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1. 发明申请

US20050228020A1 Beta secretase inhibitors 审中-公开
标题翻译： β-分泌酶抑制剂
公开(公告)号：US20050228020A1
公开(公告)日：2005-10-13
申请号：US11142885
申请日：2005-06-01
申请人： Masaomi Miyamoto , Junji Matsui , Hiroaki Fukumoto , Naoki Tarui
发明人： Masaomi Miyamoto , Junji Matsui , Hiroaki Fukumoto , Naoki Tarui
IPC分类号： A61K31/135 , A61K31/14 , A61K31/165 , A61K31/40 , A61K31/4164 , A61K31/4453 , A61P25/00 , A61P25/16 , A61P25/28 , A61P43/00 , C07C207/04 , C07C217/60 , C07C235/34 , C07D295/096 , C07D521/00 , A61K31/445
CPC分类号： C07D295/096 , A61K31/135 , A61K31/14 , A61K31/165 , A61K31/40 , A61K31/4164 , A61K31/4453 , C07C207/04 , C07C217/60 , C07C235/34 , C07C2602/10 , C07D231/12 , C07D233/56 , C07D249/08
摘要： An excellent β secretase inhibitor is provided, which comprises a compound of the general formula: wherein Ar is an aromatic group; X is a divalent group selected from —O—, —S—, —CO—, —SO—, —SO2—, —NR8—, CONR8—, —SO2NR8—, and —COO— (wherein R8 is hydrogen, etc.), a divalent C1-6 aliphatic hydrocarbon group which may contain one or two of these divalent groups, or a bond; Y is a divalent group selected from —O—, —S—, —CO—, —SO—, —SO2—, —NR8—, —CONR8—, —SO2NR8—, and —COO—, or a divalent C1-6 aliphatic hydrocarbon group which may contain one or two of these divalent groups; R1 and R2 are hydrogen, a hydrocarbon group, etc., respectively; and A is a ring which may be further substituted, or a salt thereof.
摘要翻译：提供了优异的β分泌酶抑制剂，其包含通式如下的化合物：其中Ar为芳族基团; X是选自-O - ， - S - ， - CO - ， - SO - ， - SO 2 - ， - NR 8 - ，CONR - ， - SO 2 - ， - COO-（其中R 8为氢等），可以含有一个或两个这些二价基团的二价C 1-6脂族烃基或键; Y是选自-O - ， - S - ， - CO - ， - SO - ， - SO 2 - ， - NR 8 - ， - CONR 2 - SO 2 - ， - SO 2 - ， - COO-或二价C 1-6 - 脂族基可以含有一个或两个这些二价基团的烃基; R 1和R 2分别为氢，烃基等; A是可以被进一步取代的环，或其盐。

2. 发明授权

US06613805B2 Amine compounds, their production and use 有权
标题翻译：胺化合物，其生产和使用
公开(公告)号：US06613805B2
公开(公告)日：2003-09-02
申请号：US09931140
申请日：2001-08-16
申请人： Kaneyoshi Kato , Jun Terauchi , Hiroaki Fukumoto , Mitsuru Kakihana
发明人： Kaneyoshi Kato , Jun Terauchi , Hiroaki Fukumoto , Mitsuru Kakihana
IPC分类号： A61K31137
CPC分类号： C07D213/30 , C07B2200/07 , C07C217/74 , C07C255/54 , C07C2602/10 , C07D215/14 , C07D215/20 , C07D215/58 , C07D271/06 , C07D277/64 , C07D295/096 , C07D307/80 , C07D317/54 , C07D333/16
摘要： A compound of the formula: wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or —SO2—, (iii) C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene, etc., (iv) —CO—O— or (v) —(CH2)p-X1—, —(CH2)p-X1-(CH2)q-, —(CH2)r-CO-X1-, —SO2—NR8— or —(CH2)r-SO2—NR8— wherein X1 is O or NR8, R8 is H, a hydrocarbon group which may be substituted or an acyl, p is 0 to 5, q is 1 to 5, p+q is 1 to 5, and r is 1 to 4; Y is a divalent C1-6 aliphatic hydrocarbon group optionally containing O or S, which may be substituted; R1 and R2 each is H or a lower alkyl which may be substituted, or R1 and R2 form a N-containing heterocyclic ring which may be substituted; Ring A is a benzene ring which may be further substituted; and Ring B is a 4- to 8-membered ring which may be further substituted, or a salt thereof has the effect of inhibiting amyloid-&bgr; protein production and/or secretion and is useful as a pharmaceutical composition for preventing and/or treating the neurodegenerative disease, etc.
摘要翻译：下式的化合物：其中Ar是可被取代的芳环组合基团或可被取代的稠合芳基; X是（i）键，（ii）-S-，-SO-或-SO 2 - ，（iii）C 1-6亚烷基，C 2-6亚烯基或C 2-6亚炔基等，（iv）-CO- O-或（V） - （CH 2）p -X 1 - ， - （CH 2）p -X 1 - （CH 2）q - ， - （CH 2）r -CO-X 1 - ，-SO 2 -NR 8 - 或 - （CH 2） r-SO 2 -NR 8 - ，其中X 1为O或NR 8，R 8为H，可被取代的烃基或酰基，p为0至5，q为1至5，p + q为1至5，r 是1到4; Y是任选地含有O或S的二价C 1-6脂族烃基，其可被取代; R 1和R 2各自为H或可被取代的低级烷基，或R 1和R 2形成可被取代的含氮杂环; 环A是可以被进一步取代的苯环; 环B为可进一步取代的4-至8-元环，或其盐具有抑制淀粉样蛋白β蛋白产生和/或分泌的作用，并且可用作预防和/或治疗神经变性疾病等

3. 发明授权

US06586475B1 &bgr;-amyloid protein production/secretion inhibitors 失效
标题翻译： β-淀粉样蛋白生成/分泌抑制剂
公开(公告)号：US06586475B1
公开(公告)日：2003-07-01
申请号：US09856317
申请日：2001-06-05
申请人： Kaneyoshi Kato , Jun Terauchi , Hiroaki Fukumoto , Mitsuru Kakihana
发明人： Kaneyoshi Kato , Jun Terauchi , Hiroaki Fukumoto , Mitsuru Kakihana
IPC分类号： A61K31165
CPC分类号： C07D213/82 , C07C217/60 , C07C235/34 , C07C235/50 , C07C237/22 , C07C237/42 , C07C237/44 , C07C311/21 , C07D295/088 , C07D295/13
摘要： A compound of the formula: wherein Ar is an aromatic group; X and Y are a bivalent group selected from —O—, —S—, —CO—, —SO2—, —NR8—, —CONR8—, SO2NR8 and —COO— (wherein R8 is H, a hydrocarbon group or acyl), or a bivalent C1-6 aliphatic hydrocarbon group which may contain one or two above bivalent groups; R1 and R2 are H or C1-6 alkyl, or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic ring; and ring A is a monocyclic aromatic ring, or a salt thereof or a prodrug thereof exhibits an excellent inhibitory activity of the production and/or the secretion of amyloid-&bgr; protein.
摘要翻译：下式的化合物：其中Ar是芳族基团; X和Y是选自-O - ， - S - ， - CO - ， - SO 2 - ， - NR 8 - ， - CONR 8 - ，SO 2 NR 8和-COO-（其中R 8是H，烃基或酰基），或可以含有一个或两个上述二价基团的二价C 1-6脂族烃基; R1和R2是H或C1-6烷基，或R1和R2可以与相邻的氮原子一起形成含氮杂环; 环A是单环芳环，或其盐或其前药对淀粉样蛋白-β蛋白的产生和/或分泌具有优异的抑制活性。

4. 发明授权

US06310107B1 Amine compounds, their production and use as amyloid-&bgr; production inhibitors 有权
标题翻译：胺化合物，其生产和用作淀粉样蛋白-β生产抑制剂
公开(公告)号：US06310107B1
公开(公告)日：2001-10-30
申请号：US09331460
申请日：1999-06-21
申请人： Kaneyoshi Kato , Jun Terauchi , Hiroaki Fukumoto , Mitsuru Kakihana
发明人： Kaneyoshi Kato , Jun Terauchi , Hiroaki Fukumoto , Mitsuru Kakihana
IPC分类号： A61K31137
CPC分类号： C07D213/30 , C07B2200/07 , C07C217/74 , C07C255/54 , C07C2602/10 , C07D215/14 , C07D215/20 , C07D215/58 , C07D271/06 , C07D277/64 , C07D295/096 , C07D307/80 , C07D317/54 , C07D333/16
摘要： A compound of the formula: wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or —SO2—, (iii) C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene, etc., (iv) —CO—O— or (v) —(CH2)p-X1—, —(CH2)p-X1— (CH2)q-, —(CH2)r-CO—X1—, —SO2—NR8— or —(CH2)r-SO2—NR8— wherein X1 is O or NR8, R8 is H, a hydrocarbon group which may be substituted or an acyl, p is 0 to 5, q is 1 to 5, p+q is 1 to 5, and r is 1 to 4; Y is a divalent C1-6 aliphatic hydrocarbon group optionally containing O or S, which may be substituted; R1 and R2 each is H or a lower alkyl which may be substituted, or R1 and R2 form a N-containing heterocyclic ring which may be substituted; Ring A is a benzene ring which may be further substituted; and Ring B is a 4- to 8-membered ring which may be further substituted, or a salt thereof has the effect of inhibiting amyloid-&bgr; protein production and/or secretion and is useful as a pharmaceutical composition for preventing and/or treating the neurodegenerative disease, etc.
摘要翻译：下式的化合物：其中Ar是可被取代的芳环组合基团或可被取代的稠合芳基; X是（i）键，（ii）-S-，-SO-或-SO 2 - ，（iii）C 1-6亚烷基，C 2-6亚烯基或C 2-6亚炔基等，（iv）-CO- O-或（V） - （CH 2）p -X 1 - ， - （CH 2）p -X 1 - （CH 2）q - ， - （CH 2）r -CO-X 1 - ，-SO 2 -NR 8 - 或 - （CH 2） r-SO 2 -NR 8 - ，其中X 1为O或NR 8，R 8为H，可被取代的烃基或酰基，p为0至5，q为1至5，p + q为1至5，r 是1到4; Y是任选地含有O或S的二价C 1-6脂族烃基，其可被取代; R 1和R 2各自为H或可被取代的低级烷基，或R 1和R 2形成可被取代的含氮杂环; 环A是可以被进一步取代的苯环; 环B为可进一步取代的4-至8-元环，或其盐具有抑制淀粉样蛋白β蛋白产生和/或分泌的作用，并且可用作预防和/或治疗神经变性疾病等

5. 发明授权

US07460826B2 Image forming apparatus 失效
标题翻译：图像形成装置
公开(公告)号：US07460826B2
公开(公告)日：2008-12-02
申请号：US11233530
申请日：2005-09-22
申请人： Toru Tanjo , Akinobu Nakahata , Hiroaki Fukumoto , Naruya Yotsuyanagi
发明人： Toru Tanjo , Akinobu Nakahata , Hiroaki Fukumoto , Naruya Yotsuyanagi
IPC分类号： G03G15/00
CPC分类号： G03G15/231 , G03G21/1638 , G03G2215/00544 , G03G2215/00586 , G03G2221/1675 , G03G2221/169 , G03G2221/1696
摘要： A housing body includes a first part forming a part of a first transporting path in which a medium is transported. An image forming unit is accommodated in the housing body and is adapted to form an image onto at least one face of the medium. A door cover is attached to the housing body, and the door cover includes a second part adapted to face the first part when the door cover is closed, thereby forming the part of the first transporting path together with the first part. A double-sided printing unit is detachably mounted to the second part and includes a second transporting path. The second transporting path is connected to the first transporting path and is adapted to transport the medium while turning inside out, so that the image forming unit forms images on both sides of the medium.
摘要翻译：壳体包括形成传送介质的第一传送路径的一部分的第一部分。图像形成单元容纳在壳体中并适于在介质的至少一个面上形成图像。门盖附接到壳体，并且门盖包括适于在门盖关闭时面向第一部分的第二部分，从而与第一部分一起形成第一传送路径的一部分。双面打印单元可拆卸地安装到第二部分并且包括第二传送路径。第二传送路径连接到第一传送路径，并且适于在内向外传送介质的同时，使得图像形成单元在介质的两侧形成图像。

6. 发明申请

US20050085553A1 Remedies for mild recognition deflict 审中-公开
标题翻译：补救轻度认定缺陷
公开(公告)号：US20050085553A1
公开(公告)日：2005-04-21
申请号：US10499354
申请日：2002-12-25
申请人： Masaomi Miyamato , Hideki Takahashi , Hiroaki Fukumoto , Shigenori Ohkawa
发明人： Masaomi Miyamato , Hideki Takahashi , Hiroaki Fukumoto , Shigenori Ohkawa
IPC分类号： A61K45/00 , A61K31/00 , A61K31/135 , A61K31/137 , A61K31/36 , A61K38/00 , A61P25/28 , A61P43/00 , A61K31/195
CPC分类号： A61K31/00 , A61K31/135
摘要： It is intended to provide agents for treating mild cognitive impairment which comprise compounds having an effect of inhibiting the production, secretion, aggregation, and/or accumulation of β-amyloid proteins, prodrugs thereof or salts of the same and inhibit the progress of mild cognitive impairment to Alzheimer's disease using the same.
摘要翻译：旨在提供用于治疗轻度认知障碍的药剂，其包含具有抑制β-淀粉样蛋白的生产，分泌，聚集和/或积累的作用的化合物，其前体药物或其盐，并抑制轻度认知进展使用相同的阿尔茨海默氏病的损伤。

7. 外观设计

USD656048S1 Spectrophotometers 有权
标题翻译：分光光度计
公开(公告)号：USD656048S1
公开(公告)日：2012-03-20
申请号：US29369672
申请日：2010-09-10
申请人： Wataru Suzuki , Tomoko Iwasaki , Hiromi Shishiuchi , Hiroaki Fukumoto
设计人： Wataru Suzuki , Tomoko Iwasaki , Hiromi Shishiuchi , Hiroaki Fukumoto

8. 外观设计

USD643875S1 Printer 有权
公开(公告)号：USD643875S1
公开(公告)日：2011-08-23
申请号：US29369673
申请日：2010-09-10
申请人： Wataru Suzuki , Tomoko Iwasaki , Hiromi Shishiuchi , Hiroaki Fukumoto
设计人： Wataru Suzuki , Tomoko Iwasaki , Hiromi Shishiuchi , Hiroaki Fukumoto

9. 发明授权

US07256204B2 Amine compounds, their production and use 失效
标题翻译：胺化合物，其生产和使用
公开(公告)号：US07256204B2
公开(公告)日：2007-08-14
申请号：US10645934
申请日：2003-08-21
申请人： Kaneyoshi Kato , Jun Terauchi , Hiroaki Fukumoto , Mitsuru Kakihana
发明人： Kaneyoshi Kato , Jun Terauchi , Hiroaki Fukumoto , Mitsuru Kakihana
IPC分类号： A61K31/38 , A61K31/36 , A61K31/18 , A61K31/16 , A61K31/135
CPC分类号： C07D213/30 , C07B2200/07 , C07C217/74 , C07C255/54 , C07C2602/10 , C07D215/14 , C07D215/20 , C07D215/58 , C07D271/06 , C07D277/64 , C07D295/096 , C07D307/80 , C07D317/54 , C07D333/16
摘要： A compound of the formula: wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or —SO2—, (iii) C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene, etc., (iv) —CO—O— or (v) —(CH2)p-X1—, —(CH2)p-X1—CH2)q-, —(CH2)r-CO—X1—, —SO2—NR8— or —(CH2)r-SO2—NR8— wherein X1 is O or NR8, R8 is H, a hydrocarbon group which may be substituted or an acyl, p is 0 to 5, q is 1 to 5, p+q is 1 to 5, and r is 1 to 4; Y is a divalent C1-6 aliphatic hydrocarbon group optionally containing O or S, which may be substituted; R1 and R2 each is H or a lower alkyl which may be substituted, or R1 and R2 form a N-containing heterocyclic ring which may be substituted; Ring A is a benzene ring which may be further substituted; and Ring B is a 4- to 8-membered ring which may be further substituted, or a salt thereof has the effect of inhibiting amyloid-β protein production and/or secretion and is useful as a pharmaceutical composition for preventing and/or treating the neurodegenerative disease, etc.
摘要翻译：下式的化合物：其中Ar是可被取代的芳环组合基团或可被取代的稠合芳基; X是（i）键，（ii）-S-，-SO-或-SO 2 - ，（iii）C 1-6亚烷基，C _{（2-6）亚烯基或C 2-6亚炔基等，（iv）-CO-O-或（v） - （CH 2） q - ， - （CH 2）n - ， - （CH 2 CH 2） R 2 CO-X 1 - ， - SO 2 -NR 8 - 或 - （CH _{，R 8是H，可以被取代的烃基或酰基，p是0-5，q是1至5，p + q是1至5，并且r是1至 4; Y是任选地含有可被取代的O或S的二价C 1-6烷基脂族烃基; R 1和R 2各自为H或可以被取代的低级烷基，或R 1和R 2 2 >形成可以被取代的含氮杂环; 环A是可以被进一步取代的苯环; 环B为可进一步取代的4-至8-元环，或其盐具有抑制淀粉样蛋白β蛋白产生和/或分泌的作用，并且可用作预防和/或治疗神经变性疾病等}}

10. 发明申请

US20110104821A1 ABeta-OLIGOMER MEASUREMENT METHOD 审中-公开
标题翻译： ABeta低分辨率测量方法
公开(公告)号：US20110104821A1
公开(公告)日：2011-05-05
申请号：US12990832
申请日：2009-05-07
申请人： Takahiko Tokuda , Hiroaki Fukumoto
发明人： Takahiko Tokuda , Hiroaki Fukumoto
IPC分类号： G01N33/53
CPC分类号： C07K14/4711 , C07K16/18 , C07K2317/34 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： Provided is a measurement method of an Aβ oligomer by the ELISA method, particularly, a method of selectively measuring an Aβ oligomer with a comparatively high molecular weight.[Solving Means]A measurement method of an Aβ oligomer including the following steps:(a) a step of contacting a sample possibly containing an Aβ oligomer with a monoclonal antibody that recognizes a partial peptide consisting of the amino acid sequence shown by SEQ ID NO: 1, which is bound to an insoluble carrier (first antibody) to bind the Aβ oligomer with the first antibody; and (b) a step of reacting a labeled monoclonal antibody that recognizes a partial peptide consisting of the amino acid sequence shown by SEQ ID NO: 1 (second antibody) with the Aβ oligomer bound to the first antibody in step (a).
摘要翻译：提供了一种A＆bgr的测量方法; 低聚物通过ELISA方法，特别是选择性测量A＆bgr的方法; 具有较高分子量的低聚物。 [解决方法] A＆Bgr的测定方法包括以下步骤：（a）使可能含有A＆bgr的样品接触的步骤; 寡聚体与识别由SEQ ID NO：1所示的氨基酸序列组成的部分肽的单克隆抗体，其结合于不溶性载体（第一抗体）以结合A和Bgr; 低聚物与第一抗体; 和（b）使识别由SEQ ID NO：1所示的氨基酸序列组成的部分肽（第二抗体）的标记的单克隆抗体与A＆bgr反应的步骤; 与步骤（a）中的第一抗体结合的低聚物。

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