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1. 发明授权

US09055959B2 Methods and devices for ablation 有权
公开(公告)号：US09055959B2
公开(公告)日：2015-06-16
申请号：US11785427
申请日：2007-04-17
申请人： Matthias Vaska , Stephen W. Boyd , Hanson S. Gifford , James L. Cox , Jonathan L. Podmore , John E. Crowe , Michael C Holzbaur , Timothy E. Ciciarelli , Drew Hoffmann , Casey Tansey , John W. Sliwa , Scott C. Anderson
发明人： Matthias Vaska , Stephen W. Boyd , Hanson S. Gifford , James L. Cox , Jonathan L. Podmore , John E. Crowe , Michael C Holzbaur , Timothy E. Ciciarelli , Drew Hoffmann , Casey Tansey , John W. Sliwa , Scott C. Anderson
IPC分类号： A61B18/14 , A61B17/22 , A61B17/225 , A61B18/00 , A61B18/02 , A61N1/06 , A61N7/02 , A61B5/042 , A61B19/00 , A61B17/00 , A61B17/34 , A61M25/00 , A61M25/04 , A61M25/10 , A61M25/02 , A61N1/362
CPC分类号： A61B17/22012 , A61B5/0422 , A61B17/2202 , A61B17/2251 , A61B18/00 , A61B18/02 , A61B18/1402 , A61B18/148 , A61B18/1482 , A61B18/1492 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22077 , A61B2017/2253 , A61B2017/3419 , A61B2018/00023 , A61B2018/0016 , A61B2018/00232 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00363 , A61B2018/00375 , A61B2018/00392 , A61B2018/00577 , A61B2018/00654 , A61B2018/00797 , A61B2018/00839 , A61B2018/142 , A61B2018/1467 , A61B2018/1472 , A61B2090/3614 , A61B2090/3782 , A61B2090/395 , A61B2218/002 , A61B2218/007 , A61M25/0041 , A61M25/0084 , A61M25/04 , A61M25/1002 , A61M25/1011 , A61M2025/0293 , A61M2025/1072 , A61N1/06 , A61N1/362 , A61N7/02
摘要： An ablating device has a cover which holds an interface material such as a gel. The cover contains the interface material during initial placement of the device. The ablating device may also have a removable tip or a membrane filled with fluid. In still another aspect, the ablating device may be submerged in liquid during operation.

2. 发明授权

US08308719B2 Apparatus and method for ablating tissue 失效
标题翻译：用于消融组织的装置和方法
公开(公告)号：US08308719B2
公开(公告)日：2012-11-13
申请号：US11953601
申请日：2007-12-10
申请人： John W. Sliwa , Timothy E. Ciciarelli
发明人： John W. Sliwa , Timothy E. Ciciarelli
IPC分类号： A61B18/04
CPC分类号： A61B18/02 , A61B5/0422 , A61B17/22012 , A61B17/2202 , A61B18/00 , A61B18/1402 , A61B18/148 , A61B18/1482 , A61B18/1492 , A61B34/20 , A61B2017/00039 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22077 , A61B2017/3419 , A61B2018/00023 , A61B2018/0016 , A61B2018/00232 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2018/00654 , A61B2018/00797 , A61B2018/00839 , A61B2018/142 , A61B2018/1467 , A61B2018/1472 , A61B2090/3614 , A61B2090/3782 , A61B2090/395 , A61B2218/002 , A61B2218/007 , A61N1/06 , A61N1/362 , A61N7/02 , A61N2007/0065 , A61N2007/0078 , A61N2007/027
摘要： A control system alters one or more characteristics of an ablating element to ablate tissue. In one aspect, the control system delivers energy nearer to the surface of the tissue by changing the frequency or power. In another aspect, the ablating element delivers focused ultrasound which is focused in at least one dimension. The ablating device may also have a number of ablating elements with different characteristics such as focal length.
摘要翻译：控制系统改变烧蚀元件的一个或多个特征以消融组织。在一个方面，控制系统通过改变频率或功率来传送更接近组织表面的能量。在另一方面，消融元件传递聚焦在至少一个维度上的聚焦超声。烧蚀装置还可以具有许多具有不同特征的烧蚀元件，例如焦距。

3. 发明申请

US20080194965A1 Device and method for high intensity focused ultrasound ablation with acoustic lens 有权
标题翻译：声透镜高强度聚焦超声消融的装置和方法
公开(公告)号：US20080194965A1
公开(公告)日：2008-08-14
申请号：US11703783
申请日：2007-02-08
申请人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
发明人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
IPC分类号： A61B17/00
CPC分类号： A61N7/02 , A61N2007/0056 , A61N2007/006 , A61N2007/0078
摘要： A high intensity focused ultrasound transducer includes an ultrasonic emitter having a surface that emits ultrasonic energy along a beam path, at least one low attenuation polymeric ultrasonic lens acoustically coupled to the surface in the beam path of the ultrasonic energy, such that the lens can direct the ultrasonic energy in at least one direction, and at least one stress mitigation feature, such as a kerf, a heat sink, or an acoustic matching layer, to mitigate thermal expansion mismatch stresses within the transducer. For manufacturing simplicity, the first surface is typically either flat or monotonically curvilinear. The lens may take a variety of shapes, including Fresnel features, and may focus, collimate, or defocus the ultrasonic energy. Any orientation and positioning of the at least one ultrasonic lens relative to the first ultrasonic emitter is contemplated. Manufacture is further simplified by molding, casting, or thermoforming the lens.
摘要翻译：高强度聚焦超声换能器包括具有沿着光束路径发射超声波能量的表面的超声波发射器，至少一个低衰减聚合物超声波透镜，声学耦合到超声能量的光束路径中的表面，使得透镜可以直接在至少一个方向上的超声波能量，以及至少一个应力消除特征，例如切口，散热器或声匹配层，以减轻换能器内的热膨胀失配应力。为了制造简单，第一表面通常是平坦的或单调曲线的。透镜可以采取各种形状，包括菲涅尔特征，并且可以聚焦，准直或散焦超声能量。考虑到相对于第一超声波发射器的至少一个超声波透镜的任何取向和定位。通过模制，铸造或热成型镜片进一步简化制造。

4. 发明授权

US08382689B2 Device and method for high intensity focused ultrasound ablation with acoustic lens 有权
标题翻译：声透镜高强度聚焦超声消融的装置和方法
公开(公告)号：US08382689B2
公开(公告)日：2013-02-26
申请号：US11703783
申请日：2007-02-08
申请人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
发明人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
IPC分类号： A61H1/00
CPC分类号： A61N7/02 , A61N2007/0056 , A61N2007/006 , A61N2007/0078
摘要： A high intensity focused ultrasound transducer includes an ultrasonic emitter having a surface that emits ultrasonic energy along a beam path, at least one low attenuation polymeric ultrasonic lens acoustically coupled to the surface in the beam path of the ultrasonic energy, such that the lens can direct the ultrasonic energy in at least one direction, and at least one stress mitigation feature, such as a kerf, a heat sink, or an acoustic matching layer, to mitigate thermal expansion mismatch stresses within the transducer. For manufacturing simplicity, the first surface is typically either flat or monotonically curvilinear. The lens may take a variety of shapes, including Fresnel features, and may focus, collimate, or defocus the ultrasonic energy. Any orientation and positioning of the at least one ultrasonic lens relative to the first ultrasonic emitter is contemplated. Manufacture is further simplified by molding, casting, or thermoforming the lens.
摘要翻译：高强度聚焦超声换能器包括具有沿着光束路径发射超声波能量的表面的超声波发射器，至少一个低衰减聚合物超声波透镜，声学耦合到超声能量的光束路径中的表面，使得透镜可以直接在至少一个方向上的超声波能量，以及至少一个应力消除特征，例如切口，散热器或声匹配层，以减轻换能器内的热膨胀失配应力。为了制造简单，第一表面通常是平坦的或单调曲线的。透镜可以采取各种形状，包括菲涅尔特征，并且可以聚焦，准直或散焦超声能量。考虑到相对于第一超声波发射器的至少一个超声波透镜的任何取向和定位。通过模制，铸造或热成型镜片进一步简化制造。

5. 发明授权

US08102734B2 High intensity focused ultrasound transducer with acoustic lens 有权
标题翻译：高强度聚焦超声波换能器与声透镜
公开(公告)号：US08102734B2
公开(公告)日：2012-01-24
申请号：US11703784
申请日：2007-02-08
申请人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
发明人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B8/4272 , A61B17/2251
摘要： A high intensity focused ultrasound transducer includes an ultrasonic emitter having a surface that emits ultrasonic energy along a beam path, at least one low attenuation polymeric ultrasonic lens acoustically coupled to the surface in the beam path of the ultrasonic energy, such that the lens can direct the ultrasonic energy in at least one direction, and at least one stress mitigation feature, such as a kerf, a heat sink, or an acoustic matching layer, to mitigate thermal expansion mismatch stresses within the transducer. For manufacturing simplicity, the first surface is typically either flat or monotonically curvilinear. The lens may take a variety of shapes, including Fresnel features, and may focus, collimate, or defocus the ultrasonic energy. Any orientation and positioning of the at least one ultrasonic lens relative to the first ultrasonic emitter is contemplated. Manufacture is further simplified by molding, casting, or thermoforming the lens.
摘要翻译：高强度聚焦超声换能器包括具有沿着光束路径发射超声波能量的表面的超声波发射器，至少一个低衰减聚合物超声波透镜，声学耦合到超声能量的光束路径中的表面，使得透镜可以直接在至少一个方向上的超声波能量，以及至少一个应力消除特征，例如切口，散热器或声匹配层，以减轻换能器内的热膨胀失配应力。为了制造简单，第一表面通常是平坦的或单调曲线的。透镜可以采取各种形状，包括菲涅尔特征，并且可以聚焦，准直或散焦超声能量。考虑到相对于第一超声波发射器的至少一个超声波透镜的任何取向和定位。通过模制，铸造或热成型镜片进一步简化制造。

6. 发明申请

US20080194967A1 High intensity focused ultrasound transducer with acoustic lens 有权
标题翻译：高强度聚焦超声波换能器与声透镜
公开(公告)号：US20080194967A1
公开(公告)日：2008-08-14
申请号：US11703784
申请日：2007-02-08
申请人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
发明人： John W. Sliwa , Peter Goetz , Zhenyi Ma , Jennifer Teng , Stephen Morse , Frank Callaghan , Timothy E. Ciciarelli
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B8/4272 , A61B17/2251
摘要： A high intensity focused ultrasound transducer includes an ultrasonic emitter having a surface that emits ultrasonic energy along a beam path, at least one low attenuation polymeric ultrasonic lens acoustically coupled to the surface in the beam path of the ultrasonic energy, such that the lens can direct the ultrasonic energy in at least one direction, and at least one stress mitigation feature, such as a kerf, a heat sink, or an acoustic matching layer, to mitigate thermal expansion mismatch stresses within the transducer. For manufacturing simplicity, the first surface is typically either flat or monotonically curvilinear. The lens may take a variety of shapes, including Fresnel features, and may focus, collimate, or defocus the ultrasonic energy. Any orientation and positioning of the at least one ultrasonic lens relative to the first ultrasonic emitter is contemplated. Manufacture is further simplified by molding, casting, or thermoforming the lens.
摘要翻译：高强度聚焦超声换能器包括具有沿着光束路径发射超声波能量的表面的超声波发射器，至少一个低衰减聚合物超声波透镜，声学耦合到超声能量的光束路径中的表面，使得透镜可以直接在至少一个方向上的超声波能量，以及至少一个应力消除特征，例如切口，散热器或声匹配层，以减轻换能器内的热膨胀失配应力。为了制造简单，第一表面通常是平坦的或单调曲线的。透镜可以采取各种形状，包括菲涅尔特征，并且可以聚焦，准直或散焦超声能量。考虑到相对于第一超声波发射器的至少一个超声波透镜的任何取向和定位。通过模制，铸造或热成型镜片进一步简化制造。

7. 发明授权

US09168383B2 Leadless cardiac pacemaker with conducted communication 有权
标题翻译：无引导心脏起搏器进行沟通
公开(公告)号：US09168383B2
公开(公告)日：2015-10-27
申请号：US13277151
申请日：2011-10-19
申请人： Peter M. Jacobson , Alan Ostroff , Timothy E. Ciciarelli
发明人： Peter M. Jacobson , Alan Ostroff , Timothy E. Ciciarelli
IPC分类号： A61N1/00 , A61N1/372 , A61N1/368 , A61N1/375
CPC分类号： A61N1/3727 , A61N1/368 , A61N1/3684 , A61N1/37205 , A61N1/37217 , A61N1/37288 , A61N1/3756
摘要： A leadless pacemaker for pacing a heart of a human includes a hermetic housing and at least two electrodes on or near the hermetic housing. The at least two electrodes are configured to deliver energy to stimulate the heart and to transfer information to or from at least one external device.
摘要翻译：用于起搏人心脏的无引导起搏器包括密封壳体和密封壳体上或附近的至少两个电极。所述至少两个电极被配置为递送能量以刺激心脏并将信息传送到至少一个外部设备或从至少一个外部设备传送信息。

8. 发明授权

US08186877B2 Method and system for using common subchannel to assess the operating characteristics of transducers 有权
标题翻译：使用通用子通道评估换能器运行特性的方法和系统
公开(公告)号：US08186877B2
公开(公告)日：2012-05-29
申请号：US11967217
申请日：2007-12-30
申请人： Gleb V. Klimovitch , Timothy E. Ciciarelli , Shena H. Park
发明人： Gleb V. Klimovitch , Timothy E. Ciciarelli , Shena H. Park
IPC分类号： G01K7/00
CPC分类号： A61B18/1206 , A61B18/1492 , A61B2018/00363 , A61B2018/00577 , A61B2018/00702 , A61B2018/00767 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815
摘要： A system and method for using a common subchannel to assess operating characteristics of one of a plurality of transducers that are coupled to said subchannel is disclosed. The plurality of transducers are divided into subsets and each subset is coupled to a subchannel. The system is configured to activate a selected transducer on the subchannel and the subchannel delivers operational information on the activated transducer. The present invention reduces the number of subchannels required to collect information on the plurality of transducers. The present invention may utilize one or more loading conditions to take at least one measurement, which at least one measurement is then used to derive operational information on the transducer. In one configuration, information on the amount of energy being delivered to the transducer is collected simultaneously with information on the operating temperature. In another embodiment only the temperature is measured. The present invention permits a more compact ablation device to be constructed based on the invention's ability to reduce the total number of subchannels required to collect transducer information.
摘要翻译：公开了一种用于使用公共子信道来评估耦合到所述子信道的多个换能器之一的操作特性的系统和方法。多个换能器被划分为子集，并且每个子集耦合到子信道。该系统被配置为激活子信道上的所选换能器，并且子通道在激活的换能器上传送操作信息。本发明减少了在多个换能器上收集信息所需的子信道的数量。本发明可以利用一个或多个负载条件进行至少一个测量，然后使用至少一个测量来导出换能器上的操作信息。在一个配置中，关于传送到换能器的能量的信息与关于工作温度的信息同时收集。在另一个实施例中，仅测量温度。本发明允许基于本发明减少收集换能器信息所需的子通道总数的能力来构建更紧凑的消融装置。

9. 发明授权

US5919214A Two-sided telemetry in implantable cardiac therapy devices 失效
公开(公告)号：US5919214A
公开(公告)日：1999-07-06
申请号：US967872
申请日：1997-11-12
申请人： Timothy E. Ciciarelli , Stephen T. Archer
发明人： Timothy E. Ciciarelli , Stephen T. Archer
IPC分类号： A61N1/372 , A61N1/362
CPC分类号： A61N1/37211 , A61N1/37229 , Y10S128/903
摘要： A method for ensuring two-sided telemetry in implantable cardiac therapy devices by making at least one of the following operating parameters selectable (reversible): (1) the direction of current detection of the telemetry circuitry of the implantable cardiac therapy device; (2) the direction of the magnetic field produced by the transmit coil of an external telemetry device (programming wand); (3) the direction of the magnetic field produced by the T/R coil of the implantable cardiac therapy device; and/or (4) the direction of current detection of the telemetry circuitry of the programming wand. In a presently contemplated implementation, when it is desired to read-out data from the implantable cardiac therapy device and/or to re-program the device parameters, a telemetry operation is attempted in the normal manner, i.e., it is initiated by the programming wand. If the communication is unsuccessful, then the direction of the magnetic field produced by the transmit coil of the programming wand is reversed, and the telemetry operation repeated. If the transmission of command data from the programming wand to the implantable cardiac therapy device is successful, but the transmission of read-out data from the device to the programming wand is unsuccessful, then the direction of current detection of the telemetry circuitry of the programming wand is reversed, and the telemetry operation is attempted again; alternatively, the direction of the magnetic field produced by the T/R coil of the implantable cardiac therapy device can be reversed. Thus, no matter what the orientation of the device and external telemetry device, successful two-way telemetry between the device and the programming wand is possible. Thus, the telemetry can be considered "two-sided". In an alternative embodiment, the telemetry operation can be initiated by the implantable cardiac therapy device. In this case, if the communication is unsuccessful, then the direction of the magnetic field produced by the T/R coil of the device is reversed.

10. 发明申请

US20110291736A1 Switching methods and apparatus 审中-公开
标题翻译：切换方法和装置
公开(公告)号：US20110291736A1
公开(公告)日：2011-12-01
申请号：US13206259
申请日：2011-08-09
申请人： Gleb V. Klimovitch , Timothy E. Ciciarelli , Shena H. Park
发明人： Gleb V. Klimovitch , Timothy E. Ciciarelli , Shena H. Park
IPC分类号： H03K17/00
CPC分类号： A61B18/1492 , A61B18/1206 , A61B2018/00351 , A61B2018/00577 , A61B2018/00702 , A61B2018/00791 , A61B2018/00916 , A61B2018/124 , A61B2018/1823 , A61B2018/1861 , A61N7/02
摘要： Embodiments of the invention controlling power distribution in an ablation control apparatus or the like. In one embodiment, a power switching apparatus comprises a first switch assembly having an input end to receive a power input signal, the first switch assembly having a plurality of output channels; a second switch assembly coupled to the output channels of the first switch assembly; a plurality of power receiving members coupled to the second switch assembly; and a controller controlling the first switch assembly to selectively transmit the power input signal to the output channels one at a time in a cyclical manner according to a first switching rate. The controller controls the second switch assembly to transmit the power input signal from the output channels of the first switch assembly to one subset of the power receiving members at a time according to a second switching rate, so as to transmit the power input signal to a subset of power receiving members one power receiving member at a time within the subset of power receiving members according to the first switching rate.
摘要翻译：控制消融控制装置等中的配电的本发明的实施例。在一个实施例中，功率开关装置包括具有输入端以接收功率输入信号的第一开关组件，第一开关组件具有多个输出通道; 耦合到第一开关组件的输出通道的第二开关组件; 耦合到所述第二开关组件的多个电力接收构件; 以及控制器，其控制所述第一开关组件，以根据第一开关速率以循环方式一次一个地将所述功率输入信号选择性地发送到所述输出通道。控制器控制第二开关组件，以将功率输入信号从第一开关组件的输出通道按照第二切换速率一次传输到功率接收部件的一个子集，以将功率输入信号发送到电力接收构件的子集，根据第一开关率，在电力接收构件的子集内的一个时间处有一个电力接收构件。

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