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1. 发明申请

US20130084310A1 COMPOSITIONS AND METHODS FOR PLATELET ENRICHED FIBRIN CONSTRUCTS 审中-公开
标题翻译：组合物和方法用于板材加强的纤维结构
公开(公告)号：US20130084310A1
公开(公告)日：2013-04-04
申请号：US13250086
申请日：2011-09-30
申请人： Mehmet Z. Sengun , William Parrish , Gregory R. Whittaker , Douglas A. Fifolt , Brooks J. Story
发明人： Mehmet Z. Sengun , William Parrish , Gregory R. Whittaker , Douglas A. Fifolt , Brooks J. Story
IPC分类号： A61K9/00 , A61P43/00 , B32B37/14 , A61K35/14
CPC分类号： A61K35/17 , A61K35/14 , A61K35/19 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , A61K38/363 , A61K38/55 , A61L15/32 , A61L27/225 , A61L27/38 , A61L27/54 , A61L2300/414 , A61K2300/00
摘要： Compositions and methods are provided for tissue constructs that promote wound healing. The composition comprises a dimensionally stable fibrin construct for local administration to a wound site or region. In one embodiment, the fibrin construct is a wound healing composition, including components that promote wound healing, such as platelets, growth factors, white blood cells and fibrin clots. In another embodiment, the tissue treatment composition includes (i) aggregated fibrin, (ii) blood cells, and (iii) optionally, growth factors and/or other proteins.
摘要翻译：为促进伤口愈合的组织结构提供组合物和方法。组合物包含用于局部施用于伤口部位或区域的尺寸稳定的纤维蛋白构建体。在一个实施方案中，纤维蛋白构建体是伤口愈合组合物，包括促进伤口愈合的成分，例如血小板，生长因子，白细胞和纤维蛋白凝块。在另一个实施方案中，组织处理组合物包括（i）聚集的纤维蛋白，（ii）血细胞，和（iii）任选的生长因子和/或其它蛋白质。

2. 发明授权

US10849931B2 Compositions and methods for platelet enriched fibrin constructs 有权
公开(公告)号：US10849931B2
公开(公告)日：2020-12-01
申请号：US13250086
申请日：2011-09-30
申请人： Mehmet Z. Sengun , William Parrish , Gregory R. Whittaker , Douglas A. Fifolt , Brooks J. Story
发明人： Mehmet Z. Sengun , William Parrish , Gregory R. Whittaker , Douglas A. Fifolt , Brooks J. Story
IPC分类号： A61K35/14 , A61K35/17 , A61K38/18 , A61L27/22 , A61L27/38 , A61K35/19 , A61L27/54 , A61L15/32 , A61K38/36 , A61K38/55
摘要： Compositions and methods are provided for tissue constructs that promote wound healing. The composition comprises a dimensionally stable fibrin construct for local administration to a wound site or region. In one embodiment, the fibrin construct is a wound healing composition, including components that promote wound healing, such as platelets, growth factors, white blood cells and fibrin clots. In another embodiment, the tissue treatment composition includes (i) aggregated fibrin, (ii) blood cells, and (iii) optionally, growth factors and/or other proteins.

3. 发明授权

US09555171B2 Methods and devices for collecting separate components of whole blood 有权
标题翻译：用于收集全血分离成分的方法和装置
公开(公告)号：US09555171B2
公开(公告)日：2017-01-31
申请号：US12894271
申请日：2010-09-30
申请人： Mehmet Ziya Sengun , William Parrish , Brooks J. Story , Kristian DiMatteo , Gregory R. Whittaker , Douglas Allen Fifolt
发明人： Mehmet Ziya Sengun , William Parrish , Brooks J. Story , Kristian DiMatteo , Gregory R. Whittaker , Douglas Allen Fifolt
IPC分类号： A01N1/02 , B01D21/26 , B01D21/00 , A61M1/02 , A61M1/36 , B01L3/00
CPC分类号： B04B11/04 , A61K35/16 , A61K35/19 , A61M1/029 , A61M1/3693 , A61M2202/0427 , B01D21/262 , B01D2221/10 , B01L3/5021 , B01L2300/028 , B01L2300/0832 , B01L2400/0409 , B01L2400/0478 , B01L2400/0622 , B04B5/0414 , B04B2011/046
摘要： A method provides for procuring platelet rich plasma (PRP) from a sample of whole blood in a vial. The method includes the steps of: separating the whole blood into layers through centrifugation with an upper layer containing platelet poor plasma (PPP) and a PRP layer below the upper layer containing PRP; adjusting an end point of a first range of motion of an extractor relative to a position of the PRP layer; moving the extractor through the first range of motion through the vial, PPP passing out from the upper layer through the extractor; and after the extractor reaches the end point of the first range of motion, extracting the PRP through the extractor and collecting the PRP.
摘要翻译：一种方法提供从小瓶中的全血样品中获得富血小板血浆（PRP）。该方法包括以下步骤：通过离心将全血分离成含有血小板不足等离子体（PPP）的上层和含有PRP的上层下方的PRP层; 调整提取器相对于PRP层的位置的第一运动范围的终点; 将提取器移动通过小瓶的第一运动范围，PPP从上层通过提取器传出; 并且在提取器到达第一运动范围的终点之后，通过提取器提取PRP并收集PRP。

4. 发明申请

US20120082652A1 METHODS AND DEVICES FOR COLLECTING SEPARATE COMPONENTS OF WHOLE BLOOD 有权
标题翻译：用于收集全血分离成分的方法和装置
公开(公告)号：US20120082652A1
公开(公告)日：2012-04-05
申请号：US12894271
申请日：2010-09-30
申请人： Mehmet Ziya Sengun , William Parrish , Brooks J. Story , Kristian DiMatteo , Gregory R. Whittaker , Douglas Allen Fifolt
发明人： Mehmet Ziya Sengun , William Parrish , Brooks J. Story , Kristian DiMatteo , Gregory R. Whittaker , Douglas Allen Fifolt
IPC分类号： A61K35/16 , B01D21/00 , A61P17/02 , B01D21/26
CPC分类号： B04B11/04 , A61K35/16 , A61K35/19 , A61M1/029 , A61M1/3693 , A61M2202/0427 , B01D21/262 , B01D2221/10 , B01L3/5021 , B01L2300/028 , B01L2300/0832 , B01L2400/0409 , B01L2400/0478 , B01L2400/0622 , B04B5/0414 , B04B2011/046
摘要： A method provides for procuring platelet rich plasma (PRP) from a sample of whole blood in a vial. The method includes the steps of: separating the whole blood into layers through centrifugation with an upper layer containing platelet poor plasma (PPP) and a PRP layer below the upper layer containing PRP; adjusting an end point of a first range of motion of an extractor relative to a position of the PRP layer; moving the extractor through the first range of motion through the vial, PPP passing out from the upper layer through the extractor; and after the extractor reaches the end point of the first range of motion, extracting the PRP through the extractor and collecting the PRP.
摘要翻译：一种方法提供从小瓶中的全血样品中获得富血小板血浆（PRP）。该方法包括以下步骤：通过离心将全血分离成含有血小板不足等离子体（PPP）的上层和含有PRP的上层下方的PRP层; 调整提取器相对于PRP层的位置的第一运动范围的终点; 将提取器移动通过小瓶的第一运动范围，PPP从上层通过提取器传出; 并且在提取器到达第一运动范围的终点之后，通过提取器提取PRP并收集PRP。

5. 发明申请

US20090037834A1 Site plan tool 审中-公开
标题翻译：现场计划工具
公开(公告)号：US20090037834A1
公开(公告)日：2009-02-05
申请号：US11660727
申请日：2006-03-21
申请人： William Parrish
发明人： William Parrish
IPC分类号： G06F3/048
CPC分类号： G06T11/60
摘要： The invention provides a simple to use site planning tool suitable useful in the field and capable of supporting site feasibility decision-making. Several advantages include cost savings owing to a) the expense of the tool itself (as compared with current CAD drawn site plans) and b) the compressed time-line to a decision-point regarding any site under consideration. More specifically, the invention provides a lightweight and intuitive design tool which requires no training to use, and permits a user to draw, to scale, property boundary lines within a browser interface and with or without an Internet connection. The invention further provides that a user may perform other rapid and scaled visualization concerning possible site plans, and to save site plans into a graphic file suitable for transmission and/or printing.
摘要翻译：本发明提供了一种适用于现场且能够支持现场可行性决策的易于使用的场地规划工具。一些优点包括：a）工具本身的费用（与目前的CAD绘制现场计划相比），以及b）压缩的时间线到任何正在考虑的站点的决策点。更具体地，本发明提供了一种轻量级和直观的设计工具，其不需要训练使用，并且允许用户绘制，扩展浏览器界面内的属性边界线以及在或不与互联网连接的范围内。本发明还提供用户可以对可能的站点计划执行其他快速和缩放的可视化，并且将站点计划保存到适于传输和/或打印的图形文件中。

6. 发明申请

US20120219546A1 METHODS FOR TREATING CONDITIONS MEDIATED BY THE INFLAMMATORY CYTOKINE CASCADE USING GAPDH INHIBITORS 失效
标题翻译：使用GAPDH抑制剂治疗炎症细胞因子介导的病症治疗方法
公开(公告)号：US20120219546A1
公开(公告)日：2012-08-30
申请号：US13391465
申请日：2010-08-17
申请人： Kevin Tracey , William Parrish
发明人： Kevin Tracey , William Parrish
IPC分类号： A61K39/395 , A61P1/00 , A61P1/04 , A61P1/02 , A61P1/18 , A61P31/14 , A61P11/06 , A61P37/08 , A61P37/00 , A61P9/10 , A61P17/00 , A61P15/02 , A61P13/08 , A61P11/08 , A61P11/00 , A61P33/00 , A61P31/04 , A61P31/12 , A61P31/16 , A61P31/22 , A61P31/18 , A61P31/10 , A61P33/06 , A61P17/02 , A61P7/02 , A61P29/00 , A61P9/04 , A61P25/00 , A61P27/02 , A61P19/08 , A61P19/06 , A61P21/04 , A61P5/14 , A61P19/04 , A61P37/06 , C12Q1/32 , A61P31/00
CPC分类号： C07K16/40 , C07K2317/76
摘要： The present invention is directed to a method of treating a subject at risk for or having a condition mediated by an inflammatory cytokine cascade comprising administering to the subject an amount of a GAPDH inhibitor effective to treat the subject at risk for or having a condition mediated by an inflammatory cytokine cascade.
摘要翻译：本发明涉及一种治疗处于危险中或具有由炎性细胞因子级联介导的病症的受试者的方法，其包括向所述受试者施用一定量的有效治疗所述受试者处于或具有由炎性细胞因子级联。

7. 发明授权

US08715658B2 Methods for treating conditions mediated by the inflammatory cytokine cascade using GAPDH inhibitors 失效
标题翻译：使用GAPDH抑制剂治疗由炎性细胞因子级联介导的病症的方法
公开(公告)号：US08715658B2
公开(公告)日：2014-05-06
申请号：US13391465
申请日：2010-08-17
申请人： Kevin Tracey , William Parrish
发明人： Kevin Tracey , William Parrish
IPC分类号： A61K39/395 , C07K16/40 , A61K38/02
CPC分类号： C07K16/40 , C07K2317/76
摘要： The present invention is directed to a method of treating a subject at risk for or having a condition mediated by an inflammatory cytokine cascade comprising administering to the subject an amount of a GAPDH inhibitor effective to treat the subject at risk for or having a condition mediated by an inflammatory cytokine cascade.
摘要翻译：本发明涉及一种治疗处于危险中或具有由炎性细胞因子级联介导的病症的受试者的方法，其包括向所述受试者施用一定量的有效治疗所述受试者处于或具有由炎性细胞因子级联。

8. 发明授权

US06521967B1 Three color quantum well infrared photodetector focal plane array 失效
标题翻译：三色量子阱红外光电探测器焦平面阵列
公开(公告)号：US06521967B1
公开(公告)日：2003-02-18
申请号：US09629396
申请日：2000-08-01
申请人： Sumith V. Bandara , John K. Liu , Daniel Wilson , Sarath D. Gunapala , William Parrish
发明人： Sumith V. Bandara , John K. Liu , Daniel Wilson , Sarath D. Gunapala , William Parrish
IPC分类号： H01L3100
CPC分类号： H01L27/14652 , G01J5/10 , Y10S977/72 , Y10S977/759 , Y10S977/815
摘要： A three-color QWIP focal plane array is based on a GaAs/AlGaAs material system. Three-color QWIPs enable target recognition and discriminating systems to precisely obtain the temperature of two objects in the presence of a third unknown parameter. The QWIPs are designed to reduce the normal reflection over a significant wavelength range. One aspect of the present invention involves two photon absorptions per transition in a double quantum well structure which is different from typical QWIP structures. This design is expected to significantly reduce the dark current as a result of higher thermionic barriers and therefore allow the devices to operate at elevated temperatures. The device is expected to be fabricate using a GaAs/AlxGa1−xAs material system on a semi-insulating GaAs substrate by Molecular Beam Epitacy (MBE).
摘要翻译：三色QWIP焦平面阵列基于GaAs / AlGaAs材料系统。三色QWIP使目标识别和识别系统能够在存在第三个未知参数的情况下精确获得两个物体的温度。 QWIP设计用于在明显的波长范围内减少正常反射。本发明的一个方面涉及双重量子阱结构中每个跃迁的两个光子吸收，其不同于典型的QWIP结构。由于较高的热离子屏障，预期这种设计将显着降低暗电流，因此允许器件在升高的温度下工作。该器件预计将使用GaAs / AlxGa1-xAs材料系统在半绝缘GaAs衬底上通过Molecular Beam Epitacy（MBE）进行制造。

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