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1. 发明申请

US20050247565A1 Portable bioagent concentrator 失效
标题翻译：便携式生物聚焦器
公开(公告)号：US20050247565A1
公开(公告)日：2005-11-10
申请号：US10838937
申请日：2004-05-04
申请人： H. Hsieh , Meng Lean , Bryan Preas , Armin Volkel
发明人： H. Hsieh , Meng Lean , Bryan Preas , Armin Volkel
IPC分类号： G01N27/27 , G01N27/453
CPC分类号： G01N27/453
摘要： A portable apparatus for extracting and concentrating bioagents within a fluid medium includes a container with sample solution inlet port and traveling wave grids patterned on surfaces of the container. The traveling wave grids cause bioagents to migrate to a specified surface within the container and then to an extraction port. The traveling wave grids include a substrate, across which extend a collection of closely spaced and parallel electrically conductive electrodes, and a collection of buses providing electrical communication with the collection of conductive electrodes. A voltage controller provides a multiphase electrical signal to the collection of buses and electrodes of the traveling wave grids.
摘要翻译：用于在流体介质中提取和浓缩生物体的便携式设备包括具有样品溶液入口的容器和在容器表面上图案化的行波网格。行波网格使生物体迁移到容器内的指定表面，然后迁移到提取口。行波网格包括基板，跨越其延伸紧密间隔且平行的导电电极的集合，以及提供与导电电极集合电连通的总线的集合。电压控制器提供多相电信号，用于收集行波网格的总线和电极。

2. 发明申请

US20070057748A1 Traveling wave arrays, separation methods, and purification cells 失效
标题翻译：行波阵列，分离方法和纯化细胞
公开(公告)号：US20070057748A1
公开(公告)日：2007-03-15
申请号：US11224347
申请日：2005-09-12
申请人： Meng Lean , Jeng Lu , Scott Limb , Jurgen Daniel , Armin Volkel , Huangpin Hsieh , Scott Solberg , Bryan Preas
发明人： Meng Lean , Jeng Lu , Scott Limb , Jurgen Daniel , Armin Volkel , Huangpin Hsieh , Scott Solberg , Bryan Preas
IPC分类号： H01P1/18
CPC分类号： B03C5/028
摘要： Various traveling wave grid configurations are disclosed. The grids and systems are well suited for transporting, separating, and classifying small particles dispersed in liquid or gaseous media. Also disclosed are various separation strategies and purification cells utilizing such traveling wave arrays and strategies.
摘要翻译：公开了各种行波网格结构。网格和系统非常适用于分散在液体或气体介质中的小粒子的运输，分离和分类。还公开了利用这种行波阵列和策略的各种分离策略和纯化单元。

3. 发明申请

US20060038120A1 Sample manipulator 有权
标题翻译：样品机械手
公开(公告)号：US20060038120A1
公开(公告)日：2006-02-23
申请号：US10921556
申请日：2004-08-19
申请人： Meng Lean , Francisco Torres , Huangpin Hsieh , Armin Volkel , Bryan Preas , Scott Elrod , John Fitch , Richard Bruce
发明人： Meng Lean , Francisco Torres , Huangpin Hsieh , Armin Volkel , Bryan Preas , Scott Elrod , John Fitch , Richard Bruce
IPC分类号： H01J49/00
CPC分类号： B03C1/253
摘要： A sample manipulator that utilizes electrostatic traveling waves to selectively displace one or more samples deposited on its face is disclosed. The sample manipulator enables an operator to perform a wide variety of processes upon the deposited samples. Also disclosed are strategies for separating two or more samples, focusing a sample, and passing a reagent through a sample, all conducted on the face of the sample manipulator.
摘要翻译：公开了一种使用静电行波选择性地移动沉积在其表面上的一个或多个样品的样品操纵器。样品操纵器使得操作者能够在沉积的样品上执行各种各样的处理。还公开了用于分离两个或更多个样品，聚焦样品并使试剂通过样品的策略，全部在样品操纵器的表面上进行。

4. 发明申请

US20050247564A1 Continuous flow particle concentrator 有权
标题翻译：连续流粒子集中器
公开(公告)号：US20050247564A1
公开(公告)日：2005-11-10
申请号：US10838570
申请日：2004-05-04
申请人： Armin Volkel , Meng Lean , H. Hsieh , Jurgen Daniel
发明人： Armin Volkel , Meng Lean , H. Hsieh , Jurgen Daniel
IPC分类号： B03C5/02 , G01N27/27 , G01N27/453 , G01N30/00 , G01N33/487
CPC分类号： B03C5/028 , G01N2030/0035
摘要： An apparatus for extracting and concentrating bioagents within a continuously flowing fluid medium includes a flow channel fluid inlet, in which bioagents are concentrated from three dimensions to a two-dimensional transport layer in a preconcentration area. Traveling wave grids cause the preconcentrated bioagents to migrate to one side of the flow channel and then to an extraction port. Each of the traveling wave grids includes a substrate, a collection of closely spaced and parallel electrically conductive electrodes extending across said substrate, and a collection of buses providing electrical communication with the collection of conductive electrodes. A voltage controller provides a multiphase electrical signal to the collection of buses and electrodes of the traveling wave grids. Fluid exits through an outlet port.
摘要翻译：用于在连续流动的流体介质中提取和浓缩生物体的装置包括流动通道流体入口，其中生物体从三维集中到预浓缩区域中的二维输送层。旅行波谷使预浓缩的生物标签迁移到流动通道的一侧，然后迁移到提取口。每个行波波谷包括基板，跨越所述基板的紧密间隔且平行的导电电极的集合，以及提供与导电电极集合电连通的总线的集合。电压控制器提供多相电信号，用于收集行波网格的总线和电极。流体通过出口排出。

5. 发明申请

US20060121555A1 Bio-enrichment device to enhance sample collection and detection 有权
标题翻译：生物富集装置，增强样品收集和检测
公开(公告)号：US20060121555A1
公开(公告)日：2006-06-08
申请号：US11007121
申请日：2004-12-08
申请人： Meng Lean , Armin Volkel , Peter Kiesel , Oliver Schmidt , Noble Johnson , H. Hsieh
发明人： Meng Lean , Armin Volkel , Peter Kiesel , Oliver Schmidt , Noble Johnson , H. Hsieh
IPC分类号： C12M1/34 , C12Q1/24
CPC分类号： G01N30/0005 , B03C5/028 , G01N30/08
摘要： A flow cell is disclosed for collecting and concentrating a sample dispersed in a flowing medium. The collected sample can be selectively manipulated within the cell by the use of one or more traveling wave grids. The cells are particularly useful as bio-enrichment devices and can be utilized upstream of conventional analytical or detection instruments.
摘要翻译：公开了用于收集和浓缩分散在流动介质中的样品的流动池。收集的样品可以通过使用一个或多个行波网格在单元内选择性地操纵。细胞特别可用作生物富集装置，并可用于常规分析或检测仪器的上游。

6. 发明申请

US20050136703A1 Flexible cable interconnect assembly 有权
公开(公告)号：US20050136703A1
公开(公告)日：2005-06-23
申请号：US10742501
申请日：2003-12-19
申请人： Koenraad Van Schuylenbergh , Armin Volkel , Thomas DiStefano , Michel Rosa , David Fork , Eugene Chow , Meng Lean
发明人： Koenraad Van Schuylenbergh , Armin Volkel , Thomas DiStefano , Michel Rosa , David Fork , Eugene Chow , Meng Lean
IPC分类号： H05K1/14 , H01B11/00 , H01R12/00 , H01R12/04 , H05K3/32 , H05K3/36
CPC分类号： H01R12/78 , H05K1/147 , H05K3/323 , H05K3/361 , H05K3/365 , H05K2201/044 , H05K2201/09845
摘要： A data transmission interconnect assembly (e.g., a router) capable of transmission speeds in excess of 40 Gbps in which a line-card is detachably coupled to a backplane using flexible flat cables that are bent to provide a continuous, smooth curve between the connected boards, and connected by a connection apparatus that employs cable-to-cable interface members that are transparent to the transmitted signal waves. Microspring contact structures are formed on the cables, or on a contact structure pressed against the cables, to provide interface arrangements that are smaller than a wavelength of the transmitted signal. A connector apparatus uses a cam mechanism to align the cables, and then to press a contact structure, having micro spring interface members formed thereon, against the cables. An alterative contact structure uses anisotropic conductive film.

7. 发明申请

US20050123930A1 Traveling wave grids and algorithms for biomolecule separation, transport and focusing 有权
标题翻译：用于生物分子分离，运输和聚焦的旅行波网格和算法
公开(公告)号：US20050123930A1
公开(公告)日：2005-06-09
申请号：US10727301
申请日：2003-12-03
申请人： Meng Lean , Jeng Lu , Jackson Ho , Chinwen Shih , Armin Volkel , Huangpin Hsieh , Jurgen Daniel
发明人： Meng Lean , Jeng Lu , Jackson Ho , Chinwen Shih , Armin Volkel , Huangpin Hsieh , Jurgen Daniel
IPC分类号： B03C5/02 , G01N27/447 , G01N30/02 , C12Q1/68 , G01N33/53
CPC分类号： G01N27/44773 , B03C5/028 , G01N27/44713 , G01N30/02
摘要： Various traveling wave grids and related systems are disclosed that are particularly beneficial for the separation, transport, and focusing of biomolecules or other charged species. An implementation of a vertically integrated traveling wave module is described which allows for scalability to arbitrary gel dimensions through tiling. In addition, several unique traveling wave algorithms are also described which when used in conjunction with the traveling wave grids, impart selective motion to biomolecules or other charged species.
摘要翻译：公开了对生物分子或其他带电物质的分离，运输和聚焦特别有利的各种行波网格和相关系统。描述了垂直集成的行波模块的实现，其允许通过平铺来扩展任意的凝胶尺寸。此外，还描述了当与行波网格结合使用时，对生物分子或其他带电物质赋予选择性运动的几种独特的行波算法。

8. 发明申请

US20060027034A1 Hand-held bio-agent collector 有权
公开(公告)号：US20060027034A1
公开(公告)日：2006-02-09
申请号：US10913940
申请日：2004-08-06
申请人： Meng Lean , Huangpin Hsieh , Armin Volkel , Peter Kiesel , Noble Johnson
发明人： Meng Lean , Huangpin Hsieh , Armin Volkel , Peter Kiesel , Noble Johnson
IPC分类号： G01G19/32
CPC分类号： G01N1/08
摘要： Disclosed is a compact, non-contacting device for collecting samples, and particularly minute quantities of bio-agents or particulates, from a surface. The device vibrates a region of a target surface containing the sample and collects the sample on an electrically charged pin array. The sample can be later released to a detector or other instrumentation for subsequent analysis.

9. 发明申请

US20070145249A1 Sensing photons from objects in channels 有权
标题翻译：从通道中的物体感测光子
公开(公告)号：US20070145249A1
公开(公告)日：2007-06-28
申请号：US11315992
申请日：2005-12-22
申请人： Peter Kiesel , Meng Lean , Oliver Schmidt , Armin Volkel , Noble Johnson
发明人： Peter Kiesel , Meng Lean , Oliver Schmidt , Armin Volkel , Noble Johnson
IPC分类号： H01J40/14
CPC分类号： G01N21/05 , G01N21/645 , G01N21/65 , G01N21/658 , G01N2021/0346 , G01N2021/1734 , G01N2021/6421 , G01N2021/6482
摘要： A fluidic structure includes a channel and along the channel is a series of sensing components to obtain information about objects traveling within the channel, such as droplets or other objects carried by fluid. At least one sensing component includes a set of cells of a photosensor array. The set of cells photosense a range of photon energies that emanate from objects, and include a subset of cells that photosense within subranges. A processor can receive information about objects from the sensing components and use it to obtain spectral information. The processor can perform an initial analysis using information from one set of sensing components and, based on the results, control a fluidic device in the channel, such as a gate, to retain objects, such as for concentration and more detailed analysis by other sensing components, or to purge objects from the channel.
摘要翻译：流体结构包括通道，并且沿着通道是一系列感测部件，以获得关于在通道内行进的物体的信息，例如由流体携带的液滴或其它物体。至少一个感测组件包括一组光电传感器阵列的单元。该组细胞照射从物体发出的一系列光子能量，并且包括在子范围内的光密度的子集。处理器可以从感测组件接收关于对象的信息，并使用它来获得光谱信息。处理器可以使用来自一组感测组件的信息来执行初始分析，并且基于该结果，控制通道（例如门）中的流体装置以保持对象，例如通过其他感测的浓度和更详细的分析组件，或从通道清除对象。

10. 发明申请

US20060077231A1 Electrostatic gating 有权
标题翻译：静电门控
公开(公告)号：US20060077231A1
公开(公告)日：2006-04-13
申请号：US10960599
申请日：2004-10-07
申请人： Meng Lean , John Ricciardelli , Osman Polatkan , Michael Savino , Armin Volkel
发明人： Meng Lean , John Ricciardelli , Osman Polatkan , Michael Savino , Armin Volkel
IPC分类号： B41J2/06
CPC分类号： B41J2/06
摘要： Various systems and techniques are disclosed for stopping, selectively controlling, and optimizing a flow of particles in a flowing stream. The systems and techniques utilize a multi-electrode assembly and various voltage waveforms applied to those electrodes. The particles flow past or near the electrode assembly and their flow is controlled by the configuration and arrangement of the electrodes and the voltage waveforms applied thereto. An additional strategy for countering particle leakage flow is also described.
摘要翻译：公开了用于停止，选择性地控制和优化流动流中的颗粒流的各种系统和技术。该系统和技术利用多电极组件和施加到那些电极的各种电压波形。颗粒流过或靠近电极组件，并且其流动由电极的构造和布置以及施加到其上的电压波形控制。还描述了用于抵抗颗粒泄漏流的附加策略。

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