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1. 发明授权

US06770636B2 Phenyl-and phenylalkyl-substituted ethanolamines and ethylenediamines 有权
标题翻译：苯基和苯基烷基取代的乙醇胺和乙二胺
公开(公告)号：US06770636B2
公开(公告)日：2004-08-03
申请号：US09912163
申请日：2001-07-24
申请人： Klaus Fuchs , Werner Stransky , Matthias Grauert , Adrian Carter , Wolfram Gaida , Thomas Weiser , Helmut Ensinger
发明人： Klaus Fuchs , Werner Stransky , Matthias Grauert , Adrian Carter , Wolfram Gaida , Thomas Weiser , Helmut Ensinger
IPC分类号： A61K3133
CPC分类号： C07D295/125 , C07C211/35 , C07C217/48 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/092
摘要： Compounds of formula 1, wherein: R1 is hydrogen, hydroxy, CF3, NO2, CN, halogen, C1-C8-alkyl, or C1-C8-alkoxy; R2, R3, and R4 independently of one another are hydrogen, C1-C8-alkyl, hydroxy, NO2, CN, C1-C8-alkoxyl, CF3, or halogen; R5 and R6 independently of one another are hydrogen or a group consisting of C1-C8-alkyl, C2-C8-alkenyl, C3-C8-alkynyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C6-alkylene, C5-C8-cycloalkenyl, C5-C8-cycloalkenyl-C1-C6-alkylene, C6-C10-aryl, and C6-C10-aryl-C1-C6-alkylene, each optionally substituted by a group consisting of C1-C6-alkyl, C2-C6-alkenyl, halogen, C1-C6-alkyloxy, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, hydroxy, ═O, —COOH, —CO—OC1-C4-alkyl, —CONH2, —CONH(C1-C4-alkyl), —CON(C1-C4-alkyl)2, and CF3, or R5 and R6 together with the nitrogen atom are a saturated or unsaturated 5-, 6-, 7-, or 8-membered heterocyclic group optionally containing one or two further heteroatoms consisting of sulfur, oxygen, and nitrogen, and optionally mono-, di-, or trisubstituted by a group consisting of C1-C4-alkyl, hydroxy, ═O, —COOH, —CO—OC1-C4-alkyl, —CONH2, —CONH(C1-C4-alkyl), —CON(C1-C4-alkyl)2, halogen, and benzyl; X is oxygen, —NH—, —N(CHO)—, —N(CO—C1-C6-alkyl), —N(C1-C6-alkyl), or —N(C3-C6-cycloalkyl-C1-C4-alkylene); and A is a group consisting of C1-C6-alkylene, C2-C6-alkenylene, and C3-C6-alkynylene, each optionally substituted by a group consisting of halogen, ═O, and hydroxy, or an optical isomer, enantiomer, tautomer, free base, or pharmacologically acceptable acid addition salt thereof; methods of making such compounds; pharmaceutical compositions thereof, and their use in treating or preventing certain diseases.
摘要翻译：式1的化合物，其中：R 1是氢，羟基，CF 3，NO 2，CN，卤素，C 1 -C 8 - 烷基或C 1 -C 8 - 烷氧基; R 2，R 3， 4>彼此独立地是氢，C 1 -C 8 - 烷基，羟基，NO 2，CN，C 1 -C 8 - 烷氧基，CF 3或卤素; R 5和R 6彼此独立地是氢或基团由C 1 -C 8 - 烷基，C 2 -C 8 - 烯基，C 3 -C 8 - 炔基，C 3 -C 8 - 环烷基，C 3 -C 8 - 环烷基-C 1 -C 6亚烷基，C 5 -C 8 - 环烯基，C 5 -C 8 - 环烯基 - C 1 -C 6 - 亚烷基，C 6 -C 10 - 芳基和C 6 -C 10 - 芳基-C 1 -C 6亚烷基，各自任选被C 1 -C 6 - 烷基，C 2 -C 6 - 烯基，卤素，C 1 -C 6 - 烷氧基，-NH 2，-NH（C 1 -C 4 - 烷基），-N（C 1 -C 4 - 烷基）2，羟基，= O，-COOH，-CO-OC 1 -C 4烷基，-CONH 2，-CONH C 1 -C 4烷基），-CON（C 1 -C 4 - 烷基）2和CF 3或R 5和R 6与氮原子一起为饱和或不饱和的5-，6-，7-或任选地含有一个或两个由硫，氧和氮组成的另外的杂原子的8-元杂环基，以及任选的单 - ，二 - ，或被由C 1 -C 4 - 烷基，羟基，O，-COOH，-CO-OC 1 -C 4烷基，-CONH 2，-CONH（C 1 -C 4 - 烷基），-CON（C 1 -C 4） - 烷基）2，卤素和苄基; X是氧，-NH-，-N（CHO） - ， - N（CO-C 1 -C 6烷基）， - N（C 1 -C 6 - 烷基）（C 3 -C 6 - 环烷基-C 1 -C 4 - 亚烷基）; 并且A是由C 1 -C 6亚烷基，C 2 -C 6亚烯基和C 3 -C 6亚炔基组成的基团，各自任选地被卤素，= O和羟基取代，或光学异构体，对映体，互变异构体，游离碱或其药理学上可接受的酸加成盐; 制备此类化合物的方法; 其药物组合物及其在治疗或预防某些疾病中的用途。

2. 发明申请

US20060100158A1 Statine derivatives for the treatment of Alzheimer's disease III 有权
标题翻译：用于治疗阿尔茨海默病的他汀类衍生物III
公开(公告)号：US20060100158A1
公开(公告)日：2006-05-11
申请号：US11268197
申请日：2005-11-07
申请人： Stefan Peters , Klaus Fuchs , Christian Eickmeier , Werner Stransky , Cornelia Dorner-Ciossek , Sandra Handschuh , Herbert Nar , Klaus Klinder , Marcus Kostka
发明人： Stefan Peters , Klaus Fuchs , Christian Eickmeier , Werner Stransky , Cornelia Dorner-Ciossek , Sandra Handschuh , Herbert Nar , Klaus Klinder , Marcus Kostka
IPC分类号： A61K38/06 , A61K38/05 , C07K5/06
CPC分类号： C07K5/0205 , A61K38/00
摘要： The invention relates to a compound of the formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 5，R 6，R 7和R 8如本说明书和权利要求书中所定义，以及其用于治疗或预防阿尔茨海默病和其他类似疾病的用途。

3. 发明申请

US20080293680A1 Substituted Ethane-1,2-Diamines for the Treatment of Alzheimer's Disease II 审中-公开
标题翻译：用于治疗阿尔茨海默病的取代乙烷-1,2-二胺Ⅱ
公开(公告)号：US20080293680A1
公开(公告)日：2008-11-27
申请号：US11997449
申请日：2006-08-01
申请人： Stefan Peters , Christian Eickmeier , Klaus Fuchs , Werner Stransky , Cornelia Dorner-Ciossek , Marcus Kostka , Sandra Handschuh , Herbert Nar , Klaus Bornemann , Klaus Klinder , Margit Bauer
发明人： Stefan Peters , Christian Eickmeier , Klaus Fuchs , Werner Stransky , Cornelia Dorner-Ciossek , Marcus Kostka , Sandra Handschuh , Herbert Nar , Klaus Bornemann , Klaus Klinder , Margit Bauer
IPC分类号： A61K31/65 , C07D213/02 , A61K31/44 , C07C229/02 , A61K31/19 , C07C237/00 , A61K31/164 , C12N9/99 , A61P25/00 , C07D401/02 , A61K31/4439 , A61K31/355 , A61K31/445 , A61K31/473 , A61K31/55
CPC分类号： C07K5/0207 , A61K38/03 , C07K5/021 , A61K2300/00
摘要： The invention relates to a compound of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如说明书和权利要求中所定义，以及其用于治疗或预防阿尔茨海默病和其它类似物疾病

4. 发明申请

US20060160747A1 Statine derivatives for the treatment of Alzheimer's disease II 审中-公开
标题翻译：用于治疗阿尔茨海默病的他汀类衍生物II
公开(公告)号：US20060160747A1
公开(公告)日：2006-07-20
申请号：US11268429
申请日：2005-11-07
申请人： Stefan Peters , Klaus Fuchs , Christian Eickmeier , Werner Stransky , Cornelia Dorner-Ciossek , Sandra Handschuh , Herbert Nar , Klaus Klinder , Marcus Kostka
发明人： Stefan Peters , Klaus Fuchs , Christian Eickmeier , Werner Stransky , Cornelia Dorner-Ciossek , Sandra Handschuh , Herbert Nar , Klaus Klinder , Marcus Kostka
IPC分类号： C07K5/06 , A61K38/06
CPC分类号： C07K7/02 , A61K38/00 , C07K5/0205
摘要： The invention relates to a compound of the formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 5，R 6，R 7，R 8和R 9， SUP>如说明书和权利要求书及其用于治疗或预防阿尔茨海默病和其他类似疾病的用途所定义。

5. 发明申请

US20060025345A1 Substituted ethane-1,2-diamines for the treatment of Alzheimer's disease 审中-公开
标题翻译：用于治疗阿尔茨海默氏病的取代的乙烷-1,2-二胺
公开(公告)号：US20060025345A1
公开(公告)日：2006-02-02
申请号：US11133948
申请日：2005-05-20
申请人： Stefan Peters , Christian Eickmeier , Klaus Fuchs , Werner Stransky , Cornelia Dorner-Ciossek , Marcus Kostka , Sandra Handschuh , Margit Bauer , Herbert Nar , Klaus Bornemann , Klaus Klinder , Joerg Rademann , Steffen Weik
发明人： Stefan Peters , Christian Eickmeier , Klaus Fuchs , Werner Stransky , Cornelia Dorner-Ciossek , Marcus Kostka , Sandra Handschuh , Margit Bauer , Herbert Nar , Klaus Bornemann , Klaus Klinder , Joerg Rademann , Steffen Weik
IPC分类号： A61K38/04 , C07K5/04
CPC分类号： C07K7/02 , A61K38/00 , C07C237/06 , C07K5/0207
摘要： The invention relates to a compound of the formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, A, B, and Y are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 5，R 6，R 7，R 8，R 9， R 10，R 10，R 11，R 12，R 13，A，B和Y是如说明书和权利要求书中所定义，以及其用于治疗或预防阿尔茨海默病和其他类似疾病的用途。

6. 发明授权

US07238774B2 Statine derivatives for the treatment of Alzheimer's disease III 有权
标题翻译：用于治疗阿尔茨海默病的他汀类衍生物III
公开(公告)号：US07238774B2
公开(公告)日：2007-07-03
申请号：US11268197
申请日：2005-11-07
申请人： Stefan Peters , Klaus Fuchs , Christian Eickmeier , Werner Stransky , Cornelia Dorner-Ciossek , Sandra Handschuh , Herbert Nar , Klaus Klinder , Marcus Kostka
发明人： Stefan Peters , Klaus Fuchs , Christian Eickmeier , Werner Stransky , Cornelia Dorner-Ciossek , Sandra Handschuh , Herbert Nar , Klaus Klinder , Marcus Kostka
IPC分类号： A61K38/03
CPC分类号： C07K5/0205 , A61K38/00
摘要： The invention relates to a compound of the formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 5，R 6，R 7和R 8如本说明书和权利要求书中所定义，以及其用于治疗或预防阿尔茨海默病和其他类似疾病的用途。

7. 发明申请

US20110015193A1 1, 5-DIHYDRO-PYRAZOLO (3, 4-D) PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MUDULATORS FOR THE TREATMENT OF CNS DISORDERS 有权
标题翻译： 1,5-二羟基吡唑并（3,4-D）嘧啶-4-酮衍生物及其用作治疗CNS疾病的PDE9A制剂
公开(公告)号：US20110015193A1
公开(公告)日：2011-01-20
申请号：US12744750
申请日：2008-11-27
申请人： Christian Eickmeier , Cornelia Dorner-Ciossek , Dennis Fiegen , Thomas Fox , Klaus Fuchs , Riccardo Giovannini , Niklas Heine , Martin Hendrix , Holger Rosenbrock , Gerhard Schaenzle
发明人： Christian Eickmeier , Cornelia Dorner-Ciossek , Dennis Fiegen , Thomas Fox , Klaus Fuchs , Riccardo Giovannini , Niklas Heine , Martin Hendrix , Holger Rosenbrock , Gerhard Schaenzle
IPC分类号： A61K31/5377 , C07D487/04 , A61K31/519 , C07D413/14 , A61P25/00
CPC分类号： C07D487/04
摘要： The invention relates to novel substituted pyrazolopyrimidines. Chemically, the compounds are characterised by general Formula (I): with R1 being phenyl or pyridyl, any of which is substituted with 1 to 4, preferably 1 to 3 substituents X; X independently of each other being selected from C2-C6-alky1 or Ci-C6-alkoxy, where C2-C6-alkyl and C1-C6-alkoxy are at least dihalogenated up to perhalogenated. preferably with 2 to 6 halogen substituents, and the halogen atoms being selected from the group of fluoro, chloro and bromo, preferably fluoro; R2 being phenyl or heteroaryl, where phenyl is substituted by 1 to 3 radicals and heteroaryl is optionally substituted by 1 to 3 radicals in each case independently of one another selected from the group of C1-C6-alkyI, C1-C6-alkoxy, hydroxycarbonyl, cyano, trifluoromethyl, amino, nitro, hydroxy, C1-C6-alkylamino, halogen, C6-C10-arylcarbonylamino, C1-C6-alkylcarbonylamino, C1-C6-alkylaminocarbonyl. C1-C6-alkoxycarbonyl, C6-C10-arylaminocarbonyl, heteroarylaminocarbonyl. heteroarylcarbonylamino, C1-C6-alkylsulphonyl-amino, C1-C6-alkylsulphonyl and C1-C6-alkylthio; The new compounds shall be used for the manufacture of medicaments, in particular medicaments for improving, perception, concentration, learning and/or memory in patients in need thereof.
摘要翻译：本发明涉及新的取代吡唑并嘧啶。在化学上，化合物的特征在于通式（I）：其中R 1为苯基或吡啶基，其中任何一个被1至4个，优选1至3个取代基X取代; X独立地选自C 2 -C 6 - 烷基或C 1 -C 6 - 烷氧基，其中C 2 -C 6 - 烷基和C 1 -C 6 - 烷氧基至少被二卤代化为全卤代。优选具有2至6个卤素取代基，并且卤素原子选自氟，氯和溴，优选氟; R 2是苯基或杂芳基，其中苯基被1至3个基团取代，杂芳基任选被1至3个基团取代，各自独立地选自C1-C6-烷基，C1-C6-烷氧基，羟基羰基氰基，三氟甲基，氨基，硝基，羟基，C 1 -C 6烷基氨基，卤素，C 6 -C 10 - 芳基羰基氨基，C 1 -C 6烷基羰基氨基，C 1 -C 6烷基氨基羰基。 C 1 -C 6 - 烷氧基羰基，C 6 -C 10 - 芳基氨基羰基，杂芳基氨基羰基。杂芳基羰基氨基，C 1 -C 6烷基磺酰基 - 氨基，C 1 -C 6 - 烷基磺酰基和C 1 -C 6烷硫基; 新化合物应用于制造药物，特别是用于改善，感知，集中，学习和/或记忆有需要的患者的药物。

8. 发明申请

US20100168070A1 COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：用于治疗阿尔茨海默病的化合物
公开(公告)号：US20100168070A1
公开(公告)日：2010-07-01
申请号：US12063317
申请日：2006-08-08
申请人： Niklas Heine , Klaus Fuchs , Christian Eickmeier , Stefan Peters , Cornelia Dorner-Ciossek , Sandra Handschuh , Herbert Nar , Klaus Klinder
发明人： Niklas Heine , Klaus Fuchs , Christian Eickmeier , Stefan Peters , Cornelia Dorner-Ciossek , Sandra Handschuh , Herbert Nar , Klaus Klinder
IPC分类号： A61K31/426 , A61K31/65 , A61K31/55 , A61K31/549 , A61K31/5355 , A61K31/496 , A61K31/497 , A61K31/473 , A61K31/437 , A61K31/445 , A61K31/444 , A61K31/4439 , A61K31/4402 , A61K31/433 , A61K31/427 , A61K31/4196 , A61K31/4155 , A61K31/381 , A61K31/18 , C07D417/12 , C07D413/12 , C07D409/12 , C07D401/12 , C07D213/56 , C07D277/30 , C07D333/24 , C07C311/08 , A61P25/28 , A61P25/00 , A61P9/10 , A61P3/10 , A61P35/04 , C12N9/99
CPC分类号： C07D417/12 , C07D213/40 , C07D277/28 , C07D333/20 , C07D409/12 , C07D417/14
摘要： The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1-R13, A, B, L and i are as defined in the description and in the claims. The invention also relates to the use thereof for treating Alzheimer's disease (AD) and similar diseases.
摘要翻译：本发明涉及通式（I）的取代的1,2-乙二胺，其中基团R 1 -R 13，A，B，L和i如说明书和权利要求中所定义。本发明还涉及其用于治疗阿尔茨海默病（AD）和类似疾病的用途。

9. 发明申请

US20090042867A1 COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：用于治疗阿尔茨海默病的化合物
公开(公告)号：US20090042867A1
公开(公告)日：2009-02-12
申请号：US12063304
申请日：2006-08-08
申请人： Klaus Fuchs , Christian Eickmeier , Niklas Heine , Stefan Peters , Cornelia Dorner-Ciossek , Sandra Handschuh , Herbert Nar , Klaus Klinder
发明人： Klaus Fuchs , Christian Eickmeier , Niklas Heine , Stefan Peters , Cornelia Dorner-Ciossek , Sandra Handschuh , Herbert Nar , Klaus Klinder
IPC分类号： A61K31/549 , C07D277/20 , C07D401/12 , C07D285/16 , A61P25/28 , A61K31/426 , A61K31/444
CPC分类号： C07D277/28 , C07D213/40 , C07D231/12 , C07D333/20 , C07D417/12 , C07D417/14
摘要： The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1 to R13, A, B, L, and i are defined as indicated in the description and the claims, as well as the use thereof for treating Alzheimer's disease (AD) and similar diseases.
摘要翻译：本发明涉及通式（I）的取代的1,2-乙二胺，其中基团R 1至R 13，A，B，L和i如说明书和权利要求书所述定义，以及其用于治疗阿尔茨海默病（AD）和类似疾病。

10. 发明授权

US6136527A Polypeptides derived from proteins of the hepatitis C virus, test kits containing these polypeptides and vaccines against infections of hepatitis C viruses 失效
标题翻译：衍生自丙型肝炎病毒蛋白质的多肽，含有这些多肽的试剂盒和针对丙型肝炎病毒感染的疫苗
公开(公告)号：US6136527A
公开(公告)日：2000-10-24
申请号：US78271
申请日：1993-10-15
申请人： Klaus Fuchs , Manfred Motz , Michael Roggendorf , Erwin Soutschek
发明人： Klaus Fuchs , Manfred Motz , Michael Roggendorf , Erwin Soutschek
IPC分类号： A61K39/29 , A61K39/00 , A61P31/12 , C07H21/04 , C07K14/00 , C07K14/02 , C07K14/10 , C07K14/18 , C07K14/705 , C07K19/00 , C12N1/21 , C12N15/09 , C12N15/51 , C12P21/02 , C12Q1/68 , C12R1/19 , G01N33/53 , G01N33/576
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222
摘要： The cloning and sequencing of different polypeptides from the genome of a hepatitis C virus is disclosed. The polypeptides are prepared as non-fusion proteins in good yield. The polypeptide originating from the structure protein (core) is soluble under physiological conditions. Since the polypeptides have no foreign protein portions, they are preferably used in test kits and as vaccine.
摘要翻译： PCT No.PCT / DE91 / 01020 Sec。 371日期：1993年10月15日 102（e）日期1993年10月15日PCT 1991年12月20日PCT PCT。出版物WO92 / 11370 日期1992年7月9日公开了来自丙型肝炎病毒基因组的不同多肽的克隆和测序。多肽以良好的产率制备为非融合蛋白。来自结构蛋白（核心）的多肽在生理条件下是可溶的。由于多肽不含外来蛋白质部分，因此优选用于测试试剂盒和疫苗中。

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