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1. 发明申请

US20060077231A1 Electrostatic gating 有权
标题翻译：静电门控
公开(公告)号：US20060077231A1
公开(公告)日：2006-04-13
申请号：US10960599
申请日：2004-10-07
申请人： Meng Lean , John Ricciardelli , Osman Polatkan , Michael Savino , Armin Volkel
发明人： Meng Lean , John Ricciardelli , Osman Polatkan , Michael Savino , Armin Volkel
IPC分类号： B41J2/06
CPC分类号： B41J2/06
摘要： Various systems and techniques are disclosed for stopping, selectively controlling, and optimizing a flow of particles in a flowing stream. The systems and techniques utilize a multi-electrode assembly and various voltage waveforms applied to those electrodes. The particles flow past or near the electrode assembly and their flow is controlled by the configuration and arrangement of the electrodes and the voltage waveforms applied thereto. An additional strategy for countering particle leakage flow is also described.
摘要翻译：公开了用于停止，选择性地控制和优化流动流中的颗粒流的各种系统和技术。该系统和技术利用多电极组件和施加到那些电极的各种电压波形。颗粒流过或靠近电极组件，并且其流动由电极的构造和布置以及施加到其上的电压波形控制。还描述了用于抵抗颗粒泄漏流的附加策略。

2. 发明申请

US20070057748A1 Traveling wave arrays, separation methods, and purification cells 失效
标题翻译：行波阵列，分离方法和纯化细胞
公开(公告)号：US20070057748A1
公开(公告)日：2007-03-15
申请号：US11224347
申请日：2005-09-12
申请人： Meng Lean , Jeng Lu , Scott Limb , Jurgen Daniel , Armin Volkel , Huangpin Hsieh , Scott Solberg , Bryan Preas
发明人： Meng Lean , Jeng Lu , Scott Limb , Jurgen Daniel , Armin Volkel , Huangpin Hsieh , Scott Solberg , Bryan Preas
IPC分类号： H01P1/18
CPC分类号： B03C5/028
摘要： Various traveling wave grid configurations are disclosed. The grids and systems are well suited for transporting, separating, and classifying small particles dispersed in liquid or gaseous media. Also disclosed are various separation strategies and purification cells utilizing such traveling wave arrays and strategies.
摘要翻译：公开了各种行波网格结构。网格和系统非常适用于分散在液体或气体介质中的小粒子的运输，分离和分类。还公开了利用这种行波阵列和策略的各种分离策略和纯化单元。

3. 发明申请

US20060038120A1 Sample manipulator 有权
标题翻译：样品机械手
公开(公告)号：US20060038120A1
公开(公告)日：2006-02-23
申请号：US10921556
申请日：2004-08-19
申请人： Meng Lean , Francisco Torres , Huangpin Hsieh , Armin Volkel , Bryan Preas , Scott Elrod , John Fitch , Richard Bruce
发明人： Meng Lean , Francisco Torres , Huangpin Hsieh , Armin Volkel , Bryan Preas , Scott Elrod , John Fitch , Richard Bruce
IPC分类号： H01J49/00
CPC分类号： B03C1/253
摘要： A sample manipulator that utilizes electrostatic traveling waves to selectively displace one or more samples deposited on its face is disclosed. The sample manipulator enables an operator to perform a wide variety of processes upon the deposited samples. Also disclosed are strategies for separating two or more samples, focusing a sample, and passing a reagent through a sample, all conducted on the face of the sample manipulator.
摘要翻译：公开了一种使用静电行波选择性地移动沉积在其表面上的一个或多个样品的样品操纵器。样品操纵器使得操作者能够在沉积的样品上执行各种各样的处理。还公开了用于分离两个或更多个样品，聚焦样品并使试剂通过样品的策略，全部在样品操纵器的表面上进行。

4. 发明申请

US20060027034A1 Hand-held bio-agent collector 有权
公开(公告)号：US20060027034A1
公开(公告)日：2006-02-09
申请号：US10913940
申请日：2004-08-06
申请人： Meng Lean , Huangpin Hsieh , Armin Volkel , Peter Kiesel , Noble Johnson
发明人： Meng Lean , Huangpin Hsieh , Armin Volkel , Peter Kiesel , Noble Johnson
IPC分类号： G01G19/32
CPC分类号： G01N1/08
摘要： Disclosed is a compact, non-contacting device for collecting samples, and particularly minute quantities of bio-agents or particulates, from a surface. The device vibrates a region of a target surface containing the sample and collects the sample on an electrically charged pin array. The sample can be later released to a detector or other instrumentation for subsequent analysis.

5. 发明申请

US20050247565A1 Portable bioagent concentrator 失效
标题翻译：便携式生物聚焦器
公开(公告)号：US20050247565A1
公开(公告)日：2005-11-10
申请号：US10838937
申请日：2004-05-04
申请人： H. Hsieh , Meng Lean , Bryan Preas , Armin Volkel
发明人： H. Hsieh , Meng Lean , Bryan Preas , Armin Volkel
IPC分类号： G01N27/27 , G01N27/453
CPC分类号： G01N27/453
摘要： A portable apparatus for extracting and concentrating bioagents within a fluid medium includes a container with sample solution inlet port and traveling wave grids patterned on surfaces of the container. The traveling wave grids cause bioagents to migrate to a specified surface within the container and then to an extraction port. The traveling wave grids include a substrate, across which extend a collection of closely spaced and parallel electrically conductive electrodes, and a collection of buses providing electrical communication with the collection of conductive electrodes. A voltage controller provides a multiphase electrical signal to the collection of buses and electrodes of the traveling wave grids.
摘要翻译：用于在流体介质中提取和浓缩生物体的便携式设备包括具有样品溶液入口的容器和在容器表面上图案化的行波网格。行波网格使生物体迁移到容器内的指定表面，然后迁移到提取口。行波网格包括基板，跨越其延伸紧密间隔且平行的导电电极的集合，以及提供与导电电极集合电连通的总线的集合。电压控制器提供多相电信号，用于收集行波网格的总线和电极。

6. 发明申请

US20050136703A1 Flexible cable interconnect assembly 有权
公开(公告)号：US20050136703A1
公开(公告)日：2005-06-23
申请号：US10742501
申请日：2003-12-19
申请人： Koenraad Van Schuylenbergh , Armin Volkel , Thomas DiStefano , Michel Rosa , David Fork , Eugene Chow , Meng Lean
发明人： Koenraad Van Schuylenbergh , Armin Volkel , Thomas DiStefano , Michel Rosa , David Fork , Eugene Chow , Meng Lean
IPC分类号： H05K1/14 , H01B11/00 , H01R12/00 , H01R12/04 , H05K3/32 , H05K3/36
CPC分类号： H01R12/78 , H05K1/147 , H05K3/323 , H05K3/361 , H05K3/365 , H05K2201/044 , H05K2201/09845
摘要： A data transmission interconnect assembly (e.g., a router) capable of transmission speeds in excess of 40 Gbps in which a line-card is detachably coupled to a backplane using flexible flat cables that are bent to provide a continuous, smooth curve between the connected boards, and connected by a connection apparatus that employs cable-to-cable interface members that are transparent to the transmitted signal waves. Microspring contact structures are formed on the cables, or on a contact structure pressed against the cables, to provide interface arrangements that are smaller than a wavelength of the transmitted signal. A connector apparatus uses a cam mechanism to align the cables, and then to press a contact structure, having micro spring interface members formed thereon, against the cables. An alterative contact structure uses anisotropic conductive film.

7. 发明申请

US20050123930A1 Traveling wave grids and algorithms for biomolecule separation, transport and focusing 有权
标题翻译：用于生物分子分离，运输和聚焦的旅行波网格和算法
公开(公告)号：US20050123930A1
公开(公告)日：2005-06-09
申请号：US10727301
申请日：2003-12-03
申请人： Meng Lean , Jeng Lu , Jackson Ho , Chinwen Shih , Armin Volkel , Huangpin Hsieh , Jurgen Daniel
发明人： Meng Lean , Jeng Lu , Jackson Ho , Chinwen Shih , Armin Volkel , Huangpin Hsieh , Jurgen Daniel
IPC分类号： B03C5/02 , G01N27/447 , G01N30/02 , C12Q1/68 , G01N33/53
CPC分类号： G01N27/44773 , B03C5/028 , G01N27/44713 , G01N30/02
摘要： Various traveling wave grids and related systems are disclosed that are particularly beneficial for the separation, transport, and focusing of biomolecules or other charged species. An implementation of a vertically integrated traveling wave module is described which allows for scalability to arbitrary gel dimensions through tiling. In addition, several unique traveling wave algorithms are also described which when used in conjunction with the traveling wave grids, impart selective motion to biomolecules or other charged species.
摘要翻译：公开了对生物分子或其他带电物质的分离，运输和聚焦特别有利的各种行波网格和相关系统。描述了垂直集成的行波模块的实现，其允许通过平铺来扩展任意的凝胶尺寸。此外，还描述了当与行波网格结合使用时，对生物分子或其他带电物质赋予选择性运动的几种独特的行波算法。

8. 发明申请

US20060121555A1 Bio-enrichment device to enhance sample collection and detection 有权
标题翻译：生物富集装置，增强样品收集和检测
公开(公告)号：US20060121555A1
公开(公告)日：2006-06-08
申请号：US11007121
申请日：2004-12-08
申请人： Meng Lean , Armin Volkel , Peter Kiesel , Oliver Schmidt , Noble Johnson , H. Hsieh
发明人： Meng Lean , Armin Volkel , Peter Kiesel , Oliver Schmidt , Noble Johnson , H. Hsieh
IPC分类号： C12M1/34 , C12Q1/24
CPC分类号： G01N30/0005 , B03C5/028 , G01N30/08
摘要： A flow cell is disclosed for collecting and concentrating a sample dispersed in a flowing medium. The collected sample can be selectively manipulated within the cell by the use of one or more traveling wave grids. The cells are particularly useful as bio-enrichment devices and can be utilized upstream of conventional analytical or detection instruments.
摘要翻译：公开了用于收集和浓缩分散在流动介质中的样品的流动池。收集的样品可以通过使用一个或多个行波网格在单元内选择性地操纵。细胞特别可用作生物富集装置，并可用于常规分析或检测仪器的上游。

9. 发明申请

US20060009051A1 Flexible cable interconnect assembly 有权
公开(公告)号：US20060009051A1
公开(公告)日：2006-01-12
申请号：US11226186
申请日：2005-09-13
申请人： Koenraad Schuylenbergh , Armin Volkel , Thomas DiStefano , Michel Rosa , David Fork , Eugene Chow , Meng Lean
发明人： Koenraad Schuylenbergh , Armin Volkel , Thomas DiStefano , Michel Rosa , David Fork , Eugene Chow , Meng Lean
IPC分类号： H01R12/00
CPC分类号： H01R12/78 , H05K1/147 , H05K3/323 , H05K3/361 , H05K3/365 , H05K2201/044 , H05K2201/09845
摘要： A data transmission interconnect assembly capable of transmission speeds in excess of 40 Gbps in which, for example, a line-card is detachably coupled to a backplane using flexible flat cables that are bent to provide a continuous, smooth curve between the connected boards, and connected by a connection apparatus that employs cable-to-cable interface members that are transparent to the transmitted signal waves. Microspring interface members are formed on the contact structure pressed against the cables to provide interface arrangements that are smaller than a wavelength of the transmitted signal. A connector apparatus uses a cam mechanism to align the cables, and then to press the contact structure, having the microspring interface members formed thereon, against the cables. An alterative contact structure uses anisotropic conductive film.

10. 发明申请

US20050123992A1 Concentration and focusing of bio-agents and micron-sized particles using traveling wave grids 有权
标题翻译：使用行波网格集中和聚焦生物剂和微米级颗粒
公开(公告)号：US20050123992A1
公开(公告)日：2005-06-09
申请号：US10727289
申请日：2003-12-03
申请人： Armin Volkel , Meng Lean , Huangpin Hsieh , Jurgen Daniel
发明人： Armin Volkel , Meng Lean , Huangpin Hsieh , Jurgen Daniel
IPC分类号： C12M1/34 , G01N33/53 , G01N33/543
CPC分类号： G01N33/5438
摘要： Several traveling wave grid systems are disclosed that may be used to concentrate and form highly localized regions of bio-agents or other charged species. In addition, specific detection systems are described that enable currently available detectors and sensors, including those to be developed in the future, to be used for measuring the presence and concentration of certain bio-agents or charged particles, which otherwise are present at concentrations too low to readily detect or measure.
摘要翻译：公开了几种可以用于浓缩和形成高度局部化的生物剂或其他带电物质区域的行波系统。此外，描述了使得目前可用的检测器和传感器（包括将来要开发的检测器和传感器）能够用于测量某些生物试剂或带电粒子的存在和浓度的具体检测系统，否则其浓度也是以浓度存在低易于检测或测量。

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