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1. 发明授权

US06376669B1 Dye labeled imidazoquinoline compounds 失效
标题翻译：染料标记咪唑并喹啉化合物
公开(公告)号：US06376669B1
公开(公告)日：2002-04-23
申请号：US09705072
申请日：2000-11-02
申请人： Michael J. Rice , Mark A. Tomai , Ai-Ping Wei
发明人： Michael J. Rice , Mark A. Tomai , Ai-Ping Wei
IPC分类号： C07D47104
CPC分类号： C07D471/04 , C09B11/08 , C09B57/10 , C09B69/00 , G01N33/6863
摘要： Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds are useful, inter alia, for determining the binding and/or receptor sites of the molecules.
摘要翻译：公开了具有免疫应答调节活性的染料标记的咪唑并吡啶，咪唑并吡啶和咪唑并喹啉化合物。该化合物尤其用于测定分子的结合和/或受体位点。

2. 发明授权

US06916925B1 Dye labeled imidazoquinoline compounds 失效
标题翻译：染料标记咪唑并喹啉化合物
公开(公告)号：US06916925B1
公开(公告)日：2005-07-12
申请号：US10624419
申请日：2003-07-22
申请人： Michael J. Rice , Mark A. Tomai , Ai-Ping Wei
发明人： Michael J. Rice , Mark A. Tomai , Ai-Ping Wei
IPC分类号： C07D471/04 , C09B11/08 , C09B57/10 , C09B69/00 , G01N33/68 , C07F5/02
CPC分类号： C07D471/04 , C09B11/08 , C09B57/10 , C09B69/00 , G01N33/6863
摘要： Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds arc useful, inter alia, for determining the binding and/or receptor sites of the molecules.
摘要翻译：公开了具有免疫应答调节活性的染料标记的咪唑并吡啶，咪唑并吡啶和咪唑并喹啉化合物。该化合物尤其用于测定分子的结合和/或受体位点。

3. 发明授权

US06630588B2 Dye labeled imidazoquinoline compounds 失效
公开(公告)号：US06630588B2
公开(公告)日：2003-10-07
申请号：US10078645
申请日：2002-02-19
申请人： Michael J. Rice , Mark A. Tomai , Ai-Ping Wei
发明人： Michael J. Rice , Mark A. Tomai , Ai-Ping Wei
IPC分类号： C07D47104
CPC分类号： C07D471/04 , C09B11/08 , C09B57/10 , C09B69/00 , G01N33/6863
摘要： Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds are useful, inter alia, for determining the binding and/or receptor sites of the molecules.

4. 发明授权

US07153654B2 Assay procedure using fluorogenic tracers 失效
公开(公告)号：US07153654B2
公开(公告)日：2006-12-26
申请号：US10286600
申请日：2002-10-31
申请人： Ai-Ping Wei , James N. Herron
发明人： Ai-Ping Wei , James N. Herron
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02
CPC分类号： G01N33/582 , C12Q1/6818
摘要： Fluorescent energy transfer dyes capable of moving between a more stacked configuration to exhibit fluorescent quenching and a more spaced configuration to exhibit fluorescence can be conjugated to a peptide epitope or nucleic acid for use in the detection of an unknown antibody in bulk solution. The resulting labeled peptide reagent can be used in an immunoassay procedure by placing it in bulk solution along with the unknown antibody to be detected. When the antibody binds to the peptide epitope, the pair of dyes carried by the peptide epitope will have their configuration altered from a stacked to an unstacked configuration and will exhibit a fluorescent increase in response thereto.

5. 发明申请

US20050148620A1 Sulfonamido ether substituted imidazoquinolines 审中-公开
标题翻译：磺酰胺基醚取代的咪唑并喹啉
公开(公告)号：US20050148620A1
公开(公告)日：2005-07-07
申请号：US11069035
申请日：2005-02-28
申请人： Stephen Crooks , George Griesgraber , Philip Heppner , Bryon Merrill , Ralph Roberts , Ai-Ping Wei
发明人： Stephen Crooks , George Griesgraber , Philip Heppner , Bryon Merrill , Ralph Roberts , Ai-Ping Wei
IPC分类号： A61P31/12 , A61P37/02 , C07D471/04 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and sulfonamide or sulfamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译：在1位含有醚和磺酰胺或磺酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

6. 发明申请

US20050089946A1 Fluorogenic protease substrates based on dye-dimerization 失效
标题翻译：基于染料二聚化的荧光蛋白酶底物
公开(公告)号：US20050089946A1
公开(公告)日：2005-04-28
申请号：US10930522
申请日：2004-08-31
申请人： Ai-Ping Wei , Michael Williams
发明人： Ai-Ping Wei , Michael Williams
IPC分类号： C07K7/06 , C12Q1/04 , C12Q1/37 , C12Q1/68
CPC分类号： C07K7/06 , C12Q1/37 , C12Q2337/40 , Y02A50/451
摘要： A method of biological assay comprises the steps of providing an enzyme substrate comprising two fluorescence dye groups bound to a flexible peptide, the dye groups being of proximity sufficiently close so as to allow free energy attractions to draw the dyes together to essentially self-quench fluorescence of the dye groups, wherein self quenching of fluorescence of the dye groups is effected by dye dimerization or stacking, and enzymatically cleaving the peptide to release the fluorescence dye groups from dye dimerization or stacking, thereby producing an increase in fluorescence intensity. A protease substrate for use in the method of the invention is also disclosed. This invention finds use in detection and identification of microorganisms, sterilization assurance, pharmaceutical discovery, enzyme assays, immunoassays, and other biological assays.
摘要翻译：一种生物测定方法包括以下步骤：提供包含与柔性肽结合的两个荧光染料基团的酶底物，所述染料组的接近度足够接近，以便使自由能吸引力将染料一起吸收到基本上自熄灭荧光的染料基团，其中染料基团的荧光自发淬灭通过染料二聚化或堆叠进行，并且酶切割肽以使荧光染料基团从染料二聚化或堆叠释放，从而产生荧光强度的增加。还公开了用于本发明方法的蛋白酶底物。本发明用于微生物的检测和鉴定，灭菌保证，药物发现，酶测定，免疫测定和其他生物测定。

7. 发明授权

US06576419B1 Assay procedure using fluorogenic tracers 失效
标题翻译：使用荧光示踪剂的测定程序
公开(公告)号：US06576419B1
公开(公告)日：2003-06-10
申请号：US08891114
申请日：1997-07-10
申请人： Ai-Ping Wei , James N. Herron
发明人： Ai-Ping Wei , James N. Herron
IPC分类号： C12Q108
CPC分类号： G01N33/582 , C12Q1/6818
摘要： Fluorescent energy transfer dyes capable of moving between a more stacked configuration to exhibit fluorescent quenching and a more spaced configuration to exhibit fluorescence can be conjugated to a peptide epitope or nucleic acid for use in the detection of an unknown antibody in bulk solution. The resulting labeled peptide reagent can be used in an immunoassay procedure by placing it in bulk solution along with the unknown antibody to be detected. When the antibody binds to the peptide epitope, the pair of dyes carried by the peptide epitope will have their configuration altered from a stacked to an unstacked configuration and will exhibit a fluorescent increase in response thereto.
摘要翻译：能够在更叠层的配置之间移动以展现荧光猝灭和更间隔的配置以显示荧光的荧光能量转移染料可以缀合到肽表位或核酸上，以用于检测本体溶液中的未知抗体。所得标记的肽试剂可以在免疫测定程序中使用，将其与待检测的未知抗体一起放入本体溶液中。当抗体与肽表位结合时，由肽表位携带的一对染料将具有从堆叠到未堆叠构型的改变，并且对其反应将呈现荧光增加。

8. 发明授权

US08325345B2 Methods and devices for monitoring of frying oil quality 有权
标题翻译：油炸油质量监测方法和装置
公开(公告)号：US08325345B2
公开(公告)日：2012-12-04
申请号：US12920520
申请日：2009-03-02
申请人： Abolghassem B. Mahmoodi , Milind Balwant Sabade , Ai-Ping Wei
发明人： Abolghassem B. Mahmoodi , Milind Balwant Sabade , Ai-Ping Wei
IPC分类号： G01N21/55 , G01N33/03 , G01N33/26
CPC分类号： G01N33/03 , G01N21/78 , G01N31/22
摘要： Herein are disclosed methods and devices for evaluating the quality of oils (e.g., cooking oil or flying oil). The methods can provide an indication of the free fatty acid content of the oil. The methods use an optical interrogation device to provide an indication of free fatty acid based on quantitative measurements of optical reflectance from test zones on a sampling substrate.
摘要翻译：这里公开了用于评估油（例如烹饪油或飞油）的质量的方法和装置。该方法可以提供油的游离脂肪酸含量的指示。该方法使用光学询问装置来提供游离脂肪酸的指示，其基于在取样基底上的测试区域的光学反射率的定量测量。

9. 发明申请

US20110183360A1 ANTIBODIES TO CLOSTRIDIUM DIFFICILE SPORES AND USES THEREOF 失效
标题翻译：抗精神分裂症的运动及其用途
公开(公告)号：US20110183360A1
公开(公告)日：2011-07-28
申请号：US12919254
申请日：2009-02-25
申请人： Raj Rajagopal , Ai-Ping Wei
发明人： Raj Rajagopal , Ai-Ping Wei
IPC分类号： C12N5/12 , G01N33/569 , C07K16/12 , C07K16/40 , C12N5/10 , C07H21/00 , C12N15/63 , C12N1/00
CPC分类号： G01N33/56911 , C07K16/1282 , C07K16/40 , G01N2333/33 , G01N2469/10 , G01N2800/067
摘要： The present invention provides antibodies that bind to the endospore of the bacterium Clostridium difficile, methods of making such antibodies, and methods of using such antibodies, including methods of detecting C. difficile endospores.
摘要翻译：本发明提供了结合细菌艰难梭菌的内生孢子的抗体，制备这种抗体的方法，以及使用这些抗体的方法，包括检测艰难梭菌内切孢子的方法。

10. 发明申请

US20110059532A1 MONITORING OF FRYING OIL QUALITY USING COMBINED OPTICAL INTERROGATION METHODS AND DEVICES 有权
标题翻译：使用组合光学方法和装置监测油脂质量
公开(公告)号：US20110059532A1
公开(公告)日：2011-03-10
申请号：US12920514
申请日：2009-03-02
申请人： Ai-Ping Wei , Milind Balwant Sabade , Abolghasssen B. Mahmoodi
发明人： Ai-Ping Wei , Milind Balwant Sabade , Abolghasssen B. Mahmoodi
IPC分类号： G01N33/26 , G01N33/03 , G01N30/00
CPC分类号： G01N33/03 , G01N21/643 , G01N21/78 , G01N31/22
摘要： Herein are disclosed methods and devices for optically monitoring multiple parameters of an oil sample. In one embodiment, the methods and devices can be used for determining the quality of cooking or flying oil in terms of the free fatty acid content and total polar compound content of the oil. The methods use an optical absorbtive/reflective property in evaluating the free fatty acid content, and use optical fluorescence in evaluating the total polar compound content, with both measurements using a single sampling substrate and a single measuring device.
摘要翻译：本文公开了用于光学监测油样品的多个参数的方法和装置。在一个实施方案中，方法和装置可以用于根据游离脂肪酸含量和油的总极性化合物含量来确定烹饪或飞行油的质量。该方法在评估游离脂肪酸含量时使用光学吸收/反射性质，并且使用光学荧光来评估总极性化合物含量，两次测量使用单个取样基板和单个测量装置。

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