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1. 发明申请

US20100247606A1 INTRAOCULAR SUSTAINED RELEASE DRUG DELIVERY SYSTEMS AND METHODS FOR TREATING OCULAR CONDITIONS 审中-公开
标题翻译：内镜持续释放药物输送系统及治疗眼睛病症的方法
公开(公告)号：US20100247606A1
公开(公告)日：2010-09-30
申请号：US12411250
申请日：2009-03-25
申请人： Michael R. ROBINSON , James A. Burke , Hui Liu , Werhner C. Orilla , Lon T. Spada , Scott Whitcup , Alazar N. Ghebremskel , Patrick M. Hughes , Kun Xu , Marianne M. Do
发明人： Michael R. ROBINSON , James A. Burke , Hui Liu , Werhner C. Orilla , Lon T. Spada , Scott Whitcup , Alazar N. Ghebremskel , Patrick M. Hughes , Kun Xu , Marianne M. Do
IPC分类号： A61F2/00 , A61K31/215 , A61K31/165 , A61K9/14 , A61K31/4025 , A61K31/426 , A61K31/415 , A61K31/42
CPC分类号： A61K31/557 , A61K9/0051 , A61K9/1647 , A61K9/70 , A61K31/00 , A61K31/5575
摘要： Biocompatible, bioerodible sustained release implants and microspheres for intracameral or anterior vitreal placement include an anti-hypertensive agent and a biodegradable polymer effective to treat an ocular hypertensive condition (such as glaucoma) by relapsing therapeutic amount of the anti-hypertensive agent over a period of time between 10 days and 1 year.
摘要翻译：生物相容性，生物可蚀性缓释植入物和用于乳房内或玻璃体前置放置的微球包括抗高血压剂和可生物降解的聚合物，其通过在一段时间内复发治疗量的抗高血压药物而有效治疗眼高血压病症（如青光眼）时间在10天到1年之间。

2. 发明申请

US20100278898A1 INTRAOCULAR PRESSURE REDUCTION WITH INTRACAMERAL BIMATOPROST IMPLANTS 有权
标题翻译：内镜压力降低内镜压力
公开(公告)号：US20100278898A1
公开(公告)日：2010-11-04
申请号：US12761765
申请日：2010-04-16
申请人： Patrick M. HUGHES , Michael R. ROBINSON , James A. BURKE
发明人： Patrick M. HUGHES , Michael R. ROBINSON , James A. BURKE
IPC分类号： A61F2/00 , A61K31/557
CPC分类号： A61K9/0051 , A61K9/204 , A61K31/165 , A61K31/557 , A61K31/5575 , A61K47/34
摘要： The present invention provides a method of treating an ocular condition in an eye of a patient, comprising the step of placing a biodegradable intraocular implant in an eye of the patient, the implant comprising a prostamide and a biodegradable polymer matrix that releases drug at a rate effective to sustain release of an amount of the prostamide from the implant to provide an amount of the prostamide effective to prevent or reduce a symptom of an ocular condition of the eye, wherein said ocular condition is elevated IOP and said implant is placed in an intracameral location to dilate the outflow channels of the eye emanating from Schlemm's Canal.
摘要翻译：本发明提供了一种治疗患者眼睛中的眼部病症的方法，包括将可生物降解的眼内植入物放置在患者的眼睛中的步骤，所述植入物包含前列腺酰胺和可以以一定速率释放药物的可生物降解的聚合物基质有效地维持从植入物中释放一定量的前列腺酰胺以提供一定量的前列腺酰胺，其有效预防或减少眼睛眼部症状，其中所述眼部病症升高IOP，并且所述植入物置于室内位置，以扩大从施莱姆运河发出的眼睛的流出通道。

3. 发明申请

US20100098772A1 DRUG DELIVERY SYSTEMS AND METHODS FOR TREATING NEOVASCULARIZATION 审中-公开
标题翻译：药物输送系统和治疗新生血管的方法
公开(公告)号：US20100098772A1
公开(公告)日：2010-04-22
申请号：US12255497
申请日：2008-10-21
申请人： Michael R. ROBINSON , Susan Y. Tsai , Alexandra S. Almazan , Wendy M. Blanda , Patrick M. Hughes , James A. Burke , Scott M. Whitcup
发明人： Michael R. ROBINSON , Susan Y. Tsai , Alexandra S. Almazan , Wendy M. Blanda , Patrick M. Hughes , James A. Burke , Scott M. Whitcup
IPC分类号： A61K9/14 , A61K39/395 , A61P27/02 , A61K31/7052
CPC分类号： A61K9/0051 , A61K9/0024 , A61K9/19
摘要： Anti-angiogenesis compositions, and methods of using such compositions, useful for intraocular to treat neovascularization. The compositions can have viscosities at about 25° C. of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity at 25° C. is in the range of from about 80,000 cps to about 300,000 cps.
摘要翻译：抗血管生成组合物，以及使用这些组合物的方法，可用于眼内治疗新血管形成。组合物可以在约25℃下具有至少约10cps或约100cps的粘度，在0.1 /秒的剪切速率下。在优选的实施方案中，25℃下的粘度在约80,000cps至约300,000cps的范围内。

4. 发明申请

US20100015158A1 METHOD FOR TREATING ATROPHIC AGE RELATED MACULAR DEGENERATION 有权
标题翻译：治疗白内障相关性恶化的方法
公开(公告)号：US20100015158A1
公开(公告)日：2010-01-21
申请号：US12176238
申请日：2008-07-18
申请人： Michael R. ROBINSON , Wendy M. BLANDA , Patrick M. HUGHES , James A. BURKE , Scott M. WHITCUP
发明人： Michael R. ROBINSON , Wendy M. BLANDA , Patrick M. HUGHES , James A. BURKE , Scott M. WHITCUP
IPC分类号： A61K39/395 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/0051 , A61K9/1635 , A61K9/1647 , A61K9/1652 , A61K31/712 , A61K47/36 , A61K2039/505 , C07K16/22
摘要： Compositions and methods for treating dry age related macular degeneration (dry AMD) by administration to an intraocular location of an anti-neovascular agent (such as bevacizumab) in either a liquid or solid polymeric vehicle (or both), such as a biodegradable hyaluronic acid or PLGA (or PLA).
摘要翻译：通过向液体或固体聚合物载体（或两者）中的抗新生血管性药物（例如贝伐珠单抗）的眼内部位给药，例如可生物降解的透明质酸（或两者），治疗干性年龄相关性黄斑变性（干性AMD）的组合物和方法或PLGA（或PLA）。

5. 发明申请

US20080159140A1 Dynamic Header Creation and Flow Control for A Programmable Communications Processor, and Applications Thereof 有权
标题翻译：可编程通信处理器的动态头创建和流控制及其应用
公开(公告)号：US20080159140A1
公开(公告)日：2008-07-03
申请号：US11966843
申请日：2007-12-28
申请人： Michael R. ROBINSON , Joel I. DANZIG , Thomas L. JOHNSON
发明人： Michael R. ROBINSON , Joel I. DANZIG , Thomas L. JOHNSON
IPC分类号： H04L12/26
CPC分类号： H04L47/36 , H04L12/2801 , H04L47/10 , H04L47/21 , H04L47/29 , H04L49/90 , H04L49/901 , H04L49/9042 , H04L69/22
摘要： A method, system and computer program product for creating dynamic custom headers and for controlling flow rate of Downstream External Physical layer Interface (DEPI) packets are described herein. The method comprises concatenating or fragmenting a packet descriptor of a DEPU packet based on one or more of associated packet size, maximum transmission unit, packet type, channel configuration information and flow control mode. The method further comprises creating a header for the packet based on data in a programmable header template and storing the header in a header buffer, determining whether to transmit the packet based on one of a flow meter or a maximum transmission unit size and transmitting the packet by sending the packet descriptor to an output direct memory access (DMA) controller. A flow meter flow control mode determines if a packet is to be transmitted based on packet size, bucket size, a low threshold and a high threshold. A maximum transmission unit flow control mode determines if a packet is to transmitted based on packet size and a maximum transmission unit size. The header can be customized for Packet Streaming Protocol (PSP) mode or Moving Picture Experts Group Transport Stream (MPT) mode and includes dynamic customizable fields such as User Datagram Protocol (UDP) port identification, flow identification and session identification.
摘要翻译：本文描述了用于创建动态定制头部和用于控制下游外部物理层接口（DEPI）分组的流量的方法，系统和计算机程序产品。该方法包括基于相关联的分组大小，最大传输单元，分组类型，信道配置信息和流控制模式中的一个或多个来连接或分段DEPU分组的分组描述符。该方法还包括基于可编程头部模板中的数据创建分组头部，并将头部存储在头部缓冲器中，基于流量计或最大传输单元大小之一确定是否发送分组，并发送分组通过将分组描述符发送到输出直接存储器访问（DMA）控制器。流量计流量控制模式基于分组大小，桶大小，低阈值和高阈值来确定是否要发送分组。最大传输单元流量控制模式基于分组大小和最大传输单元大小确定是否要发送分组。可以为分组流协议（PSP）模式或运动图像专家组传输流（MPT）模式定制报头，并且包括诸如用户数据报协议（UDP）端口标识，流识别和会话识别之类的动态可定制字段。

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