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    • 3. 发明授权
    • Cosmetic and pharmaceutical preparations containing photostable UV filters
    • 含有光稳定紫外线过滤器的化妆品和药物制剂
    • US06545174B2
    • 2003-04-08
    • US09765624
    • 2001-01-22
    • Thorsten HabeckSylke HaremzaVolker SchehlmannHorst WestenfelderThomas WünschMichael DrögemüllerVolker Bomm
    • Thorsten HabeckSylke HaremzaVolker SchehlmannHorst WestenfelderThomas WünschMichael DrögemüllerVolker Bomm
    • C07C6976
    • C07C235/34A61K8/35A61K8/37A61K8/40A61K8/42A61K31/12A61K31/122A61K31/216A61K31/277A61K2800/52A61Q1/04A61Q17/04C07C69/618C07C233/11
    • 4,4-Diarylbutadienes of the formula I, where the diene system has the Z,Z; Z,E; E,Z or E,E configuration or a mixture thereof, and where the variables independently of one another have the following meanings: R1 and R2 are hydrogen, C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl, C1-C12-alkoxy, C1-C20-alkoxycarbonyl, C1-C12-alkylamino, C1-C12-dialkylamino, aryl, hetaryl, unsubstituted or substituted, substituents which confer solubility in water and are selected from the group consisting of carboxylate, sulfonate, or ammonium residues; R3 is COOR5, CONR5R6; R4 is COOR6, CONR5R6; R5 and R6 are hydrogen, C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C7-C10-bicycloalkyl, C3-C10-cycloalkenyl, C7-C10-bicycloalkenyl, aryl, hetaryl, unsubstituted or substituted; n is 1 to 3; and R3 and R4 are not COOCH3 when R1 and R2 are hydrogen, are used as photostable UV filters in cosmetic and pharmaceutical preparations to protect the human skin or human hair from the sun's rays, alone or together with compounds which absorb in the UV region and are known per se for cosmetic and pharmaceutical preparations.
    • 式I的4,4-二芳基丁二烯,其中二烯体系具有Z,Z; Z,E; E,Z或E,E构型或其混合物,其中彼此独立的变量具有以下含义:R 1和R 2为氢,C 1 -C 20 - 烷基,C 2 -C 10 - 烯基,C 3 -C 10 - 环烷基, C 3 -C 10 - 环烯基,C 1 -C 12 - 烷氧基,C 1 -C 20烷氧基羰基,C 1 -C 12 - 烷基氨基,C 1 -C 12 - 二烷基氨基,芳基,杂芳基,未取代或取代的取代基,其赋予在水中的溶解性并且选自 由羧酸盐,磺酸盐或铵残基组成; R3为COOR5,CONR5R6; R4是COOR6,CONR5R6; R 5和R 6是氢,C 1 -C 20烷基,C 2 -C 10 - 烯基,C 3 -C 10 - 环烷基,C 7 -C 10 - 双环烷基,C 3 -C 10 - 环烯基,C 7 -C 10 - 双环烯基,芳基,杂芳基,未取代或取代的; n为1〜3; 当R 1和R 2为氢时,R 3和R 4不是COOCH 3,用作化妆品和药物制剂中的光稳定性UV过滤剂,以保护人皮肤或人类头发免受太阳光线的影响,单独或与在UV区域吸收的化合物一起, 本身就是化妆品和药物制剂。
    • 8. 发明授权
    • Use of isoindolinone derivatives as stabilizers for organic materials
    • 异吲哚啉酮衍生物作为有机材料的稳定剂的使用
    • US06210657B1
    • 2001-04-03
    • US09207624
    • 1998-12-09
    • Thorsten HabeckSylke HaremzaHubert TrauthVolker SchehlmannHorst Westenfelder
    • Thorsten HabeckSylke HaremzaHubert TrauthVolker SchehlmannHorst Westenfelder
    • A61K742
    • A61K31/4035C08K5/3417C09D7/48C09K15/30Y10S514/844Y10S514/97Y10S514/972
    • Isoindolinone derivatives of the formula I, in which the variables have the following meanings: R1 is hydrogen, COOR4, COR4, CONR4R5, CN, C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl, aryl or heteroaryl, substituted or unsubstituted; R1 and R2 together are C7-C10-bicycloalkyl or C7-C10-bicycloalkenyl; R3 is hydrogen, C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl, C1-C12-alkoxy, C1-C20-alkoxycarbonyl, C1-C12-alkylamino, C1-C12-dialkylamino, aryl or heteroaryl, substituted or unsubstituted, substituents which confer solubility in water, selected from the group consisting of carboxylate, sulfonate or ammonium radicals; R4 and R5 independently of one another are hydrogen, C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl; aryl or heteroaryl, substituted or unsubstituted; are used as stabilizers for organic materials.
    • 式I的异吲哚啉酮衍生物,其中变量具有以下含义:R1是氢,COOR4,COR4,CONR4R5,CN,C1-C20-烷基,C2-C10-烯基,C3-C10-环烷基,C3-C10- 环烯基,芳基或杂芳基,取代或未取代的; R1和R2一起是C7-C10-双环烷基或C7-C10-双环烯基; R3是氢,C1-C20-烷基,C2-C10-烯基,C3-C10-环烷基,C3 -C 10 - 环烯基,C 1 -C 12 - 烷氧基,C 1 -C 20 - 烷氧基羰基,C 1 -C 12 - 烷基氨基,C 1 -C 12 - 二烷基氨基,芳基或杂芳基,取代或未取代的赋予水溶性的取代基, 羧酸酯,磺酸酯或铵基; R 4和R 5彼此独立地是氢,C 1 -C 20 - 烷基,C 2 -C 10 - 烯基,C 3 -C 10 - 环烷基,C 3 -C 10 - 环烯基; 芳基或杂芳基,取代或未取代的;被用作有机材料的稳定剂。
    • 9. 发明授权
    • Cosmetic and pharmaceutical preparations comprising photostable UV
filters
    • 包含光稳定型紫外线过滤器的化妆品和药物制剂
    • US6090374A
    • 2000-07-18
    • US172672
    • 1998-10-15
    • Thorsten HabeckSylke HaremzaVolker SchehlmannHorst WestenfelderThomas Wunsch
    • Thorsten HabeckSylke HaremzaVolker SchehlmannHorst WestenfelderThomas Wunsch
    • A61K8/00A61K8/40A61K31/00A61P17/00A61P17/16A61Q1/04A61Q17/04A61K7/42A61K7/00A61K7/44
    • A61Q17/04A61K8/40A61Q1/04A61K2800/52
    • The use of substituted .alpha.-methylstyrene derivatives of the formula I, ##STR1## where the variables have the following meanings: R.sup.1 C.sub.4 -C.sub.10 -alkoxy, C.sub.1 -C.sub.12 -alkylamino, C.sub.1 -C.sub.12 -dialkylamino, substituents which confer solubility in water and which are selected from the group consisting of carboxylate, sulfonate or ammonium residues;R.sup.2 hydrogen, C.sub.2 -C.sub.10 -alkyl, C.sub.1 -C.sub.12 -alkoxy;R.sup.3 COOR.sup.5, COR.sup.5, CONR.sup.5 R.sup.6, CN;R.sup.4 COOR.sup.5, COR.sup.5, CONR.sup.5 R.sup.6, CN; where the substituents R.sup.3 and R.sup.4 are identical in each case;R.sup.5 andR.sup.6 independently of one another hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.2 -C.sub.10 -alkenyl, C.sub.3 -C.sub.10 -cycloalkyl, C.sub.3 -C.sub.10 -cycloalkenyl, aryl, hetaryl, unsubstituted or substituted;as photostable UV filters in cosmetic and pharmaceutical preparations to protect the human skin or human hair from the sun's rays, alone or together with UV-absorbing compounds known per se for cosmetic and pharmaceutical preparations.
    • 使用式I的取代的α-甲基苯乙烯衍生物,其中变量具有以下含义:R 1 C 4 -C 10 - 烷氧基,C 1 -C 12 - 烷基氨基,C 1 -C 12 - 二烷基氨基,赋予在水中溶解度并且被选择的取代基 由羧酸盐,磺酸盐或铵残基组成的组; R2氢,C2-C10-烷基,C1-C12-烷氧基; R3 COOR5,COR5,CONR5R6,CN; R4 COOR5,COR5,CONR5R6,CN; 其中取代基R 3和R 4在每种情况下相同; R 5和R 6彼此独立地为氢,C 1 -C 12 - 烷基,C 2 -C 10 - 烯基,C 3 -C 10 - 环烷基,C 3 -C 10 - 环烯基,芳基,杂芳基,未取代或取代的; 作为化妆品和药物制剂中的光稳定紫外线过滤器,用于保护人体皮肤或人体毛发免受太阳光线的照射,或者与本身已知的用于化妆品和药物制剂的紫外线吸收化合物一起使用。
    • 10. 发明授权
    • Photo-stable cosmetic and pharmaceutical formulations containing UV-filters
    • 光稳定的化妆品和药物配方含有紫外线过滤器
    • US06407247B1
    • 2002-06-18
    • US09494474
    • 2000-01-31
    • Thorsten HabeckAlexander AumüllerVolker SchehlmannHorst WestenfelderThomas Wünsch
    • Thorsten HabeckAlexander AumüllerVolker SchehlmannHorst WestenfelderThomas Wünsch
    • C07D22102
    • C07D275/03A61K8/411A61K8/42A61K8/466A61K8/49A61K8/498A61K8/4986A61Q1/04A61Q17/04C07C229/56C07C229/60C07C255/30C07C255/58C07C309/46C07D319/06C07D333/38
    • A method of using compounds of formula I in which the C═C double bond is present in E and/or Z configuration and the variables have the following meanings: R1 denotes COOR5, COR5, CONR5R6, CN, O═S(—R5)═O, O═S(═OR5)═O, R7O—P(—OR8)═O; R2 denotes COOR6, COR6, CONR5R6, CN, O═S(—R6)═O, O═S(═OR6)═O, R7O—P(—OR8)═O; R3 denotes hydrogen, an optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic radical having in each case up to 18 carbon atoms; R4 denotes an optionally substituted aromatic or heteroaromatic radical containing from 5 to 12 ring atoms; R5 to R8 independently denote hydrogen, an open-chain or branched-chain aliphatic, araliphatic, cycloaliphatic or optionally substituted aromatic radical containing in each case up to 18 carbon atoms, where the variables R3 to R8 may also form, together with the carbon atoms to which they are attached, a 5-membered or 6-membered ring, which may be anellated if desired, as UV filters, particularly UV-A filters, in cosmetic and pharmaceutical formulations for the protection of the human skin or human hair from solar radiation, alone or together with compounds known per se in cosmetic and pharmaceutical formulations and capable of absorbing radiation in the UV range.
    • 在E和/或Z构型中使用存在C = C双键的式Iin化合物的方法,并且变量具有以下含义:R 1表示COOR 5,COR 5,CONR 5 R 6,CN,O = S(-R 5)= O = S(= OR5)= O,R7O-P(-OR8)= O; R2表示COOR6,COR6,CONR5R6,CN,O = S(-R6)= O,O = S(= OR6)= O,R7O-P(-OR8)= O; R3表示氢,任选取代的脂族,脂环族,芳脂族或芳族基团,其中每种情况下最多可达18个碳原子; R4表示任选取代的芳族或杂芳族基团, 12个环原子; R5至R8独立地表示氢,开链或支链脂族,芳脂族,脂环族或任选取代的芳族基团,其中每种情况最多可包含18个碳原子,其中变量R3至R8也可以形成, 它们所连接的碳原子,5元或6元环,如果需要,可以将其作为UV滤光器,特别是UV-A滤光器,在化妆品和药物中 用于保护人类皮肤或人类头发免受太阳辐射,单独或与化妆品和药物制剂中本身已知的化合物一起并且能够吸收UV范围内的辐射。