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1. 发明授权

US06051583A 2,3,3a,4,9,9a-hexahydro-8-hydroxy-1H-benz[f]indoles, processes for preparing them and their use as pharmaceutical compositions 有权
标题翻译： 2,3,3a，4,9,9a-六氢-8-羟基-1H-苯并[f]吲哚，其制备方法及其作为药物组合物的用途
公开(公告)号：US06051583A
公开(公告)日：2000-04-18
申请号：US365064
申请日：1999-07-30
申请人： Matthias Grauert , Christoph Hoenke , Adrian Carter , Wolf-Dietrich Bechtel , Thomas Weiser , Rainer Palluk , Uwe Pschorn
发明人： Matthias Grauert , Christoph Hoenke , Adrian Carter , Wolf-Dietrich Bechtel , Thomas Weiser , Rainer Palluk , Uwe Pschorn
IPC分类号： A61K31/403 , A61P3/08 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P23/02 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07D209/60 , A61K31/40 , C07D209/56 , C07D215/00 , C07D215/16 , C07D401/00
CPC分类号： C07D209/60
摘要： The present invention relates to new substituted 2,3,3a,4,9,9a-hexahydro-8-hydroxy-1H-benz[f]indole derivatives, processes for preparing them and their use as pharmaceutical compositions. The indole derivatives according to the invention correspond to general formula 1:
摘要翻译：本发明涉及新的取代的2,3,3a，4,9,9a-六氢-8-羟基-1H-苯并[f]吲哚衍生物，其制备方法及其作为药物组合物的用途。根据本发明的吲哚衍生物对应于通式1：

2. 发明授权

US06455538B1 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ols 有权
标题翻译： 1,2,3,4,5,6-六氢-2,6-亚甲基-3-苯并吖庚因-10-ols
公开(公告)号：US06455538B1
公开(公告)日：2002-09-24
申请号：US09523473
申请日：2000-03-10
申请人： Matthias Grauert , Adrian Carter , Wolf-Dietrich Bechtel , Thomas Weiser , Rainer Palluk , Uwe Pschorn
发明人： Matthias Grauert , Adrian Carter , Wolf-Dietrich Bechtel , Thomas Weiser , Rainer Palluk , Uwe Pschorn
IPC分类号： A61K31439
CPC分类号： C07D221/26
摘要： Compounds of general formula I wherein X is a single bond, —O—, C-C4-alkylene, or an alkylene bridge having 1 to 8 carbon atoms which may be branched or unbranched and optionally have one or two oxygen atom(s) anywhere in the bridge; R1 is hydrogen, methyl, ethyl, or phenyl; R2 is hydrogen or methyl; R3 is hydrogen, fluorine, chlorine, bromine, hydroxy, methyl, or methoxy; R4 is hydrogen, methyl, or ethyl; R5 is hydrogen, methyl, or ethyl; R6 is hydrogen, methyl, or ethyl; R7 is tert-butyl, cyclohexyl, phenyl optionally substituted by R9 and R10, which may be identical or different, or; R8 is hydrogen or C1-C4-alkyl; Z is oxygen, NH, or sulfur; R9 is hydrogen, methyl, fluorine, chlorine, bromine, or methoxy; R10 is hydrogen, methyl, fluorine, chlorine, bromine, or methoxy; optionally in the form of the individual optical isomers, mixtures of the individual enantiomers or racemates as well as in the form of the free bases or the corresponding acid addition salts with pharmaceutically acceptable acids.
摘要翻译：通式I的化合物，其中X是单键，-O-，C-C4-亚烷基或具有1至8个碳原子的亚烷基桥，其可以是支链或非支链的，并且任选地在一个或多个氧原子中具有一个或两个氧原子桥梁 R1是氢，甲基，乙基或苯基; R2是氢或甲基; R3是氢，氟，氯，溴，羟基，甲基或甲氧基; R4是氢，甲基或乙基; R5是氢，甲基或乙基; R6是氢，甲基或乙基; R 7是叔丁基，环己基，任选被R 9和R 10取代的苯基，其可以相同或不同，或者R 8是氢或C 1 -C 4 - 烷基; Z是氧，NH或硫; R9是氢，甲基，氟，氯，溴或甲氧基; R 10为氢，甲基，氟，氯，溴或甲氧基; 任选以各种旋光异构体的形式，各个对映异构体或外消旋体的混合物，以及游离碱的形式或与药学上可接受的酸的相应的酸加成盐。

3. 发明授权

US06441237B1 Substituted 3-phenoxy- and 3-phenylalkyloxy-2-phenyl-propylamines 有权
标题翻译：取代的3-苯氧基 - 和3-苯基烷氧基-2-苯基 - 丙胺
公开(公告)号：US06441237B1
公开(公告)日：2002-08-27
申请号：US09507992
申请日：2000-02-18
申请人： Werner Stransky , Matthias Grauert , Adrian Carter , Thomas Weiser , Wolf-Dietrich Bechtel , Helmut Ensinger , Ralf Richard H. Lotz , Rainer Palluk , Uwe Pschorn
发明人： Werner Stransky , Matthias Grauert , Adrian Carter , Thomas Weiser , Wolf-Dietrich Bechtel , Helmut Ensinger , Ralf Richard H. Lotz , Rainer Palluk , Uwe Pschorn
IPC分类号： C07C21500
CPC分类号： C07D295/088 , C07C217/48 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/66 , C07D233/48 , C07D307/52 , C07D309/14
摘要： The present patent application relates to new substituted 3-phenoxy- or 3-phenylalkyloxy-2-phenyl-propylamines of general formula 1, processes for preparing them and their use as pharmaceutical compositions.
摘要翻译：本专利申请涉及通式1的新的取代的3-苯氧基或3-苯基烷氧基-2-苯基 - 丙胺，其制备方法及其作为药物组合物的用途。

4. 发明授权

US06245777B1 N-(5-phenyl-tetrahydrofuranyl)methyl- and N-(6-phenyl-tetrahydropyranyl)methyl-substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols 有权
标题翻译： N-（5-苯基 - 四氢呋喃基）甲基和N-（6-苯基 - 四氢吡喃基）甲基取代的1,2,3,4,5,6-六氢-2,6-亚甲基-3-苯并吖辛因-10- ols
公开(公告)号：US06245777B1
公开(公告)日：2001-06-12
申请号：US09510555
申请日：2000-02-22
申请人： Matthias Grauert , Hans Briem , Matthias Hoffmann , Adrian Carter , Thomas Weiser , Wolf-Dietrich Bechtel , Rainer Palluk
发明人： Matthias Grauert , Hans Briem , Matthias Hoffmann , Adrian Carter , Thomas Weiser , Wolf-Dietrich Bechtel , Rainer Palluk
IPC分类号： A61K314748
CPC分类号： C07D405/06
摘要： The present invention relates to N-(5-phenyl-tetrahydrofuranyl)methyl- and N-(6-phenyl-tetrahydropyranyl)methyl-substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols of general formula 1, processes for preparing such compounds, pharmaceutical compositions containing such compounds and methods for using such compounds for the treatment of various diseases caused by a functional disorder resulting from overstimulation.
摘要翻译：本发明涉及N-（5-苯基 - 四氢呋喃基）甲基和N-（6-苯基 - 四氢吡喃基）甲基取代的1,2,3,4,5,6-六氢-2,6-亚甲基-3 - 苯扎佐星-10-ols，通式1的制备方法，制备这些化合物的方法，含有这些化合物的药物组合物和使用这些化合物治疗由过度刺激引起的功能障碍引起的各种疾病的方法。

5. 发明授权

US06770636B2 Phenyl-and phenylalkyl-substituted ethanolamines and ethylenediamines 有权
标题翻译：苯基和苯基烷基取代的乙醇胺和乙二胺
公开(公告)号：US06770636B2
公开(公告)日：2004-08-03
申请号：US09912163
申请日：2001-07-24
申请人： Klaus Fuchs , Werner Stransky , Matthias Grauert , Adrian Carter , Wolfram Gaida , Thomas Weiser , Helmut Ensinger
发明人： Klaus Fuchs , Werner Stransky , Matthias Grauert , Adrian Carter , Wolfram Gaida , Thomas Weiser , Helmut Ensinger
IPC分类号： A61K3133
CPC分类号： C07D295/125 , C07C211/35 , C07C217/48 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/092
摘要： Compounds of formula 1, wherein: R1 is hydrogen, hydroxy, CF3, NO2, CN, halogen, C1-C8-alkyl, or C1-C8-alkoxy; R2, R3, and R4 independently of one another are hydrogen, C1-C8-alkyl, hydroxy, NO2, CN, C1-C8-alkoxyl, CF3, or halogen; R5 and R6 independently of one another are hydrogen or a group consisting of C1-C8-alkyl, C2-C8-alkenyl, C3-C8-alkynyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C6-alkylene, C5-C8-cycloalkenyl, C5-C8-cycloalkenyl-C1-C6-alkylene, C6-C10-aryl, and C6-C10-aryl-C1-C6-alkylene, each optionally substituted by a group consisting of C1-C6-alkyl, C2-C6-alkenyl, halogen, C1-C6-alkyloxy, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, hydroxy, ═O, —COOH, —CO—OC1-C4-alkyl, —CONH2, —CONH(C1-C4-alkyl), —CON(C1-C4-alkyl)2, and CF3, or R5 and R6 together with the nitrogen atom are a saturated or unsaturated 5-, 6-, 7-, or 8-membered heterocyclic group optionally containing one or two further heteroatoms consisting of sulfur, oxygen, and nitrogen, and optionally mono-, di-, or trisubstituted by a group consisting of C1-C4-alkyl, hydroxy, ═O, —COOH, —CO—OC1-C4-alkyl, —CONH2, —CONH(C1-C4-alkyl), —CON(C1-C4-alkyl)2, halogen, and benzyl; X is oxygen, —NH—, —N(CHO)—, —N(CO—C1-C6-alkyl), —N(C1-C6-alkyl), or —N(C3-C6-cycloalkyl-C1-C4-alkylene); and A is a group consisting of C1-C6-alkylene, C2-C6-alkenylene, and C3-C6-alkynylene, each optionally substituted by a group consisting of halogen, ═O, and hydroxy, or an optical isomer, enantiomer, tautomer, free base, or pharmacologically acceptable acid addition salt thereof; methods of making such compounds; pharmaceutical compositions thereof, and their use in treating or preventing certain diseases.
摘要翻译：式1的化合物，其中：R 1是氢，羟基，CF 3，NO 2，CN，卤素，C 1 -C 8 - 烷基或C 1 -C 8 - 烷氧基; R 2，R 3， 4>彼此独立地是氢，C 1 -C 8 - 烷基，羟基，NO 2，CN，C 1 -C 8 - 烷氧基，CF 3或卤素; R 5和R 6彼此独立地是氢或基团由C 1 -C 8 - 烷基，C 2 -C 8 - 烯基，C 3 -C 8 - 炔基，C 3 -C 8 - 环烷基，C 3 -C 8 - 环烷基-C 1 -C 6亚烷基，C 5 -C 8 - 环烯基，C 5 -C 8 - 环烯基 - C 1 -C 6 - 亚烷基，C 6 -C 10 - 芳基和C 6 -C 10 - 芳基-C 1 -C 6亚烷基，各自任选被C 1 -C 6 - 烷基，C 2 -C 6 - 烯基，卤素，C 1 -C 6 - 烷氧基，-NH 2，-NH（C 1 -C 4 - 烷基），-N（C 1 -C 4 - 烷基）2，羟基，= O，-COOH，-CO-OC 1 -C 4烷基，-CONH 2，-CONH C 1 -C 4烷基），-CON（C 1 -C 4 - 烷基）2和CF 3或R 5和R 6与氮原子一起为饱和或不饱和的5-，6-，7-或任选地含有一个或两个由硫，氧和氮组成的另外的杂原子的8-元杂环基，以及任选的单 - ，二 - ，或被由C 1 -C 4 - 烷基，羟基，O，-COOH，-CO-OC 1 -C 4烷基，-CONH 2，-CONH（C 1 -C 4 - 烷基），-CON（C 1 -C 4） - 烷基）2，卤素和苄基; X是氧，-NH-，-N（CHO） - ， - N（CO-C 1 -C 6烷基）， - N（C 1 -C 6 - 烷基）（C 3 -C 6 - 环烷基-C 1 -C 4 - 亚烷基）; 并且A是由C 1 -C 6亚烷基，C 2 -C 6亚烯基和C 3 -C 6亚炔基组成的基团，各自任选地被卤素，= O和羟基取代，或光学异构体，对映体，互变异构体，游离碱或其药理学上可接受的酸加成盐; 制备此类化合物的方法; 其药物组合物及其在治疗或预防某些疾病中的用途。

6. 发明授权

US06683089B2 N-allyoxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-10-ols 有权
标题翻译： N-烯丙氧基-1,2,3,4,5,6-六氢-2,6-亚甲基-3-苯并吖辛因-10-ols
公开(公告)号：US06683089B2
公开(公告)日：2004-01-27
申请号：US10354516
申请日：2003-01-30
申请人： Adrian Carter , Helmut Ensinger , Matthias Grauert , Detlef Andre Stiller , Thomas Weiser
发明人： Adrian Carter , Helmut Ensinger , Matthias Grauert , Detlef Andre Stiller , Thomas Weiser
IPC分类号： A61K31349
CPC分类号： C07D221/26
摘要： The present invention relates to 1,2,3,4,5,6-hexahydro-2,6-methano-3 -benzazocin-10-ols of general formula 1 wherein the groups R1, R2, R3, R4, R5, R6, R7, R8 and R9 have the meanings as set forth herein, processes for preparing them, pharmaceutical compositions thereof and their use in treating or preventing a disease or disorder by blocking the voltage-dependent sodium channel.
摘要翻译：本发明涉及通式1的1,2,3,4,5,6-六氢-2,6-亚甲基-3-苯并唑辛-10-ols，其中R 1，R 2，R 2， R 3，R 5，R 5，R 7，R 8和R 9具有如本文所述的含义，制备方法，其药物组合物及其制备方法用于通过阻断电压依赖性钠通道来治疗或预防疾病或病症。

7. 发明授权

US06387921B1 Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions 有权
标题翻译：取代的1,2,3,4,5,6-六氢-2,6-亚甲基-3-苯并吖嗪及其作为药物组合物的用途
公开(公告)号：US06387921B1
公开(公告)日：2002-05-14
申请号：US09995382
申请日：2001-11-27
申请人： Matthias Grauert , Adrian Carter , Thomas Weiser , Helmut Ensinger , Wolfram Gaida , Joachim Mierau
发明人： Matthias Grauert , Adrian Carter , Thomas Weiser , Helmut Ensinger , Wolfram Gaida , Joachim Mierau
IPC分类号： A61K314748
CPC分类号： C07D405/06 , C07D221/26
摘要： Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines of general formula 1: wherein: R1 and R2, which are identical or different, are each hydrogen, C1-C6-alkyl, C1--C6-alkyloxy, OH, F, Cl, or Br; R3 is hydrogen, F, Cl, Br, methyl, ethyl, OH, or methoxy; R4 and R5, which are identical or different, are each hydrogen, methyl, or ethyl; R6 is hydrogen; X is NH2, NH—(C1-C6-alkyl), N(C1-C6-alkyl)2, the two C1-C6-alkyl groups of which are identical or different, NH—COH, NH—CO(C1-C6-alkyl), or F; A is —(CH2)3—, —CH2—CH2—O—, —CH2—O—CH2—, —(CH2)4—, —CH(C1-C6-alkyl)-O—CH2—, —(CH2)2—O—CH2—, —(CH2)3—O—, —(CH2)5—, —CH2—O—(CH2)3—, —(CH2)2—O—(CH2)2—, —(CH2)3—O—CH2—, —(CH2)4—O—, —CH2—O—CH2—CH2—O—, the racemates thereof, the enantiomers thereof, the diastereomers thereof, and mixtures thereof, and the pharmacologically acceptable acid addition salts thereof, processes for preparing them, and their use as pharmaceutical compositions.
摘要翻译：取代的通式1的1,2,3,4,5,6-六氢-2,6-亚甲基-3-苯并吖嗪：其中：R 1和R 2各自相同或不同，为氢，C 1 -C 6 - 烷基，C 1 -C 6烷氧基，OH，F，Cl或Br; R 3是氢，F，Cl，Br，甲基，乙基，OH或甲氧基; R 4和R 5各自相同或不同，甲基或乙基; R6是氢; X是NH2，NH-（C1-C6-烷基），N（C1-C6-烷基）2，它们的两个C1-C6-烷基相同或不同，NH- COH，NH-CO（C1-C6-烷基）或F; A是 - （CH2）3-，-CH2-CH2-O-，-CH2-O-CH2-， - （CH2）（C 1 -C 6 - 烷基）-O-CH 2 - ， - （CH 2）2 -O-CH 2 - ， - （CH 2）3 -O - ， - （CH 2）， - （CH 2）2 -O-（CH 2）2 - ， - （CH 2）3 -O-CH 2 - ， - （CH 2）4 -O - ， - CH 2 -O-CH 2 -CH 2 -O-，，其对映异构体，其非对映体及其混合物，及其药学上可接受的酸加成盐，其制备方法及其作为药物组合物的用途。

8. 发明授权

US06355652B1 Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions 有权
标题翻译：取代的1,2,3,4,5,6-六氢-2,6-亚甲基-3-苯并吖嗪及其作为药物组合物的用途
公开(公告)号：US06355652B1
公开(公告)日：2002-03-12
申请号：US09699748
申请日：2000-10-30
申请人： Matthias Grauert , Adrian Carter , Thomas Weiser , Helmut Ensinger , Wolfram Gaida , Joachim Mierau
发明人： Matthias Grauert , Adrian Carter , Thomas Weiser , Helmut Ensinger , Wolfram Gaida , Joachim Mierau
IPC分类号： A61K31439
CPC分类号： C07D405/06 , C07D221/26
摘要： Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines of general formula 1: wherein: R1 and R2, which may be identical or different, are each hydrogen, C1-C6-alkyl, C1-C6-alkyloxy, OH, F, Cl, or Br; R3 is hydrogen, F, Cl, Br, methyl, ethyl, OH, or methoxy; R4, R5, and R6, which may be identical or different, are each hydrogen, methyl, or ethyl; X is NH2, NH-(C1-C6-alkyl), N(C1-C6-alkyl)2, the two C1-C6-alkyl groups of which may be identical or different, NH—COH, NH—CO(C1-C6-alkyl), or F; A is —(CH2)3—, —CH2—CH2—O—, —CH2—O—CH2—, —(CH2)4—, —CH(C1-C6-alkyl)-O—CH2—, —(CH2)2—O—CH213 , —(CH2)3—O—, —(CH2)5—, —CH2—O—(CH2)3—, —(CH2)2—O—(CH2)2—, —(CH2)3—O—CH2—, —(CH2)4—O—, —CH2—O—CH2—CH2—O—, the racemates thereof, the enantiomers thereof, the diastereomers thereof, and mixtures thereof, and the pharmacologically acceptable acid addition salts thereof, processes for preparing them, and their use as pharmaceutical compositions.
摘要翻译：取代的通式1的1,2,3,4,5,6-六氢-2,6-亚甲基-3-苯并吖嗪：其中：R 1和R 2可以相同或不同，各自为氢，C 1 -C 6 - 烷基，C 1 -C 6烷氧基，OH，F，Cl或Br; R 3是氢，F，Cl，Br，甲基，乙基，OH或甲氧基; R 4，R 5和R 6可以相同或不同，各自为氢，甲基或乙基; X为NH 2，NH-（C 1 -C 6 - 烷基），N（C 1 -C 6烷基）2，其两个C 1 -C 6 - 烷基可以相同或不同，NH -COH，NH-CO（C 1 -C 6烷基）或F; A是 - （CH 2）3 - ， - CH 2 -CH 2 -O - ， - CH 2 -O-CH 2 - ， - （CH 2） CH（C 1 -C 6 - 烷基）-O-CH 2 - ， - （CH 2）2 -O-CH 2 13， - （CH 2）3 -O-， - （CH 2）， - （CH 2）2 -O-（CH 2）2 - ， - （CH 2）3 -O-CH 2 - ， - （CH 2）4 -O - ， - CH 2 -O-CH 2 -CH 2 -O-，，其对映异构体，其非对映体及其混合物，及其药学上可接受的酸加成盐，其制备方法及其作为药物组合物的用途。

9. 发明授权

US07517995B2 Thiazolyl-dihydro-cyclopentapyrazole 有权
标题翻译：噻唑基 - 二氢环戊吡唑
公开(公告)号：US07517995B2
公开(公告)日：2009-04-14
申请号：US11690356
申请日：2007-03-23
申请人： Steffen Breitfelder , Udo Maier , Christoph Hoenke , Anne T. Joergensen , Alexander Pautsch , Trixi Brandl , Matthias Grauert , Matthias Hoffmann , Stefan Scheuerer , Klaus Erb , Michael Pieper , Ingo Pragst
发明人： Steffen Breitfelder , Udo Maier , Christoph Hoenke , Anne T. Joergensen , Alexander Pautsch , Trixi Brandl , Matthias Grauert , Matthias Hoffmann , Stefan Scheuerer , Klaus Erb , Michael Pieper , Ingo Pragst
IPC分类号： A61K31/429 , C07D513/04
CPC分类号： C07D513/04
摘要： Disclosed are compounds of general formula (I), wherein the groups R1, R2, Ra and Rb have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-cyclopentapyrazoles and the use thereof as pharmaceutical compositions.
摘要翻译：公开了通式（I）的化合物，其中基团R 1，R 2，R a和R b具有权利要求书和说明书中给出的含义，互变异构体，外消旋体，对映异构体，非对映异构体及其混合物，以及任选的药理学可接受的酸加成盐，溶剂合物和水合物，以及制备这些噻唑基 - 二氢环戊吡唑的方法及其作为药物组合物的用途。

10. 发明授权

US08232286B2 Inhibitors of PI3-kinases 有权
标题翻译： PI3激酶抑制剂
公开(公告)号：US08232286B2
公开(公告)日：2012-07-31
申请号：US12366248
申请日：2009-02-05
申请人： Steffen Breitfelder , Udo Maier , Trixi Brandl , Christoph Hoenke , Matthias Grauert , Alexander Pautsch , Matthias Hoffmann , Frank Kalkbrenner , Anne T. Joergensen , Gerhard Schaenze , Stefan Peters , Frank Buettner , Eckhart Bauer
发明人： Steffen Breitfelder , Udo Maier , Trixi Brandl , Christoph Hoenke , Matthias Grauert , Alexander Pautsch , Matthias Hoffmann , Frank Kalkbrenner , Anne T. Joergensen , Gerhard Schaenze , Stefan Peters , Frank Buettner , Eckhart Bauer
IPC分类号： C07D487/04 , A61K31/519 , A61P11/06 , A61P19/02 , A61P17/06
CPC分类号： C07D513/04 , C07D277/84
摘要： New compounds of formula 1 are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.
摘要翻译：提供新的式1化合物，其由于其药物活性，因为PI3-激酶调节剂可用于治疗炎症或过敏性疾病的治疗领域。这些实例包括炎性和过敏性呼吸道疾病，胃肠道炎症性疾病和运动器官，炎性和过敏性皮肤疾病，炎症性眼病，鼻粘膜疾病，涉及自身免疫反应或炎症的炎性或过敏性疾病。

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