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1. 发明授权

US08618145B2 Small molecular compounds capable of accelerating proliferation of stem cells and use thereof 有权
标题翻译：能够促进干细胞增殖的小分子化合物及其用途
公开(公告)号：US08618145B2
公开(公告)日：2013-12-31
申请号：US13320203
申请日：2009-05-12
申请人： Mei Han , Yan Feng , Yuanyuan Sun
发明人： Mei Han , Yan Feng , Yuanyuan Sun
IPC分类号： A61K31/4245 , C07D271/113
CPC分类号： C07D271/07
摘要： The invention provides small molecule compounds capable of accelerating proliferation of stem cells and uses thereof. The compounds play an important role in the research of stem cell proliferation mechanism. The invention further relates to the uses of the compounds and relevant compounds thereof in the preparation of stem cell proliferation accelerators and the preparation of medicines accelerating stem cell proliferation. The invention also relates to the uses of the compounds in the preparation of medicines for the treatment of various diseases arising from functional cells loss or damage. The diseases arising from stem cell trauma comprise diseases related to the degeneration or damage of nervous system cells, blood system diseases, diseases related to the loss or damage of cardiovascular cells, skin burn and the like.
摘要翻译：本发明提供能够促进干细胞增殖的小分子化合物及其用途。该化合物在干细胞增殖机制研究中起着重要作用。本发明还涉及化合物及其相关化合物在制备干细胞增殖促进剂中的用途以及加速干细胞增殖的药物的制备。本发明还涉及该化合物在制备用于治疗由功能性细胞损失或损伤引起的各种疾病的药物中的用途。由干细胞创伤引起的疾病包括与神经系统细胞的退化或损伤相关的疾病，血液系统疾病，与心血管细胞的损失或损伤有关的疾病，皮肤灼伤等。

2. 发明申请

US20120053214A1 THE LITTLE MOLECULE COMPOUND WHICH USED FOR PROMOTING THE STEM CELLS HYPERPLASIA AND THE USE THEREOF 有权
标题翻译：用于促进干细胞高分子的小分子化合物及其用途
公开(公告)号：US20120053214A1
公开(公告)日：2012-03-01
申请号：US13320203
申请日：2009-05-12
申请人： Mei Han , Yan Feng , Yuanyuan Sun
发明人： Mei Han , Yan Feng , Yuanyuan Sun
IPC分类号： A61K31/4245 , C12N5/02 , A61P9/00 , A61P17/00 , A61P7/00 , A61P25/00 , A61P25/28 , A61P25/16 , A61P25/08 , A61P25/22 , A61P7/06 , A61P35/02 , A61P37/00 , A61P17/02 , C07D271/113
CPC分类号： C07D271/07
摘要： The invention provides small molecule compounds capable of accelerating proliferation of stem cells and uses thereof. The compounds play an important role in the research of stem cell proliferation mechanism. The invention further relates to the uses of the compounds and relevant compounds thereof in the preparation of stem cell proliferation accelerators and the preparation of medicines accelerating stem cell proliferation. The invention also relates to the uses of the compounds in the preparation of medicines for the treatment of various diseases arising from functional cells loss or damage. The diseases arising from stem cell trauma comprise diseases related to the degeneration or damage of nervous system cells, blood system diseases, diseases related to the loss or damage of cardiovascular cells, skin burn and the like.
摘要翻译：本发明提供能够促进干细胞增殖的小分子化合物及其用途。该化合物在干细胞增殖机制研究中起着重要作用。本发明还涉及化合物及其相关化合物在制备干细胞增殖促进剂中的用途以及促进干细胞增殖的药物的制备。本发明还涉及该化合物在制备用于治疗由功能性细胞损失或损伤引起的各种疾病的药物中的用途。由干细胞创伤引起的疾病包括与神经系统细胞的退化或损伤相关的疾病，血液系统疾病，与心血管细胞的损失或损伤有关的疾病，皮肤灼伤等。

3. 发明授权

US10640457B2 Histone acetyltransferase activators and uses thereof 有权
公开(公告)号：US10640457B2
公开(公告)日：2020-05-05
申请号：US13493490
申请日：2012-06-11
申请人： Yan Feng , Mauro Fa , Ottavio Arancio , Shixian Deng , Donald W. Landry , Yitshak Francis
发明人： Yan Feng , Mauro Fa , Ottavio Arancio , Shixian Deng , Donald W. Landry , Yitshak Francis
IPC分类号： A61K49/00 , C07C235/64 , C07C323/67 , C07C323/42 , C07D213/82 , C07D213/75 , C07C235/56 , C07C237/40 , C07D239/52 , C07D333/38 , C12Q1/48 , C07C323/44 , C07C323/60
CPC分类号： C07C235/64 , C07C235/56 , C07C237/40 , C07C323/42 , C07C323/44 , C07C323/60 , C07C323/67 , C07D213/75 , C07D213/82 , C07D239/52 , C07D333/38 , C12Q1/48 , C07C2601/08 , G01N2500/04 , G01N2800/2814
摘要： The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.

4. 发明授权

US08773752B2 Narrow band fiber Raman optical amplifier 有权
标题翻译：窄带光纤拉曼光放大器
公开(公告)号：US08773752B2
公开(公告)日：2014-07-08
申请号：US12812370
申请日：2009-01-16
申请人： Luke R. Taylor , Yan Feng , Wolfgang Hackenberg , Ronald Holzlöhner , Domenico Bonaccini Calia
发明人： Luke R. Taylor , Yan Feng , Wolfgang Hackenberg , Ronald Holzlöhner , Domenico Bonaccini Calia
IPC分类号： H04B10/17 , H01S3/30
CPC分类号： H01S3/302
摘要： Optical Raman fiber amplifier (20), with an amplification fiber, wherein at least one section thereof has a ratio of Raman gain coefficient gR to Brillouin gB gain coefficient of gR/gB larger than 0.001 at the fiber operating temperature and a vacuum wavelength of 1064 nm. The invention further refers to a corresponding light source, the use of a fiber and a method of amplifying light.
摘要翻译：具有放大光纤的光拉曼光纤放大器（20），其中至少一个部分在光纤工作温度下的拉曼增益系数gR与布里渊gB增益系数gR / gB大于0.001，真空波长为1064 nm。本发明还涉及相应的光源，光纤的使用和放大光的方法。

5. 发明授权

US08106021B2 Benzylbenzene derivatives and methods of use 有权
标题翻译：苄苯衍生物和使用方法
公开(公告)号：US08106021B2
公开(公告)日：2012-01-31
申请号：US12917367
申请日：2010-11-01
申请人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07H7/04 , C07D309/10 , C07D407/12
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

6. 外观设计

USD638688S1 Electrical receptacle and inlet valve cover plate 有权
标题翻译：电气插座和进口阀盖板
公开(公告)号：USD638688S1
公开(公告)日：2011-05-31
申请号：US29347207
申请日：2009-10-23
申请人： James George Sheremeta , Daniel David Richard Mika , Yan Feng
设计人： James George Sheremeta , Daniel David Richard Mika , Yan Feng

7. 发明授权

US07838499B2 Benzylbenzene derivatives and methods of use 有权
标题翻译：苄苯衍生物和使用方法
公开(公告)号：US07838499B2
公开(公告)日：2010-11-23
申请号：US12197095
申请日：2008-08-22
申请人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
IPC分类号： A01N43/04 , A61K31/70 , C07H1/00 , C07H5/02
CPC分类号： C07H7/04 , C07D309/10 , C07D407/12
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

8. 发明授权

US07803778B2 Glucose transport inhibitors and methods of use 有权
标题翻译：葡萄糖转运抑制剂和使用方法
公开(公告)号：US07803778B2
公开(公告)日：2010-09-28
申请号：US11752226
申请日：2007-05-22
申请人： Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Jiajia Dong , Brian Seed , Michael J. Hadd
发明人： Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Jiajia Dong , Brian Seed , Michael J. Hadd
IPC分类号： A01N43/04 , C07H1/00 , C07H3/00 , C08B37/00
CPC分类号： C07D311/96 , C07D407/12 , C07H7/04 , C07H19/00
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

9. 发明申请

US20100140917A1 Vacuum fitting connection 审中-公开
标题翻译：真空接头连接
公开(公告)号：US20100140917A1
公开(公告)日：2010-06-10
申请号：US12592775
申请日：2009-12-01
申请人： James George Sheremeta , Yan Feng
发明人： James George Sheremeta , Yan Feng
IPC分类号： A47L9/24 , F16L35/00
CPC分类号： A47L5/38 , A47L9/242 , F16L25/0045 , F16L41/021
摘要： A vacuum connection to connect a vacuum fitting to a corrugated hose has an air tube which defines an air channel and fits into the corrugated pipe. The connecting has a securing mechanism to secure the air tube to the corrugated hose. The air tube has an outer diameter which corresponds to the inner diameter of the corrugated hose to create an air tight seal. The securing mechanism has radial projections which are radially biased towards the air tube and engage one or more of the corrugations of the corrugated pipe to secure the vacuum fitting to the corrugated pipe. When the corrugated pipe is to be removed from the fitting, the radial projections may be moved against the biasing force to disengage the corrugations and permit removal of the corrugated pipe from the fitting. The opening of the air tube has a chamfered edge to create a smooth transition from the air channel of the air tube to the corrugated pipe thereby decreasing vacuum loss, debris accumulation and excessive noise.
摘要翻译：将真空接头连接到波纹软管的真空接头具有限定空气通道并配合到波纹管中的空气管。连接件具有固定机构以将空气管固定到波纹软管。空气管具有对应于波纹软管的内径的外径，以产生气密密封。固定机构具有径向偏压朝向空气管并且接合波纹管的一个或多个波纹以将真空接头固定到波纹管的径向突起。当波纹管从配件中取出时，径向突起可以抵抗偏压力而移动，以使波纹脱离并允许从配件中移除波纹管。空气管的开口具有倒角边缘，以形成从空气管的空气通道到波纹管的平滑过渡，从而减少真空损失，碎屑积聚和过大的噪声。

10. 发明申请

US20050025710A1 Reconstitutable formulation and aqueous suspension of gas-filled microvesicles for diagnostic imaging 审中-公开
标题翻译：用于诊断成像的气体填充微泡的可重构制剂和水悬浮液
公开(公告)号：US20050025710A1
公开(公告)日：2005-02-03
申请号：US10630375
申请日：2003-07-29
申请人： Michel Schneider , Yan Feng , Jean Brochot , David Lazurus
发明人： Michel Schneider , Yan Feng , Jean Brochot , David Lazurus
IPC分类号： A61K49/18 , A61K49/22 , A61K49/00
CPC分类号： A61K49/1815 , A61K49/225
摘要： The invention relates to a formulation comprising a dry material (e.g. lyophilised or spray dried) comprising at least one film forming surfactant and a gas or a gas mixture usable in diagnostic imaging, to a process for the preparation thereof and to a suspension obtainable by reconstituting said formulation with an aqueous carrier for use in contrast imaging. The invention also relates to a container comprising the dry material in contact with a gas. The gas associated with the dry material is at a pressure lower than the atmospheric pressure.
摘要翻译：本发明涉及包含干物质（例如冻干或喷雾干燥的）的制剂，其包含至少一种成膜表面活性剂和可用于诊断成像的气体或气体混合物，其制备方法和可通过重构获得的悬浮液所述制剂具有用于对比成像的水性载体。本发明还涉及包含与气体接触的干燥材料的容器。与干燥材料相关联的气体处于低于大气压的压力。

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