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    • 1. 发明授权
    • Peptides and processes for producing cyclic peptides
    • 肽和制备环肽的方法
    • US5428129A
    • 1995-06-27
    • US726843
    • 1991-07-08
    • Masutaka OhsakiSatoshi KishidaTakashi Inoue
    • Masutaka OhsakiSatoshi KishidaTakashi Inoue
    • C07K1/02C07K1/04C07K7/02C07K7/56C07K14/585
    • C07K14/585Y02P20/55
    • In this invention, a peptide of the following general formula is subjected to cyclization reaction to produce a cyclic peptide, preferably a synthetic calcitonin derivative (elcatonin) which is a useful medicine. ##STR1## (wherein A and B form a peptide of the formula Ser-Asn-Leu-Ser-Thr (SEQ ID NO: 47); X means a hydroxyl group, a carboxy-protecting group, an amino acid residue or a peptide residue; provided that the side-chain carboxyl group of .alpha.-L-aminosuberic acid is condensed with an amino acid or a peptide).The cyclic peptide can be obtained by subjecting a peptide of the above general formula to (1) cyclization reaction by chemical condensation, (2) cyclization reaction in the presence of an alkali metal salt and (3) reactions using the techniques of liquid phase synthesis and solid phase synthesis in combination.
    • 在本发明中,使下述通式的肽进行环化反应,生成作为有用药物的环状肽,优选合成降钙素衍生物(依卡曲宁)。 (其中A和B形成式Ser-Asn-Leu-Ser-Thr(SEQ ID NO:47)的肽; X表示羟基,羧基保护基,氨基酸残基或肽 残基;条件是α-L-氨基苏木酸的侧链羧基与氨基酸或肽缩合)。 环状肽可以通过使上述通式的肽进行化学缩合的(1)环化反应,(2)在碱金属盐的存在下的环化反应和(3)使用液相合成技术的反应来获得 和固相合成。
    • 2. 发明授权
    • Peptides and processes for producing cyclic peptides
    • 肽和制备环肽的方法
    • US5508382A
    • 1996-04-16
    • US83217
    • 1993-06-28
    • Masutaka OhsakiSatoshi KishidaTakashi Inoue
    • Masutaka OhsakiSatoshi KishidaTakashi Inoue
    • C07K1/02C07K1/04C07K7/02C07K7/56C07K14/585
    • C07K14/585Y02P20/55
    • A peptide of the following general formula is subjected to cyclization reaction to produce a cyclic peptide, preferably a synthetic calcitonin derivative (elcatonin) which is a useful medicine. ##STR1## (wherein A and B form a peptide of the formula Ser-Asn-Leu-Ser-Thr (SEQ ID NO: 43); X means a hydroxyl group, a carboxy-protecting group, an amino acid residue or a peptide residue; provided that the side-chain carboxyl group of .alpha.-L-aminosuberic acid is condensed with an amino acid or a peptide). The cyclic peptide can be obtained by subjecting a peptide of the above general formula to (1) cyclization reaction by chemical condensation, (2) cyclization reaction in the presence of an alkali metal salt and (3) reactions using the techniques of liquid phase synthesis and solid phase synthesis in combination.
    • 将下述通式的肽进行环化反应,生成环状肽,优选为有用药物的合成降钙素衍生物(依卡宁)。 (其中A和B形成式Ser-Asn-Leu-Ser-Thr(SEQ ID NO:43)的肽; X表示羟基,羧基保护基,氨基酸残基或肽 残基;条件是α-L-氨基苏木酸的侧链羧基与氨基酸或肽缩合)。 环状肽可以通过使上述通式的肽进行化学缩合的(1)环化反应,(2)在碱金属盐的存在下的环化反应和(3)使用液相合成技术的反应来获得 和固相合成。
    • 10. 发明授权
    • Semiconductor device using a group III nitride-based semiconductor
    • 使用III族氮化物基半导体的半导体器件
    • US08674407B2
    • 2014-03-18
    • US12919640
    • 2009-03-12
    • Yuji AndoYasuhiro OkamotoKazuki OtaTakashi InoueTatsuo NakayamaHironobu Miyamoto
    • Yuji AndoYasuhiro OkamotoKazuki OtaTakashi InoueTatsuo NakayamaHironobu Miyamoto
    • H01L29/66
    • H01L29/7783H01L29/2003H01L29/4236H01L29/518H01L29/7785
    • The present invention provides a semiconductor device having such a structure formed by sequentially laminating a lower barrier layer composed of lattice-relaxed AlxGa1-xN (0≦x≦1), a channel layer composed of InyGa1-yN (0≦y≦1) with compressive strain and a contact layer composed of AlzGa1-zN (0≦z≦1), wherein a two-dimensional electron gas is produced in the vicinity of an interface of said InyGa1-yN channel layer with said AlzGa1-zN contact layer; a gate electrode is formed so as to be embedded in the recessed portion with intervention of an insulating film, which recessed portion is formed by removing a part of said AlzGa1-zN contact layer by etching it away until said InyGa1-yN channel layer is exposed; and, ohmic electrodes are formed on the AlzGa1-zN contact layer. Thus, the semiconductor device has superior uniformity and reproducibility of the threshold voltage while maintaining a low gate leakage current, and is also applicable to the enhancement mode type.
    • 本发明提供一种具有这样的结构的半导体器件,该半导体器件通过依次层叠由晶格弛豫的Al x Ga 1-x N(0 @ x @ 1)构成的下阻挡层,由InyGa1-yN(0 @ y @ 1) 具有压应变和由Al z Ga 1-z N(0 @ z @ 1)组成的接触层,其中在所述In y Ga 1-y N沟道层与所述Al z Ga 1-z N接触层的界面附近产生二维电子气; 通过介入绝缘膜形成嵌入在凹陷部分中的栅电极,该凹陷部分通过蚀刻除去所述AlzGa1-zN接触层的一部分而形成,直到所述In y Ga 1-y N沟道层暴露 ; 并且在AlzGa1-zN接触层上形成欧姆电极。 因此,半导体器件在保持低栅极漏电流的同时具有优异的阈值电压的均匀性和再现性,并且也适用于增强型。