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1. 发明授权

US08377889B2 Adiponectin receptor fragments and methods of use 有权
标题翻译：脂联素受体片段和使用方法
公开(公告)号：US08377889B2
公开(公告)日：2013-02-19
申请号：US13211558
申请日：2011-08-17
申请人： Michael Pugia , Rui Ma
发明人： Michael Pugia , Rui Ma
IPC分类号： A61K38/17
CPC分类号： C07K14/72 , A61K38/00
摘要： Methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using C-terminal fragments of adiponectin receptor R1. Methods of causing the secretion of insulin in healthy and diabetic patients using C-terminal fragments of adiponectin receptor R1 are also disclosed. In addition, methods are disclosed of increasing the insulin levels in healthy patients using C-terminal fragments of adiponectin receptor R1. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed.
摘要翻译：公开了使用脂联素受体R1的C末端片段治疗糖尿病，异常脂肪细胞活性和胰岛素抵抗的方法。还公开了使用脂联素受体R1的C末端片段在健康和糖尿病患者中分泌胰岛素的方法。此外，公开了使用脂联素受体R1的C末端片段增加健康患者的胰岛素水平的方法。另外，处理异常脂肪细胞活性，治疗代谢综合征，引起胰岛素分泌，增加胰岛素水平，抑制胰岛素降解酶，治疗阿尔茨海默氏病，治疗与脂联素水平相关的心血管疾病，抑制ADAM-17酶，治疗与公开了TNF-α和治疗与HER2-neu相关的病症。还公开了组合物，剂型和试剂盒。

2. 发明授权

US11953159B2 System and method for cryogenic vaporization with parallel vaporizer arrangements 有权
公开(公告)号：US11953159B2
公开(公告)日：2024-04-09
申请号：US17517031
申请日：2021-11-02
申请人： Chao Liang , Seth A. Potratz , Lee J. Rosen , Hanfei Tuo , Rui Ma
发明人： Chao Liang , Seth A. Potratz , Lee J. Rosen , Hanfei Tuo , Rui Ma
IPC分类号： F17C7/04 , F17C13/02
CPC分类号： F17C7/04 , F17C13/026 , F17C2250/032 , F17C2250/0439
摘要： A cryogenic vaporization system and a method for controlling the system are provided. The system includes a first vaporizer arrangement and a second vaporizer arrangement configured for receiving a liquid cryogen and outputting a superheated vapor. The second vaporizer arrangement is connected in parallel with the first vaporizer arrangement, and includes one or more banks of ambient air vaporizer (AAV) units or loose fill media with a high heat capacity. The second vaporizer arrangement has a different configuration than that of the first vaporizer arrangement. The system further includes at least one control valve controlling provision of the liquid cryogen to at least one of the first vaporizer arrangement and the second vaporizer arrangement.

3. 发明授权

US08865648B2 Monomeric and dimeric forms of adiponectin receptor fragments and methods of use 有权
标题翻译：脂联素受体片段的单体和二聚体形式和使用方法
公开(公告)号：US08865648B2
公开(公告)日：2014-10-21
申请号：US13265968
申请日：2010-04-13
申请人： Michael J. Pugia , Rui Ma
发明人： Michael J. Pugia , Rui Ma
IPC分类号： A61K38/00 , A61K38/26 , A61K38/22 , C07K14/605 , A61K38/28 , C07K14/575 , C07K7/06 , C07K7/02 , C07K7/64 , C07K11/00 , C07K14/47 , C07K14/785 , A61K39/00 , C07K14/005 , G01N33/574
CPC分类号： C07K14/705 , G01N33/574 , G01N33/57415 , G01N33/6872 , G01N2333/575 , G01N2800/2821 , G01N2800/52 , G01N2800/56
摘要： Methods are disclosed for determining progression of a condition, onset of a condition, or efficacy of treatment of a condition characterized by an adipocyte imbalance in a patient. In addition, methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using monomeric, homodimeric, and heterodimeric forms of certain C-terminal fragments of adiponectin receptor. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, inhibiting a protease, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed.
摘要翻译：公开了用于确定条件进展，条件开始或治疗以患者脂肪细胞不平衡为特征的病症的功效的方法。此外，公开了使用脂联素受体的某些C末端片段的单体，同二聚体和异二聚体形式治疗糖尿病，异常脂肪细胞活性和胰岛素抵抗的方法。此外，治疗异常脂肪细胞活性，治疗代谢综合征，引起胰岛素分泌，增加胰岛素水平，抑制胰岛素降解酶，治疗阿尔茨海默病，治疗与脂联素水平相关的心血管疾病，抑制ADAM-17酶，抑制蛋白酶，治疗公开了与TNF-α相关的病症和治疗与HER2-neu相关的病症。还公开了组合物，剂型和试剂盒。

4. 发明申请

US20140086379A1 DRIVING CIRCUIT, SHIFTING REGISTER, GATE DRIVER, ARRAY SUBSTRATE AND DISPLAY DEVICE 审中-公开
标题翻译：驱动电路，移位寄存器，门驱动器，阵列基板和显示器件
公开(公告)号：US20140086379A1
公开(公告)日：2014-03-27
申请号：US13805886
申请日：2012-11-09
申请人： Rui Ma , Xianjie Shao , Guolei Wang , Ming Hu , Byung Cheon Lim , Zhizhong Tu
发明人： Rui Ma , Xianjie Shao , Guolei Wang , Ming Hu , Byung Cheon Lim , Zhizhong Tu
IPC分类号： G11C19/28 , H03K5/00
CPC分类号： G11C19/28 , H03K5/00
摘要： The disclosure relates to the field of liquid crystal display, and provides a driving circuit, a shifting register, a gate driver, an array substrate and a display device. The driving circuit comprises a pull-up module, a first pull-down module, a second pull-down module, a pull-up driving module, a pull-down driving module and a resetting module, wherein the first pull-down module outputs a switching-off signal to the output terminal according to a signal input from the clock retarding signal input terminal and a signal at a pull-down node; a second pull-down module, when the signal input from the signal input terminal is at a low level, outputs a switching-off signal to the pull-up node and the output terminal according to a signal input from a clock signal input terminal; wherein when the signal input from the signal input terminal is at a high level, the signal input from the clock retarding signal input terminal is also at a high level, and the signal input from the clock signal input terminal and that input from the clock retarding signal input terminal are opposite in phase. The driving circuit according to the disclosure can effectively remove the defect of the threshold voltage drifting due to the gate being applied to a bias voltage stress, and can also decrease the noise of the output voltage.
摘要翻译：本公开涉及液晶显示领域，并提供驱动电路，移位寄存器，栅极驱动器，阵列基板和显示装置。驱动电路包括上拉模块，第一下拉模块，第二下拉模块，上拉驱动模块，下拉驱动模块和复位模块，其中第一下拉模块输出根据从时钟延迟信号输入端子输入的信号和在下拉节点处的信号将输出端子切断信号; 第二下拉模块，当从所述信号输入端子输入的信号处于低电平时，根据从时钟信号输入端子输入的信号，向所述上拉节点和所述输出端子输出关断信号; 其中，当从信号输入端输入的信号处于高电平时，从时钟延迟信号输入端输入的信号也处于高电平，从时钟信号输入端输入的信号和从时钟延迟信号输入的信号信号输入端子相位相反。根据本公开的驱动电路可以有效地消除由于栅极被施加到偏置电压应力而导致的阈值电压漂移的缺陷，并且还可以降低输出电压的噪声。

5. 发明授权

US08570902B2 Method and terminal for selecting random access resource 有权
标题翻译：选择随机存取资源的方法和终端
公开(公告)号：US08570902B2
公开(公告)日：2013-10-29
申请号：US13203446
申请日：2009-09-25
申请人： Zhongda Du , Rui Ma , Bin Yu
发明人： Zhongda Du , Rui Ma , Bin Yu
IPC分类号： H04L12/28
CPC分类号： H04W74/008 , H04W36/0077 , H04W74/0833
摘要： The present invention discloses a method and terminal for selecting a random access resource, the method includes: the terminal receives the physical downlink control channel signaling sent by a system; the terminal determines the first subframe which meets a condition A and contains a random access resource from the subsequent subframes of the subframe receiving the physical downlink control channel signaling, the condition A is that the time difference between the first subframe and the subframe receiving the physical downlink control channel signaling is greater than or equal to k, k is the time delay defined by the physical layer of the terminal; and the terminal starts a selection on the subframe containing a random access source from the first subframe.
摘要翻译：本发明公开了一种选择随机接入资源的方法和终端，该方法包括：终端接收系统发送的物理下行控制信道信令; 终端确定满足条件A的第一子帧，并且从接收物理下行链路控制信道信令的子帧的后续子帧中包含随机接入资源，条件A是第一子帧与接收物理的子帧之间的时间差下行控制信道信令大于或等于k，k是由终端的物理层定义的时延; 并且终端从包含来自第一子帧的随机接入源的子帧开始选择。

6. 发明申请

US20130244270A1 MICROFLUIDIC DEVICE FOR CELL MOTILITY SCREENING AND CHEMOTAXIS TESTING 审中-公开
标题翻译：用于细胞动力学筛选和化学检测的微流体装置
公开(公告)号：US20130244270A1
公开(公告)日：2013-09-19
申请号：US13814426
申请日：2011-08-10
申请人： Lan Xie , Rui Ma , Chao Han , Wanli Xing , Jing Cheng
发明人： Lan Xie , Rui Ma , Chao Han , Wanli Xing , Jing Cheng
IPC分类号： C12Q1/02
CPC分类号： C12Q1/025 , B01L3/5027 , B01L2300/0816 , B01L2300/0864 , G01N33/5029
摘要： The present invention relates to a microfluidic device used for cell motility screening and chemotaxis testing which comprises microfluidic channels and chambers. Cells which can secret a chemoattractant or chemorepellent are selectively planted in the microfluidic device and a stable chemoattractant or chemorepellent gradient can be established in the channels.
摘要翻译：本发明涉及用于细胞运动筛选和趋化性测试的微流体装置，其包括微流体通道和腔室。可以将化学引诱物或化学引诱物分泌的细胞选择性地种植在微流体装置中，并且可以在通道中建立稳定的化学引诱物或化学增益梯度。

7. 发明申请

US20120113887A1 Method And System For Mobility Management Of A Terminal On A Radio Relay System 审中-公开
标题翻译：无线电中继系统终端的移动性管理方法与系统
公开(公告)号：US20120113887A1
公开(公告)日：2012-05-10
申请号：US13258388
申请日：2009-12-21
申请人： Xiaoqin Shen , Lifeng Han , Rui Ma
发明人： Xiaoqin Shen , Lifeng Han , Rui Ma
IPC分类号： H04W36/32 , H04W88/04
CPC分类号： H04W36/0033 , H04B7/2606 , H04W84/047 , H04W92/20
摘要： A method and system for mobility management of a User Equipment (UE) in a radio relay system is used for resolving the technical problem of performing a UE handover between different relay stations belonging to a same Donor eNodeB (DeNB). The method comprises that: an X2 interface link is established between the relay stations belonging to one DeNB; a source relay station transmits a handover request to a target relay station, and the target relay station performs admission control; when the target relay station permits the UE to access, the source relay station performs forwarding of UE context and cached data; after the UE has successfully accessed the target relay station, the target relay station notifies the DeNB that the path has changed, and the DeNB performs a path handover. In the handover flow of the disclosure, only some control for forwarding data is needed between the source relay station and the target relay station, the forwarding through the DeNB and the processing with a Mobility Management Unit (MME) or a Serving GateWay (GW) are not needed, therefore the handover flow is simplified, and handover delay is decreased to a certain extent.
摘要翻译：用于无线电中继系统中的用户设备（UE）的移动性管理的方法和系统用于解决在属于同一个供体eNodeB（DeNB）的不同中继站之间进行UE切换的技术问题。该方法包括：在属于一个DeNB的中继站之间建立X2接口链路; 源中继站向目标中继站发送切换请求，目标中继站进行准入控制; 当目标中继站允许UE接入时，源中继站执行UE上下文和缓存数据的转发; 在UE成功访问目标中继站之后，目标中继站通知DeNB路径已经改变，并且DeNB执行路径切换。在本公开的切换流程中，在源中继站和目标中继站之间仅需要转发数据的一些控制，通过DeNB的转发以及移动性管理单元（MME）或服务网关（GW）的处理，因此切换流程被简化，切换延迟降低到一定程度。

8. 发明申请

US20110078206A1 TAGGING METHOD AND APPARATUS BASED ON STRUCTURED DATA SET 有权
标题翻译：基于结构化数据集的标记方法和设备
公开(公告)号：US20110078206A1
公开(公告)日：2011-03-31
申请号：US12860112
申请日：2010-08-20
申请人： Jian Chen , Ben Fei , Rui Ma , Zhong Su , Xian Wu
发明人： Jian Chen , Ben Fei , Rui Ma , Zhong Su , Xian Wu
IPC分类号： G06F17/30
CPC分类号： G06F17/30 , G06F17/3071 , G06F17/30722 , G06F17/30864
摘要： A tagging method and apparatus, including computer program products, based on a structured data set are provided, the tagging method comprising: creating classification models for respective nodes in the structured data set of an event; acquiring public opinions on the event; and tagging the opinions to corresponding nodes of the structured data set using the created classification models. The tagging method and apparatus of the present disclosure are able to provide well-ordered, focused public opinions for each event to users, and to exhibit the evolution of the public opinions along with time.
摘要翻译：提供了一种基于结构化数据集的包括计算机程序产品的标记方法和装置，所述标记方法包括：为事件的结构化数据集中的各个节点创建分类模型; 收集有关事件的意见; 并使用创建的分类模型将意见标记到结构化数据集的相应节点。本公开的标签方法和装置能够为用户提供针对每个事件的良好有序的集中的舆论，并且随着时间展现舆论的演变。

9. 发明申请

US20080260032A1 METHOD AND APPARATUS FOR CAPTION DETECTION 有权
标题翻译：用于检测的方法和装置
公开(公告)号：US20080260032A1
公开(公告)日：2008-10-23
申请号：US11736225
申请日：2007-04-17
申请人： Wei Hu , Rui Ma
发明人： Wei Hu , Rui Ma
IPC分类号： G06K9/20
CPC分类号： G06K9/3266 , G06K9/325 , H04N21/4884
摘要： Machine-readable media, methods, apparatus and system for caption detection are described. In some embodiments, a plurality of text boxes may be detected from a plurality of frames. A first percentage of the plurality of text boxes whose locations on the plurality of frames fall into a location range may be obtained. A second percentage of the plurality of text boxes whose sizes fall into a size range may be obtained. Then, it may be determined if the first percentage and the location range are acceptable and if the second percentage and the size range are acceptable.
摘要翻译：描述了用于字幕检测的机器可读介质，方法，装置和系统。在一些实施例中，可以从多个帧中检测多个文本框。可以获得其多个帧中的位置落入位置范围的多个文本框的第一百分比。可以获得尺寸落入尺寸范围的多个文本框的第二百分比。然后，可以确定第一百分比和位置范围是否可接受，以及第二百分比和尺寸范围是否可接受。

10. 发明申请

US20070279906A1 Mounting arrangement for LED lamps 失效
标题翻译： LED灯具安装方式
公开(公告)号：US20070279906A1
公开(公告)日：2007-12-06
申请号：US11806135
申请日：2007-05-30
申请人： Xi He , Rui Ma , Giovanni Scilla
发明人： Xi He , Rui Ma , Giovanni Scilla
IPC分类号： F21V33/00
CPC分类号： F21V23/009 , F21K9/23 , F21V23/002 , F21Y2115/10 , Y10S362/80
摘要： A LED lighting arrangement includes a support body having mounted thereon one or more LED lighting sources and a driver or feeding the LED lighting sources. The support body includes a high-voltage section carrying the driver and a low-voltage section carrying, mounted on a heat sink, the light sources. An insulation barrier is provided between the high voltage section and the low-voltage section of the board with a twisted pair forming a wiring that traverses the insulation barrier to connect the driver and the LED lighting sources.
摘要翻译： LED照明装置包括其上安装有一个或多个LED照明源和驱动器或馈送LED照明源的支撑体。支撑体包括承载驱动器的高压部分和安装在散热器上的光源的低压部分。绝缘屏障设置在板的高压部分和低压部分之间，双绞线形成穿过绝缘屏障的布线，以连接驱动器和LED照明源。

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