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1. 发明申请

US20110104821A1 ABeta-OLIGOMER MEASUREMENT METHOD 审中-公开
标题翻译： ABeta低分辨率测量方法
公开(公告)号：US20110104821A1
公开(公告)日：2011-05-05
申请号：US12990832
申请日：2009-05-07
申请人： Takahiko Tokuda , Hiroaki Fukumoto
发明人： Takahiko Tokuda , Hiroaki Fukumoto
IPC分类号： G01N33/53
CPC分类号： C07K14/4711 , C07K16/18 , C07K2317/34 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： Provided is a measurement method of an Aβ oligomer by the ELISA method, particularly, a method of selectively measuring an Aβ oligomer with a comparatively high molecular weight.[Solving Means]A measurement method of an Aβ oligomer including the following steps:(a) a step of contacting a sample possibly containing an Aβ oligomer with a monoclonal antibody that recognizes a partial peptide consisting of the amino acid sequence shown by SEQ ID NO: 1, which is bound to an insoluble carrier (first antibody) to bind the Aβ oligomer with the first antibody; and (b) a step of reacting a labeled monoclonal antibody that recognizes a partial peptide consisting of the amino acid sequence shown by SEQ ID NO: 1 (second antibody) with the Aβ oligomer bound to the first antibody in step (a).
摘要翻译：提供了一种A＆bgr的测量方法; 低聚物通过ELISA方法，特别是选择性测量A＆bgr的方法; 具有较高分子量的低聚物。 [解决方法] A＆Bgr的测定方法包括以下步骤：（a）使可能含有A＆bgr的样品接触的步骤; 寡聚体与识别由SEQ ID NO：1所示的氨基酸序列组成的部分肽的单克隆抗体，其结合于不溶性载体（第一抗体）以结合A和Bgr; 低聚物与第一抗体; 和（b）使识别由SEQ ID NO：1所示的氨基酸序列组成的部分肽（第二抗体）的标记的单克隆抗体与A＆bgr反应的步骤; 与步骤（a）中的第一抗体结合的低聚物。

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