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1. 发明申请

US20130168547A1 Time-Of-Flight Mass Spectrometer 有权
标题翻译：飞行时间质谱仪
公开(公告)号：US20130168547A1
公开(公告)日：2013-07-04
申请号：US13821202
申请日：2011-09-06
申请人： Masaru Nishiguchi , Shinji Miyauchi , Yoshihiro Ueno
发明人： Masaru Nishiguchi , Shinji Miyauchi , Yoshihiro Ueno
IPC分类号： H01J49/40
CPC分类号： H01J49/405
摘要： Provided is a time-of-flight mass spectrometer having a reflectron which eliminates energy dependency of the flight time of ions having the same m/z while ensuring a high degree of design freedom. An electric field created by the reflectron is virtually divided into a decelerating region for decelerating ions and a reflecting region for reflecting ions. For an ion having a mass-to-charge ratio which has departed with initial energy higher than Ud, the total flight time required for the ion to travel through a free-flight region and the decelerating region into the reflecting region and return will be equal to the total flight time required for an ion of the same mass-to-charge ratio to make a round trip in which the ion turns around at a point of the reference potential value at the boundary between the decelerating region and the reflecting region or in the decelerating region.
摘要翻译：提供了具有反射器的飞行时间质谱仪，其消除具有相同m / z的离子的飞行时间的能量依赖性，同时确保高度的设计自由度。由反射镜产生的电场实际上被分成用于使离子减速的减速区域和用于反射离子的反射区域。对于具有高于Ud的初始能量已经离开的质荷比的离子，离子通过自由飞行区域和减速区域进入反射区域并返回所需的总飞行时间将相等到相同质荷比的离子所需的总飞行时间进行往返，其中离子在减速区域和反射区域之间的边界处的参考电位值的点处转动，或者在减速区域。

2. 发明授权

US08664592B2 Time-of-flight mass spectrometer 有权
标题翻译：飞行时间质谱仪
公开(公告)号：US08664592B2
公开(公告)日：2014-03-04
申请号：US13821202
申请日：2011-09-06
申请人： Masaru Nishiguchi , Shinji Miyauchi , Yoshihiro Ueno
发明人： Masaru Nishiguchi , Shinji Miyauchi , Yoshihiro Ueno
IPC分类号： H01J49/00 , H01J49/06 , G01N27/62
CPC分类号： H01J49/405
摘要： Provided is a time-of-flight mass spectrometer having a reflectron which eliminates energy dependency of the flight time of ions having the same m/z while ensuring a high degree of design freedom. An electric field created by the reflectron is virtually divided into a decelerating region for decelerating ions and a reflecting region for reflecting ions. For an ion having a mass-to-charge ratio which has departed with initial energy higher than Ud, the total flight time required for the ion to travel through a free-flight region and the decelerating region into the reflecting region and return will be equal to the total flight time required for an ion of the same mass-to-charge ratio to make a round trip in which the ion turns around at a point of the reference potential value at the boundary between the decelerating region and the reflecting region or in the decelerating region.
摘要翻译：提供了具有反射器的飞行时间质谱仪，其消除具有相同m / z的离子的飞行时间的能量依赖性，同时确保高度的设计自由度。由反射镜产生的电场实际上被分成用于使离子减速的减速区域和用于反射离子的反射区域。对于具有高于Ud的初始能量已经离开的质荷比的离子，离子通过自由飞行区域和减速区域进入反射区域并返回所需的总飞行时间将相等到相同质荷比的离子所需的总飞行时间进行往返，其中离子在减速区域和反射区域之间的边界处的参考电位值的点处转动，或者在减速区域。

3. 发明授权

US08134123B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08134123B2
公开(公告)日：2012-03-13
申请号：US12594450
申请日：2008-01-17
申请人： Masaru Nishiguchi , Yoshihiro Ueno , Daisuke Okumura , Hiroto Itoi
发明人： Masaru Nishiguchi , Yoshihiro Ueno , Daisuke Okumura , Hiroto Itoi
IPC分类号： H01J49/42
CPC分类号： H01J49/063 , H01J49/004 , H01J49/065 , H01J49/4235
摘要： One virtual rod electrode is composed by a plurality of electrode plane plates arranged in the ion optical axis direction, and four virtual rod electrodes are arranged around the ion optical axis to form a virtual quadrupole rod type ion transport optical system (30). In one virtual rod electrode, the interval between the adjacent electrode plane plates is set to be large in the anterior area (30A) and small in the posterior area (30B). As the interval between electrodes becomes larger, high-order multipole field components increase and therefore the ion acceptance is increased, which enables an efficient acceptance of ions coming from the previous stage. On the other hand, if the interval between electrodes is small, the quadrupole field components relatively increase and the ion beam's convergence is improved. Therefore, ions can be effectively introduced into a quadrupole mass filter for example in the subsequent stage, which contributes to the enhancement of the mass analysis' sensitivity and accuracy.
摘要翻译：一个虚拟棒状电极由离子光轴方向排列的多个电极平面板构成，四根虚拟棒电极配置在离子光轴的周围，形成虚拟四极杆型离子传输光学系统（30）。在一个虚拟棒状电极中，相邻的电极平板之间的间隔在前部区域（30A）中被设定得较大，而后部区域（30B）较小。随着电极之间的间隔变大，高阶多极场分量增加，因此离子接受度增加，这使得能够有效地接受来自前一阶段的离子。另一方面，如果电极之间的间隔小，则四极场成分相对增加，离子束的会聚也提高。因此，离子可以有效地引入四极质量过滤器中，例如在后续阶段，这有助于提高质量分析的灵敏度和精度。

4. 发明授权

US07928372B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07928372B2
公开(公告)日：2011-04-19
申请号：US12016522
申请日：2008-01-18
申请人： Shinichi Yamaguchi , Masaru Nishiguchi , Kiyoshi Ogawa , Yoshihiro Ueno
发明人： Shinichi Yamaguchi , Masaru Nishiguchi , Kiyoshi Ogawa , Yoshihiro Ueno
IPC分类号： B01D59/44
CPC分类号： H01J49/38 , H01J49/408
摘要： A mass spectrometer is provided in which ions are favorably introduced into a loop orbit or favorably led out from the loop orbit without affecting the motion of the ions flying along the loop orbit. An ion-introduction orbit 5 is set to correspond to the orbit (ejection orbit portion 4) of ions after being bent by the sector-shaped electric field E1 in the loop orbit 4. When ions are introduced, a voltage applied to the electrode unit 11 is put to zero to release the sector-shaped electric field E1. Then the ions emitted along the ion-introduction orbit 5 fly straight in the electrode unit 11. The direction and position of the ions coming out from the exit end of the electric field is the same as those ions flying along the loop orbit 4. Therefore, there is no need for placing a deflection electrode for introducing/leading-out ions on the loop orbit.
摘要翻译：提供质谱仪，其中离子有利地被引入环轨道或有利地从环轨道引出，而不影响沿着环路轨道飞行的离子的运动。离子引入轨道5被设置为对应于在环路轨道4中的扇形电场E1弯曲之后的离子的轨道（喷射轨道部分4）。当离子被引入时，施加到电极单元的电压 11被置零以释放扇形电场E1。然后沿离子引入轨道5发射的离子在电极单元11中直线飞行。从电场出射端出来的离子的方向和位置与沿着环轨道4飞行的那些离子相同。因此，不需要在环轨道上放置用于引入/引出离子的偏转电极。

5. 发明申请

US20100116979A1 MASS SPECTROMETER 有权
标题翻译：质谱仪
公开(公告)号：US20100116979A1
公开(公告)日：2010-05-13
申请号：US12594450
申请日：2008-01-17
申请人： Masaru Nishiguchi , Yoshihiro Ueno , Daisuke Okumura , Hiroto Itoi
发明人： Masaru Nishiguchi , Yoshihiro Ueno , Daisuke Okumura , Hiroto Itoi
IPC分类号： H01J49/00
CPC分类号： H01J49/063 , H01J49/004 , H01J49/065 , H01J49/4235
摘要： One virtual rod electrode is composed by a plurality of electrode plain plates arranged in the ion optical axis direction, and four virtual rod electrodes are arranged around the ion optical axis to form a virtual quadrupole rod type ion transport optical system (30). In one virtual rod electrode, the interval between the adjacent electrode plain plates is set to be large in the anterior area (30A) and small in the posterior area (30B). As the interval between electrodes becomes larger, high-order multipole field components increase and therefore the ion acceptance is increased, which enables an efficient acceptance of ions coming from the previous stage. On the other hand, if the interval between electrodes is small, the quadrupole field components relatively increase and the ion beam's convergence is improved. Therefore, ions can be effectively introduced into a quadrupole mass filter for example in the subsequent stage, which contributes to the enhancement of the mass analysis' sensitivity and accuracy.
摘要翻译：一个虚拟棒状电极由离子光轴方向排列的多个电极平板构成，四根虚拟棒状电极配置在离子光轴的周围，形成虚拟四极杆型离子传输光学系统（30）。在一个虚拟棒状电极中，相邻的电极平板之间的间隔在前部区域（30A）中设定得较大，后部区域（30B）较小。随着电极之间的间隔变大，高阶多极场分量增加，因此离子接受度增加，这使得能够有效地接受来自前一阶段的离子。另一方面，如果电极之间的间隔小，则四极场成分相对增加，离子束的会聚也提高。因此，离子可以有效地引入四极质量过滤器中，例如在后续阶段，这有助于提高质量分析的灵敏度和精度。

6. 发明授权

US08658969B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08658969B2
公开(公告)日：2014-02-25
申请号：US12920306
申请日：2008-03-05
申请人： Masaru Nishiguchi
发明人： Masaru Nishiguchi
IPC分类号： H01J49/00
CPC分类号： H01J49/063 , H01J49/065
摘要： One virtual rod electrode (11) is composed by arraying a plurality of plate electrodes (111, . . . , 118) along an ion beam axis, and a quadrupole ion optical element (1) is constructed by arranging four virtual rod electrodes (11, 12, 13 and 14) around an ion beam axis C. A voltage-applying unit alternately applies two radio-frequency voltages having a phase difference of 180 degrees for each of the plate electrodes in one virtual rod electrode. By this voltage application, the quadrupole component of the radio-frequency electric field created within a space surrounded by the four virtual rod electrodes is decreased, while higher-order multipole components are increased. The quadrupole component yields high ion convergence and mass selectivity, while the higher-order components provide high ion transmission efficiency and ion acceptance. The general ion transport efficiency can be improved by appropriately adjusting the ion optical characteristics according to the installation environment of the ion optical system and the conditions before and after the ion optical system.
摘要翻译：一个虚拟棒状电极（11）通过沿离子束轴排列多个平板电极（111 ... 118）而构成，并且通过配置四个虚拟棒电极（11）构成四极离子光学元件（1），12,13和14）。电压施加单元在一个虚拟棒电极中为每个平板电极交替地施加具有180度的相位差的两个射频电压。通过该电压施加，由四个虚拟棒电极围绕的空间内产生的射频电场的四极分量减小，而高阶多极分量增加。四极组件产生高离子收敛和质量选择性，而高阶组分提供高离子传输效率和离子接受度。通过根据离子光学系统的安装环境和离子光学系统前后的条件适当调整离子光学特性，可以提高一般的离子传输效率。

7. 发明申请

US20100282965A1 MASS ANALYSIS METHOD AND MASS ANALYSIS SYSTEM 有权
标题翻译：质量分析方法和质量分析系统
公开(公告)号：US20100282965A1
公开(公告)日：2010-11-11
申请号：US12747728
申请日：2007-12-13
申请人： Masaru Nishiguchi , Shigeki Kajihara
发明人： Masaru Nishiguchi , Shigeki Kajihara
IPC分类号： H01J49/40
CPC分类号： H01J49/408
摘要： A measurement is performed in a no-passing mode, in which ions having different masses are prevented from making a complete turn through a loop orbit, to obtain a time-of-flight spectrum without the passing of ions having different masses (S1 and S2). From the time of flight and other information of the peaks appearing on the time-of-flight spectrum (S3), the number of turns and the time of flight in the loop-turn mode are predicted. Based on this prediction, a set of segments are defined on a time-of-flight spectrum in the loop-turn mode. The time widths of those segments are determined taking into account the spreads of the time widths of the aforementioned peaks. Since the number of turns is unique within each segment, the numbers of turns and the masses of the peaks can be uniquely determined as long as none of the segments overlap each other. Accordingly, it is determined whether there is any overlapped portion in the segments defined on the time-of-flight spectrum in the loop-turn mode under provisionally predetermined conditions. When a condition under which no overlapping occurs has been found, the segment setting is fixed (S4-S6). As a result, the timing for switching an ejection switch, which is used for ejecting ions from the loop orbit, is also determined. Based on this timing, a measurement in the loop-turn mode is performed (S7).
摘要翻译：在不通过模式中进行测量，其中防止具有不同质量的离子通过环轨道完全转动，以获得不具有不同质量的离子通过的飞行时间谱（S1和S2 ）。从飞行时间和飞行时间频谱出现的峰值的其他信息（S3），可以预测回转模式下的匝数和飞行时间。基于该预测，在循环模式中在飞行时间频谱上定义一组段。考虑到上述峰值的时间宽度的扩展，确定了这些段的时间宽度。由于每个段内的匝数是唯一的，只要没有一个段彼此重叠，可以唯一地确定峰的匝数和质量。因此，在临时预定条件下，确定在循环转弯模式下在飞行时间频谱上定义的段中是否存在任何重叠部分。当发现不发生重叠的条件时，段设定是固定的（S4-S6）。结果，也确定了用于从环路轨道喷射离子的喷射开关切换的定时。基于该定时，执行环路转向模式中的测量（S7）。

8. 发明授权

US5462808A Highly rigid composite material and process for its manufacture 失效
标题翻译：高刚性复合材料及其制造工艺
公开(公告)号：US5462808A
公开(公告)日：1995-10-31
申请号：US300034
申请日：1994-09-02
申请人： Kazutaka Asabe , Masaru Nishiguchi , Sukeyoshi Yamamoto
发明人： Kazutaka Asabe , Masaru Nishiguchi , Sukeyoshi Yamamoto
IPC分类号： C21D8/00 , C22C33/02 , C23C8/00 , B22F3/00 , C22C29/00
CPC分类号： C23C8/00 , C21D8/005 , C22C33/0228 , C21D2241/01 , C21D2241/02 , Y10T428/12028 , Y10T428/12049 , Y10T428/12056
摘要： A high-rigidity composite material having a Young's modulus larger than 25,000 kgf/mm.sup.2 is disclosed, in which particles are dispersed in a matrix of a ferritic steel, and the degree of accumulation of {111} planes in a plane perpendicular to a given direction, in terms of X-ray diffraction intensity, is 30 times larger than that of equiaxial polycrystals.
摘要翻译：公开了一种杨氏模量大于25,000kgf / mm2的高刚性复合材料，其中颗粒分散在铁素体钢的基质中，并且{111}面在垂直于给定方向的平面中的累积程度，在X射线衍射强度方面，是等轴多晶体的30倍以上。

9. 发明授权

US08026480B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08026480B2
公开(公告)日：2011-09-27
申请号：US12600375
申请日：2007-05-22
申请人： Shinichi Yamaguchi , Masaru Nishiguchi
发明人： Shinichi Yamaguchi , Masaru Nishiguchi
IPC分类号： H01J49/48 , H01J49/40 , B01D59/44
CPC分类号： H01J49/408
摘要： A basic ion optical system (2) in which the temporal focusing of ions is ensured includes a plurality of sector-shaped electrodes (11, 12, 13, and 14), an ion injection slit (15), and an ion ejection slit (16), which are placed on the same plane. A plurality of basic ion optical systems (2) are placed in such a manner as to be mutually separated at predetermined intervals in the direction approximately orthogonal to their planes. The ion ejection slit (16) of the lower-stage basic ion optical system (2) and the ion injection slit (15) of the next-stage basic ion optical system (2) are connected to each other via another basic ion optical system (3) in which the temporal focusing of the ions is ensured. Accordingly, the flight distance can be elongated while assuredly achieving the temporal focusing of the ions as an entire ion optical system (1), and a three-dimensional space can be efficiently utilized to compactify the ion optical system (1).
摘要翻译：确保离子的时间聚焦的基本离子光学系统（2）包括多个扇形电极（11,12,13,14），离子注入狭缝（15）和离子喷射狭缝（ 16），它们放置在同一平面上。多个基本离子光学系统（2）以与其平面大致正交的方向以预定间隔相互分离的方式放置。下级碱性离子光学系统（2）的离子喷射狭缝（16）和下一级碱性离子光学系统（2）的离子注入狭缝（15）通过另一种碱性离子光学系统（3），其中确保离子的时间聚焦。因此，飞行距离可以延长，同时可靠地实现作为整个离子光学系统（1）的离子的时间聚焦，并且可以有效地利用三维空间来压缩离子光学系统（1）。

10. 发明申请

US20110012017A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20110012017A1
公开(公告)日：2011-01-20
申请号：US12920306
申请日：2008-03-05
申请人： Masaru Nishiguchi
发明人： Masaru Nishiguchi
IPC分类号： H01J49/26 , H01J49/06 , H01J49/24
CPC分类号： H01J49/063 , H01J49/065
摘要： One virtual rod electrode (11) is composed by arraying a plurality of plate electrodes (111, . . . , 118) along an ion beam axis, and a quadrupole ion optical element (1) is constructed by arranging four virtual rod electrodes (11, 12, 13 and 14) around an ion beam axis C. A voltage-applying unit alternately applies two radio-frequency voltages having a phase difference of 180 degrees for each of the plate electrodes in one virtual rod electrode. By this voltage application, the quadrupole component of the radio-frequency electric field created within a space surrounded by the four virtual rod electrodes is decreased, while higher-order multipole components are increased. The quadrupole component yields high ion convergence and mass selectivity, while the higher-order components provide high ion transmission efficiency and ion acceptance. The general ion transport efficiency can be improved by appropriately adjusting the ion optical characteristics according to the installation environment of the ion optical system and the conditions before and after the ion optical system.
摘要翻译：一个虚拟棒状电极（11）通过沿离子束轴排列多个平板电极（111 ... 118）而构成，并且通过配置四个虚拟棒电极（11）构成四极离子光学元件（1），12,13和14）。电压施加单元在一个虚拟棒电极中为每个平板电极交替地施加具有180度的相位差的两个射频电压。通过该电压施加，由四个虚拟棒电极围绕的空间内产生的射频电场的四极分量减小，而高阶多极分量增加。四极组件产生高离子收敛和质量选择性，而高阶组分提供高离子传输效率和离子接受度。通过根据离子光学系统的安装环境和离子光学系统前后的条件适当调整离子光学特性，可以提高一般的离子传输效率。

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