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1. 发明授权

US06403360B1 KCNQ potassium channels and methods of modulating same 失效
公开(公告)号：US06403360B1
公开(公告)日：2002-06-11
申请号：US09105058
申请日：1998-06-26
申请人： Michael A. Blanar , Paul C. Levesque , Wayne A. Little , Michael G. Neubauer , Wen-Pin Yang
发明人： Michael A. Blanar , Paul C. Levesque , Wayne A. Little , Michael G. Neubauer , Wen-Pin Yang
IPC分类号： C12N1511
CPC分类号： C07K14/705 , A61K48/00
摘要： The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.

2. 发明授权

US07482431B2 KCNQ2 potassium channels 有权
标题翻译： KCNQ2钾通道
公开(公告)号：US07482431B2
公开(公告)日：2009-01-27
申请号：US11707363
申请日：2007-02-16
申请人： Michael A. Blanar , Paul C. Levesque , Wayne A. Little , Michael G. Neubauer , Wen-Pin Yang
发明人： Michael A. Blanar , Paul C. Levesque , Wayne A. Little , Michael G. Neubauer , Wen-Pin Yang
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , A61K48/00
摘要： The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.
摘要翻译：本发明涉及定义钾通道的KCNQ蛋白。特别地，本发明涉及本文报道的人KCNQ2，人类KCNQ3，鼠KCNQ2和大鼠KCNQ2蛋白。 KCNQ2和KCNQ3蛋白是神经系统选择性的，可能参与神经传递和神经保护。本发明的KCNQ2和KCNQ3可用于测定蛋白质的调节剂，其可用于治疗诸如共济失调，myokymia，癫痫发作，阿尔茨海默氏病，帕金森病，年龄相关记忆丧失，学习缺陷，运动神经元疾病，癫痫，中风等。

3. 发明授权

US07262289B2 KCNQ potassium channels and methods of modulating same 有权
标题翻译： KCNQ钾通道及其调节方法
公开(公告)号：US07262289B2
公开(公告)日：2007-08-28
申请号：US10131685
申请日：2002-04-24
申请人： Michael A. Blanar , Wen-Pin Yang , Paul C. Levesque , Michael G. Neubauer , Wayne A. Little
发明人： Michael A. Blanar , Wen-Pin Yang , Paul C. Levesque , Michael G. Neubauer , Wayne A. Little
IPC分类号： C12N14/705
CPC分类号： C07K14/705 , A61K48/00
摘要： The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.
摘要翻译：本发明涉及定义钾通道的KCNQ蛋白。特别地，本发明涉及本文报道的人KCNQ2，人类KCNQ3，鼠KCNQ2和大鼠KCNQ2蛋白。 KCNQ2和KCNQ3蛋白是神经系统选择性的，可能参与神经传递和神经保护。本发明的KCNQ2和KCNQ3可用于测定蛋白质的调节剂，其可用于治疗诸如共济失调，myokymia，癫痫发作，阿尔茨海默氏病，帕金森病，年龄相关记忆丧失，学习缺陷，运动神经元疾病，癫痫，中风等。

4. 发明授权

US07041496B2 DNA encoding rodent KCNQ2 potassium channel 有权
标题翻译：编码啮齿动物KCNQ2钾通道的DNA
公开(公告)号：US07041496B2
公开(公告)日：2006-05-09
申请号：US10128870
申请日：2002-04-24
申请人： Michael A. Blanar , Steven Dworetzky , Wen-Pin Yang , Paul C. Levesque , Valentin K. Gribkoff , Michael G. Neubauer , Wayne A. Little
发明人： Michael A. Blanar , Steven Dworetzky , Wen-Pin Yang , Paul C. Levesque , Valentin K. Gribkoff , Michael G. Neubauer , Wayne A. Little
IPC分类号： C12N15/11 , C12N5/10 , C12N15/63
CPC分类号： C07K14/705 , A61K48/00
摘要： The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.
摘要翻译：本发明涉及定义钾通道的KCNQ蛋白。特别地，本发明涉及本文报道的人KCNQ2，人类KCNQ3，鼠KCNQ2和大鼠KCNQ2蛋白。 KCNQ2和KCNQ3蛋白是神经系统选择性的，可能参与神经传递和神经保护。本发明的KCNQ2和KCNQ3可用于测定蛋白质的调节剂，其可用于治疗诸如共济失调，myokymia，癫痫发作，阿尔茨海默氏病，帕金森病，年龄相关记忆丧失，学习缺陷，运动神经元疾病，癫痫，中风等。

5. 发明授权

US07459532B2 Variants of the TRP channel family member, LTRPC3G 有权
标题翻译： TRP通道家族成员LTRPC3G的变体
公开(公告)号：US07459532B2
公开(公告)日：2008-12-02
申请号：US11985981
申请日：2007-11-19
申请人： Ning Lee , Jian Chen , Shujian Wu , Michael A. Blanar , Paul C. Levesque , Lucy Sun
发明人： Ning Lee , Jian Chen , Shujian Wu , Michael A. Blanar , Paul C. Levesque , Lucy Sun
IPC分类号： C07K14/435 , C07K14/705 , C12P21/02 , A61K38/17
CPC分类号： C07K14/705 , C07H21/04 , C07K16/28 , C07K2317/21 , C07K2317/56 , C07K2317/622
摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

6. 发明授权

US07344882B2 Polynucleotides encoding variants of the TRP channel family member, LTRPC3 有权
标题翻译：编码TRP通道家族成员LTRPC3变体的多核苷酸
公开(公告)号：US07344882B2
公开(公告)日：2008-03-18
申请号：US10842313
申请日：2004-05-10
申请人： Ning Lee , Jian Chen , Shujian Wu , Michael A. Blanar , Paul C. Levesque , Lucy Sun
发明人： Ning Lee , Jian Chen , Shujian Wu , Michael A. Blanar , Paul C. Levesque , Lucy Sun
IPC分类号： C12N5/10 , C12N15/12 , C12N15/63 , C12N1/21
CPC分类号： C07K14/705 , C07H21/04 , C07K16/28 , C07K2317/21 , C07K2317/56 , C07K2317/622
摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽的新型多核苷酸，其片段和同系物。还提供了用于产生所述多肽的载体，宿主细胞，抗体以及重组和合成方法。本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

7. 发明申请

US20080318257A1 Polynucelotides encoding novel variants of the TRP channel family member, LTRPC3 有权
公开(公告)号：US20080318257A1
公开(公告)日：2008-12-25
申请号：US12220155
申请日：2008-07-22
申请人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Michael A. Blanar , David K. Bol , Paul C. Levesque , Lucy Sun
发明人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Michael A. Blanar , David K. Bol , Paul C. Levesque , Lucy Sun
IPC分类号： G01N33/53 , C07K16/18 , C12N5/06 , G01N33/566
CPC分类号： C07K14/705 , C07H21/04 , C07K16/28 , C07K2317/21 , C07K2317/56 , C07K2317/622
摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

8. 发明授权

US07705133B2 Antibodies which bind variants of the TRP channel family member, LTRPC3 有权
标题翻译：结合TRP通道家族成员LTRPC3的变体的抗体
公开(公告)号：US07705133B2
公开(公告)日：2010-04-27
申请号：US12220155
申请日：2008-07-22
申请人： Ning Lee , Jian Chen , Shujian Wu , Michael A. Blanar , Paul C. Levesque , Lucy Sun
发明人： Ning Lee , Jian Chen , Shujian Wu , Michael A. Blanar , Paul C. Levesque , Lucy Sun
IPC分类号： C07K16/28 , C07K16/18 , A61K39/395
CPC分类号： C07K14/705 , C07H21/04 , C07K16/28 , C07K2317/21 , C07K2317/56 , C07K2317/622
摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

9. 发明授权

US07541434B2 Polypeptide for a TRP channel family member, TRP-PLIK2, and splice variants 有权
标题翻译：用于TRP通道家族成员的多肽，TRP-PLIK2和剪接变体
公开(公告)号：US07541434B2
公开(公告)日：2009-06-02
申请号：US11726234
申请日：2007-03-21
申请人： Ning Lee , Jian Chen , Shujian Wu , Han Chang , Michael A. Blanar
发明人： Ning Lee , Jian Chen , Shujian Wu , Han Chang , Michael A. Blanar
IPC分类号： C07K14/47 , C12N15/07 , C12N15/64 , C12P21/02
CPC分类号： C07K14/705
摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段及其同源物。本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法多肽。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

10. 发明申请

US20080274505A1 Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof 有权
标题翻译：编码新型TRP通道家族成员的多核苷酸，LTRPC3及其剪接变体
公开(公告)号：US20080274505A1
公开(公告)日：2008-11-06
申请号：US12152547
申请日：2008-05-15
申请人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Liana M. Lee , Michael A. Blanar , David Bol , Paul C. Lavesque , Lucy Sun
发明人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Liana M. Lee , Michael A. Blanar , David Bol , Paul C. Lavesque , Lucy Sun
IPC分类号： C12N15/12 , C12N15/63 , C12P21/00 , C12N5/10
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码LTRPC3多肽的新型多核苷酸，其片段及其同源物。本发明还提供了分别编码LTRPC3多肽，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

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