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1. 发明授权

US08129560B2 Process for the synthesis of mandipropamid and derivatives thereof 有权
标题翻译：槲寄生及其衍生物的合成方法
公开(公告)号：US08129560B2
公开(公告)日：2012-03-06
申请号：US12063907
申请日：2006-08-08
申请人： Martin Charles Bowden , Thomas Aitcheson Clark , Fanny Giordano , Beat Jau , Hans-Dieter Schneider , Gottfried Seifert , Martin Zeller , Dominik Faber , Juerg Wiss
发明人： Martin Charles Bowden , Thomas Aitcheson Clark , Fanny Giordano , Beat Jau , Hans-Dieter Schneider , Gottfried Seifert , Martin Zeller , Dominik Faber , Juerg Wiss
IPC分类号： C07C255/37 , C07C231/02 , C07C231/06 , C07C43/23 , C07C213/02
CPC分类号： C07C231/12 , C07C33/46 , C07C59/70 , C07C69/734 , C07C213/02 , C07C235/34 , C07C251/16 , C07C255/37 , C07C315/04 , C07C319/20 , C07C317/46 , C07C323/62
摘要： A process for the preparation of a compound of formula (I), the process comprising: (i) the reaction of a compound of formula (III), with a compound of formula (IV) to give a compound of formula (II), and (ii) the reaction of the compound of formula (II) with a leaving group, to give the compound of formula (I).
摘要翻译：一种制备式（I）化合物的方法，该方法包括：（i）式（III）化合物与式（IV）化合物的反应，得到式（II）化合物，和（ii）式（II）化合物与离去基团的反应，得到式（I）化合物。

2. 发明申请

US20090118532A1 Process for the Synthesis of Mandipropamid and Derivatives Thereof 有权
公开(公告)号：US20090118532A1
公开(公告)日：2009-05-07
申请号：US12063907
申请日：2006-08-08
申请人： Martin Charles Bowden , Thomas Aitcheson Clark , Fanny Giordano , Beat Jau , Hans-Dieter Schneider , Gottfried Seifert , Martin Zeller , Dominik Faber , Juerg Wiss
发明人： Martin Charles Bowden , Thomas Aitcheson Clark , Fanny Giordano , Beat Jau , Hans-Dieter Schneider , Gottfried Seifert , Martin Zeller , Dominik Faber , Juerg Wiss
IPC分类号： C07C255/37 , C07C231/02 , C07C231/06 , C07C43/23 , C07C213/02
CPC分类号： C07C231/12 , C07C33/46 , C07C59/70 , C07C69/734 , C07C213/02 , C07C235/34 , C07C251/16 , C07C255/37 , C07C315/04 , C07C319/20 , C07C317/46 , C07C323/62
摘要： A process for the preparation of a compound of formula (I) wherein: R is an alkynyl group; R1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, phenyl and phenylalkyl, it being possible in turn for all of the receding groups to carry one or more identical or different halogen atoms; alkoxy; alkenyloxy; alkynyloxy; alkoxyalkyl; haloalkoxy; alkylthio; haloalkylthio; alkysulfonyl; formyl; alkanoyl; hydroxy; halogen; cyano; nitro; amino; alkylamino; dialkylamino; carboxyl; alkoxycarbonyl; alkenyloxycarbonyl; or alkynyloxycarbonyl; and n is an integer from 0 to 3, said process comprising: (i) the reaction of a compound of formula (III) wherein R, R1 and n are as hereinbefore defined; m and m′ are independently 0 or 1; when m and m′ are both 0, A is an alkyl, alkenyl or alkynyl group (suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; when one of m and m′ is 0 and the other is 1, A is an alkanediyl, alkenediyl or alkynediyl group containing at least two carbon atoms (and suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; when m and m′ are both 1, A is an alkanetriyl, alkenetriyl or alkynetriyl group containing at least three carbon atoms (and suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; and wherein if the group A contains three or more carbon atoms, one or more of the carbon atoms may each optionally be replaced with an oxygen atom, provided that there is at least one carbon atom between any two oxygen atoms in the molecule, with a compound of formula (IV) to give a compound of formula (II) wherein R, R1 and n are as hereinbefore defined, and (ii) the reaction of a compound of formula (II) with, wherein L is a leaving group, to give the compound of formula (I) as hereinbefore defined, is disclosed.

3. 发明授权

US08227619B2 Process for the preparation of amides 失效
标题翻译：酰胺的制备方法
公开(公告)号：US08227619B2
公开(公告)日：2012-07-24
申请号：US12992781
申请日：2009-05-11
申请人： Martin Charles Bowden , David Anthony Jackson , Alexandre Christian Saint-Dizier , George Robert Hodges
发明人： Martin Charles Bowden , David Anthony Jackson , Alexandre Christian Saint-Dizier , George Robert Hodges
IPC分类号： C07D209/56 , C07D307/93 , C07D333/78 , C07D487/08
CPC分类号： C07D231/14
摘要： The invention relates to a process for the preparation of fungicidally active compounds such as tricyclic amine derivatives (I). The process involves coupling of a carboxylic 5 acid e.g. a compound of formula (II) with an aniline, e.g. a compound of formula (III) in the presence of a boronic acid catalystor an antimony catalyst (II)(III)(I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y and Het are defined in the specification.
摘要翻译：本发明涉及一种制备杀真菌活性化合物如三环胺衍生物（I）的方法。该方法包括偶联羧酸5酸，例如式（II）的化合物与苯胺，例如在硼酸催化剂或其中R1，R2，R3，R4，R5，R6，R7，X，Y和Het定义在锑催化剂（II）（III）（I）的存在下，式（III）的化合物规格。

4. 发明授权

US06323343B1 Process for the preparation of 8-azabicyclo(3.2.1)octane derivatives 失效
标题翻译：制备8-氮杂双环（3.2.1）辛烷衍生物的方法
公开(公告)号：US06323343B1
公开(公告)日：2001-11-27
申请号：US09555463
申请日：2000-05-30
申请人： Martin Charles Bowden , Stephen Martin Brown , Douglas John Smith , Trevor Robert Perrior
发明人： Martin Charles Bowden , Stephen Martin Brown , Douglas John Smith , Trevor Robert Perrior
IPC分类号： C07D45102
CPC分类号： C07D451/02
摘要： A process for preparing a compound of formula (IV), wherein R1 is C1-4alkyl, CH2(C1-3haloalkyl), benzyl, CH2(C2-5akenyl or CH2(C2-5alkynyl), which comprises reducing a compound of formula (III). Compounds of formula (IV) are agrochemical intermediates.
摘要翻译：一种制备式（IV）化合物的方法，其中R 1是C 1-4烷基，CH 2（C 1-3卤代烷基），苄基，CH 2（C 2-烯基或CH 2（C 2-5炔基）），其包括将式）式（Ⅳ）化合物是农药中间体。

5. 发明授权

US5670697A Preparation of cyclopropane esters 失效
标题翻译：制备环丙烷酯
公开(公告)号：US5670697A
公开(公告)日：1997-09-23
申请号：US451288
申请日：1995-05-26
申请人： Martin Charles Bowden , Michael Drysdale Turnbull
发明人： Martin Charles Bowden , Michael Drysdale Turnbull
IPC分类号： B01J21/16 , B01J31/02 , B01J31/04 , C07B61/00 , C07C20060101 , C07C41/60 , C07C43/32 , C07C67/27 , C07C67/30 , C07C67/317 , C07C69/65 , C07C69/743 , C07C69/747 , C07C69/74
CPC分类号： C07C43/32 , C07C69/65 , C07C69/743
摘要： There is disclosed a process for the preparation of a lower alkyl ester of 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane carboxylic acid which comprises the steps of (a) reacting a compound of formula: CF.sub.3 --CXCl--CH(OH)--CH.dbd.C(CH.sub.3).sub.2 (I) wherein X is chloro or bromo, with a tri-lower-alkyl orthoacetate containing up to four carbon atoms in each alkyl groups in the presence of at least a catalytic amount of an acid catalyst at an elevated temperature for a sufficient time to obtain a compound of formula: CF.sub.3 --CXCl--CH.dbd.CH--C(CH.sub.3).sub.2 --CH.sub.2 CO.sub.2 R(III) wherein R is an alkyl group containing up to four carbon atoms, and (b) treating said compound of formula (III) with at least one molar equivalent of a base to obtain said alkyl ester of 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane carboxylic acid. The products are useful as intermediates for insecticides.
摘要翻译：公开了制备3-（2-氯-3,3,3-三氟丙-1-烯-1-基）-2,2-二甲基环丙烷羧酸的低级烷基酯的方法，该方法包括以下步骤：（a）使其中X是氯或溴的式：CF 3 -CClCl-CH（OH）-CH = C（CH 3）2（I）的化合物与含有至多四个碳原子的三低级烷基原乙酸酯反应每个烷基在至少一种催化量的酸催化剂存在下在升高的温度下持续足够的时间以得到式CF 3 -CClCl-CH = CH-C（CH 3）2 -CH 2 CO 2 R（III）的化合物，其中 R是含有至多4个碳原子的烷基，和（b）用至少一摩尔当量碱处理式（III）化合物，得到所述3-（2-氯-3,3， 3-三氟丙-1-烯-1-基）-2,2-二甲基环丙烷羧酸。该产品可用作杀虫剂的中间体。

6. 发明申请

US20100240907A1 PROCESSES FOR THE PREPARATION OF PYRAZOLES 有权
标题翻译：制备吡唑的方法
公开(公告)号：US20100240907A1
公开(公告)日：2010-09-23
申请号：US12666179
申请日：2008-06-16
申请人： Martin Charles Bowden , Brian David Gott , David Anthony Jackson , Lacob Gutsu
发明人： Martin Charles Bowden , Brian David Gott , David Anthony Jackson , Lacob Gutsu
IPC分类号： C07D231/12 , C07C243/14
CPC分类号： C07C251/76 , C07D231/12 , C07D231/14
摘要： The present invention relates to novel processes for the production of compounds of formula (I) wherein Hal and Hal′ are independently selected from Cl and F, and R1 is selected from Cl, F and H.
摘要翻译：本发明涉及制备式（I）化合物的新方法，其中Hal和Hal'独立地选自Cl和F，R 1选自Cl，F和H.

7. 发明授权

US06316624B1 Process for the preparation of substituted 8-azabicyclo[3,2,1]octanes 失效
标题翻译：制备取代的8-氮杂双环[3,2,1]辛烷的方法
公开(公告)号：US06316624B1
公开(公告)日：2001-11-13
申请号：US09555429
申请日：2000-05-30
申请人： Martin Charles Bowden , Stephen Martin Brown
发明人： Martin Charles Bowden , Stephen Martin Brown
IPC分类号： C07D45102
CPC分类号： C07D451/02 , C07D491/10
摘要： A process for preparing a compound of formula (IV) wherein R1 is C1-4 alkyl, C1-4 haloalkyl, benzyl, C3-6 alkenyl or C3-6 alkyny, (provided that the &agr;-carbon atom of R1 is neither unsaturated nor substituted with halogen), which comprises reacting a compound of formula (III) with a source of hydroxylamine in the presence of an acid. Compounds of formula (IV) are agrochemical intermediates.
摘要翻译：制备式（IV）化合物的方法，其中R 1为C 1-4烷基，C 1-4卤代烷基，苄基，C 3-6烯基或C 3-6炔基（条件是R 1的α-碳原子既不饱和也不是被卤素取代），其包括在酸的存在下使式（III）化合物与羟胺源反应。式（Ⅳ）化合物是农药中间体。

8. 发明授权

US6156904A Process 失效
标题翻译：处理
公开(公告)号：US6156904A
公开(公告)日：2000-12-05
申请号：US469822
申请日：1999-12-22
申请人： Martin Charles Bowden , Stephen Martin Brown
发明人： Martin Charles Bowden , Stephen Martin Brown
IPC分类号： C07D277/20 , C07D277/36
CPC分类号： C07D277/36
摘要： 5-Chloro-2-(4,4-difluorobutylthio)thiazole is prepared from 2-mercaptotriazole by a multistep process involving S-alkylation, chlorination and dehydrochlorination and is converted by oxidation to the corresponding sulfone which is useful as an agricultural nematicide.
摘要翻译：通过涉及S-烷基化，氯化和脱氯化氢的多步法由2-巯基三唑制备5-氯-2-（4,4-二氟丁基硫代）噻唑，并通过氧化转化成可用作农业杀线虫剂的相应的砜。

9. 发明授权

US5760269A 4,4,4-Trichlorobutyl methanesulfonate 失效
标题翻译： 4,4,4-三氯丁基甲磺酸酯
公开(公告)号：US5760269A
公开(公告)日：1998-06-02
申请号：US761251
申请日：1996-12-06
申请人： Martin Charles Bowden , Trevor Robert Perrior
发明人： Martin Charles Bowden , Trevor Robert Perrior
IPC分类号： C07C29/12 , C07C29/09 , C07C31/36 , C07C303/30 , C07C309/66 , C07C319/14 , C07C319/20 , C07C323/03 , C07C323/05
CPC分类号： C07C319/14 , C07C29/095 , C07C309/66
摘要： The invention provides the novel compound 4,4,4-trichlorobutyl methanesufonate, useful as an intermediate in the production of certain agricultural pesticides, and a process for its manufacture.
摘要翻译：本发明提供了可用作生产某些农药的中间体的新型化合物4,4,4-三氯丁基甲磺酸酯及其制备方法。

10. 发明授权

US5731475A Preparation of cyclopropane esters 失效
标题翻译：制备环丙烷酯
公开(公告)号：US5731475A
公开(公告)日：1998-03-24
申请号：US826650
申请日：1997-04-04
申请人： Martin Charles Bowden , Michael Drysdale Turnbull
发明人： Martin Charles Bowden , Michael Drysdale Turnbull
IPC分类号： B01J21/16 , B01J31/02 , B01J31/04 , C07B61/00 , C07C20060101 , C07C41/60 , C07C43/32 , C07C67/27 , C07C67/30 , C07C67/317 , C07C69/65 , C07C69/743 , C07C69/747 , C07C43/30
CPC分类号： C07C43/32 , C07C69/65 , C07C69/743
摘要： There is disclosed a process for the preparation of a lower alkyl ester of 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane carboxylic acid which comprises the steps of (a) reacting a compound of formula: CF.sub.3 --CXCl--CH(OH)--CH.dbd.C(CH.sub.3).sub.2 (I) wherein X is chloro or bromo, with a tri-lower-alkyl orthoacetate containing up to four carbon atoms in each alkyl groups in the presence of at least a catalytic amount of an acid catalyst at an elevated temperature for a sufficient time to obtain a compound of formula: CF.sub.3 --CXCl--CH.dbd.CH--C(CH.sub.3).sub.2 --CH.sub.2 CO.sub.2 R (III) wherein R is an alkyl group containing up to four carbon atoms, and (b) treating said compound of formula (III) with at least one molar equivalent of a base to obtain said alkyl ester of 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane carboxylic acid. The products are useful as intermediates for insecticides.
摘要翻译：公开了制备3-（2-氯-3,3,3-三氟丙-1-烯-1-基）-2,2-二甲基环丙烷羧酸的低级烷基酯的方法，该方法包括以下步骤：（a）使其中X是氯或溴的式：CF 3 -CClCl-CH（OH）-CH = C（CH 3）2（I）的化合物与含有至多四个碳原子的三低级烷基原乙酸酯反应每个烷基在至少一种催化量的酸催化剂存在下在升高的温度下持续足够的时间以获得式CF 3 -CClCl-CH = CH-C（CH 3）2 -CH 2 CO 2 R（III）的化合物，其中 R是含有至多4个碳原子的烷基，和（b）用至少一摩尔当量碱处理式（III）化合物，得到所述3-（2-氯-3,3， 3-三氟丙-1-烯-1-基）-2,2-二甲基环丙烷羧酸。该产品可用作杀虫剂的中间体。

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