delivery systems and methods 有权
标题翻译：药物输送系统和方法
公开(公告)号：US08353862B2
公开(公告)日：2013-01-15
申请号：US11934218
申请日：2007-11-02
申请人： Werhner C. Orilla , James A. Burke
发明人： Werhner C. Orilla , James A. Burke
IPC分类号： A61M31/00
CPC分类号： A61F9/00736 , A61F9/0008 , A61F9/0017 , A61F9/007 , A61M5/178 , A61M5/31515 , A61M37/0069 , A61M2005/31598
摘要： A delivery system includes a housing along with a tip connected to one end of the housing. A first cannula extending from the tip is provided for inserting a rod implant into tissue. A second cannula, concentrically disposed within the first cannula, is utilized to force the rod implant from the first cannula and for ejecting a fluid behind the inserted rod implant in the tissue.
摘要翻译：输送系统包括壳体以及连接到壳体的一端的尖端。提供从尖端延伸的第一插管用于将杆植入物插入组织。同心地设置在第一插管内的第二套管用于迫使杆植入物从第一套管中推出并将弹性体喷射在组织中的插入的杆植入物之后。

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