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1. 发明授权

US06613805B2 Amine compounds, their production and use 有权
标题翻译：胺化合物，其生产和使用
公开(公告)号：US06613805B2
公开(公告)日：2003-09-02
申请号：US09931140
申请日：2001-08-16
申请人： Kaneyoshi Kato , Jun Terauchi , Hiroaki Fukumoto , Mitsuru Kakihana
发明人： Kaneyoshi Kato , Jun Terauchi , Hiroaki Fukumoto , Mitsuru Kakihana
IPC分类号： A61K31137
CPC分类号： C07D213/30 , C07B2200/07 , C07C217/74 , C07C255/54 , C07C2602/10 , C07D215/14 , C07D215/20 , C07D215/58 , C07D271/06 , C07D277/64 , C07D295/096 , C07D307/80 , C07D317/54 , C07D333/16
摘要： A compound of the formula: wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or —SO2—, (iii) C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene, etc., (iv) —CO—O— or (v) —(CH2)p-X1—, —(CH2)p-X1-(CH2)q-, —(CH2)r-CO-X1-, —SO2—NR8— or —(CH2)r-SO2—NR8— wherein X1 is O or NR8, R8 is H, a hydrocarbon group which may be substituted or an acyl, p is 0 to 5, q is 1 to 5, p+q is 1 to 5, and r is 1 to 4; Y is a divalent C1-6 aliphatic hydrocarbon group optionally containing O or S, which may be substituted; R1 and R2 each is H or a lower alkyl which may be substituted, or R1 and R2 form a N-containing heterocyclic ring which may be substituted; Ring A is a benzene ring which may be further substituted; and Ring B is a 4- to 8-membered ring which may be further substituted, or a salt thereof has the effect of inhibiting amyloid-&bgr; protein production and/or secretion and is useful as a pharmaceutical composition for preventing and/or treating the neurodegenerative disease, etc.
摘要翻译：下式的化合物：其中Ar是可被取代的芳环组合基团或可被取代的稠合芳基; X是（i）键，（ii）-S-，-SO-或-SO 2 - ，（iii）C 1-6亚烷基，C 2-6亚烯基或C 2-6亚炔基等，（iv）-CO- O-或（V） - （CH 2）p -X 1 - ， - （CH 2）p -X 1 - （CH 2）q - ， - （CH 2）r -CO-X 1 - ，-SO 2 -NR 8 - 或 - （CH 2） r-SO 2 -NR 8 - ，其中X 1为O或NR 8，R 8为H，可被取代的烃基或酰基，p为0至5，q为1至5，p + q为1至5，r 是1到4; Y是任选地含有O或S的二价C 1-6脂族烃基，其可被取代; R 1和R 2各自为H或可被取代的低级烷基，或R 1和R 2形成可被取代的含氮杂环; 环A是可以被进一步取代的苯环; 环B为可进一步取代的4-至8-元环，或其盐具有抑制淀粉样蛋白β蛋白产生和/或分泌的作用，并且可用作预防和/或治疗神经变性疾病等

2. 发明授权

US06586475B1 &bgr;-amyloid protein production/secretion inhibitors 失效
标题翻译： β-淀粉样蛋白生成/分泌抑制剂
公开(公告)号：US06586475B1
公开(公告)日：2003-07-01
申请号：US09856317
申请日：2001-06-05
申请人： Kaneyoshi Kato , Jun Terauchi , Hiroaki Fukumoto , Mitsuru Kakihana
发明人： Kaneyoshi Kato , Jun Terauchi , Hiroaki Fukumoto , Mitsuru Kakihana
IPC分类号： A61K31165
CPC分类号： C07D213/82 , C07C217/60 , C07C235/34 , C07C235/50 , C07C237/22 , C07C237/42 , C07C237/44 , C07C311/21 , C07D295/088 , C07D295/13
摘要： A compound of the formula: wherein Ar is an aromatic group; X and Y are a bivalent group selected from —O—, —S—, —CO—, —SO2—, —NR8—, —CONR8—, SO2NR8 and —COO— (wherein R8 is H, a hydrocarbon group or acyl), or a bivalent C1-6 aliphatic hydrocarbon group which may contain one or two above bivalent groups; R1 and R2 are H or C1-6 alkyl, or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic ring; and ring A is a monocyclic aromatic ring, or a salt thereof or a prodrug thereof exhibits an excellent inhibitory activity of the production and/or the secretion of amyloid-&bgr; protein.
摘要翻译：下式的化合物：其中Ar是芳族基团; X和Y是选自-O - ， - S - ， - CO - ， - SO 2 - ， - NR 8 - ， - CONR 8 - ，SO 2 NR 8和-COO-（其中R 8是H，烃基或酰基），或可以含有一个或两个上述二价基团的二价C 1-6脂族烃基; R1和R2是H或C1-6烷基，或R1和R2可以与相邻的氮原子一起形成含氮杂环; 环A是单环芳环，或其盐或其前药对淀粉样蛋白-β蛋白的产生和/或分泌具有优异的抑制活性。

3. 发明授权

US06310107B1 Amine compounds, their production and use as amyloid-&bgr; production inhibitors 有权
标题翻译：胺化合物，其生产和用作淀粉样蛋白-β生产抑制剂
公开(公告)号：US06310107B1
公开(公告)日：2001-10-30
申请号：US09331460
申请日：1999-06-21
申请人： Kaneyoshi Kato , Jun Terauchi , Hiroaki Fukumoto , Mitsuru Kakihana
发明人： Kaneyoshi Kato , Jun Terauchi , Hiroaki Fukumoto , Mitsuru Kakihana
IPC分类号： A61K31137
CPC分类号： C07D213/30 , C07B2200/07 , C07C217/74 , C07C255/54 , C07C2602/10 , C07D215/14 , C07D215/20 , C07D215/58 , C07D271/06 , C07D277/64 , C07D295/096 , C07D307/80 , C07D317/54 , C07D333/16
摘要： A compound of the formula: wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or —SO2—, (iii) C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene, etc., (iv) —CO—O— or (v) —(CH2)p-X1—, —(CH2)p-X1— (CH2)q-, —(CH2)r-CO—X1—, —SO2—NR8— or —(CH2)r-SO2—NR8— wherein X1 is O or NR8, R8 is H, a hydrocarbon group which may be substituted or an acyl, p is 0 to 5, q is 1 to 5, p+q is 1 to 5, and r is 1 to 4; Y is a divalent C1-6 aliphatic hydrocarbon group optionally containing O or S, which may be substituted; R1 and R2 each is H or a lower alkyl which may be substituted, or R1 and R2 form a N-containing heterocyclic ring which may be substituted; Ring A is a benzene ring which may be further substituted; and Ring B is a 4- to 8-membered ring which may be further substituted, or a salt thereof has the effect of inhibiting amyloid-&bgr; protein production and/or secretion and is useful as a pharmaceutical composition for preventing and/or treating the neurodegenerative disease, etc.
摘要翻译：下式的化合物：其中Ar是可被取代的芳环组合基团或可被取代的稠合芳基; X是（i）键，（ii）-S-，-SO-或-SO 2 - ，（iii）C 1-6亚烷基，C 2-6亚烯基或C 2-6亚炔基等，（iv）-CO- O-或（V） - （CH 2）p -X 1 - ， - （CH 2）p -X 1 - （CH 2）q - ， - （CH 2）r -CO-X 1 - ，-SO 2 -NR 8 - 或 - （CH 2） r-SO 2 -NR 8 - ，其中X 1为O或NR 8，R 8为H，可被取代的烃基或酰基，p为0至5，q为1至5，p + q为1至5，r 是1到4; Y是任选地含有O或S的二价C 1-6脂族烃基，其可被取代; R 1和R 2各自为H或可被取代的低级烷基，或R 1和R 2形成可被取代的含氮杂环; 环A是可以被进一步取代的苯环; 环B为可进一步取代的4-至8-元环，或其盐具有抑制淀粉样蛋白β蛋白产生和/或分泌的作用，并且可用作预防和/或治疗神经变性疾病等

4. 发明申请

US20050228020A1 Beta secretase inhibitors 审中-公开
标题翻译： β-分泌酶抑制剂
公开(公告)号：US20050228020A1
公开(公告)日：2005-10-13
申请号：US11142885
申请日：2005-06-01
申请人： Masaomi Miyamoto , Junji Matsui , Hiroaki Fukumoto , Naoki Tarui
发明人： Masaomi Miyamoto , Junji Matsui , Hiroaki Fukumoto , Naoki Tarui
IPC分类号： A61K31/135 , A61K31/14 , A61K31/165 , A61K31/40 , A61K31/4164 , A61K31/4453 , A61P25/00 , A61P25/16 , A61P25/28 , A61P43/00 , C07C207/04 , C07C217/60 , C07C235/34 , C07D295/096 , C07D521/00 , A61K31/445
CPC分类号： C07D295/096 , A61K31/135 , A61K31/14 , A61K31/165 , A61K31/40 , A61K31/4164 , A61K31/4453 , C07C207/04 , C07C217/60 , C07C235/34 , C07C2602/10 , C07D231/12 , C07D233/56 , C07D249/08
摘要： An excellent β secretase inhibitor is provided, which comprises a compound of the general formula: wherein Ar is an aromatic group; X is a divalent group selected from —O—, —S—, —CO—, —SO—, —SO2—, —NR8—, CONR8—, —SO2NR8—, and —COO— (wherein R8 is hydrogen, etc.), a divalent C1-6 aliphatic hydrocarbon group which may contain one or two of these divalent groups, or a bond; Y is a divalent group selected from —O—, —S—, —CO—, —SO—, —SO2—, —NR8—, —CONR8—, —SO2NR8—, and —COO—, or a divalent C1-6 aliphatic hydrocarbon group which may contain one or two of these divalent groups; R1 and R2 are hydrogen, a hydrocarbon group, etc., respectively; and A is a ring which may be further substituted, or a salt thereof.
摘要翻译：提供了优异的β分泌酶抑制剂，其包含通式如下的化合物：其中Ar为芳族基团; X是选自-O - ， - S - ， - CO - ， - SO - ， - SO 2 - ， - NR 8 - ，CONR - ， - SO 2 - ， - COO-（其中R 8为氢等），可以含有一个或两个这些二价基团的二价C 1-6脂族烃基或键; Y是选自-O - ， - S - ， - CO - ， - SO - ， - SO 2 - ， - NR 8 - ， - CONR 2 - SO 2 - ， - SO 2 - ， - COO-或二价C 1-6 - 脂族基可以含有一个或两个这些二价基团的烃基; R 1和R 2分别为氢，烃基等; A是可以被进一步取代的环，或其盐。

5. 发明申请

US20050095239A1 Methods and compositions for treating Alzheimer's disease 审中-公开
标题翻译：治疗阿尔茨海默病的方法和组合物
公开(公告)号：US20050095239A1
公开(公告)日：2005-05-05
申请号：US10664414
申请日：2003-09-17
申请人： G. Rebeck , Amy Deng , Hiroaki Fukumoto , Michael Irizarry , Michael Fitzgerald
发明人： G. Rebeck , Amy Deng , Hiroaki Fukumoto , Michael Irizarry , Michael Fitzgerald
IPC分类号： A61K31/195 , A61K31/66 , A61K31/7088 , A61K39/395 , A61K45/06 , A61K48/00 , A61P25/28 , C07K16/18 , C12Q1/02
CPC分类号： C07K16/18 , A61K2039/505
摘要： The present invention provides methods for reducing the efflux of cholesterol and/or secreted Aβ in the brain, as well as methods for treating Alzheimer's disease, by inhibit the expression and/or activity of LXR and/or ABCA1. Compositions comprising agents for performing the methods also are provided.
摘要翻译：本发明提供通过抑制LXR和/或ABCA1的表达和/或活性来减少脑中胆固醇和/或分泌的Aβ的流出以及治疗阿尔茨海默氏病的方法。还提供了包括用于执行方法的试剂的组合物。

6. 发明授权

US06219965B1 Plant growth sheet structure, natural turf sheet structure, method of growing turf and method of laying turf sheet structure 失效
标题翻译：植物生长片结构，天然草皮片结构，草皮生长方法和草皮片结构的铺设方法
公开(公告)号：US06219965B1
公开(公告)日：2001-04-24
申请号：US08615247
申请日：1997-07-15
申请人： Yoshio Ishikawa , Hiroaki Fukumoto , Toshimasa Hirasawa , Tatsuo Hatado , Akira Taga , Kaoru Yamada
发明人： Yoshio Ishikawa , Hiroaki Fukumoto , Toshimasa Hirasawa , Tatsuo Hatado , Akira Taga , Kaoru Yamada
IPC分类号： A01B7900
CPC分类号： E01C13/083 , A01G20/20 , E01C2013/006 , E01C2013/086 , Y10T428/23957 , Y10T428/23979
摘要： This invention provides a plant growth sheet structure which includes a base web layer and a core layer integrally coupled together in this order, a base web layer, a plant seed holding layer and a core layer integrally coupled together in this order, or a base web layer, a core layer, a plant seed holding layer and a cover web layer integrally coupled together in this order, and is provided at its surface with plant protection projections, and also provides a natural turf sheet structure including a natural turf grown on the plant growth sheet structure. This invention also provides a turf growing method in which a semi-artificial turf sheet structure including an artificial turf portion and a natural turf portion is laid over a concrete wall surface for performing hydroponics of the natural turf portion, and also provides a method of laying a turf sheet structure, in which a similar semi-artificial sheet structure is accommodated in an outdoor accommodating place for growing a natural turf portion, and is transferred to and laid in large-scale facilities on demand.
摘要翻译：本发明提供了一种植物生长片材结构，其包括依次整体地结合在一起的基底纤维网层和芯层，基本纤维网层，植物种子保持层和以该顺序整体连接在一起的芯层，层，核心层，植物种子保持层和覆盖纤维网层，并且在其表面上设置有植物保护突起，并且还提供包括在植物上生长的天然草皮的天然草皮片结构生长片结构。本发明还提供了一种草皮生长方法，其中将包含人造草皮部分和天然草皮部分的半人造草皮片结构放置在用于进行天然草皮部分的水培的混凝土墙面上，并且还提供铺设方法草皮片结构，其中类似的半人造片结构容纳在用于种植天然草皮部分的室外容纳场所中，并且根据需要被转移并放置在大型设施中。

7. 发明授权

US5601886A Artificial turf 失效
标题翻译：人造草坪
公开(公告)号：US5601886A
公开(公告)日：1997-02-11
申请号：US446770
申请日：1995-06-05
申请人： Yoshio Ishikawa , Hiroaki Fukumoto
发明人： Yoshio Ishikawa , Hiroaki Fukumoto
IPC分类号： E01C13/00 , D02G3/02 , D02G3/44 , D05C17/02 , E01C13/08 , A41G1/00
CPC分类号： E01C13/08 , Y10S273/13 , Y10T428/23979
摘要： An artificial turf of the invention is disclosed in which tufts of artificial grass filaments are implanted on a backing structure to form a pile surface, and tufts of assist filaments, which are shorter than the artificial grass filaments, are implanted between the tufts of the artificial grass filaments. This construction prevents the artificial grass filaments from folding for a long period of time since the assist filaments support the artificial grass filaments, so that a soft and resilient feel resembling natural turf can be obtained. When using longer lengths of artificial grass filaments, it is possible to obtain an appearance similar to natural turf and to enhance sliding characteristics on a turf surface, whereby sliding actions in a soccer game or the like can be performed readily. Furthermore, in the case of providing a sand layer over the backing cloth with the tips of the artificial grass filaments projected from the surface of the sand layer, the obtained artificial turf maintains a softness suitable for use in courts, playgrounds or the like for a long period of time.
摘要翻译： PCT No.PCT / JP93 / 01843 Sec。 371日期：1995年6月5日 102（e）日期1995年6月5日PCT 1993年12月20日PCT PCT。第WO95 / 09949号公报日期：1995年04月13日公开了本发明的人造草坪，其中将一束人造草丝植入背衬结构以形成绒头表面，并且将比人造草丝更短的辅助细丝簇植入在人造草丝的簇绒。这种结构防止人造草丝长时间折叠，因为辅助细丝支撑人造草丝，从而可以获得类似于天然草皮的柔软和弹性的感觉。当使用较长长度的人造草丝时，可以获得与天然草皮类似的外观，并且增强草皮表面的滑动特性，从而可以容易地进行足球比赛中的滑动动作。此外，在从背衬布上提供砂层的情况下，从沙层的表面突出有人造草丝的尖端，所获得的人造草皮保持适合用于法庭，游乐场等的柔软度，用于很长一段时间

8. 外观设计

USD656048S1 Spectrophotometers 有权
标题翻译：分光光度计
公开(公告)号：USD656048S1
公开(公告)日：2012-03-20
申请号：US29369672
申请日：2010-09-10
申请人： Wataru Suzuki , Tomoko Iwasaki , Hiromi Shishiuchi , Hiroaki Fukumoto
设计人： Wataru Suzuki , Tomoko Iwasaki , Hiromi Shishiuchi , Hiroaki Fukumoto

9. 外观设计

USD643875S1 Printer 有权
公开(公告)号：USD643875S1
公开(公告)日：2011-08-23
申请号：US29369673
申请日：2010-09-10
申请人： Wataru Suzuki , Tomoko Iwasaki , Hiromi Shishiuchi , Hiroaki Fukumoto
设计人： Wataru Suzuki , Tomoko Iwasaki , Hiromi Shishiuchi , Hiroaki Fukumoto

10. 发明授权

US07256204B2 Amine compounds, their production and use 失效
标题翻译：胺化合物，其生产和使用
公开(公告)号：US07256204B2
公开(公告)日：2007-08-14
申请号：US10645934
申请日：2003-08-21
申请人： Kaneyoshi Kato , Jun Terauchi , Hiroaki Fukumoto , Mitsuru Kakihana
发明人： Kaneyoshi Kato , Jun Terauchi , Hiroaki Fukumoto , Mitsuru Kakihana
IPC分类号： A61K31/38 , A61K31/36 , A61K31/18 , A61K31/16 , A61K31/135
CPC分类号： C07D213/30 , C07B2200/07 , C07C217/74 , C07C255/54 , C07C2602/10 , C07D215/14 , C07D215/20 , C07D215/58 , C07D271/06 , C07D277/64 , C07D295/096 , C07D307/80 , C07D317/54 , C07D333/16
摘要： A compound of the formula: wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or —SO2—, (iii) C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene, etc., (iv) —CO—O— or (v) —(CH2)p-X1—, —(CH2)p-X1—CH2)q-, —(CH2)r-CO—X1—, —SO2—NR8— or —(CH2)r-SO2—NR8— wherein X1 is O or NR8, R8 is H, a hydrocarbon group which may be substituted or an acyl, p is 0 to 5, q is 1 to 5, p+q is 1 to 5, and r is 1 to 4; Y is a divalent C1-6 aliphatic hydrocarbon group optionally containing O or S, which may be substituted; R1 and R2 each is H or a lower alkyl which may be substituted, or R1 and R2 form a N-containing heterocyclic ring which may be substituted; Ring A is a benzene ring which may be further substituted; and Ring B is a 4- to 8-membered ring which may be further substituted, or a salt thereof has the effect of inhibiting amyloid-β protein production and/or secretion and is useful as a pharmaceutical composition for preventing and/or treating the neurodegenerative disease, etc.
摘要翻译：下式的化合物：其中Ar是可被取代的芳环组合基团或可被取代的稠合芳基; X是（i）键，（ii）-S-，-SO-或-SO 2 - ，（iii）C 1-6亚烷基，C _{（2-6）亚烯基或C 2-6亚炔基等，（iv）-CO-O-或（v） - （CH 2） q - ， - （CH 2）n - ， - （CH 2 CH 2） R 2 CO-X 1 - ， - SO 2 -NR 8 - 或 - （CH _{，R 8是H，可以被取代的烃基或酰基，p是0-5，q是1至5，p + q是1至5，并且r是1至 4; Y是任选地含有可被取代的O或S的二价C 1-6烷基脂族烃基; R 1和R 2各自为H或可以被取代的低级烷基，或R 1和R 2 2 >形成可以被取代的含氮杂环; 环A是可以被进一步取代的苯环; 环B为可进一步取代的4-至8-元环，或其盐具有抑制淀粉样蛋白β蛋白产生和/或分泌的作用，并且可用作预防和/或治疗神经变性疾病等}}

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