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1. 发明授权

US09155891B2 Current management system for a stimulation output stage of an implantable neurostimulation system 有权
标题翻译：用于可植入神经刺激系统的刺激输出阶段的当前管理系统
公开(公告)号：US09155891B2
公开(公告)日：2015-10-13
申请号：US12886279
申请日：2010-09-20
申请人： Stephen T. Archer
发明人： Stephen T. Archer
IPC分类号： A61N1/36
CPC分类号： A61N1/36157 , A61N1/36125
摘要： A current management system for use in the stimulation output stage of a neurostimulation system can be programmed to steer different amounts of current through different stimulation electrodes to vary how strongly the tissue adjacent each electrode is stimulated during a particular programmed stimulation episode. An stimulation electrode drive circuit associated with each electrode that is available for stimulation allows independent control of the flow of current through that electrode. A reference electrode is provided in the circuit to source or sink current as necessary to balance the currents going into and out of the patient, so that no stimulation electrode is required to serve that purpose. More specifically, by configuring the circuit to maintain a constant potential at the reference electrode (e.g., a potential that is approximately half way between a top and bottom voltage rail), the reference electrode will source or sink currents as necessary to cause the net current flow into the patient to be equal to the net current flowing out of the patient, thus satisfying Kirchhoff's current law.
摘要翻译：用于神经刺激系统的刺激输出阶段的当前管理系统可以被编程为通过不同的刺激电极引导不同量的电流，以改变在特定的程序化刺激发作期间刺激相邻每个电极的组织的强度。与可用于刺激的每个电极相关联的刺激电极驱动电路允许独立地控制通过该电极的电流。在电路中提供参考电极以根据需要来源或吸收电流以平衡进入和流出患者的电流，使得不需要刺激电极来满足该目的。更具体地，通过将电路配置为在参考电极处保持恒定电位（例如，在顶部和底部电压轨道之间的大约一半的电位），参考电极将根据需要来源或吸收电流以使净电流流入患者等于流出患者的净流量，从而满足基尔霍夫现行的法律。

2. 发明申请

US20120071950A1 Current Management System for a Stimulation Output Stage of an Implantable Neurostimulation System 有权
标题翻译：可植入神经刺激系统刺激输出阶段的现行管理系统
公开(公告)号：US20120071950A1
公开(公告)日：2012-03-22
申请号：US12886279
申请日：2010-09-20
申请人： Stephen T. Archer
发明人： Stephen T. Archer
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/36157 , A61N1/36125
摘要： A current management system for use in the stimulation output stage of a neurostimulation system can be programmed to steer different amounts of current through different stimulation electrodes to vary how strongly the tissue adjacent each electrode is stimulated during a particular programmed stimulation episode. An stimulation electrode drive circuit associated with each electrode that is available for stimulation allows independent control of the flow of current through that electrode. A reference electrode is provided in the circuit to source or sink current as necessary to balance the currents going into and out of the patient, so that no stimulation electrode is required to serve that purpose. More specifically, by configuring the circuit to maintain a constant potential at the reference electrode (e.g., a potential that is approximately half way between a top and bottom voltage rail), the reference electrode will source or sink currents as necessary to cause the net current flow into the patient to be equal to the net current flowing out of the patient, thus satisfying Kirchhoff's current law.
摘要翻译：用于神经刺激系统的刺激输出阶段的当前管理系统可以被编程为通过不同的刺激电极引导不同量的电流，以改变在特定的程序化刺激发作期间刺激相邻每个电极的组织的强度。与可用于刺激的每个电极相关联的刺激电极驱动电路允许独立地控制通过该电极的电流。在电路中提供参考电极以根据需要来源或吸收电流以平衡进入和流出患者的电流，使得不需要刺激电极来满足该目的。更具体地，通过将电路配置为在参考电极处保持恒定的电位（例如，在顶部和底部电压轨道之间的大约一半的电位），参考电极将根据需要来源或吸收电流以使净电流流入患者等于流出患者的净流量，从而满足基尔霍夫现行的法律。

3. 发明授权

US07813793B2 Seizure sensing and detection using an implantable device 有权
标题翻译：使用可植入装置进行检测和检测
公开(公告)号：US07813793B2
公开(公告)日：2010-10-12
申请号：US10973091
申请日：2004-10-25
申请人： Benjamin D. Pless , Stephen T. Archer , Craig M. Baysinger , Barbara Gibb , Suresh Gurunathan , Bruce Kirkpatrick , Thomas K. Tcheng
发明人： Benjamin D. Pless , Stephen T. Archer , Craig M. Baysinger , Barbara Gibb , Suresh Gurunathan , Bruce Kirkpatrick , Thomas K. Tcheng
IPC分类号： A61B5/00
CPC分类号： A61B5/4094 , A61B5/04012 , A61B5/0476 , A61B5/0478 , A61B5/6868 , A61B5/7203 , A61B5/7242 , A61B5/7246 , A61B5/7264 , A61B5/7275 , G06F19/00
摘要： A system and method for detecting and predicting neurological events with an implantable device uses a relatively low-power central processing unit in connection with signal processing circuitry to identify features (including half waves) and calculate window-based characteristics (including line lengths and areas under the curve of the waveform) in an electrographic signal received from a patient's brain. The features and window-based characteristics are combinable in various ways according to the invention to detect and predict neurological events in real time, enabling responsive action by the implantable device.
摘要翻译：使用可植入装置检测和预测神经病学的系统和方法使用与信号处理电路相关联的相对低功率的中央处理单元来识别特征（包括半波）并计算基于窗口的特征（包括线路长度和面积在从患者的大脑接收的电图信号中波形的曲线）。根据本发明的特征和基于窗口的特征可以以各种方式组合以实时检测和预测神经病学事件，从而能够实现可植入装置的响应作用。

4. 发明授权

US06810285B2 Seizure sensing and detection using an implantable device 有权
标题翻译：使用可植入装置进行检测和检测
公开(公告)号：US06810285B2
公开(公告)日：2004-10-26
申请号：US09896092
申请日：2001-06-28
申请人： Benjamin D. Pless , Stephen T. Archer , Craig M. Baysinger , Barbara Gibb , Suresh K. Gurunathan , Bruce Kirkpatrick , Thomas K. Tcheng
发明人： Benjamin D. Pless , Stephen T. Archer , Craig M. Baysinger , Barbara Gibb , Suresh K. Gurunathan , Bruce Kirkpatrick , Thomas K. Tcheng
IPC分类号： A61B50476
CPC分类号： A61B5/4094 , A61B5/04012 , A61B5/0476 , A61B5/0478 , A61B5/6868 , A61B5/7203 , A61B5/7242 , A61B5/7246 , A61B5/7264 , A61B5/7275 , G06F19/00
摘要： A system and method for detecting and predicting neurological events with an implantable device uses a relatively low-power central processing unit in connection with signal processing circuitry to identify features (including half waves) and calculate window-based characteristics (including line lengths and areas under the curve of the waveform) in an electrographic signal received from a patient's brain. The features and window-based characteristics are combinable in various ways according to the invention to detect and predict neurological events in real time, enabling responsive action by the implantable device.
摘要翻译：使用可植入装置检测和预测神经病学的系统和方法使用与信号处理电路相关联的相对低功率的中央处理单元来识别特征（包括半波）并计算基于窗口的特征（包括线路长度和面积在从患者的大脑接收的电图信号中波形的曲线）。根据本发明的特征和基于窗口的特征可以以各种方式组合以实时检测和预测神经病学事件，从而能够实现可植入装置的响应作用。

5. 发明授权

US06690974B2 Stimulation signal generator for an implantable device 有权
标题翻译：用于可植入装置的刺激信号发生器
公开(公告)号：US06690974B2
公开(公告)日：2004-02-10
申请号：US09952901
申请日：2001-09-11
申请人： Stephen T. Archer , Benjamin D. Pless
发明人： Stephen T. Archer , Benjamin D. Pless
IPC分类号： A61N100
CPC分类号： A61N1/36064
摘要： An implantable multimodal neurostimulator having improved efficacy in treating epilepsy and other neurological disorders and processes of using that neurostimulator are described herein. The neurostimulator itself generally has two modes of electrical stimulation. The first involves delivering a non-responsive electrical stimulation signal that is applied to the central nervous system to reduce the likelihood of a seizure or other undesirable neurological even from occurring. Various waveform morphologies are described for non-responsive stimulation signals. A second mode involves delivering a responsive electrical stimulation signal when epileptiform waveforms are impending or extant. The responsive electrical stimulation signal is intended to terminate epileptiform activity, e.g., to desynchronize abnormally synchronous brain electrical activity.
摘要翻译：本文描述了具有改善的治疗癫痫和其它神经障碍的功效的植入式多模式神经刺激器和使用该神经刺激器的过程。神经刺激器本身通常具有两种电刺激模式。第一个涉及提供应用于中枢神经系统的无反应性电刺激信号，以减少甚至发生癫痫发作或其他不希望的神经系统的可能性。描述了用于无响应刺激信号的各种波形形态。第二模式涉及当癫痫样波形即将到来或现存时递送响应电刺激信号。响应性电刺激信号旨在终止癫痫样活动，例如使异常同步的脑电活动失步。

6. 发明授权

US5968083A Active overload detection and protection circuit for implantable cardiac therapy devices 失效
标题翻译：用于可植入心脏治疗装置的主动过载检测和保护电路
公开(公告)号：US5968083A
公开(公告)日：1999-10-19
申请号：US968242
申请日：1997-11-12
申请人： Timothy E. Ciciarelli , Stephen T. Archer
发明人： Timothy E. Ciciarelli , Stephen T. Archer
IPC分类号： A61N1/08 , A61N1/37
CPC分类号： A61N1/37 , A61N1/08 , A61N1/3718
摘要： An active overload detection and protection circuit for protecting a host device (e.g., an implantable cardiac therapy device) from potential damage due to high voltage transients applied to an I/O node thereof. The protection circuit includes an I/O circuit coupled to the I/O node, the I/O circuit having low-impedance and high-impedance modes, a current overload detection circuit coupled to the I/O circuit which detects a current overload condition induced by a high voltage transient, and which generates an overload detect signal in response, and, a mode changing circuit which changes the mode of the I/O circuit from the low-impedance mode to the high-impedance mode in response to the overload detect signal. The protection circuit further includes a reset circuit which generates a reset signal a prescribed time after the overload detect signal is generated, wherein the mode changing circuit is responsive to the reset signal to change the mode of the I/O circuit. The current overload detection circuit includes circuitry which ensures that the overload detect signal is generated only when an overload current flowing through the I/O circuit is greater than a prescribed threshold level for at least a prescribed time period. The mode changing circuit includes logic circuitry which generates a mode change control signal only when both the overload detect signal and a first control signal are present.
摘要翻译：用于保护主机设备（例如，可植入心脏治疗设备）的主动过载检测和保护电路免受由于施加到其I / O节点的高电压瞬变而引起的潜在损害。保护电路包括耦合到I / O节点的I / O电路，I / O电路具有低阻抗和高阻抗模式，耦合到I / O电路的电流过载检测电路，其检测电流过载条件由高电压瞬变引起的并且产生响应的过载检测信号;以及模式改变电路，其响应于过载而将I / O电路的模式从低阻抗模式改变为高阻抗模式检测信号。保护电路还包括复位电路，其在产生过载检测信号之后的规定时间产生复位信号，其中模式改变电路响应于复位信号改变I / O电路的模式。电流过载检测电路包括确保仅在流过I / O电路的过载电流大于规定阈值电平至少规定时间段时才产生过载检测信号的电路。模式改变电路包括仅在存在过载检测信号和第一控制信号的情况下才产生模式改变控制信号的逻辑电路。

7. 发明授权

US5534814A High input impedance gate driver circuit with Miller protection and delayed turnoff 失效
标题翻译：高输入阻抗栅极驱动电路，具有米勒保护和延迟关断
公开(公告)号：US5534814A
公开(公告)日：1996-07-09
申请号：US359807
申请日：1994-12-20
申请人： Stephen T. Archer
发明人： Stephen T. Archer
IPC分类号： H03K17/567 , H03K17/687 , H03B1/00 , H03K17/72
CPC分类号： H03K17/567
摘要： A gate driver circuit includes a timing circuit, an anti-Miller surge protection circuit, and charging and discharging circuits for driving an output transistor, such as an IGBT. The anti-Miller surge protection circuit prevents the output transistor from being accidentally turned on. The gate driver circuit provides a high impedance input, so as to allow such a gate driver circuit to be driven by a relatively smaller isolation transformer. Further, the timing circuit in the gate driver circuit of the present invention allows such isolation transformer a relative lower frequency of operation. In one embodiment, the capacitance of the output transistor's gate terminal is used to determine the time constant of the timing circuit.
摘要翻译：栅极驱动器电路包括定时电路，反米勒浪涌保护电路，以及用于驱动诸如IGBT的输出晶体管的充电和放电电路。反米勒浪涌保护电路可防止输出晶体管意外导通。栅极驱动器电路提供高阻抗输入，以允许这种栅极驱动器电路由相对较小的隔离变压器驱动。此外，本发明的栅极驱动器电路中的定时电路允许这种隔离变压器相对较低的工作频率。在一个实施例中，输出晶体管的栅极端子的电容用于确定定时电路的时间常数。

8. 发明申请

US20100331717A1 Seizure Sensing and Detection Using an Implantable Device 审中-公开
标题翻译：使用可植入装置进行检测和检测
公开(公告)号：US20100331717A1
公开(公告)日：2010-12-30
申请号：US12880138
申请日：2010-09-12
申请人： Benjamin D. Pless , Stephen T. Archer , Craig M. Baysinger , Barbara Gibb , Suresh Gurunathan , Bruce Kirkpatrick , Thomas K. Tcheng
发明人： Benjamin D. Pless , Stephen T. Archer , Craig M. Baysinger , Barbara Gibb , Suresh Gurunathan , Bruce Kirkpatrick , Thomas K. Tcheng
IPC分类号： A61B5/0476
CPC分类号： A61B5/4094 , A61B5/04012 , A61B5/0476 , A61B5/0478 , A61B5/6868 , A61B5/7203 , A61B5/7242 , A61B5/7246 , A61B5/7264 , A61B5/7275
摘要： A system and method for detecting and predicting neurological events with an implantable device uses a relatively low-power central processing unit in connection with signal processing circuitry to identify features (including half waves) and calculate window-based characteristics (including line lengths and areas under the curve of the waveform) in an electrographic signal received from a patient's brain. The features and window-based characteristics are combinable in various ways according to the invention to detect and predict neurological events in real time, enabling responsive action by the implantable device.
摘要翻译：使用可植入装置检测和预测神经病学的系统和方法使用与信号处理电路相关联的相对低功率的中央处理单元来识别特征（包括半波）并计算基于窗口的特征（包括线路长度和面积在从患者的大脑接收的电图信号中波形的曲线）。根据本发明的特征和基于窗口的特征可以以各种方式组合以实时检测和预测神经病学事件，从而能够实现可植入装置的响应动作。

9. 发明授权

US5919214A Two-sided telemetry in implantable cardiac therapy devices 失效
公开(公告)号：US5919214A
公开(公告)日：1999-07-06
申请号：US967872
申请日：1997-11-12
申请人： Timothy E. Ciciarelli , Stephen T. Archer
发明人： Timothy E. Ciciarelli , Stephen T. Archer
IPC分类号： A61N1/372 , A61N1/362
CPC分类号： A61N1/37211 , A61N1/37229 , Y10S128/903
摘要： A method for ensuring two-sided telemetry in implantable cardiac therapy devices by making at least one of the following operating parameters selectable (reversible): (1) the direction of current detection of the telemetry circuitry of the implantable cardiac therapy device; (2) the direction of the magnetic field produced by the transmit coil of an external telemetry device (programming wand); (3) the direction of the magnetic field produced by the T/R coil of the implantable cardiac therapy device; and/or (4) the direction of current detection of the telemetry circuitry of the programming wand. In a presently contemplated implementation, when it is desired to read-out data from the implantable cardiac therapy device and/or to re-program the device parameters, a telemetry operation is attempted in the normal manner, i.e., it is initiated by the programming wand. If the communication is unsuccessful, then the direction of the magnetic field produced by the transmit coil of the programming wand is reversed, and the telemetry operation repeated. If the transmission of command data from the programming wand to the implantable cardiac therapy device is successful, but the transmission of read-out data from the device to the programming wand is unsuccessful, then the direction of current detection of the telemetry circuitry of the programming wand is reversed, and the telemetry operation is attempted again; alternatively, the direction of the magnetic field produced by the T/R coil of the implantable cardiac therapy device can be reversed. Thus, no matter what the orientation of the device and external telemetry device, successful two-way telemetry between the device and the programming wand is possible. Thus, the telemetry can be considered "two-sided". In an alternative embodiment, the telemetry operation can be initiated by the implantable cardiac therapy device. In this case, if the communication is unsuccessful, then the direction of the magnetic field produced by the T/R coil of the device is reversed.

10. 发明授权

US5609618A Apparatus and method for inducing fibrillation 失效
标题翻译：用于诱发纤颤的装置和方法
公开(公告)号：US5609618A
公开(公告)日：1997-03-11
申请号：US568036
申请日：1995-12-06
申请人： Stephen T. Archer
发明人： Stephen T. Archer
IPC分类号： A61N1/38 , A61N1/39 , A61N1/32
CPC分类号： A61N1/3943 , A61N1/385
摘要： A method and apparatus for inducing fibrillation in a patient's heart by delivering an alternating current stimulus to the heart from a DC-to DC converter. The hardware of a conventional implantable cardioverter/defibrillator (ICD) is utilized with a modification to the control algorithms. Particularly, when it is desired to induce fibrillation in a patient's heart, typically during ICD implant defibrillation threshold (DFT) testing, a command is delivered from an external instrument to the ICD to deliver the fibrillation shock. The DC-to-DC converter which is normally used to charge the ICD high voltage capacitors is activated and immediately thereafter a first pair the high voltage output switches of the output stage are closed for about 4 milliseconds. This delivers an initial pulse of one polarity. Following an interval of about 4 milliseconds, a second pair of the high voltage output switches are closed for 4 milliseconds delivering an opposite polarity pulse. The output current from the DC-to-DC converter is provided to the defibrillation electrodes and through the patient's heart. This stimulus of alternating polarity pulses is continued for a predetermined time of between about 30 milliseconds to 5 seconds. At that point all the output switches are opened and the converter is shut off. This stimulus delivered directly to the patient's heart induces fibrillation.
摘要翻译：一种用于通过从DC到DC转换器向心脏递送交流电刺激来在患者心脏中诱导原纤维颤动的方法和装置。传统的植入式心律转复除颤器（ICD）的硬件被用于控制算法的修改。特别地，当期望在患者心脏中诱发纤维颤动时，通常在ICD植入物除颤阈值（DFT）测试期间，将命令从外部仪器传送至ICD以递送原纤维颤动。通常用于对ICD高电压电容器充电的DC-DC转换器被激活，并且紧接着，第一对输出级的高电压输出开关闭合约4毫秒。这提供了一个极性的初始脉冲。在大约4毫秒的间隔之后，第二对高电压输出开关闭合4毫秒，传递相反的极性脉冲。来自DC-DC转换器的输出电流被提供给除颤电极并通过患者的心脏。交替极性脉冲的刺激持续约30毫秒至5秒的预定时间。此时，所有输出开关都打开，转换器关闭。这种直接传递给患者心脏的刺激会诱发纤维颤动。

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