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1. 发明授权

US09745414B2 Hyperbranched amino acid-based poly(ester urea)s for regenerative medicine and drug delivery 有权
公开(公告)号：US09745414B2
公开(公告)日：2017-08-29
申请号：US14939216
申请日：2015-11-12
申请人： Matthew Becker , Jiayi Yu
发明人： Matthew Becker , Jiayi Yu
IPC分类号： C08G63/685
CPC分类号： C08G63/685 , C08G83/005
摘要： One or more embodiments of the present invention provide a hyperbranched amino-acid-based PEU polymer for use in regenerative medicine and/or drug delivery applications has tunable mechanical and thermal properties, but is sufficiently stable to permit such things as ethyloxide sterilization without degradation and/or significant loss of function. These hyperbranched amino acid-based poly(ester urea) (PEU) by interfacial polycondensation between linear and branched amino acid-based polyester monomers and a urea forming material such as trisphosgene or phosgene. By controlling the amount of branched monomer incorporated into the copolymer, the mechanical properties and water uptake abilities of the resulting hyperbranched amino acid-based PEUs may be tuned. The hyperbranched PEUs nanofibers are sterilizable with ETO and are stable for long periods of ETO sterilization, elevated temperature and exposure to aqueous environments. In various embodiments, these hyperbranched amino acid-based PEUs are also biodegradable and can be formed into fibers.

2. 发明申请

US20160130390A1 HYPERBRANCHED AMINO ACID-BASED POLY(ESTER UREA)S FOR REGENERATIVE MEDICINE AND DRUG DELIVERY 审中-公开
标题翻译：用于再生医药和药物递送的超级基于氨基酸的聚合物（ESTER UREA）S
公开(公告)号：US20160130390A1
公开(公告)日：2016-05-12
申请号：US14939216
申请日：2015-11-12
申请人： Matthew Becker , Jiayi Yu
发明人： Matthew Becker , Jiayi Yu
IPC分类号： C08G63/685
CPC分类号： C08G63/685 , C08G83/005
摘要： One or more embodiments of the present invention provide a hyperbranched amino-acid-based PEU polymer for use in regenerative medicine and/or drug delivery applications has tunable mechanical and thermal properties, but is sufficiently stable to permit such things as ethyloxide sterilization without degradation and/or significant loss of function. These hyperbranched amino acid-based poly(ester urea) (PEU) by interfacial polycondensation between linear and branched amino acid-based polyester monomers and a urea forming material such as trisphosgene or phosgene. By controlling the amount of branched monomer incorporated into the copolymer, the mechanical properties and water uptake abilities of the resulting hyperbranched amino acid-based PEUs may be tuned. The hyperbranched PEUs nanofibers are sterilizable with ETO and are stable for long periods of ETO sterilization, elevated temperature and exposure to aqueous environments. In various embodiments, these hyperbranched amino acid-based PEUs are also biodegradable and can be formed into fibers.
摘要翻译：本发明的一个或多个实施方案提供了用于再生医学和/或药物递送应用中的超支化氨基酸基PEU聚合物具有可调节的机械和热性质，但是足够稳定以允许诸如乙酸氧化酶灭菌而不降解， /或显着的功能丧失。这些超支化氨基酸基聚（酯脲）（PEU）通过直链和支链氨基酸类聚酯单体之间的界面缩聚和尿素形成材料如三光气或光气。通过控制掺入共聚物中的支化单体的量，可以调节所得到的超支化氨基酸基PEU的机械性能和吸水能力。超支化PEU纳米纤维可以用ETO进行灭菌，对于长时间的ETO灭菌，升高的温度和暴露于水性环境是稳定的。在各种实施方案中，这些基于超支化氨基酸的PEU也是可生物降解的并且可以形成纤维。

3. 发明申请

US20180244821A1 BIOMIMETIC SYNTHETIC RUBBER AND METHODS FOR CONTROLLING ITS PHYSICAL PROPERTIES THROUGH BACKBONE DOUBLE BOND STEREOCHEMISTRY BY MONOMER SELECTION AND END GROUP MODIFICATION 审中-公开
公开(公告)号：US20180244821A1
公开(公告)日：2018-08-30
申请号：US15756256
申请日：2016-08-29
申请人： Matthew L. Becker , Andrew P. Dove , Vinh X. Truong , Craig A. Bell , Ian A. Barker , Jiayi Yu
发明人： Matthew L. Becker , Andrew P. Dove , Vinh X. Truong , Craig A. Bell , Ian A. Barker , Jiayi Yu
IPC分类号： C08F238/00 , C08F2/46 , C08F4/609
CPC分类号： C08F238/00 , C08F2/46 , C08F4/6095 , C08F2500/01 , C08F2500/04 , C08F2500/21 , C08F228/02
摘要： In various embodiments, the present invention provides a strong, synthetic elastomer materials (and related methods for making same) with mechanical properties that are controlled by the stereochemically-defined double bonds within their backbone, yet have physical properties that are derived from monomer selection and defined, modifiable, chain end groups. The use of the organocatalyzed, stereospecific addition of thiols to activated alkynes, affords isolated high molar mass materials (>100 kDa) via step-growth polymerization with high levels of cis- or trans-double bond content. Furthermore, in various aspects of the present invention, it has been found that changing the monomer composition and chain end groups provides additional control over the materials' physical properties to provide more efficient compounding with polar additives. Using this approach to elastomer synthesis, further end group modification and toughening through various vulcanization strategies are also possible.

4. 发明授权

US10968303B2 Biomimetic synthetic rubber and methods for controlling its physical properties through backbone double bond stereochemistry by monomer selection and end group modification 有权
公开(公告)号：US10968303B2
公开(公告)日：2021-04-06
申请号：US15756256
申请日：2016-08-29
申请人： Matthew L. Becker , Andrew P. Dove , Vinh X. Truong , Craig A. Bell , Ian A. Barker , Jiayi Yu
发明人： Matthew L. Becker , Andrew P. Dove , Vinh X. Truong , Craig A. Bell , Ian A. Barker , Jiayi Yu
IPC分类号： C08G75/045 , C08F238/00 , C08F2/46 , C08F4/609
摘要： In various embodiments, the present invention provides a strong, synthetic elastomer materials (and related methods for making same) with mechanical properties that are controlled by the stereochemically-defined double bonds within their backbone, yet have physical properties that are derived from monomer selection and defined, modifiable, chain end groups. The use of the organocatalyzed, stereospecific addition of thiols to activated alkynes, affords isolated high molar mass materials (>100 kDa) via step-growth polymerization with high levels of cis- or trans-double bond content. Furthermore, in various aspects of the present invention, it has been found that changing the monomer composition and chain end groups provides additional control over the materials' physical properties to provide more efficient compounding with polar additives. Using this approach to elastomer synthesis, further end group modification and toughening through various vulcanization strategies are also possible.

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