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    • 8. 发明申请
    • OPTICALLY ACTIVE 2,2'-BIPHENOL DERIVATIVE AND PRODUCTION METHOD OF SAME
    • 具有活性的2,2'-联苯酚衍生物及其制备方法
    • US20100280284A1
    • 2010-11-04
    • US12811805
    • 2009-01-06
    • Yoshikazu ItoYasushi KubotaTsutomu Inoue
    • Yoshikazu ItoYasushi KubotaTsutomu Inoue
    • C07C39/15
    • C07B57/00C07B2200/07C07C37/00C07C37/11C07C37/50C07C39/367C07C39/15
    • An optically active 2,2′-biphenol derivative and a production method that enables simple and efficient production of this compound. More specifically, an optically active biphenol derivative represented by the following formulas (1) and (2), a method for optically resolving a biphenol derivative represented by formula (2′), a production method of an optically active biphenol derivative (1) comprising a step for reacting a Brønsted acid with a biphenol derivative (2), and a production method of an optically active biphenol derivative (3) comprising a step for reacting a Lewis acid with an optically active biphenol derivative (1) or an optically active biphenol derivative (2). In the following formulas, R represents, for example, a primary or secondary alkyl group having 1 to 10 carbon atoms, * represents an axially asymmetric center, X represents a halogen atom, and R2 represents a tertiary alkyl group having 4 to 6 carbon atoms.
    • 一种光学活性的2,2'-联苯酚衍生物和能够简单且有效地生产该化合物的制备方法。 更具体地,由下式(1)和(2)表示的光学活性联苯酚衍生物,用于光学拆分由式(2')表示的联苯酚衍生物的方法,光学活性联苯酚衍生物(1)的制备方法,包括 将布朗斯台德酸与联苯酚衍生物(2)反应的步骤和光学活性联苯酚衍生物(3)的制备方法,其包括使路易斯酸与光学活性联苯酚衍生物(1)或光学活性联苯酚 衍生物(2)。 在下式中,R表示例如碳原子数1〜10的伯或仲烷基,*表示轴向不对称中心,X表示卤素原子,R 2表示碳原子数4〜6的叔烷基 。