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1. 发明申请

US20050025710A1 Reconstitutable formulation and aqueous suspension of gas-filled microvesicles for diagnostic imaging 审中-公开
标题翻译：用于诊断成像的气体填充微泡的可重构制剂和水悬浮液
公开(公告)号：US20050025710A1
公开(公告)日：2005-02-03
申请号：US10630375
申请日：2003-07-29
申请人： Michel Schneider , Yan Feng , Jean Brochot , David Lazurus
发明人： Michel Schneider , Yan Feng , Jean Brochot , David Lazurus
IPC分类号： A61K49/18 , A61K49/22 , A61K49/00
CPC分类号： A61K49/1815 , A61K49/225
摘要： The invention relates to a formulation comprising a dry material (e.g. lyophilised or spray dried) comprising at least one film forming surfactant and a gas or a gas mixture usable in diagnostic imaging, to a process for the preparation thereof and to a suspension obtainable by reconstituting said formulation with an aqueous carrier for use in contrast imaging. The invention also relates to a container comprising the dry material in contact with a gas. The gas associated with the dry material is at a pressure lower than the atmospheric pressure.
摘要翻译：本发明涉及包含干物质（例如冻干或喷雾干燥的）的制剂，其包含至少一种成膜表面活性剂和可用于诊断成像的气体或气体混合物，其制备方法和可通过重构获得的悬浮液所述制剂具有用于对比成像的水性载体。本发明还涉及包含与气体接触的干燥材料的容器。与干燥材料相关联的气体处于低于大气压的压力。

2. 发明申请

US20130101520A1 ULTRASOUND CONTRAST AGENTS AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译：超声对比剂及其制备和使用方法
公开(公告)号：US20130101520A1
公开(公告)日：2013-04-25
申请号：US13612236
申请日：2012-09-12
申请人： Michel SCHNEIDER , Feng Yan , David Lazarus , Jean Brochot , Jerome Puginier
发明人： Michel SCHNEIDER , Feng Yan , David Lazarus , Jean Brochot , Jerome Puginier
IPC分类号： A61K49/22
CPC分类号： A61K49/223 , A61K49/227
摘要： The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents.
摘要翻译：本发明涉及气体填充微泡的可注射悬浮液，以及制备和使用它们的方法，特别是作为超声造影剂。

3. 发明申请

US20090076477A1 Automatic Liquid Injection System and Method 审中-公开
标题翻译：自动注液系统及方法
公开(公告)号：US20090076477A1
公开(公告)日：2009-03-19
申请号：US12208878
申请日：2008-09-11
申请人： Michel Schneider , Christophe Golay , Laurent Jakob , Jean Brochot , Feng Yan , Christian Mathieu
发明人： Michel Schneider , Christophe Golay , Laurent Jakob , Jean Brochot , Feng Yan , Christian Mathieu
IPC分类号： A61M5/00 , A61B6/00
CPC分类号： A61M5/1456 , A61B2017/22008 , A61B2090/3925 , A61B2090/3933 , A61M5/007 , A61M2205/6072 , B01F9/0016 , B01F11/0002 , B01F2003/0035
摘要： A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
摘要翻译：一种功率辅助方法和注射器装置，用于可控地向患者输送分散药物或诊断活性剂，其均匀性在整个递送期间保留。所公开的诊断活性剂是用于超声诊断成像的气体微泡悬浮液和其中脂质体囊泡装载碘化化合物的脂质体制剂。

4. 发明申请

US20120093732A1 ULTRASOUND CONTRAST AGENTS AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译：超声对比剂及其制备和使用方法
公开(公告)号：US20120093732A1
公开(公告)日：2012-04-19
申请号：US13224129
申请日：2011-09-01
申请人： Michel Schneider , Feng Yan , David Lazarus , Jean Brochot , Jerome Puginier
发明人： Michel Schneider , Feng Yan , David Lazarus , Jean Brochot , Jerome Puginier
IPC分类号： A61B8/00 , A61K49/22
CPC分类号： A61K49/223 , A61K49/227
摘要： The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents.
摘要翻译：本发明涉及气体填充微泡的可注射悬浮液，以及制备和使用它们的方法，特别是作为超声造影剂。

5. 发明授权

US07534239B1 Automatic liquid injection system and method 有权
标题翻译：自动注液系统及方法
公开(公告)号：US07534239B1
公开(公告)日：2009-05-19
申请号：US09576422
申请日：2000-05-22
申请人： Michel Schneider , Laurent Jakob , Christophe Golay , Jean Brochot , Feng Yan
发明人： Michel Schneider , Laurent Jakob , Christophe Golay , Jean Brochot , Feng Yan
IPC分类号： A61M31/00
CPC分类号： A61M5/1456 , A61B2017/22008 , A61B2090/3925 , A61B2090/3933 , A61M5/007 , A61M2205/6072 , B01F9/0016 , B01F11/0002 , B01F2003/0035
摘要： A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
摘要翻译：一种功率辅助方法和注射器装置，用于可控地向患者输送分散药物或诊断活性剂，其均匀性在整个递送期间保留。所公开的诊断活性剂是用于超声诊断成像的气体微泡悬浮液和其中脂质体囊泡装载碘化化合物的脂质体制剂。

6. 发明授权

US5830435A Method of storing frozen microbubble suspensions 失效
标题翻译：储存冷冻微泡悬浮液的方法
公开(公告)号：US5830435A
公开(公告)日：1998-11-03
申请号：US909100
申请日：1997-08-12
申请人： Feng Yan , Michel Schneider , Jean Brochot
发明人： Feng Yan , Michel Schneider , Jean Brochot
IPC分类号： A61K49/00 , A61K49/22 , A61K49/04 , A61K9/127
CPC分类号： A61K49/223
摘要： Disclosed are suspensions of gas microbubbles immobilised within a frozen aqueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is a physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by an evanescent envelope or a tangible membrane. The suspensions, when in liquid form, are injectable and useful as a contrast agents in ultrasonic imaging of blood pool and tissue of living beings. The gas microbubbles are immobilised within the carrier by freezing a suspension of microbubbles with average sizes below 50 .mu.m, preferably below 10 .mu.m and more preferably between 2 .mu.m and 8 .mu.m, to a temperature between -1.degree. C. and -76.degree. C. and maintaining this temperature for prolonged periods of time. The microbubbles may be stabilised by a surfactant such as a lamellar phospholipid or may comprise a membrane made of synthetic or natural polymer or protein. A method of cold storage of microbubble suspensions as well as their use is also disclosed.
摘要翻译：公开了固定在包含通常的添加剂和稳定剂的冷冻含水载体液体中的气体微泡的悬浮液，其中载体液体是生理上可接受的，固定化气体微泡是由ev逝包膜或有形膜结合的微泡。当液体形式时，悬浮液是可注射的，并且可用作血液池和生物组织的超声成像中的造影剂。将气体微泡固定在载体中，将平均尺寸低于50μm，优选低于10μm，更优选在2μm和8μm之间的微泡悬浮液冷冻至-1℃至-1℃的温度， 76℃，并保持该温度较长时间。微泡可以通过表面活性剂如片状磷脂来稳定，或者可以包含由合成或天然聚合物或蛋白质制成的膜。还公开了微泡悬浮液的冷藏方法及其用途。

7. 发明授权

US5827504A Method of echographic imaging using frozen gasbubble suspensions 失效
标题翻译：使用冷冻气泡悬浮液的回波成像方法
公开(公告)号：US5827504A
公开(公告)日：1998-10-27
申请号：US909099
申请日：1997-08-12
申请人： Feng Yan , Michel Schneider , Jean Brochot
发明人： Feng Yan , Michel Schneider , Jean Brochot
IPC分类号： A61K49/00 , A61K49/22 , A61K49/04
CPC分类号： A61K49/223
摘要： Disclosed are suspensions of gas microbubbles immobilised within a frozen aqueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is a physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by an evanescent envelope or a tangible membrane. The suspensions, when in liquid form, are injectable and useful as a contrast agents in ultrasonic imaging of blood pool and tissue of living beings. The gas microbubbles are immobilised within the carrier by freezing a suspension of microbubbles with average sizes below 50 .mu.m, preferably below 10 .mu.m and more preferably between 2 .mu.m and 8 .mu.m, to a temperature between -1.degree. C. and -76.degree. C. and maintaining this temperature for prolonged periods of time. The microbubbles may be stabilised by a surfactant such as a lamellar phospholipid or may comprise a membrane made of synthetic or natural polymer or protein. A method of cold storage of microbubble suspensions as well as their use is also disclosed.
摘要翻译：公开了固定在包含通常的添加剂和稳定剂的冷冻含水载体液体中的气体微泡的悬浮液，其中载体液体是生理上可接受的，固定化气体微泡是由ev逝包膜或有形膜结合的微泡。当液体形式时，悬浮液是可注射的，并且可用作血液池和生物组织的超声成像中的造影剂。将气体微泡固定在载体中，将平均尺寸低于50μm，优选低于10μm，更优选在2μm和8μm之间的微泡悬浮液冷冻至-1℃至-1℃的温度， 76℃，并保持该温度较长时间。微泡可以通过表面活性剂如片状磷脂来稳定，或者可以包含由合成或天然聚合物或蛋白质制成的膜。还公开了微泡悬浮液的冷藏方法及其用途。

8. 发明授权

US5445813A Stable microbubble suspensions as enhancement agents for ultrasound echography 失效
标题翻译：稳定的微泡悬浮液作为超声波回波成像的增强剂
公开(公告)号：US5445813A
公开(公告)日：1995-08-29
申请号：US134671
申请日：1993-10-12
申请人： Michel Schneider , Jean Brochot , Jerome Puginier , Feng Yan
发明人： Michel Schneider , Jean Brochot , Jerome Puginier , Feng Yan
IPC分类号： A61K47/24 , A61B8/08 , A61B8/12 , A61B8/13 , A61K9/127 , A61K49/00 , A61K49/22 , B01F3/04 , B01J13/02
CPC分类号： A61K49/225 , A61K49/223
摘要： Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.
摘要翻译：公开了在超声波回波成像中可用作造影剂的水性载体液体中的气体填充微泡的可注射悬浮液。悬浮液包含两亲性化合物，其中至少一种可以是层状磷脂作为微泡的稳定剂，以防止随时间和压力而塌陷。载体液体中磷脂的浓度低于0.01％wt，但至少等于或高于磷脂分子仅存在于气体微泡液界面的浓度。还公开了制备空气或气体填充的微泡的稳定悬浮液的方法。

9. 发明申请

US20120265065A1 Automatic Liquid Injection System and Method 审中-公开
标题翻译：自动注液系统及方法
公开(公告)号：US20120265065A1
公开(公告)日：2012-10-18
申请号：US13467301
申请日：2012-05-09
申请人： Michel Schneider , Christophe Golay , Laurent Jakob , Jean Brochot , Feng Yan , Christian Mathieu
发明人： Michel Schneider , Christophe Golay , Laurent Jakob , Jean Brochot , Feng Yan , Christian Mathieu
IPC分类号： A61M5/20 , A61B6/00
CPC分类号： A61M5/1456 , A61B2017/22008 , A61B2090/3925 , A61B2090/3933 , A61M5/007 , A61M2205/6072 , B01F9/0016 , B01F11/0002 , B01F2003/0035
摘要： A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
摘要翻译：一种功率辅助方法和注射器装置，用于可控地向患者输送分散药物或诊断活性剂，其均匀性在整个递送期间保留。所公开的诊断活性剂是用于超声诊断成像的气体微泡悬浮液和其中脂质体囊泡装载碘化化合物的脂质体制剂。

10. 发明授权

US06726650B2 Automatic liquid injection system and method 有权
标题翻译：自动注液系统及方法
公开(公告)号：US06726650B2
公开(公告)日：2004-04-27
申请号：US09204067
申请日：1998-12-03
申请人： Michel Schneider , Christophe Golay , Laurent Jakob , Jean Brochot , Feng Yan , Christian Mathieu
发明人： Michel Schneider , Christophe Golay , Laurent Jakob , Jean Brochot , Feng Yan , Christian Mathieu
IPC分类号： A61M3700
CPC分类号： A61M5/1456 , A61B2017/22008 , A61B2090/3925 , A61B2090/3933 , A61M5/007 , A61M2205/6072 , B01F9/0016 , B01F11/0002 , B01F2003/0035
摘要： A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
摘要翻译：一种功率辅助方法和注射器装置，用于可控地向患者输送分散药物或诊断活性剂，其均匀性在整个递送期间保留。所公开的诊断活性剂是用于超声诊断成像的气体微泡悬浮液和其中脂质体囊泡装载碘化化合物的脂质体制剂。

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