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1. 发明公开

US20230148372A1 Degradable, Printable Poly(Propylene Fumarate)-Based ABA Triblock Elastomers 审中-公开
公开(公告)号：US20230148372A1
公开(公告)日：2023-05-11
申请号：US17976584
申请日：2022-10-28
申请人： Matthew BECKER , Shannon PETERSEN
发明人： Matthew BECKER , Shannon PETERSEN
IPC分类号： C08G63/60 , C08G63/83 , C09D167/06 , C08G81/00 , C08J3/24 , B33Y70/00
CPC分类号： C08G63/60 , C08G63/83 , C09D167/06 , C08G81/00 , C08J3/24 , B33Y70/00 , C08J2367/02
摘要： In various embodiments, the present invention is directed to ABA triblock copolymers having crosslinkable poly(propylene fumarate A blocks and a more flexible poly(lactone) B block formed by sequential ring-opening polymerization and ring-opening copolymerization. These ABA triblock polymers made using ring-opening polymerization of one or more lactone monomers using a bifunctional initiator to form a poly(lactone) B block having terminal hydroxyl groups and the ring-opening copolymerization of maleic anhydride and propylene oxide followed by isomerization of the maleate double bond using an organic base to form the poly(propylene fumarate)(PPF) A blocks. When crosslinked photochemically using, for example, a continuous liquid interface production digital light processing (DLP) Carbon M2 printer, these ABA type triblock copolymers form durable elastomers with tunable degradation and elastic properties. In various embodiments, these polymers are shown to undergo slow, hydrolytic degradation in vitro with minimal loss of mechanical performance during degradation.

2. 发明授权

US10227440B2 Softening thermoplastic polyurethanes using ionomer technology 有权
公开(公告)号：US10227440B2
公开(公告)日：2019-03-12
申请号：US15166948
申请日：2016-05-27
申请人： Matthew Becker , Robert A. Weiss , Zachary Kurtiss Zander , Don S. Wardius , Karl W. Haider , Bruce D. Lawrey
发明人： Matthew Becker , Robert A. Weiss , Zachary Kurtiss Zander , Don S. Wardius , Karl W. Haider , Bruce D. Lawrey
IPC分类号： C08G18/10 , C08G18/08 , C08G18/60 , C08G18/76 , C08G18/42 , C08G18/44 , C08G18/48
摘要： In one or more embodiments, the present invention provides a novel approach to the addition of plasticizers for softening TPUs, i.e., lowering the durometer and the melt viscosity. This approach involves incorporating bonded sulfonate groups with quaternary ammonium counterions into the TPU. In one or more embodiments of the present invention, the softening of TPU is achieved by incorporating an ionic diol, such as N,N-bis (2-hydoxyethyl)-2-aminoethane-sulfonic acid (BES), coupled with various bulky alkyl ammonium cations, during the chain extension step of the TPU synthesis. It is believed that that steric hindrance of the bulky quaternary ammonium groups weakens the dipole-dipole interactions of the sulfonate groups and/or lowers the crystallinity of the hard block, thereby creating additional free volume that softens the polymer and lowers the melt viscosity.

3. 发明申请

US20170210852A1 DEGRADABLE AMINO ACID-BASED POLY (ESTER UREA) COPOLYMER ADHESIVES 审中-公开
公开(公告)号：US20170210852A1
公开(公告)日：2017-07-27
申请号：US15328983
申请日：2015-07-21
申请人： Matthew BECKER , Jinjun ZHOU , Adrian DEFANTE , Ali DHINOJWALA
发明人： Matthew BECKER , Jinjun ZHOU , Adrian DEFANTE , Ali DHINOJWALA
IPC分类号： C08G71/02 , A61L26/00 , A61Q19/00 , C09J175/02 , A61K8/84
CPC分类号： C08G71/02 , A61K8/0204 , A61K8/84 , A61K8/85 , A61K9/0014 , A61K47/34 , A61K2800/10 , A61L26/0019 , A61Q1/025 , A61Q19/00 , C09J175/02
摘要： The present invention is directed to a novel group of amino acid-based poly(ester urea)s (PEUs) for use in biodegradable adhesive and related methods for their making and use. These novel amino acid-based PEUs have a wide variation in mechanical properties and degradation behavior that can be tuned by varying the amino acids and polyols used to form the polyester monomers that form the PEUs. Importantly, these novel PEUs have been shown to be non-toxic in vitro and in vivo and may be suitable to a wide variety of biomedical and other uses. In some embodiments, the adhesive properties of these degradable amino acid-based poly(ester urea) adhesives has been further improved by the incorporation of controlled amounts of catechol functional groups into the side chains of the PEU via post-polymerization functionalization chemistry.

4. 发明申请

US20160237212A1 METHODS FOR POST-FABRICATION FUNCTIONALIZATION OF POLY(ESTER UREAS) 有权
标题翻译：聚酯（ESTER UREAS）后制备功能化方法
公开(公告)号：US20160237212A1
公开(公告)日：2016-08-18
申请号：US15026069
申请日：2014-09-30
申请人： MATTHEW BECKER , Fei Lin
发明人： MATTHEW BECKER , Fei Lin
IPC分类号： C08G71/02 , C07C247/04 , C07C227/18 , C07C229/34
CPC分类号： C08G71/02 , C07C227/18 , C07C229/34 , C07C247/04 , C07C275/16 , C08G2230/00 , C09D175/02
摘要： Amino acid-based poly(ester urea)s (PEU) are emerging as a class of polymers that have shown promise in regenerative medicine applications. Embodiments of the invention relate to the synthesis of PEUs carrying pendent “clickable” groups on modified tyrosine amino acids. The pendent species include alkyne, azide, alkene, tyrosine-phenol, and ketone groups. PEUs with Mw exceeding 100k Da were obtained via interfacial polycondensation methods and the concentration of pendent groups was varied by copolymerization. The incorporation of derivatizable functionalities is demonstrated using 1H NMR and UV-Vis spectroscopy methods. Electrospinning was used to fabricate PEU nanofibers with a diameters ranging from 350 nm to 500 nm. The nanofiber matricies possess mechanical strengths suitable for tissue engineering (Young's modulus: 300±45 MPa; tensile stress: 8.5±1.2 MPa). A series of bioactive peptides and fluorescent molecules were conjugated to the surface of the nanofibers following electrospinning using bio-orthogonal reactions in aqueous media.
摘要翻译：氨基酸基聚（酯尿素）（PEU）正在出现，这些聚合物在再生医学应用中已显示出希望。本发明的实施方案涉及在修饰的酪氨酸氨基酸上携带侧面的“可点击”基团的PEU的合成。悬挂物种包括炔烃，叠氮化物，烯烃，酪氨酸 - 苯酚和酮基团。通过界面缩聚方法得到Mw超过100kDa的PEU，通过共聚改变侧基的浓度。使用1 H NMR和UV-Vis光谱法证明可衍生化官能度的结合。使用静电纺丝制造直径范围为350nm至500nm的PEU纳米纤维。纳米纤维素材具有适用于组织工程的机械强度（杨氏模量：300±45MPa;拉伸应力：8.5±1.2MPa）。在水性介质中使用生物正交反应进行静电纺丝后，将一系列生物活性肽和荧光分子缀合到纳米纤维的表面。

5. 外观设计

USD740410S1 Catheter insertion device 有权
标题翻译：导管插入装置
公开(公告)号：USD740410S1
公开(公告)日：2015-10-06
申请号：US29451282
申请日：2013-03-29
申请人： Chris Korkuch , Drew Pieprzyk , Jeff Kuehn , Matthew Becker
设计人： Chris Korkuch , Drew Pieprzyk , Jeff Kuehn , Matthew Becker

6. 发明申请

US20150197600A1 POLYMERIC STRUCTURES CONTAINING STRAINED CYCLOALKYNE FUNCTIONALITY FOR POST-FABRICATION AZIDEALKYNE CYCLOADDITION FUNCTIONALIZATION 审中-公开
标题翻译：包含应变循环丝氨酸功能的聚合物结构用于后制备AZIDEALKYNE循环功能化
公开(公告)号：US20150197600A1
公开(公告)日：2015-07-16
申请号：US14418649
申请日：2013-07-31
申请人： Matthew Becker , Jukuan Zheng
发明人： Matthew Becker , Jukuan Zheng
IPC分类号： C08G63/91 , C07C271/34
CPC分类号： C08G63/91 , A61L27/14 , A61L27/38 , A61L2400/12 , C07C271/34 , C08G63/6852 , C08G63/912 , C08G69/10 , C08G69/48 , C08G85/004 , D01F6/60 , D01F6/625 , D06M11/58
摘要： A method of creating biocompatible polymeric structures includes the steps of: providing a biocompatible polymer including a strained cycloalkyne end group; forming a polymeric structure from the biocompatible polymer such that the strained cycloalkyne end group remains on the biocompatible polymer; providing an azide tethered molecule; and, after forming the polymeric structure, reacting the azide tethered molecule with the cycloalkyne in an azide alkyne cycloaddition reaction to further functionalize the polymeric structure.
摘要翻译：制备生物相容性聚合物结构的方法包括以下步骤：提供包含应变环炔端基的生物相容性聚合物; 从所述生物相容性聚合物形成聚合物结构，使得所述应变的环炔基端基保留在所述生物相容性聚合物上; 提供叠氮化物束缚分子; 并且在形成聚合物结构之后，在叠氮化物炔环加成反应中使叠氮化物束缚分子与环炔反应，以使聚合物结构进一步官能化。

7. 发明申请

US20110166938A1 Methods For Advertising 审中-公开
标题翻译：广告方法
公开(公告)号：US20110166938A1
公开(公告)日：2011-07-07
申请号：US12984756
申请日：2011-01-05
申请人： Alexander Deridder , Matthew Becker , Stephen Moore
发明人： Alexander Deridder , Matthew Becker , Stephen Moore
IPC分类号： G06Q30/00
CPC分类号： G06Q30/0261 , G06Q30/02
摘要： A web conversion method based on phone calls is disclosed. Some embodiments comprise distributing a multiplicity of ads across a multiplicity of online media channels, displaying a unique advertiser phone number on each ad for a limited time every time a prospect visits a webpage hosting the ad, determining that the prospect called the advertiser phone number within the limited time, determining that the geographical zone of the prospect at the time of the call encompasses the geographical location of the IP address at where the unique phone number is displayed, and charging an advertiser for the ad that displayed the advertiser phone number.
摘要翻译：公开了一种基于电话呼叫的网页转换方法。一些实施例包括在多个在线媒体频道上分配多个广告，每当潜在客户访问托管广告的网页时，在有限的时间内在每个广告上显示唯一的广告商电话号码，确定潜在客户称广告主电话号码在在有限的时间内，确定呼叫时的潜在客户的地理区域包含显示唯一电话号码所在IP地址的地理位置，并向广告商收取显示广告主电话号码的广告。

8. 发明申请

US20050068885A1 Signal modulation 失效
标题翻译：信号调制
公开(公告)号：US20050068885A1
公开(公告)日：2005-03-31
申请号：US10676565
申请日：2003-09-30
申请人： Matthew Becker , Karl Wyatt
发明人： Matthew Becker , Karl Wyatt
IPC分类号： H04J7/00 , H04L25/49 , H04L25/493 , H03C1/52 , H04J3/02
CPC分类号： H04L25/4917 , H04J7/00 , H04L25/493
摘要： According to an embodiment of the invention, a method and apparatus for signal modulation are described. According to an embodiment of the invention, a method comprises producing and transferring a modulated signal. The modulation of the signal is over a plurality of amplitude levels, including at least a first amplitude level, a second amplitude level and a third amplitude level, and over a plurality of time slots, including at least a first time slot, a second time slot, and a third time slot. The modulated signal transitions from the first amplitude level to the second amplitude level in the first phase slot, remains at the second amplitude level in the second time slot, and transitions from the second amplitude level to the third amplitude level in a third time slot.
摘要翻译：根据本发明的实施例，描述了用于信号调制的方法和装置。根据本发明的实施例，一种方法包括产生和传送调制信号。信号的调制在多个幅度水平上，包括至少第一幅度电平，第二幅度电平和第三幅度电平以及多个时隙，包括至少第一时隙，第二时间插槽和第三个时隙。调制信号从第一相位时隙中的第一幅度电平转换到第二幅度电平在第二时隙中保持在第二幅度电平，并且在第三时隙中从第二幅度电平转变到第三幅度电平。

9. 发明授权

US06701498B2 Black box timing model for latch-based systems 失效
标题翻译：基于闩锁的系统的黑盒时序模型
公开(公告)号：US06701498B2
公开(公告)日：2004-03-02
申请号：US10008930
申请日：2001-11-08
申请人： Matthew Becker , Chen Li Lin
发明人： Matthew Becker , Chen Li Lin
IPC分类号： G06F1750
CPC分类号： G06F17/5031
摘要： A method of creating a black box timing model for a digital circuit. The digital circuit is characterized by a block model having at least one input and at least one output. The method determines a delay statement for the output of the block model. The method also determines an input set-up constraint for the input of the block model. The input set-up constraint is based upon the delay statement. The model is then used with a static timing analyzer to accurately model a flow-through circuit.
摘要翻译：一种为数字电路创建黑匣子时序模型的方法。数字电路的特征在于具有至少一个输入和至少一个输出的块模型。该方法确定块模型的输出的延迟语句。该方法还确定块模型的输入的输入设置约束。输入设置约束基于delay语句。然后将该模型与静态定时分析仪一起使用以精确地建模流通电路。

10. 发明授权

US06611949B2 Path filtering for latch-based systems 有权
标题翻译：基于锁存器的系统的路径过滤
公开(公告)号：US06611949B2
公开(公告)日：2003-08-26
申请号：US10007560
申请日：2001-11-08
申请人： Matthew Becker , Eileen You
发明人： Matthew Becker , Eileen You
IPC分类号： G06F945
CPC分类号： G06F17/5031
摘要： A method and a system for static timing analysis of a latch-based circuit. A netlist data structure represents the latch-based circuit. The method statically analyzes the netlist data structure and produces timing information for signal paths within the latch-based circuit. The signal paths are filtered using path termination information, which specifies where paths end. The path termination information distinguishes a first signal path that terminates at a latch from a second signal path that flows through that same latch.
摘要翻译：一种用于基于锁存器电路的静态时序分析的方法和系统。网表数据结构表示基于锁存器的电路。该方法静态分析网表数据结构，并为基于锁存器的电路中的信号路径产生定时信息。使用路径终止信息来过滤信号路径，该信息指定路径在哪里结束。路径终止信息区分在锁存器处终止的第一信号路径与流过同一锁存器的第二信号路径。

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