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1. 发明授权

US5428129A Peptides and processes for producing cyclic peptides 失效
标题翻译：肽和制备环肽的方法
公开(公告)号：US5428129A
公开(公告)日：1995-06-27
申请号：US726843
申请日：1991-07-08
申请人： Masutaka Ohsaki , Satoshi Kishida , Takashi Inoue
发明人： Masutaka Ohsaki , Satoshi Kishida , Takashi Inoue
IPC分类号： C07K1/02 , C07K1/04 , C07K7/02 , C07K7/56 , C07K14/585
CPC分类号： C07K14/585 , Y02P20/55
摘要： In this invention, a peptide of the following general formula is subjected to cyclization reaction to produce a cyclic peptide, preferably a synthetic calcitonin derivative (elcatonin) which is a useful medicine. ##STR1## (wherein A and B form a peptide of the formula Ser-Asn-Leu-Ser-Thr (SEQ ID NO: 47); X means a hydroxyl group, a carboxy-protecting group, an amino acid residue or a peptide residue; provided that the side-chain carboxyl group of .alpha.-L-aminosuberic acid is condensed with an amino acid or a peptide).The cyclic peptide can be obtained by subjecting a peptide of the above general formula to (1) cyclization reaction by chemical condensation, (2) cyclization reaction in the presence of an alkali metal salt and (3) reactions using the techniques of liquid phase synthesis and solid phase synthesis in combination.
摘要翻译：在本发明中，使下述通式的肽进行环化反应，生成作为有用药物的环状肽，优选合成降钙素衍生物（依卡曲宁）。（其中A和B形成式Ser-Asn-Leu-Ser-Thr（SEQ ID NO：47）的肽; X表示羟基，羧基保护基，氨基酸残基或肽残基;条件是α-L-氨基苏木酸的侧链羧基与氨基酸或肽缩合）。环状肽可以通过使上述通式的肽进行化学缩合的（1）环化反应，（2）在碱金属盐的存在下的环化反应和（3）使用液相合成技术的反应来获得和固相合成。

2. 发明授权

US5508382A Peptides and processes for producing cyclic peptides 失效
标题翻译：肽和制备环肽的方法
公开(公告)号：US5508382A
公开(公告)日：1996-04-16
申请号：US83217
申请日：1993-06-28
申请人： Masutaka Ohsaki , Satoshi Kishida , Takashi Inoue
发明人： Masutaka Ohsaki , Satoshi Kishida , Takashi Inoue
IPC分类号： C07K1/02 , C07K1/04 , C07K7/02 , C07K7/56 , C07K14/585
CPC分类号： C07K14/585 , Y02P20/55
摘要： A peptide of the following general formula is subjected to cyclization reaction to produce a cyclic peptide, preferably a synthetic calcitonin derivative (elcatonin) which is a useful medicine. ##STR1## (wherein A and B form a peptide of the formula Ser-Asn-Leu-Ser-Thr (SEQ ID NO: 43); X means a hydroxyl group, a carboxy-protecting group, an amino acid residue or a peptide residue; provided that the side-chain carboxyl group of .alpha.-L-aminosuberic acid is condensed with an amino acid or a peptide). The cyclic peptide can be obtained by subjecting a peptide of the above general formula to (1) cyclization reaction by chemical condensation, (2) cyclization reaction in the presence of an alkali metal salt and (3) reactions using the techniques of liquid phase synthesis and solid phase synthesis in combination.
摘要翻译：将下述通式的肽进行环化反应，生成环状肽，优选为有用药物的合成降钙素衍生物（依卡宁）。（其中A和B形成式Ser-Asn-Leu-Ser-Thr（SEQ ID NO：43）的肽; X表示羟基，羧基保护基，氨基酸残基或肽残基;条件是α-L-氨基苏木酸的侧链羧基与氨基酸或肽缩合）。环状肽可以通过使上述通式的肽进行化学缩合的（1）环化反应，（2）在碱金属盐的存在下的环化反应和（3）使用液相合成技术的反应来获得和固相合成。

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