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1. 发明申请

US20080274505A1 Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof 有权
标题翻译：编码新型TRP通道家族成员的多核苷酸，LTRPC3及其剪接变体
公开(公告)号：US20080274505A1
公开(公告)日：2008-11-06
申请号：US12152547
申请日：2008-05-15
申请人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Liana M. Lee , Michael A. Blanar , David Bol , Paul C. Lavesque , Lucy Sun
发明人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Liana M. Lee , Michael A. Blanar , David Bol , Paul C. Lavesque , Lucy Sun
IPC分类号： C12N15/12 , C12N15/63 , C12P21/00 , C12N5/10
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码LTRPC3多肽的新型多核苷酸，其片段及其同源物。本发明还提供了分别编码LTRPC3多肽，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

2. 发明授权

US07223557B2 Polynucleotide encoding a TRP channel family member, TRP-PLIK2 有权
标题翻译：编码TRP通道家族成员的多核苷酸TRP-PLIK2
公开(公告)号：US07223557B2
公开(公告)日：2007-05-29
申请号：US10153244
申请日：2002-05-22
申请人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Han Chang , Liana M. Le , Michael A. Blanar , David Bol
发明人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Han Chang , Liana M. Le , Michael A. Blanar , David Bol
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/02 , C12N5/06 , C07K14/705
CPC分类号： C07K14/705
摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段和同源物。本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法多肽。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

3. 发明申请

US20080118952A1 Polynucelotides encoding novel variants of the TRP channel family member, LTRPC3 有权
标题翻译： Polynucelotides编码TRP通道家族成员LTRPC3的新型变体
公开(公告)号：US20080118952A1
公开(公告)日：2008-05-22
申请号：US11985981
申请日：2007-11-19
申请人： Ning Lee , Jian Chen , John Feder , Shujian Wu , Michael Blanar , David Bol , Paul Levesque , Lucy Sun
发明人： Ning Lee , Jian Chen , John Feder , Shujian Wu , Michael Blanar , David Bol , Paul Levesque , Lucy Sun
IPC分类号： C12P21/04 , C07K16/00
CPC分类号： C07K14/705 , C07H21/04 , C07K16/28 , C07K2317/21 , C07K2317/56 , C07K2317/622
摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

4. 发明申请

US20070172880A1 Polynucleotide encoding a novel TRP channel family member, TRP-PLIK2, and splice variants thereof 有权
标题翻译：编码新型TRP通道家族成员的多核苷酸，TRP-PLIK2及其剪接变体
公开(公告)号：US20070172880A1
公开(公告)日：2007-07-26
申请号：US11726234
申请日：2007-03-21
申请人： Ning Lee , Jian Chen , John Feder , Shujian Wu , Han Chang , Liana Lee , Michael Blanar , David Bol
发明人： Ning Lee , Jian Chen , John Feder , Shujian Wu , Han Chang , Liana Lee , Michael Blanar , David Bol
IPC分类号： C12Q1/68 , G01N33/53 , A61K38/17 , C07K14/705 , C07K16/28 , C07H21/04 , C12P21/06
CPC分类号： C07K14/705
摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段和同源物。本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法多肽。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

5. 发明授权

US07304141B2 Human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1 有权
标题翻译：人类含有亮氨酸的重复含有蛋白质主要在骨髓HLRRBM1中表达
公开(公告)号：US07304141B2
公开(公告)日：2007-12-04
申请号：US11107572
申请日：2005-04-15
申请人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol
发明人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol
IPC分类号： C07K14/47 , C12N15/12 , C12N5/20 , C12P21/02
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/53 , C07K14/47
摘要： The present invention provides novel polynucleotides encoding HLRRBM1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRBM1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly immune diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码HLRRBM1多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HLRRBM1多肽应用于诊断，治疗和/或预防与这些多肽，特别是免疫疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

6. 发明申请

US20080213918A1 Polynucleotides encoding two novel human G-protein coupled receptors, HGPRBMY28 and HGPRBMY29, and splice variants thereof 审中-公开
公开(公告)号：US20080213918A1
公开(公告)日：2008-09-04
申请号：US11891836
申请日：2007-08-13
申请人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol , Donald R. Hawken
发明人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol , Donald R. Hawken
IPC分类号： G01N33/566 , C07K16/18
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

7. 发明申请

US20120010385A1 SPLICE VARIANTS OF HUMAN G-PROTEIN COUPLED RECEPTOR HGPRBMY29 (HGPRMBY29SV2) 有权
标题翻译：人G蛋白偶联受体HGPRBMY29（HGPRBMY29SV2）的差异变体
公开(公告)号：US20120010385A1
公开(公告)日：2012-01-12
申请号：US11891240
申请日：2007-08-09
申请人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol , Donald R. Hawken
发明人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol , Donald R. Hawken
IPC分类号： C07K14/00 , C07H21/04
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

8. 发明授权

US07345148B2 Human G-protein coupled receptor, HGPRBMY29sv1 polypeptides 有权
标题翻译：人G蛋白偶联受体，HGPRBMY29sv1多肽
公开(公告)号：US07345148B2
公开(公告)日：2008-03-18
申请号：US11070456
申请日：2005-03-02
申请人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol
发明人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00 , C12N1/20 , C12N15/74
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

9. 发明授权

US07276354B2 Polynucleotides encoding a novel human G-protein coupled receptor splice variant, HGPRBMY29SV2 有权
标题翻译：编码新型人G蛋白偶联受体剪接变体的多核苷酸HGPRBMY29SV2
公开(公告)号：US07276354B2
公开(公告)日：2007-10-02
申请号：US11071761
申请日：2005-03-03
申请人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol
发明人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol
IPC分类号： C12P21/06 , C07H21/04 , C12N15/74 , C12N1/20
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生这些多肽的重组和合成方法。还提供了载体，宿主细胞，抗体以及用于产生这些多肽的重组和合成方法。本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

10. 发明授权

US07049096B2 Polynucleotides encoding a novel human G-protein coupled receptor splice variant HGPRBMY29sv1 有权
标题翻译：编码新型人G蛋白偶联受体剪接变体HGPRBMY29sv1的多核苷酸
公开(公告)号：US07049096B2
公开(公告)日：2006-05-23
申请号：US10120604
申请日：2002-04-11
申请人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol , Donald R. Hawken
发明人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol , Donald R. Hawken
IPC分类号： C12P21/06 , C12N1/20 , C12N15/00 , C12N15/74 , C07H21/04
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

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