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1. 发明申请

US20090120923A1 WATER HEATER OF ENDORSEMENT WITH IONIZED IGNITION AND ELECTRONIC CONTROL OF TEMPERATURE, FOR SOLAR HEATERS OF THE TYPE THERMOSIPHON 失效
标题翻译：带有点火点火和电子温度控制的加热器，用于恒温恒温器的太阳能加热器
公开(公告)号：US20090120923A1
公开(公告)日：2009-05-14
申请号：US12128990
申请日：2008-05-29
申请人： MARIA GUADALUPE RUIZ MAYEN , GILBERTO SANCHEZ VILLALOBOS
发明人： MARIA GUADALUPE RUIZ MAYEN , GILBERTO SANCHEZ VILLALOBOS
IPC分类号： F23Q7/22
CPC分类号： F23Q3/00 , F24D12/02 , F24D2200/04 , F24D2200/14 , F24H1/26 , F24H9/2035 , Y02B10/20 , Y02B10/70 , Y02B30/14
摘要： A backup water heater for a solar water heater operates by means of an electronic card that initiates the operation of the heater in response to temperature and flow signals. A burner is lit gradually by an electrical spark emitted by a spark plug connected to the electronic card, which controls gas feed to the burner. As soon as the burner is lit, the electric current generated by the first spark plug is transformed by the ionization effect, changing the polarization of the current, which is detected by another spark plug that emits the change signal to the electronic card for further control of the water heater.
摘要翻译：用于太阳能热水器的备用热水器通过电子卡操作，该电子卡响应于温度和流量信号启动加热器的操作。通过连接到电子卡片的火花塞发出的电火花逐渐点燃燃烧器，该火花塞控制燃烧器的气体供给。一旦燃烧器点亮，第一火花塞产生的电流就会被电离效应所改变，改变了电流的极化，该电流被另一个火花塞检测到，该火花塞发出改变信号给电子卡进一步控制的热水器。

2. 发明授权

US06252950B1 Predictive bursty real-time traffic control for telecommunications switching systems 有权
标题翻译：电信交换系统的预测突发实时业务控制
公开(公告)号：US06252950B1
公开(公告)日：2001-06-26
申请号：US09163614
申请日：1998-09-30
申请人： David Allen Duty , Jose Guadalupe Ruiz
发明人： David Allen Duty , Jose Guadalupe Ruiz
IPC分类号： H04M1500
CPC分类号： H04M3/365
摘要： A traffic control system (and associated method) according to the present invention includes a feedback control mechanism in which the controlled variable is processor occupancy, the controlling variable is the amount of resources necessary to satisfy the operational requirements of the switching system, and the set point is the average expected load based on a Poisson arrival rate. Current processor occupancy is compared, on an instantaneous basis against the set point to determine if it exceeds the average expected load. If so, the controlling variable is adjusted to allocate additional resources to process the offered traffic load. The process continues until the traffic burst expires. Additional resources may be obtained by eliminating or deferring non-essential work, and by allocating additional call registers, effectively accepting work in larger increments or batches. By instantly and proactively responding to traffic bursts, this traffic control system aids the switching system in weathering brief periods of high traffic, without actually reaching an overload condition and invoking overload controls. As a result, switching system capacity is increased, and other performance characteristics are improved.
摘要翻译：根据本发明的交通控制系统（及相关方法）包括其中控制变量是处理器占用的反馈控制机构，控制变量是满足交换系统的操作要求所需的资源量，并且该组点是基于泊松到达率的平均预期负荷。当前处理器占用率与瞬时基准值进行比较，以确定其是否超过平均预期负载。如果是这样，则调整控制变量以分配额外的资源来处理所提供的业务负载。流程持续到流量爆发到期。可以通过消除或推迟非必要工作，并分配额外的呼叫记录，以更大的增量或批量有效接受工作来获得更多的资源。通过立即主动响应流量突发，这种交通控制系统有助于交换系统在短时间内流量高，而不会实际达到过载状况，并调用过载控制。结果，提高了交换系统容量，提高了其他性能特性。

3. 发明授权

US5521210A Ophthalmic use of muscarinic agonists having increased duration of activity 失效
标题翻译：具有增加活动持续时间的毒蕈碱激动剂的眼科用途
公开(公告)号：US5521210A
公开(公告)日：1996-05-28
申请号：US48829
申请日：1993-04-13
申请人： Elizabeth WoldeMussie , Roger F. Steinert , Guadalupe Ruiz
发明人： Elizabeth WoldeMussie , Roger F. Steinert , Guadalupe Ruiz
IPC分类号： A61K31/40
CPC分类号： A61K31/40 , Y10S514/912 , Y10S514/913
摘要： A method for inducing prolonged pseudoaccommodation includes the instillation of an ophthalmic formulation into an eye for contracting the iris sphincter muscle, but not the ciliary muscle, in order to cause sphincter muscle contraction for a period of greater than about one hour per installation. The method further provides for the stabilization of an implanted intraocular lens immediately after surgery and for reducing glare following radial keratotomy.
摘要翻译：用于诱导长时间假性调节的方法包括将眼用制剂滴入眼睛以将虹膜括约肌肌肉而不是睫状肌收缩，以便每次安装大于约1小时引起括约肌收缩。该方法进一步提供了在手术后立即稳定植入的眼内晶状体，并且用于减小径向角膜切开术后的眩光。

4. 发明申请

US20080131484A1 INTRAOCULAR DRUG DELIVERY SYSTEMS 有权
标题翻译：内分泌药物输送系统
公开(公告)号：US20080131484A1
公开(公告)日：2008-06-05
申请号：US11565917
申请日：2006-12-01
申请人： Michael R. Robinson , Wendy M. Blanda , Patrick M. Hughes , Guadalupe Ruiz , Werhner C. Orilla , Scott M. Whitcup
发明人： Michael R. Robinson , Wendy M. Blanda , Patrick M. Hughes , Guadalupe Ruiz , Werhner C. Orilla , Scott M. Whitcup
IPC分类号： A61K9/00 , A61K31/56 , A61F9/00 , A61K31/498 , A61P27/02 , A61K31/565 , A61K31/495
CPC分类号： A61K31/565 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K9/10 , A61K9/1635 , A61K9/1694 , A61K9/5031 , A61K31/498 , A61K31/557 , A61K47/34 , Y10S514/913
摘要： Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 10 days and one year or longer.
摘要翻译：尺寸适于植入眼部或部位的可生物降解植入物以及用于治疗眼部病症的方法。植入物以治疗有效量提供活性剂在10天至1年或更长时间内的延长释放。

5. 发明授权

US5559151A Method for reducing intraocular pressure in the mammalian eye by administration of chloride channel blockers 失效
标题翻译：通过施用氯化物通道阻断剂降低哺乳动物眼睛眼内压的方法
公开(公告)号：US5559151A
公开(公告)日：1996-09-24
申请号：US346660
申请日：1994-11-30
申请人： Joseph S. Adorante , Elizabeth WoldeMussie , Guadalupe Ruiz
发明人： Joseph S. Adorante , Elizabeth WoldeMussie , Guadalupe Ruiz
IPC分类号： A61K45/00 , A61K31/00 , A61K31/137 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/24 , A61K31/245 , A61K31/26 , A61P27/02 , A61P27/06
CPC分类号： A61K31/00 , A61K31/137 , A61K31/192 , A61K31/196 , A61K31/26 , Y10S514/912 , Y10S514/913
摘要： Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains, as the active ingredient, one or more compounds having chloride channel blocking activity. Examples of chloride channel blockers utilized in the pharmaceutical composition and method of treatment are: ##STR1## wherein R is hydrogen or a pharmaceutically-acceptable cation, e.g. an alkali or alkaline earth metal, or a quaternary amine; or R represents a ester-forming moiety, e.g. a lower alkyl radical, having up to six carbon atoms, that may be derived from a lower alkanol.
摘要翻译：公开了用于治疗哺乳动物眼中的青光眼和/或高眼压症的药物组合物和方法，其通过向哺乳动物眼睛施用本发明的药物组合物，其含有一种或多种具有氯通道阻断活性的化合物作为活性成分。在药物组合物和治疗方法中使用的氯化物通道阻断剂的实例是：其中R是氢或药学上可接受的阳离子，例如，碱金属或碱土金属或季胺; 或R表示酯形成部分，例如。具有至多6个碳原子的低级烷基，其可以衍生自低级链烷醇。

6. 发明授权

US08969415B2 Intraocular drug delivery systems 有权
标题翻译：眼内药物输送系统
公开(公告)号：US08969415B2
公开(公告)日：2015-03-03
申请号：US11565917
申请日：2006-12-01
申请人： Michael R. Robinson , Wendy M. Blanda , Patrick M. Hughes , Guadalupe Ruiz , Werhner C. Orilla , Scott M. Whitcup , Devin F. Welty , Joan-En Lin , Lon T. Spada
发明人： Michael R. Robinson , Wendy M. Blanda , Patrick M. Hughes , Guadalupe Ruiz , Werhner C. Orilla , Scott M. Whitcup , Devin F. Welty , Joan-En Lin , Lon T. Spada
IPC分类号： A61K31/165 , A61F2/00 , A61K31/565 , A61F9/00 , A61K9/00 , A61K9/16 , A61K9/50 , A61K31/498 , A61K31/557 , A61K9/10
CPC分类号： A61K31/565 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K9/10 , A61K9/1635 , A61K9/1694 , A61K9/5031 , A61K31/498 , A61K31/557 , A61K47/34 , Y10S514/913
摘要： Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 10 days and one year or longer.
摘要翻译：尺寸适于植入眼部或部位的可生物降解植入物以及用于治疗眼部病症的方法。植入物以治疗有效量提供活性剂在10天至1年或更长时间内的延长释放。

7. 发明授权

US5891911A Method for reducing intraocular pressure in the mammalian eye by administration of calcium chelators 失效
标题翻译：通过施用钙螯合剂降低哺乳动物眼睛眼内压的方法
公开(公告)号：US5891911A
公开(公告)日：1999-04-06
申请号：US260648
申请日：1995-07-28
申请人： Joseph S. Adorante , Elizabeth WoldeMussie , Guadalupe Ruiz
发明人： Joseph S. Adorante , Elizabeth WoldeMussie , Guadalupe Ruiz
IPC分类号： A61K31/00 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/23 , A61K47/48
CPC分类号： A61K47/4813 , A61K31/00 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/23 , Y10S514/912
摘要： Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains as the active ingredient one or more compounds having calcium chelating activity. Examples of calcium chelating agents utilized in the pharmaceutical composition and method of treatment are: ##STR1## and lower alkyl and alkoxyalkyl esters thereof.
摘要翻译：公开了药物组合物和方法，用于通过向哺乳动物眼睛施用含有作为活性成分的一种或多种具有钙螯合活性的化合物的本发明的药物组合物来治疗哺乳动物眼中的青光眼和/或高眼压症。用于药物组合物和治疗方法的钙螯合剂的实例是：其低级烷基和烷氧基烷基酯。

8. 发明授权

US5573758A Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers 失效
公开(公告)号：US5573758A
公开(公告)日：1996-11-12
申请号：US431170
申请日：1995-04-28
申请人： Joseph S. Adorante , Elizabeth WoldeMussie , Guadalupe Ruiz
发明人： Joseph S. Adorante , Elizabeth WoldeMussie , Guadalupe Ruiz
IPC分类号： A61K45/00 , A61K31/00 , A61K31/407 , A61K31/475 , A61K31/49 , A61K35/64 , A61K38/17 , A61P27/02 , A61K31/74
CPC分类号： A61K9/0048 , A61K31/00 , A61K31/407 , A61K31/49 , A61K38/1767 , Y10S514/912 , Y10S514/913 , Y10S514/914
摘要： Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains, as the active ingredient, one or more compounds having potassium channel blocking activity. Examples of potassium channel blockers utilized in the pharmaceutical composition and method of treatment are quinine, tremogenic indole alkaloids, such as Penitrem A and paspalicine, and insect toxins such as charybdotoxin and iberiotoxin.

9. 外观设计

USD603491S1 Water heater 有权
公开(公告)号：USD603491S1
公开(公告)日：2009-11-03
申请号：US29305261
申请日：2008-03-17
申请人： Gilberto Sanchez Villalobos , Maria Guadalupe Ruiz Mayen
设计人： Gilberto Sanchez Villalobos , Maria Guadalupe Ruiz Mayen

10. 发明授权

US5866605A Method for providing a neuroprotective effect to the mammalian eye by administration of chloride channel blockers 失效
标题翻译：通过施用氯化物通道阻断剂向哺乳动物眼睛提供神经保护作用的方法
公开(公告)号：US5866605A
公开(公告)日：1999-02-02
申请号：US998912
申请日：1997-12-29
申请人： Joseph S. Adorante , Elizabeth WoldeMussie , Guadalupe Ruiz
发明人： Joseph S. Adorante , Elizabeth WoldeMussie , Guadalupe Ruiz
IPC分类号： A61K45/00 , A61K31/00 , A61K31/137 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/24 , A61K31/245 , A61K31/26 , A61P27/02 , A61P27/06
CPC分类号： A61K31/00 , A61K31/137 , A61K31/192 , A61K31/196 , A61K31/26 , Y10S514/912 , Y10S514/913
摘要： Pharmaceutical compositions and a method are disclosed for providing neuroprotective effect to the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains, as the active ingredient, one or more compounds having chloride channel blocking activity. Examples of chloride channel blockers utilized in the pharmaceutical composition and method of treatment are: ##STR1## wherein R is hydrogen or a pharmaceutically-acceptable cation, e.g. an alkali or alkaline earth metal, or a quaternary amine; or R represents a ester-forming moiety, e.g. a lower alkyl radical, having up to six carbon 20 atoms, that may be derived from a lower alkanol.
摘要翻译：公开了药物组合物和方法，通过向哺乳动物眼睛施用含有作为活性成分的一种或多种具有氯化物通道阻断活性的化合物的本发明的药物组合物，向哺乳动物眼睛提供神经保护作用。在药物组合物和治疗方法中使用的氯化物通道阻断剂的实例是：其中R是氢或药学上可接受的阳离子，例如，碱金属或碱土金属或季胺; 或R表示酯形成部分，例如。具有至多6个碳原子的低级烷基，其可以衍生自低级链烷醇。

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