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1. 发明授权

US06923246B2 Billet, horizontal continuous casting process, and thixocasting process 失效
标题翻译：坯料，水平连续铸造工艺和触媒工艺
公开(公告)号：US06923246B2
公开(公告)日：2005-08-02
申请号：US10401044
申请日：2003-03-28
申请人： Masayuki Tsuchiya , Hiroaki Ueno , Yasushi Fujinaga , Chiaki Ushigome , Susumu Nishikawa
发明人： Masayuki Tsuchiya , Hiroaki Ueno , Yasushi Fujinaga , Chiaki Ushigome , Susumu Nishikawa
IPC分类号： B22D11/00 , B22D11/14 , B22D17/00
CPC分类号： B22D11/143 , B22D11/00 , B22D17/007
摘要： A billet for a thixocasting process and a thixocasting process using the billet allows casting using a thixocasting process to be realized at low production cost without permeation of an oxide film to the inside of the billet in injection molding. In a billet used for a thixocasting process continuously cast by intermittently drawing out, the interval of the oscillation marks is 10 mm or less and the maximum tilt angle of the oscillation marks relative to a cross section which is at a right angle to the drawing out direction is 45° or less.
摘要翻译：用于触变工艺的坯料和使用该坯料的触变工艺允许使用触媒工艺进行铸造，以低生产成本实现，而不会在注射成型中将氧化膜渗透到坯料的内部。在用于通过间歇抽出连续铸造的触媒处理的坯料中，振动标记的间隔为10mm以下，振动标记相对于与拉拔成直角的截面的最大倾斜角方向为45°以下。

2. 发明授权

US06810941B2 Injection mold for semi-solidified Fe alloy 有权
标题翻译：半固态Fe合金注塑模具
公开(公告)号：US06810941B2
公开(公告)日：2004-11-02
申请号：US10158580
申请日：2002-05-30
申请人： Masayuki Tsuchiya , Hiroaki Ueno , Isamu Takagi , Naokuni Muramatsu , Masato Yasuda
发明人： Masayuki Tsuchiya , Hiroaki Ueno , Isamu Takagi , Naokuni Muramatsu , Masato Yasuda
IPC分类号： B22C300
CPC分类号： B22D17/2209 , B22D17/007
摘要： An injection mold for casting a semi-solidified Fe alloy includes a scalping gate for eliminating surface oxide film of a semi-solidified Fe alloy injected into the mold cavity from a pressure chamber. The scalping gate is arranged between the pressure chamber and a runner that is in communication with the mold cavity. The mold halves and the scalping gate are each formed of a copper alloy having a thermal conductivity of not less than 120 W/(m·K) and a hardness of not less than 180 HB. The mold halves and the scalping gate each have a cermet layer consisting essentially of at least one member selected from a group consisting of Co, Cu, Cr and Ni. The cermet layer is formed by electro-spark deposition, via an intermediate layer of Ni alloy, which is also formed by electro-spark deposition.
摘要翻译：用于铸造半固化Fe合金的注射模具包括用于消除从压力室注入到模腔中的半固化Fe合金的表面氧化膜的刮刀。烫平门布置在压力室和与模腔连通的转轮之间。半模和烫金闸门均由热导率不低于120W /（m.K），硬度不低于180HB的铜合金形成。模具半部和剥皮门各自具有金属陶瓷层，金属陶瓷层基本上由选自Co，Cu，Cr和Ni中的至少一种构成。金属陶瓷层通过电火花沉积，通过也由电火花沉积形成的Ni合金中间层形成。

3. 发明授权

US06616777B1 Fe alloy material for thixocasting and method for heating the same 有权
标题翻译： Fe合金材料用于触媒和加热它的方法
公开(公告)号：US06616777B1
公开(公告)日：2003-09-09
申请号：US09508458
申请日：2000-03-10
申请人： Masayuki Tsuchiya , Hiroaki Ueno
发明人： Masayuki Tsuchiya , Hiroaki Ueno
IPC分类号： C22C3700
CPC分类号： C21D6/008 , B22D17/007 , C21D6/00 , C22C37/10 , C22C38/02 , C22C38/04 , C22C38/08
摘要： A thixocast Fe-based alloy material is provided, from which a cast product having mechanical properties uniform over the whole thereof can be produced. The Fe-based alloy material comprises 1.8% by weight≦C≦2.5% by weight, 1.0% by weight≦Si≦3.0% by weight, 0.1% by weight≦Mn≦1.5% by weight, 0.5% by weight≦Ni≦3.0% by weight, and as the balance, iron (Fe) including inevitable impurities. The eutectic crystal amount Ec is in a range of 10% by weight
摘要翻译：提供了一种触变Fe基合金材料，由此可以生产出具有整体机械性能均匀的铸造产品.Fe基合金材料包含1.8重量％<= C <2.5重量％，1.0 重量百分比<= Si <= 3.0％重量，0.1％（重量）<= Mn <= 1.5％（重量），0.5％（重量）

4. 发明申请

US20070012415A1 Cast-iron thixocasting apparatus and method 审中-公开
标题翻译：铸铁触媒装置及方法
公开(公告)号：US20070012415A1
公开(公告)日：2007-01-18
申请号：US10569511
申请日：2004-08-24
申请人： Masayuki Tsuchiya , Hiroaki Ueno , Chiaki Ushigome , Toshiro Maekawa , Syuichi Shikai
发明人： Masayuki Tsuchiya , Hiroaki Ueno , Chiaki Ushigome , Toshiro Maekawa , Syuichi Shikai
IPC分类号： B22D17/10
CPC分类号： B22C9/06 , B22D17/007
摘要： Disclosed is an apparatus for and a method of thixocasting a cast iron, that can effectively prevent the scale from mixing in the die (cavity) thereby to obtain sound iron castings having good mechanical properties. The apparatus includes at least a pair of dies that can freely opened and closed to define a cavity to be filled under a pressure, and an injector that injects the semi-molten iron into the cavity through a hole in a gate at the entry of the cavity so as to throttle the entry. The gate is a separate member disposed at the entry of the cavity every time an injection casting operation is carried out and is taken out together with the casting after the injection casting operation.
摘要翻译：本发明公开了一种能够有效地防止鳞片在模具（空腔）中混合从而获得具有良好机械性能的铁铸件的铸铁镶嵌装置和方法。该装置包括至少一对可以自由地打开和关闭以限定要在压力下填充的空腔的模具;以及喷射器，其通过门中的孔将半熔融铁注入空腔中以便节流入口。闸门是每次执行注射操作时设置在空腔入口处的单独构件，并且在注射铸造操作之后与铸件一起取出。

5. 发明授权

US06863744B2 Iron based alloy material for thixocasting process and method for casting the same 有权
标题翻译：用于触变过程的铁基合金材料及其铸造方法
公开(公告)号：US06863744B2
公开(公告)日：2005-03-08
申请号：US10235855
申请日：2002-09-06
申请人： Masayuki Tsuchiya , Hiroaki Ueno
发明人： Masayuki Tsuchiya , Hiroaki Ueno
IPC分类号： B22D18/02 , B22D17/00 , C22C1/00 , C22C33/08 , C22C37/06 , C22C37/10 , C22C38/00 , C22C38/02 , C22C38/36 , C22C38/34
CPC分类号： C22C33/08 , B22D17/007 , C22C1/005 , C22C37/06 , C22C37/10
摘要： An iron based alloy material for a thixocasting process and a method for casting the material which extends the service life of dies by inhibiting solidification contraction, and in which casting defects such as size variations and cracks can be inhibited. The material comprises 1.6 wt %≦C≦2.5 wt % and 3.0 wt %
摘要翻译：用于触变过程的铁基合金材料和通过抑制凝固收缩延长模具使用寿命的铸造材料的方法，并且其中可以抑制诸如尺寸变化和裂纹的铸造缺陷。该材料包含1.6重量％<= C <= 2.5重量％和3.0重量％

6. 发明公开

US20240165978A1 PRINTING APPARATUS, PRINTING SYSTEM, PRINTING METHOD, AND NON-TRANSITORY RECORDING MEDIUM 审中-公开
公开(公告)号：US20240165978A1
公开(公告)日：2024-05-23
申请号：US18460013
申请日：2023-09-01
申请人： Jun Hitosugi , Masayuki Tsuchiya , Yoshihito Tsuboi , Kenji Ishii
发明人： Jun Hitosugi , Masayuki Tsuchiya , Yoshihito Tsuboi , Kenji Ishii
IPC分类号： B41J29/19
CPC分类号： B41J29/19
摘要： A printing apparatus includes a print execution device and an illumination device. The print execution device includes a plurality of heads to print an image on a print medium based on print data. The illumination device irradiates the printed image on the print medium with illumination light from behind a printed face of the print medium.

7. 发明授权

US08946386B2 Proteins expressed in NK cells 有权
标题翻译：在NK细胞中表达的蛋白质
公开(公告)号：US08946386B2
公开(公告)日：2015-02-03
申请号：US10574045
申请日：2004-09-29
申请人： Kouji Matsushima , Shinichi Hashimoto , Masayuki Tsuchiya , Yuichi Hirata , Kenji Yoshida , Kazuyuki Ojima
发明人： Kouji Matsushima , Shinichi Hashimoto , Masayuki Tsuchiya , Yuichi Hirata , Kenji Yoshida , Kazuyuki Ojima
IPC分类号： A61K38/17 , C07K14/705 , A61K31/00 , G01N33/564 , G01N33/566
CPC分类号： C07K14/705 , A61K31/00 , G01N33/564 , G01N33/566 , G01N2500/00
摘要： Purified immunocytes were analyzed for expression frequencies, and the NKIR gene expressed specifically in natural killer (NK) cells was successfully identified. The NKIR gene encodes a receptor. Agonists and antagonists for the receptor can be identified by using the receptor.
摘要翻译：分析纯化的免疫细胞的表达频率，并且成功鉴定了在自然杀伤（NK）细胞中特异表达的NKIR基因。 NKIR基因编码受体。用于受体的激动剂和拮抗剂可以通过使用受体来鉴定。

8. 发明授权

US08257703B2 Anti-ganglioside antibodies and compositions 有权
标题翻译：抗神经节苷脂抗体及组合物
公开(公告)号：US08257703B2
公开(公告)日：2012-09-04
申请号：US12727162
申请日：2010-03-18
申请人： Reiko Irie , Hiroyuki Tsunoda , Tomoyuki Igawa , Yasuo Sekimori , Masayuki Tsuchiya
发明人： Reiko Irie , Hiroyuki Tsunoda , Tomoyuki Igawa , Yasuo Sekimori , Masayuki Tsuchiya
IPC分类号： A61K39/395
CPC分类号： C07K16/3084 , C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/734 , G01N33/6854 , G01N33/686
摘要： IgM can be obtained in the form of a pentamer by placing the genes encoding the H, L, and J chains on the same vector to transform appropriate host cells. The gene encoding the J chain may be introduced by co-transfection. When no J chain is expressed, the IgM is produced as a hexamer. The transformants obtained according to the present invention achieve a high yield of IgM. The present invention also provides methods which enable separation and quantification of polymeric IgM.
摘要翻译：通过将编码H，L和J链的基因置于相同载体上以转化合适的宿主细胞，可以以五聚体的形式获得IgM。编码J链的基因可以通过共转染来引入。当没有J链表达时，IgM作为六聚体产生。根据本发明获得的转化体获得高产量的IgM。本发明还提供能够分离和定量聚合物IgM的方法。

9. 发明申请

US20120156724A1 HUMANIZED ANTI-CD47 ANTIBODY 有权
标题翻译：人类抗CD47抗体
公开(公告)号：US20120156724A1
公开(公告)日：2012-06-21
申请号：US13329658
申请日：2011-12-19
申请人： Yasufumi Kikuchi , Shinsuke Uno , Yasuko Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
发明人： Yasufumi Kikuchi , Shinsuke Uno , Yasuko Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
IPC分类号： C12P21/00 , C12N15/63 , C12N1/19 , C12N5/10 , C12N1/15 , C12N15/13 , C12N1/21
CPC分类号： C07K16/2803 , C07K2317/24 , C07K2317/50 , C07K2317/73
摘要： The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between diabody-forming fragments; genes encoding any one of said antibodies; vectors containing said genes; host cells containing said vectors; processes for preparing antibodies comprising the step of culturing said host cells; and therapeutic agents for hematological disorders comprising said antibodies.
摘要翻译：本发明涉及与CD47结合的人源化抗体; 结合人CD47的双抗体，其特征在于二糖键存在于形成双抗体的片段之间; 编码任何一种所述抗体的基因; 含有所述基因的载体; 含有所述载体的宿主细胞; 制备抗体的方法包括培养所述宿主细胞的步骤; 和包含所述抗体的血液病症治疗剂。

10. 发明授权

US08008076B2 Method of producing a nucleic acid encoding an antibody 失效
标题翻译：生产编码抗体的核酸的方法
公开(公告)号：US08008076B2
公开(公告)日：2011-08-30
申请号：US11587701
申请日：2005-04-27
申请人： Masayuki Tsuchiya , Masami Suzuki , Kenji Yoshida , Etsuko Fujii , Miho Watanabe , Koichi Matsubara , Yu Jau Chen , Juliana Sim
发明人： Masayuki Tsuchiya , Masami Suzuki , Kenji Yoshida , Etsuko Fujii , Miho Watanabe , Koichi Matsubara , Yu Jau Chen , Juliana Sim
IPC分类号： C12N15/63 , C12N5/06 , C12N1/20 , C07H21/04
CPC分类号： A01K67/027 , A01K2267/01 , A61K35/16 , C07K16/00 , C07K16/30
摘要： An objective of the present invention is to facilitate the acquisition of antibody-producing cells that are infiltrating virus-infected cells, cancer cells, abnormal cells forming a benign hyperplasia, and the like, and to improve the efficiency of the production of antibodies as well as nucleic acids encoding them from the antibody-producing cells.The present inventors discovered that, when cancer tissues comprising infiltrating lymphocytes are transplanted into highly immunodeficient animals that do not have T cells, B cells, and NK cells and further exhibit a low IFN production ability, the differentiation and proliferation of infiltrating lymphocytes are unexpectedly promoted, and the number of plasma cells that produce antibodies recognizing cancer tissues increases dramatically, plasma cells can be separated easily, and antibodies or nucleic acids encoding them can be easily prepared from the plasma cells.
摘要翻译：本发明的目的是便于获得渗透病毒感染细胞的抗体产生细胞，癌细胞，形成良性增生的异常细胞等，以及提高抗体生产的效率作为从抗体产生细胞编码它们的核酸。本发明人发现，当将包含浸润性淋巴细胞的癌组织移植到不具有T细胞，B细胞和NK细胞的高度免疫缺陷的动物中并且进一步表现出低的IFN产生能力时，意外地促进了浸润性淋巴细胞的分化和增殖并且产生识别癌组织的抗体的浆细胞的数量急剧增加，可以容易地分离浆细胞，并且可以容易地从浆细胞制备抗体或编码它们的核酸。

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