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1. 发明授权

US09149369B2 Methods and devices for delivering and affixing tissue scaffolds 有权
标题翻译：用于递送和固定组织支架的方法和装置
公开(公告)号：US09149369B2
公开(公告)日：2015-10-06
申请号：US13542004
申请日：2012-07-05
申请人： Mehmet Z. Sengun , Kristian Dimatteo
发明人： Mehmet Z. Sengun , Kristian Dimatteo
IPC分类号： A61F2/46 , A61F2/30
CPC分类号： A61F2/4618 , A61F2002/30766 , A61F2002/4627
摘要： Methods and devices are provided for delivering and affixing tissue replacements. In one embodiment, a tissue scaffold can be delivered into a patient through a cannula to a cavity formed at a defect site in tissue, e.g., cartilage. A delivery shaft can be used to deliver the scaffold through the cannula, and a loading device can help load the scaffold onto the delivery shaft. A delivery guide device can position and temporarily hold the scaffold within the cavity. The delivery guide device can guide one or more surgical instruments to the scaffold to affix the scaffold within the cavity, e.g., to bone underlying the scaffold, using at least one securing mechanism.
摘要翻译：提供了用于递送和贴附组织替代物的方法和装置。在一个实施例中，组织支架可以通过套管递送到患者体内，形成在组织例如软骨中的缺损部位。输送轴可用于通过套管递送支架，并且装载装置可以帮助将支架装载到输送轴上。输送引导装置可以将支架放置并暂时保持在腔内。输送引导装置可以使用至少一个固定机构将一个或多个外科器械引导至支架以将支架固定在腔内，例如骨架下面的骨骼上。

2. 发明申请

US20100249758A1 METHODS AND DEVICES FOR PREPARING AND IMPLANTING TISSUE SCAFFOLDS 有权
标题翻译：用于制备和植入组织病变的方法和装置
公开(公告)号：US20100249758A1
公开(公告)日：2010-09-30
申请号：US12412492
申请日：2009-03-27
申请人： Mehmet Z. Sengun , Kristian DiMatteo
发明人： Mehmet Z. Sengun , Kristian DiMatteo
IPC分类号： A61B17/00
CPC分类号： A61F2/30756 , A61B17/32053 , A61B90/06 , A61B90/39 , A61B2017/00738 , A61B2017/00969 , A61B2017/320052 , A61B2090/061 , A61B2090/3904 , A61B2090/3937 , A61F2/02 , A61F2002/30759 , A61F2002/30766 , A61L27/3641 , A61L27/3654 , A61L2430/06 , A61L2430/34
摘要： Methods and devices are provided for preparing and implanting tissue scaffolds. Various embodiments of scribing tools are provided that are configured to mark one or more predetermined shapes around a defect site in tissue. The shape or shapes marked in tissue can be used to cut a tissue scaffold having a shape that matches the shape or shapes marked in tissue. In one embodiment, the scribing tool used to mark a shape in tissue can also be used to cut the tissue scaffold.
摘要翻译：提供了用于制备和植入组织支架的方法和装置。提供了划线工具的各种实施例，其被配置为在组织中的缺陷部位周围标记一个或多个预定形状。组织中标记的形状或形状可用于切割具有与组织中标记的形状或形状匹配的形状的组织支架。在一个实施例中，用于标记组织中的形状的划线工具也可用于切割组织支架。

3. 发明授权

US08241298B2 Methods and devices for delivering and affixing tissue scaffolds 有权
标题翻译：用于递送和固定组织支架的方法和装置
公开(公告)号：US08241298B2
公开(公告)日：2012-08-14
申请号：US12412499
申请日：2009-03-27
申请人： Mehmet Z. Sengun , Kristian DiMatteo
发明人： Mehmet Z. Sengun , Kristian DiMatteo
IPC分类号： A61F2/84
CPC分类号： A61F2/4618 , A61F2002/30766 , A61F2002/4627
摘要： Methods and devices are provided for delivering and affixing tissue replacements. In one embodiment, a tissue scaffold can be delivered into a patient through a cannula to a cavity formed at a defect site in tissue, e.g., cartilage. A delivery shaft can be used to deliver the scaffold through the cannula, and a loading device can help load the scaffold onto the delivery shaft. A delivery guide device can position and temporarily hold the scaffold within the cavity. The delivery guide device can guide one or more surgical instruments to the scaffold to affix the scaffold within the cavity, e.g., to bone underlying the scaffold, using at least one securing mechanism.
摘要翻译：提供了用于递送和贴附组织替代物的方法和装置。在一个实施例中，组织支架可以通过套管递送到患者体内，形成在组织例如软骨中的缺损部位。输送轴可用于通过套管递送支架，并且装载装置可以帮助将支架装载到输送轴上。输送引导装置可以将支架放置并暂时保持在腔内。输送引导装置可以使用至少一个固定机构将一个或多个外科器械引导至支架以将支架固定在腔内，例如骨架下面的骨骼上。

4. 发明授权

US08308814B2 Methods and devices for preparing and implanting tissue scaffolds 有权
标题翻译：用于制备和植入组织支架的方法和装置
公开(公告)号：US08308814B2
公开(公告)日：2012-11-13
申请号：US12412492
申请日：2009-03-27
申请人： Mehmet Z. Sengun , Kristian DiMatteo
发明人： Mehmet Z. Sengun , Kristian DiMatteo
IPC分类号： A61F2/02
CPC分类号： A61F2/30756 , A61B17/32053 , A61B90/06 , A61B90/39 , A61B2017/00738 , A61B2017/00969 , A61B2017/320052 , A61B2090/061 , A61B2090/3904 , A61B2090/3937 , A61F2/02 , A61F2002/30759 , A61F2002/30766 , A61L27/3641 , A61L27/3654 , A61L2430/06 , A61L2430/34
摘要： Methods and devices are provided for preparing and implanting tissue scaffolds. Various embodiments of scribing tools are provided that are configured to mark one or more predetermined shapes around a defect site in tissue. The shape or shapes marked in tissue can be used to cut a tissue scaffold having a shape that matches the shape or shapes marked in tissue. In one embodiment, the scribing tool used to mark a shape in tissue can also be used to cut the tissue scaffold.
摘要翻译：提供了用于制备和植入组织支架的方法和装置。提供了划线工具的各种实施例，其被配置为在组织中的缺陷部位周围标记一个或多个预定形状。组织中标记的形状或形状可用于切割具有与组织中标记的形状或形状匹配的形状的组织支架。在一个实施例中，用于标记组织中的形状的划线工具也可用于切割组织支架。

5. 发明申请

US20120271432A1 METHODS AND DEVICES FOR DELIVERING AND AFFIXING TISSUE SCAFFOLDS 审中-公开
标题翻译：用于传递和补充组织病变的方法和装置
公开(公告)号：US20120271432A1
公开(公告)日：2012-10-25
申请号：US13542004
申请日：2012-07-05
申请人： Mehmet Z. Sengun , Kristian DiMatteo
发明人： Mehmet Z. Sengun , Kristian DiMatteo
IPC分类号： A61F2/02 , B65B1/04
CPC分类号： A61F2/4618 , A61F2002/30766 , A61F2002/4627
摘要： Methods and devices are provided for delivering and affixing tissue replacements. In one embodiment, a tissue scaffold can be delivered into a patient through a cannula to a cavity formed at a defect site in tissue, e.g., cartilage. A delivery shaft can be used to deliver the scaffold through the cannula, and a loading device can help load the scaffold onto the delivery shaft. A delivery guide device can position and temporarily hold the scaffold within the cavity. The delivery guide device can guide one or more surgical instruments to the scaffold to affix the scaffold within the cavity, e.g., to bone underlying the scaffold, using at least one securing mechanism.
摘要翻译：提供了用于递送和贴附组织替代物的方法和装置。在一个实施例中，组织支架可以通过套管递送到患者体内，形成在组织例如软骨中的缺损部位。输送轴可用于通过套管递送支架，并且装载装置可以帮助将支架装载到输送轴上。输送引导装置可以将支架放置并暂时保持在腔内。输送引导装置可以使用至少一个固定机构将一个或多个外科器械引导至支架以将支架固定在腔内，例如骨架下面的骨骼上。

6. 发明申请

US20100249801A1 METHODS AND DEVICES FOR DELIVERING AND AFFIXING TISSUE SCAFFOLDS 有权
标题翻译：用于传递和补充组织病变的方法和装置
公开(公告)号：US20100249801A1
公开(公告)日：2010-09-30
申请号：US12412499
申请日：2009-03-27
申请人： Mehmet Z. Sengun , Kristian DiMatteo
发明人： Mehmet Z. Sengun , Kristian DiMatteo
IPC分类号： A61B17/10 , A61B17/08
CPC分类号： A61F2/4618 , A61F2002/30766 , A61F2002/4627
摘要： Methods and devices are provided for delivering and affixing tissue replacements. In one embodiment, a tissue scaffold can be delivered into a patient through a cannula to a cavity formed at a defect site in tissue, e.g., cartilage. A delivery shaft can be used to deliver the scaffold through the cannula, and a loading device can help load the scaffold onto the delivery shaft. A delivery guide device can position and temporarily hold the scaffold within the cavity. The delivery guide device can guide one or more surgical instruments to the scaffold to affix the scaffold within the cavity, e.g., to bone underlying the scaffold, using at least one securing mechanism.
摘要翻译：提供了用于递送和贴附组织替代物的方法和装置。在一个实施例中，组织支架可以通过套管递送到患者体内，形成在组织例如软骨中的缺损部位。输送轴可用于通过套管递送支架，并且装载装置可以帮助将支架装载到输送轴上。输送引导装置可以将支架放置并暂时保持在腔内。输送引导装置可以使用至少一个固定机构将一个或多个外科器械引导至支架以将支架固定在腔内，例如骨架下面的骨骼上。

7. 发明授权

US10849931B2 Compositions and methods for platelet enriched fibrin constructs 有权
公开(公告)号：US10849931B2
公开(公告)日：2020-12-01
申请号：US13250086
申请日：2011-09-30
申请人： Mehmet Z. Sengun , William Parrish , Gregory R. Whittaker , Douglas A. Fifolt , Brooks J. Story
发明人： Mehmet Z. Sengun , William Parrish , Gregory R. Whittaker , Douglas A. Fifolt , Brooks J. Story
IPC分类号： A61K35/14 , A61K35/17 , A61K38/18 , A61L27/22 , A61L27/38 , A61K35/19 , A61L27/54 , A61L15/32 , A61K38/36 , A61K38/55
摘要： Compositions and methods are provided for tissue constructs that promote wound healing. The composition comprises a dimensionally stable fibrin construct for local administration to a wound site or region. In one embodiment, the fibrin construct is a wound healing composition, including components that promote wound healing, such as platelets, growth factors, white blood cells and fibrin clots. In another embodiment, the tissue treatment composition includes (i) aggregated fibrin, (ii) blood cells, and (iii) optionally, growth factors and/or other proteins.

8. 发明申请

US20130317532A1 METHODS AND DEVICES FOR CUTTING AND REMOVING TISSUE FROM A BODY 有权
标题翻译：用于从体内切割和去除组织的方法和装置
公开(公告)号：US20130317532A1
公开(公告)日：2013-11-28
申请号：US13478240
申请日：2012-05-23
申请人： David B. Spenciner , Mehmet Z. Sengun
发明人： David B. Spenciner , Mehmet Z. Sengun
IPC分类号： A61B17/32
CPC分类号： A61B17/1659 , A61B17/1604 , A61B17/1644 , A61B17/32002 , A61B2017/320028 , A61B2217/005
摘要： Methods and devices are provided for cutting and removing tissue from a body. In one exemplary embodiment, a surgical device is provided having a suction shaft and a cutting assembly. The suction shaft can have an inner passageway configured to receive tissue. The cutting assembly can include an outer shaft having at least one opening formed in a sidewall thereof configured to receive tissue. The cutting assembly can be configured to mate with the suction shaft, and it can include a cutting element configured to move relative to the opening to cut tissue disposed through the opening. Suction can be applied to cause the cut tissue to flow proximally through the suction shaft and away from the cutting assembly.
摘要翻译：提供了用于从身体切割和去除组织的方法和装置。在一个示例性实施例中，提供具有抽吸轴和切割组件的外科装置。抽吸轴可以具有构造成接收组织的内部通道。切割组件可以包括具有形成在其侧壁中的至少一个开口的外轴，其构造成接收组织。切割组件可被构造成与抽吸轴配合，并且其可以包括构造成相对于开口移动的切割元件，以切割通过开口设置的组织。可以施加吸力以使切割的组织向近侧流过抽吸轴并远离切割组件。

9. 发明授权

US08425517B2 Abrasive cutting system and method 有权
标题翻译：磨料切割系统及方法
公开(公告)号：US08425517B2
公开(公告)日：2013-04-23
申请号：US13188983
申请日：2011-07-22
申请人： Mehmet Z. Sengun , Elizabeth Heneberry , Ian D. McRury , Kevin J. Ranucci , Douglas W. Dunn
发明人： Mehmet Z. Sengun , Elizabeth Heneberry , Ian D. McRury , Kevin J. Ranucci , Douglas W. Dunn
IPC分类号： A61B17/00
CPC分类号： A61B17/3203 , A61B17/1644 , A61B17/32037 , A61B2017/1648
摘要： A high pressure fluid jet system is provided, which is useful for cutting hard material during a surgical procedure. The cutting of hard material is more efficient as the system delivers abrasive solid particles with the high pressure fluid. A method of effecting cutting during a surgical procedure is also provided. In an exemplary embodiment, a surgical tool that is effective to deliver a pressurized stream of fluid through a nozzle is provided, and the pressurized stream of fluid is delivered through the surgical tool and out of the nozzle to hard material within a patient to effect cutting of the hard material within the patient in a desired pattern. The fluid that cuts the hard material can include a delivery liquid having a plurality of abrasive solid particles that are formed from an organic material. The abrasive solid particles can be entrained in the pressurized fluid stream or the pressurized fluid stream can erode a solid or suspension form of the abrasive particles.
摘要翻译：提供了一种高压流体喷射系统，可用于在外科手术过程中切割硬质材料。硬质材料的切割更有效，因为系统用高压流体输送磨料固体颗粒。还提供了一种在外科手术过程中进行切割的方法。在一个示例性实施例中，提供了有效地通过喷嘴输送加压流体流的手术工具，并且加压的流体流通过外科手术工具输送到患者体内的硬质材料以进行切割的患者内的硬质材料。切割硬质材料的流体可以包括具有由有机材料形成的多个磨料固体颗粒的输送液体。研磨的固体颗粒可以夹带在加压流体流中，或者加压的流体流可以侵蚀磨料颗粒的固体或悬浮液形式。

10. 发明授权

US08915961B2 Methods and devices for anchoring a graft to bone 有权
标题翻译：将移植物固定在骨上的方法和装置
公开(公告)号：US08915961B2
公开(公告)日：2014-12-23
申请号：US13489070
申请日：2012-06-05
申请人： Mehmet Z. Sengun , Eduard Grinberg , Michael S. Varieur , Dennis M. Burke
发明人： Mehmet Z. Sengun , Eduard Grinberg , Michael S. Varieur , Dennis M. Burke
IPC分类号： A61F2/08
CPC分类号： A61B17/8811 , A61B17/56 , A61B17/8805 , A61F2/0811 , A61F2002/0858 , A61F2002/087 , A61F2002/0888 , A61F2210/0085 , A61F2250/0003
摘要： Methods and devices are provided for anchoring graft to bone. In one exemplary embodiment, a bone cavity is created in bone, a graft is partially advanced into the bone cavity, and a hardenable filler material is inserted into the cavity. The hardenable filler material can change from a viscous first state to a harder second state, compressing the graft against the walls of the bone cavity and thereby anchoring the graft within the cavity. The hardenable filler material can be inserted in an open sac, a closed sac, other carriers or housings, or directly into the bone cavity.
摘要翻译：提供了将移植物锚定到骨头上的方法和装置。在一个示例性实施例中，在骨中产生骨腔，移植物部分地进入骨腔，并且可硬化填充材料插入腔中。可硬化的填充材料可以从粘性第一状态改变到更硬的第二状态，将移植物压靠在骨腔的壁上，从而将移植物锚定在腔内。可硬化的填充材料可以插入开放的囊，封闭囊，其他载体或外壳中，或者直接插入到骨腔中。

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