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1. 发明授权

US08377889B2 Adiponectin receptor fragments and methods of use 有权
标题翻译：脂联素受体片段和使用方法
公开(公告)号：US08377889B2
公开(公告)日：2013-02-19
申请号：US13211558
申请日：2011-08-17
申请人： Michael Pugia , Rui Ma
发明人： Michael Pugia , Rui Ma
IPC分类号： A61K38/17
CPC分类号： C07K14/72 , A61K38/00
摘要： Methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using C-terminal fragments of adiponectin receptor R1. Methods of causing the secretion of insulin in healthy and diabetic patients using C-terminal fragments of adiponectin receptor R1 are also disclosed. In addition, methods are disclosed of increasing the insulin levels in healthy patients using C-terminal fragments of adiponectin receptor R1. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed.
摘要翻译：公开了使用脂联素受体R1的C末端片段治疗糖尿病，异常脂肪细胞活性和胰岛素抵抗的方法。还公开了使用脂联素受体R1的C末端片段在健康和糖尿病患者中分泌胰岛素的方法。此外，公开了使用脂联素受体R1的C末端片段增加健康患者的胰岛素水平的方法。另外，处理异常脂肪细胞活性，治疗代谢综合征，引起胰岛素分泌，增加胰岛素水平，抑制胰岛素降解酶，治疗阿尔茨海默氏病，治疗与脂联素水平相关的心血管疾病，抑制ADAM-17酶，治疗与公开了TNF-α和治疗与HER2-neu相关的病症。还公开了组合物，剂型和试剂盒。

2. 发明申请

US20060263902A1 Dispensing of a diagnostic liquid onto a diagnostic reagent 有权
公开(公告)号：US20060263902A1
公开(公告)日：2006-11-23
申请号：US11135928
申请日：2005-05-23
申请人： Michael Pugia , James Profitt , Lloyd Schulman , Chris Zimmerle , Hai-Hang Kuo
发明人： Michael Pugia , James Profitt , Lloyd Schulman , Chris Zimmerle , Hai-Hang Kuo
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01J2219/0036 , B01J2219/00378 , B01J2219/00385 , B01J2219/00527 , B01J2219/00545 , B01J2219/00641 , B01J2219/00725 , B01J2219/0074 , B01L2400/0487 , G01N33/52 , G01N35/1016 , G01N2035/00158 , Y10T436/144444 , Y10T436/2575
摘要： Biological fluid samples are deposited by methods that produce a uniform layer of the sample over a reagent-containing surface. In one embodiment, a nozzle having multiple openings is used to deposit a sample over the reagent-containing surface simultaneously. In an alternative embodiment, single droplets of the sample are deposited in a pattern on the surface, preferably in a sequence of parallel lines. The reaction between the biological sample and the reagents is read from a spectrographic image of the reagent-containing surface obtained by optical methods.

3. 发明授权

US08846346B2 Detection of soluble adiponectin receptor peptides and use in diagnosis and therapeutics 有权
公开(公告)号：US08846346B2
公开(公告)日：2014-09-30
申请号：US13326393
申请日：2011-12-15
申请人： Michael Pugia
发明人： Michael Pugia
IPC分类号： C12P21/04 , G01N33/68
CPC分类号： G01N33/6893 , G01N2800/042 , G01N2800/32 , G01N2800/52
摘要： The present invention relates to soluble C-terminal fragments of the adiponectin receptor and their use in the diagnosis and management of disorders.

4. 发明申请

US20140038890A1 ADIPONECTIN RECEPTOR C-TERMINAL FRAGMENTS (CTF)-IMMUNOGLOBULIN 有权
标题翻译： ADIPONECTIN受体C-末端片段（CTF）-IMMUNOGLOBULIN
公开(公告)号：US20140038890A1
公开(公告)日：2014-02-06
申请号：US14111506
申请日：2012-02-22
申请人： Michael Pugia
发明人： Michael Pugia
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , G01N33/574 , G01N33/6857 , G01N33/74 , G01N2800/042 , G01N2800/085
摘要： Methods of detecting a first species' Ig-CTF in a biological sample comprising exposing the biological sample to a first antibody of a second species that preferentially binds the first species' Ig-CTF or an antigen binding fragment of the antibody, forming a mixture, exposing the mixture to a second antibody or antigen-binding fragment of a third species that preferentially binds the first species' Ig, and detecting the Ig-CTF in the biological sample.
摘要翻译：检测生物样品中第一种Ig-CTF的方法，包括将生物样品暴露于优先结合抗体的第一物种Ig-CTF或抗原结合片段的第二物种的第一抗体，形成混合物，将混合物暴露于优先结合第一物种Ig的第三物种的第二抗体或抗原结合片段，并检测生物样品中的Ig-CTF。

5. 发明申请

US20130149720A1 DETECTION OF SOLUBLE ADIPONECTIN RECEPTOR PEPTIDES AND USE IN DIAGNOSIS AND THERAPEUTICS 有权
标题翻译：检测可溶性ADIPONECTIN受体肽并用于诊断和治疗
公开(公告)号：US20130149720A1
公开(公告)日：2013-06-13
申请号：US13326380
申请日：2011-12-15
申请人： Michael Pugia
发明人： Michael Pugia
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/042 , G01N2800/32 , G01N2800/52
摘要： The present invention relates to soluble C-terminal fragments of the adiponectin receptor and their use in the diagnosis and management of disorders.
摘要翻译：本发明涉及脂联素受体的可溶性C末端片段及其在病症诊断和治疗中的用途。

6. 发明申请

US20060141546A1 Bacterial test method by glycated label binding 审中-公开
公开(公告)号：US20060141546A1
公开(公告)日：2006-06-29
申请号：US11034897
申请日：2005-01-13
申请人： Michael Pugia , Manju Basu , Robert Hatch , James Profitt
发明人： Michael Pugia , Manju Basu , Robert Hatch , James Profitt
IPC分类号： G01N33/554 , C12Q1/04
CPC分类号： G01N33/569
摘要： A method for measuring the bacteria content of fluids such as urine and blood, in which a glycoprotein or glycopeptide is attached to the bacteria and a label attached to or inherent to the glycoprotein or glycopeptide provides a means for determining the amount of bacteria present. A preferred glycoprotein is alkaline phosphatase, which is an enzyme capable of attaching to all bacteria present in the fluid sample and inherently includes a label moiety in that color can be developed by addition of known reagents.

7. 发明授权

US09291629B2 Adiponectin receptor C-terminal fragments (CTF)-immunoglobulin 有权
标题翻译：脂联素受体C-末端片段（CTF） - 免疫球蛋白
公开(公告)号：US09291629B2
公开(公告)日：2016-03-22
申请号：US14111506
申请日：2012-02-22
申请人： Michael Pugia
发明人： Michael Pugia
IPC分类号： G01N33/53 , G01N33/68 , G01N33/574 , G01N33/74
CPC分类号： G01N33/6854 , G01N33/574 , G01N33/6857 , G01N33/74 , G01N2800/042 , G01N2800/085
摘要： Methods of detecting a first species' Ig-CTF in a biological sample comprising exposing the biological sample to a first antibody of a second species that preferentially binds the first species' Ig-CTF or an antigen binding fragment of the antibody, forming a mixture, exposing the mixture to a second antibody or antigen-binding fragment of a third species that preferentially binds the first species' Ig, and detecting the Ig-CTF in the biological sample.
摘要翻译：检测生物样品中第一种Ig-CTF的方法，包括将生物样品暴露于优先结合抗体的第一物种Ig-CTF或抗原结合片段的第二物种的第一抗体，形成混合物，将混合物暴露于优先结合第一物种Ig的第三物种的第二抗体或抗原结合片段，并检测生物样品中的Ig-CTF。

8. 发明授权

US08632990B2 Detection of soluble adiponectin receptor peptides and use in diagnosis and therapeutics 有权
标题翻译：检测可溶性脂联素受体肽并用于诊断和治疗
公开(公告)号：US08632990B2
公开(公告)日：2014-01-21
申请号：US13326380
申请日：2011-12-15
申请人： Michael Pugia
发明人： Michael Pugia
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/042 , G01N2800/32 , G01N2800/52
摘要： The present invention relates to soluble C-terminal fragments of the adiponectin receptor and their use in the diagnosis and management of disorders.
摘要翻译：本发明涉及脂联素受体的可溶性C末端片段及其在病症诊断和治疗中的用途。

9. 发明授权

US08093017B2 Detection of soluble adiponectin receptor peptides and use in diagnostics and therapeutics 有权
标题翻译：检测可溶性脂联素受体肽并用于诊断和治疗
公开(公告)号：US08093017B2
公开(公告)日：2012-01-10
申请号：US12096076
申请日：2006-02-23
申请人： Michael Pugia
发明人： Michael Pugia
IPC分类号： C12P21/04
CPC分类号： G01N33/6893 , G01N2800/042 , G01N2800/32 , G01N2800/52
摘要： The present invention relates to soluble C-terminal fragments of the adiponectin receptor and their use in the diagnosis and management of disorders.
摘要翻译：本发明涉及脂联素受体的可溶性C末端片段及其在病症诊断和治疗中的用途。

10. 发明申请

US20050129572A1 Liquid permeable composition in dry reagent devices 有权
标题翻译：干燥试剂装置中的透液性组合物
公开(公告)号：US20050129572A1
公开(公告)日：2005-06-16
申请号：US10966858
申请日：2004-10-14
申请人： Lloyd Schulman , Michael Pugia , Spencer Lin , Karlheinz Hildenbrand
发明人： Lloyd Schulman , Michael Pugia , Spencer Lin , Karlheinz Hildenbrand
IPC分类号： G01N33/52 , G01N33/543 , G01N31/22
CPC分类号： G01N33/54393 , G01N33/525
摘要： A device for detecting an analyte in a fluid sample includes a liquid permeable composition for making a physical separation between compositions of the sample or for reacting with components. The liquid permeable composition has adhesive properties and can be used to make a multi-layered test strip or the composition can be used in the sample wells of microfluidic devices.
摘要翻译：用于检测流体样品中的分析物的装置包括用于在样品组合物之间进行物理分离或与组分反应的液体可渗透组合物。液体可渗透组合物具有粘合性能，并且可用于制备多层测试条，或者该组合物可用于微流体装置的样品孔中。

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