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1. 发明授权

US06242565B1 Method for preparing a peptide derivative, and intermediates for the preparation of the peptide derivative, and method for preparing the intermediates 失效
标题翻译：制备肽衍生物的方法和用于制备肽衍生物的中间体及其制备方法
公开(公告)号：US06242565B1
公开(公告)日：2001-06-05
申请号：US09129644
申请日：1998-08-05
申请人： Satoshi Kishida , Akihiro Nakanishi , Hitoshi Kimura
发明人： Satoshi Kishida , Akihiro Nakanishi , Hitoshi Kimura
IPC分类号： C02K500
CPC分类号： C07K7/16 , Y02P20/55
摘要： A method for preparing a peptide derivative of formula (I) or a salt thereof: which method comprises the steps of removing two MBzl groups from a compound of formula (II) or a salt thereof: wherein MBzl represents a 4-methoxybenzyl group which serves as a protective group for a thiol group, and R1 and R2 represent hydrogen or a protective group for Trp or Arg respectively; and subsequently oxidizing in an aqueous medium having a pH from 4 to 6 to form an intramolecular disulphide bond; intermediates useful for preparing the compounds of formula (I) and preparation of the intermediates.
摘要翻译：制备式（I）的肽衍生物或其盐的方法：该方法包括从式（II）化合物或其盐除去两个MBz1基团的步骤：其中，MBz1表示服用的4-甲氧基苄基作为硫醇基的保护基，R1和R2分别表示氢或Trp或Arg的保护基; 随后在pH为4〜6的水性介质中氧化，形成分子内二硫键; 可用于制备式（I）化合物和中间体的制备的中间体。

2. 发明申请

US20100013825A1 DISPLAY DEVICE AND METHOD FOR DRIVING THE DISPLAY DEVICE 审中-公开
标题翻译：用于驱动显示装置的显示装置和方法
公开(公告)号：US20100013825A1
公开(公告)日：2010-01-21
申请号：US12528276
申请日：2007-03-14
申请人： Hiroyuki Takahashi , Satoshi Kishida , Yoshimasa Kaneko
发明人： Hiroyuki Takahashi , Satoshi Kishida , Yoshimasa Kaneko
IPC分类号： G09G5/00 , G09G3/30
CPC分类号： G09G3/3216 , G09G3/3266 , G09G2310/0251
摘要： This invention provides a display device constituted of a display panel in which pixels including light-emitting elements E11 to Emn are connected in the form of a matrix at each intersection between a plurality of data lines A1 to Am and a plurality of scan lines K1 to Kn, a scan driver connected to the scan lines and selectively scanning each of the scan lines, and a data driver supplying a display signal to each of the pixels.Timings of charging and discharging a charge, charged and discharged in a parasitic capacitance of each of the light emitting elements, are dispersed, and a level of radiation noise generated at this time can be reduced.
摘要翻译：本发明提供一种显示装置，其由显示面板构成，其中包括发光元件E11至Emn的像素以矩阵的形式连接在多条数据线A1至Am与多条扫描线K1至 Kn，连接到扫描线并选择性地扫描每条扫描线的扫描驱动器，以及向每个像素提供显示信号的数据驱动器。对每个发光元件的寄生电容进行充电和放电的充电和放电的定时分散，并且可以减少此时产生的辐射噪声水平。

3. 发明授权

US5508382A Peptides and processes for producing cyclic peptides 失效
标题翻译：肽和制备环肽的方法
公开(公告)号：US5508382A
公开(公告)日：1996-04-16
申请号：US83217
申请日：1993-06-28
申请人： Masutaka Ohsaki , Satoshi Kishida , Takashi Inoue
发明人： Masutaka Ohsaki , Satoshi Kishida , Takashi Inoue
IPC分类号： C07K1/02 , C07K1/04 , C07K7/02 , C07K7/56 , C07K14/585
CPC分类号： C07K14/585 , Y02P20/55
摘要： A peptide of the following general formula is subjected to cyclization reaction to produce a cyclic peptide, preferably a synthetic calcitonin derivative (elcatonin) which is a useful medicine. ##STR1## (wherein A and B form a peptide of the formula Ser-Asn-Leu-Ser-Thr (SEQ ID NO: 43); X means a hydroxyl group, a carboxy-protecting group, an amino acid residue or a peptide residue; provided that the side-chain carboxyl group of .alpha.-L-aminosuberic acid is condensed with an amino acid or a peptide). The cyclic peptide can be obtained by subjecting a peptide of the above general formula to (1) cyclization reaction by chemical condensation, (2) cyclization reaction in the presence of an alkali metal salt and (3) reactions using the techniques of liquid phase synthesis and solid phase synthesis in combination.
摘要翻译：将下述通式的肽进行环化反应，生成环状肽，优选为有用药物的合成降钙素衍生物（依卡宁）。（其中A和B形成式Ser-Asn-Leu-Ser-Thr（SEQ ID NO：43）的肽; X表示羟基，羧基保护基，氨基酸残基或肽残基;条件是α-L-氨基苏木酸的侧链羧基与氨基酸或肽缩合）。环状肽可以通过使上述通式的肽进行化学缩合的（1）环化反应，（2）在碱金属盐的存在下的环化反应和（3）使用液相合成技术的反应来获得和固相合成。

4. 发明授权

US5428129A Peptides and processes for producing cyclic peptides 失效
标题翻译：肽和制备环肽的方法
公开(公告)号：US5428129A
公开(公告)日：1995-06-27
申请号：US726843
申请日：1991-07-08
申请人： Masutaka Ohsaki , Satoshi Kishida , Takashi Inoue
发明人： Masutaka Ohsaki , Satoshi Kishida , Takashi Inoue
IPC分类号： C07K1/02 , C07K1/04 , C07K7/02 , C07K7/56 , C07K14/585
CPC分类号： C07K14/585 , Y02P20/55
摘要： In this invention, a peptide of the following general formula is subjected to cyclization reaction to produce a cyclic peptide, preferably a synthetic calcitonin derivative (elcatonin) which is a useful medicine. ##STR1## (wherein A and B form a peptide of the formula Ser-Asn-Leu-Ser-Thr (SEQ ID NO: 47); X means a hydroxyl group, a carboxy-protecting group, an amino acid residue or a peptide residue; provided that the side-chain carboxyl group of .alpha.-L-aminosuberic acid is condensed with an amino acid or a peptide).The cyclic peptide can be obtained by subjecting a peptide of the above general formula to (1) cyclization reaction by chemical condensation, (2) cyclization reaction in the presence of an alkali metal salt and (3) reactions using the techniques of liquid phase synthesis and solid phase synthesis in combination.
摘要翻译：在本发明中，使下述通式的肽进行环化反应，生成作为有用药物的环状肽，优选合成降钙素衍生物（依卡曲宁）。（其中A和B形成式Ser-Asn-Leu-Ser-Thr（SEQ ID NO：47）的肽; X表示羟基，羧基保护基，氨基酸残基或肽残基;条件是α-L-氨基苏木酸的侧链羧基与氨基酸或肽缩合）。环状肽可以通过使上述通式的肽进行化学缩合的（1）环化反应，（2）在碱金属盐的存在下的环化反应和（3）使用液相合成技术的反应来获得和固相合成。

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