专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09745414B2 Hyperbranched amino acid-based poly(ester urea)s for regenerative medicine and drug delivery 有权
公开(公告)号：US09745414B2
公开(公告)日：2017-08-29
申请号：US14939216
申请日：2015-11-12
申请人： Matthew Becker , Jiayi Yu
发明人： Matthew Becker , Jiayi Yu
IPC分类号： C08G63/685
CPC分类号： C08G63/685 , C08G83/005
摘要： One or more embodiments of the present invention provide a hyperbranched amino-acid-based PEU polymer for use in regenerative medicine and/or drug delivery applications has tunable mechanical and thermal properties, but is sufficiently stable to permit such things as ethyloxide sterilization without degradation and/or significant loss of function. These hyperbranched amino acid-based poly(ester urea) (PEU) by interfacial polycondensation between linear and branched amino acid-based polyester monomers and a urea forming material such as trisphosgene or phosgene. By controlling the amount of branched monomer incorporated into the copolymer, the mechanical properties and water uptake abilities of the resulting hyperbranched amino acid-based PEUs may be tuned. The hyperbranched PEUs nanofibers are sterilizable with ETO and are stable for long periods of ETO sterilization, elevated temperature and exposure to aqueous environments. In various embodiments, these hyperbranched amino acid-based PEUs are also biodegradable and can be formed into fibers.

2. 发明申请

US20160130390A1 HYPERBRANCHED AMINO ACID-BASED POLY(ESTER UREA)S FOR REGENERATIVE MEDICINE AND DRUG DELIVERY 审中-公开
标题翻译：用于再生医药和药物递送的超级基于氨基酸的聚合物（ESTER UREA）S
公开(公告)号：US20160130390A1
公开(公告)日：2016-05-12
申请号：US14939216
申请日：2015-11-12
申请人： Matthew Becker , Jiayi Yu
发明人： Matthew Becker , Jiayi Yu
IPC分类号： C08G63/685
CPC分类号： C08G63/685 , C08G83/005
摘要： One or more embodiments of the present invention provide a hyperbranched amino-acid-based PEU polymer for use in regenerative medicine and/or drug delivery applications has tunable mechanical and thermal properties, but is sufficiently stable to permit such things as ethyloxide sterilization without degradation and/or significant loss of function. These hyperbranched amino acid-based poly(ester urea) (PEU) by interfacial polycondensation between linear and branched amino acid-based polyester monomers and a urea forming material such as trisphosgene or phosgene. By controlling the amount of branched monomer incorporated into the copolymer, the mechanical properties and water uptake abilities of the resulting hyperbranched amino acid-based PEUs may be tuned. The hyperbranched PEUs nanofibers are sterilizable with ETO and are stable for long periods of ETO sterilization, elevated temperature and exposure to aqueous environments. In various embodiments, these hyperbranched amino acid-based PEUs are also biodegradable and can be formed into fibers.
摘要翻译：本发明的一个或多个实施方案提供了用于再生医学和/或药物递送应用中的超支化氨基酸基PEU聚合物具有可调节的机械和热性质，但是足够稳定以允许诸如乙酸氧化酶灭菌而不降解， /或显着的功能丧失。这些超支化氨基酸基聚（酯脲）（PEU）通过直链和支链氨基酸类聚酯单体之间的界面缩聚和尿素形成材料如三光气或光气。通过控制掺入共聚物中的支化单体的量，可以调节所得到的超支化氨基酸基PEU的机械性能和吸水能力。超支化PEU纳米纤维可以用ETO进行灭菌，对于长时间的ETO灭菌，升高的温度和暴露于水性环境是稳定的。在各种实施方案中，这些基于超支化氨基酸的PEU也是可生物降解的并且可以形成纤维。

3. 发明授权

US11931478B2 Post-3D printing functionalization of polymer scaffolds for enhanced bioactivity 有权
公开(公告)号：US11931478B2
公开(公告)日：2024-03-19
申请号：US16609772
申请日：2018-05-03
申请人： Matthew Becker , Yanyi Xu
发明人： Matthew Becker , Yanyi Xu
IPC分类号： A61L27/18 , A61L27/38 , A61L27/44 , A61L27/54 , A61L27/56 , A61L27/58
CPC分类号： A61L27/18 , A61L27/3808 , A61L27/3821 , A61L27/3834 , A61L27/44 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/25 , A61L2300/252 , A61L2300/404 , A61L2300/412 , A61L2300/414 , A61L2430/02
摘要： In various aspects, the present invention is directed to novel bioactive peptide loaded poly(propylene fumarate) (PPF) tissue scaffolds and related methods for their making and use. In various embodiments, these bioactive peptide loaded poly(propylene fumarate) tissue scaffolds are formed by forming a PPF structure or matrix using photochemical 3-D printing techniques and then loading that printed PPF structure or matrix with a bioactive peptides or other bioactive compounds that have, or have been functionalized to have, a thiol functional group at or near its terminus. The thiol groups on the bioactive peptides or other compound will react with exposed alkene functional groups on the PPF polymer matrix via a thiol-ene “click” reaction, thereby binding these bioactive peptides or other compounds to the tissue scaffolds. The bioactive peptide loaded PPF tissue scaffolds of the present invention are particularly useful in repairing bone defects.

4. 发明授权

US09758671B2 Strain-promoted crosslinking of PEG-based hydrogels via copper-free cycloaddition 有权
公开(公告)号：US09758671B2
公开(公告)日：2017-09-12
申请号：US14418507
申请日：2013-07-31
申请人： Matthew Becker , Robert A. Weiss
发明人： Matthew Becker , Robert A. Weiss
IPC分类号： C12N5/00 , C08L71/00 , C08G65/325 , C08G65/333 , C08L71/02 , C08L89/00 , A61K9/06 , A61K47/34
CPC分类号： C08L71/00 , A61K9/06 , A61K47/34 , C08G65/325 , C08G65/33389 , C08L71/02 , C08L89/00 , C08L2205/02
摘要： The present invention is directed to a covalently crosslinked hydrogel comprising the strain-promoted reaction product of an 8-member cycloalkyne functionalized polyalkylene glycol and a multi-arm glycerol exytholate triazide and methods for making them. Because the precursor materials can be manipulated without causing crosslinking, provided the strain threshold is not reached, these hydrogels permit mechanical control over when (and where) cross linking occurs and are easier to use than prior strain-activated or temperature-activated systems. These novel hydrogels do not require a catalyst to cross link, thus avoiding the biocompatibility problems common to many catalysts. Nor is the crosslinking process affected by the presence of catalysts or other substances, which have interfered with crosslinking in known strain induced hydrogels. Because of their crosslinking reaction kinetics, these novel hydrogels can encapsulate and transport highly sensitive cells and other biological additives and have no known toxic byproducts.

5. 发明申请

US20170086978A1 MODULAR DEVICE FOR PREVENTING COMPRESSION AND INSTABILITY IN A SEGMENTAL DEFECT REPAIR SCAFFOLD 审中-公开
公开(公告)号：US20170086978A1
公开(公告)日：2017-03-30
申请号：US15310981
申请日：2015-05-13
申请人： Matthew Becker , Ennio Tasciotti , Bradley Weiner , Avraam Isayev
发明人： Matthew Becker , Ennio Tasciotti , Bradley Weiner , Avraam Isayev
IPC分类号： A61F2/28 , A61L27/18 , A61L27/36 , A61L27/24 , A61L27/58
CPC分类号： A61F2/2846 , A61F2002/30235 , A61L27/18 , A61L27/24 , A61L27/3604 , A61L27/3683 , A61L27/58 , A61L2430/02
摘要： The present invention relates to a polymer scaffold design and method for treating segmental long bone defects without amputation that permits permanent regrowth of bone in the area of the segmental defect, without external fixation or other problems inherent in current systems. The polymer scaffold is preferably made from a poly(ester urea) polymer and includes an outer shell, sized to fit over a segmental defect in a bone, and a collagen containing material. In some embodiments, the collagen containing material is placed in a polymer insert sized to fit within the segmental bone defect and within said outer shell. In some embodiments, the outer shell may contain struts running longitudinal struts along the inside surface of the outer shell. In some of these embodiments, the insert will have a corresponding set of grooves sized to receive the struts.

6. 发明授权

US07900098B2 Receiver for recovering and retiming electromagnetically coupled data 有权
标题翻译：用于恢复和重新定位电磁耦合数据的接收器
公开(公告)号：US07900098B2
公开(公告)日：2011-03-01
申请号：US12080262
申请日：2008-04-01
申请人： Matthew Becker , Zibing Yang , Qiang Zhang , Todd Hinck , Larry Tate
发明人： Matthew Becker , Zibing Yang , Qiang Zhang , Todd Hinck , Larry Tate
IPC分类号： G06F11/00 , G01R31/28 , G01R11/30 , G01R31/02 , G01R19/00 , G01R23/02 , G01R23/14 , G01R25/00 , H03K3/00
CPC分类号： H04L25/05 , G06F11/2733
摘要： In one embodiment, the present invention includes a system having an electromagnetic coupler probe to electromagnetically sample signals from a device under test or a link under test and a receiver, e.g., configured as an integrated circuit that is to receive the sampled electromagnetic signals from the probe and output digital signals corresponding thereto. Other embodiments are described and claimed.
摘要翻译：在一个实施例中，本发明包括具有电磁耦合器探针以对来自被测器件或被测链路的信号进行电磁采样的系统，以及接收器，例如被配置为集成电路，该集成电路将从探测和输出与之对应的数字信号。描述和要求保护其他实施例。

7. 发明申请

US20080290007A1 CENTRIFUGAL LENGTH SEPARATION OF CARBON NANOTUBES 审中-公开
标题翻译：碳纳米管的离心长度分离
公开(公告)号：US20080290007A1
公开(公告)日：2008-11-27
申请号：US12122288
申请日：2008-05-16
申请人： Jeffrey Alan Fagan , Matthew Becker
发明人： Jeffrey Alan Fagan , Matthew Becker
IPC分类号： B07C5/12
CPC分类号： B82Y30/00 , B01D21/26 , B82Y40/00 , C01B32/172 , C01B32/174 , C01B2202/02 , C01B2202/34
摘要： Processes for separating carbon nanotubes according to their length are described. The processes involve forming highly dispersed systems of the nanotubes followed by creating an array of layers in a centrifugation vessel. Each layer contains dispersed nanotubes with varying proportions of a density adjusting agent. The vessel array includes a first layer containing the nanotubes to be separated, and one or more layers of lesser density disposed above the first layer. Upon centrifuging for a sufficient period of time, a series of liquid fractions form in the vessel. The average length of nanotubes in a respective fraction is different than the average length of nanotubes in the other fractions.
摘要翻译：描述了根据其长度分离碳纳米管的方法。该方法包括形成纳米管的高分散体系，然后在离心容器中产生一层层。每层包含不同比例的密度调节剂的分散的纳米管。容器阵列包括含有待分离的纳米管的第一层和设置在第一层上方的一层或多层较小的密度。在离心足够长的时间后，在容器中形成一系列液体馏分。相应级分中纳米管的平均长度不同于其他级分中纳米管的平均长度。

8. 发明申请

US20050261582A1 Intracorporeal probe with disposable probe body 审中-公开
标题翻译：带一次性探头体的体内探头
公开(公告)号：US20050261582A1
公开(公告)日：2005-11-24
申请号：US10848086
申请日：2004-05-18
申请人： Matthew Becker , Kevin Mack , Otto Gertler , Mark Schafer , Rod Denlinger , Angela Lassandro , Stanley Kniezewski , Dana Randolph , Jason Lassandro , Bill Regan
发明人： Matthew Becker , Kevin Mack , Otto Gertler , Mark Schafer , Rod Denlinger , Angela Lassandro , Stanley Kniezewski , Dana Randolph , Jason Lassandro , Bill Regan
IPC分类号： A61B8/00 , A61B8/06
CPC分类号： A61B8/06 , A61B8/12 , A61B8/4422
摘要： An ultrasonic probe for flow rate measurement is disclosed having a plurality of transducers mounted on a flexible cable configured to be inserted in a body cavity to obtain cardiac or other biometric telemetry. The flexible cable is provided with a disposable body which covers and microbially isolates the flexible cable and transducers. The disposable body is flexible and permits rotation of the flexible cable within it. Removal and replacement of the disposable body allows the probe to be used again without sterilization of the probe itself. A sensor window may be provided in the disposable body to allow transmission of ultrasonic signals, said window being provided with an anechoic surface treatment to reduce reception spurious ultrasonic echoes due to the material of the sensor window.
摘要翻译：公开了一种用于流量测量的超声波探头，其具有安装在柔性电缆上的多个换能器，其被配置为插入体腔以获得心脏或其它生物测定遥测。柔性电缆设置有一个一次性主体，其覆盖和微小地隔离柔性电缆和换能器。一次性体是柔性的，并允许柔性电缆在其内旋转。一次性物体的移除和更换允许探头再次使用，而不需要对探头本身进行灭菌。可以在一次性本体中提供传感器窗口以允许超声波信号的传输，所述窗口提供消声表面处理以减少由于传感器窗口的材料而导致的寄生超声波回波。

9. 发明授权

US10227440B2 Softening thermoplastic polyurethanes using ionomer technology 有权
公开(公告)号：US10227440B2
公开(公告)日：2019-03-12
申请号：US15166948
申请日：2016-05-27
申请人： Matthew Becker , Robert A. Weiss , Zachary Kurtiss Zander , Don S. Wardius , Karl W. Haider , Bruce D. Lawrey
发明人： Matthew Becker , Robert A. Weiss , Zachary Kurtiss Zander , Don S. Wardius , Karl W. Haider , Bruce D. Lawrey
IPC分类号： C08G18/10 , C08G18/08 , C08G18/60 , C08G18/76 , C08G18/42 , C08G18/44 , C08G18/48
摘要： In one or more embodiments, the present invention provides a novel approach to the addition of plasticizers for softening TPUs, i.e., lowering the durometer and the melt viscosity. This approach involves incorporating bonded sulfonate groups with quaternary ammonium counterions into the TPU. In one or more embodiments of the present invention, the softening of TPU is achieved by incorporating an ionic diol, such as N,N-bis (2-hydoxyethyl)-2-aminoethane-sulfonic acid (BES), coupled with various bulky alkyl ammonium cations, during the chain extension step of the TPU synthesis. It is believed that that steric hindrance of the bulky quaternary ammonium groups weakens the dipole-dipole interactions of the sulfonate groups and/or lowers the crystallinity of the hard block, thereby creating additional free volume that softens the polymer and lowers the melt viscosity.

10. 外观设计

USD740410S1 Catheter insertion device 有权
标题翻译：导管插入装置
公开(公告)号：USD740410S1
公开(公告)日：2015-10-06
申请号：US29451282
申请日：2013-03-29
申请人： Chris Korkuch , Drew Pieprzyk , Jeff Kuehn , Matthew Becker
设计人： Chris Korkuch , Drew Pieprzyk , Jeff Kuehn , Matthew Becker

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式