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1. 发明授权

US08129560B2 Process for the synthesis of mandipropamid and derivatives thereof 有权
标题翻译：槲寄生及其衍生物的合成方法
公开(公告)号：US08129560B2
公开(公告)日：2012-03-06
申请号：US12063907
申请日：2006-08-08
申请人： Martin Charles Bowden , Thomas Aitcheson Clark , Fanny Giordano , Beat Jau , Hans-Dieter Schneider , Gottfried Seifert , Martin Zeller , Dominik Faber , Juerg Wiss
发明人： Martin Charles Bowden , Thomas Aitcheson Clark , Fanny Giordano , Beat Jau , Hans-Dieter Schneider , Gottfried Seifert , Martin Zeller , Dominik Faber , Juerg Wiss
IPC分类号： C07C255/37 , C07C231/02 , C07C231/06 , C07C43/23 , C07C213/02
CPC分类号： C07C231/12 , C07C33/46 , C07C59/70 , C07C69/734 , C07C213/02 , C07C235/34 , C07C251/16 , C07C255/37 , C07C315/04 , C07C319/20 , C07C317/46 , C07C323/62
摘要： A process for the preparation of a compound of formula (I), the process comprising: (i) the reaction of a compound of formula (III), with a compound of formula (IV) to give a compound of formula (II), and (ii) the reaction of the compound of formula (II) with a leaving group, to give the compound of formula (I).
摘要翻译：一种制备式（I）化合物的方法，该方法包括：（i）式（III）化合物与式（IV）化合物的反应，得到式（II）化合物，和（ii）式（II）化合物与离去基团的反应，得到式（I）化合物。

2. 发明申请

US20090118532A1 Process for the Synthesis of Mandipropamid and Derivatives Thereof 有权
公开(公告)号：US20090118532A1
公开(公告)日：2009-05-07
申请号：US12063907
申请日：2006-08-08
申请人： Martin Charles Bowden , Thomas Aitcheson Clark , Fanny Giordano , Beat Jau , Hans-Dieter Schneider , Gottfried Seifert , Martin Zeller , Dominik Faber , Juerg Wiss
发明人： Martin Charles Bowden , Thomas Aitcheson Clark , Fanny Giordano , Beat Jau , Hans-Dieter Schneider , Gottfried Seifert , Martin Zeller , Dominik Faber , Juerg Wiss
IPC分类号： C07C255/37 , C07C231/02 , C07C231/06 , C07C43/23 , C07C213/02
CPC分类号： C07C231/12 , C07C33/46 , C07C59/70 , C07C69/734 , C07C213/02 , C07C235/34 , C07C251/16 , C07C255/37 , C07C315/04 , C07C319/20 , C07C317/46 , C07C323/62
摘要： A process for the preparation of a compound of formula (I) wherein: R is an alkynyl group; R1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, phenyl and phenylalkyl, it being possible in turn for all of the receding groups to carry one or more identical or different halogen atoms; alkoxy; alkenyloxy; alkynyloxy; alkoxyalkyl; haloalkoxy; alkylthio; haloalkylthio; alkysulfonyl; formyl; alkanoyl; hydroxy; halogen; cyano; nitro; amino; alkylamino; dialkylamino; carboxyl; alkoxycarbonyl; alkenyloxycarbonyl; or alkynyloxycarbonyl; and n is an integer from 0 to 3, said process comprising: (i) the reaction of a compound of formula (III) wherein R, R1 and n are as hereinbefore defined; m and m′ are independently 0 or 1; when m and m′ are both 0, A is an alkyl, alkenyl or alkynyl group (suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; when one of m and m′ is 0 and the other is 1, A is an alkanediyl, alkenediyl or alkynediyl group containing at least two carbon atoms (and suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; when m and m′ are both 1, A is an alkanetriyl, alkenetriyl or alkynetriyl group containing at least three carbon atoms (and suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; and wherein if the group A contains three or more carbon atoms, one or more of the carbon atoms may each optionally be replaced with an oxygen atom, provided that there is at least one carbon atom between any two oxygen atoms in the molecule, with a compound of formula (IV) to give a compound of formula (II) wherein R, R1 and n are as hereinbefore defined, and (ii) the reaction of a compound of formula (II) with, wherein L is a leaving group, to give the compound of formula (I) as hereinbefore defined, is disclosed.

3. 发明申请

US20090124800A1 PROCESS FOR THE PREPARATION OF [1,4,5]-OXADIAZEPINE DERIVATIVES 审中-公开
标题翻译：制备[1,4,5] - 氧亚氨基衍生物的方法
公开(公告)号：US20090124800A1
公开(公告)日：2009-05-14
申请号：US11577805
申请日：2005-10-25
申请人： Dominik Faber , Beat Jau
发明人： Dominik Faber , Beat Jau
IPC分类号： C07D273/06
CPC分类号： C07D273/06
摘要： A process for the preparation of [1,4,5]-oxadiazepine derivatives by reaction of 4,5-diacyl-[1,4,5]-oxadiazepines with a base.
摘要翻译：通过4,5-二酰基 - [1,4,5] - 恶二唑并与碱反应制备[1,4,5] - 恶二氮杂衍生物的方法。

4. 发明申请

US20110207925A1 PROCESS FOR THE PREPARATION OF [1,4,5]-OXADIAZEPINE DERIVATIVES 审中-公开
标题翻译：制备[1,4,5] - 氧亚氨基衍生物的方法
公开(公告)号：US20110207925A1
公开(公告)日：2011-08-25
申请号：US13100601
申请日：2011-05-04
申请人： Dominik Faber , Beat Jau
发明人： Dominik Faber , Beat Jau
IPC分类号： C07D285/36
CPC分类号： C07D273/06
摘要： A process for the preparation of [1,4,5]-oxadiazepine derivatives by reaction of 4,5-diacyl-[1,4,5]-oxadiazepines with a base.
摘要翻译：通过4,5-二酰基 - [1,4,5] - 恶二唑并与碱反应制备[1,4,5] - 恶二氮杂衍生物的方法。

5. 发明授权

US06498265B2 3-amino-2-mercaptobenzoic acid derivatives and processes for their preparation 有权
标题翻译： 3-氨基-2-巯基苯甲酸衍生物及其制备方法
公开(公告)号：US06498265B2
公开(公告)日：2002-12-24
申请号：US09963046
申请日：2001-09-25
申请人： Walter Kunz , Beat Jau
发明人： Walter Kunz , Beat Jau
IPC分类号： C07C32700
CPC分类号： C07D285/14 , C07C323/63 , C07C327/26 , C07C335/22 , C07D277/82
摘要： Compounds of the formula I and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III In the compounds of the formulae I and III: X is halogen, n is 0,1,2 or 3; Z is CN, CO—A or CS—A, A is hydrogen, halogen, OR1, SR2 and N(R3)R4; R1 to R4 are hydrogen, a substituted or unsubstituted, open-chain, saturated or unsaturated hydrocarbon radical containing not more than 8 carbon atoms, a substituted or unsubstituted cyclic, saturated or unsaturated hydrocarbon radical containing not more than 10 carbon atoms, substituted or unsubstituted benzyl or phenethyl, a substituted or unsubstituted alkanoyl group containing not more than 8 carbon atoms, a substituted or unsubstituted benzoyl group or a substituted or unsubstituted heterocyclyl radical; or R3 and R4, together with the nitrogen atom to which they are bonded, are a 5- or 6-membered, substituted or unsubstituted heterocyclic radical having 1-3 heteroatoms O, S and/or N. Processes for the preparation of compounds of the formula I are described.
摘要翻译：式I及其二硫化物及其盐的化合物是制备具有式III的杀微生物和植物免疫作用的化合物的重要的中间产物。在式I和III的化合物中：X为卤素，n为0,1 ，2或3; Z是CN，CO-A或CS-A，A是氢，卤素，OR1，SR2和N（R3）R4; R1至R4是氢，取代或未取代的开链，饱和或含有不超过8个碳原子的不饱和烃基，取代或未取代的含有不超过10个碳原子的环状，饱和或不饱和烃基，取代或未取代的苄基或苯乙基，取代或未取代的含有不超过8个碳原子的烷酰基取代或未取代的苯甲酰基或取代或未取代的杂环基; 或R 3和R 4与它们所键合的氮原子一起是具有1-3个杂原子O，S和/或N的5或6元取代或未取代的杂环基。描述了式I。

6. 发明授权

US06693194B2 Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine 有权
标题翻译：制备4,6-二甲氧基-2-（甲基磺酰基）-1,3-嘧啶的方法
公开(公告)号：US06693194B2
公开(公告)日：2004-02-17
申请号：US10332248
申请日：2003-01-06
申请人： Beat Jau , Bernhard Urwyler
发明人： Beat Jau , Bernhard Urwyler
IPC分类号： C07D23960
CPC分类号： C07D405/12 , C07D239/60
摘要： Process for preparing 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine by reacting 4,6dichloro-2-(methyltio)-1,3-pyrimidine in an inert organic solvent with an alkali metal methoxide, transfer of the resulting 4,6-dimethoxy-2-(methylthio)-1,3-pyrimidine into an aqueous-acidic medium and subsequent oxidation of this compound, of appropriate in the presence of a catalyst, wherein the oxidation is followed by a purification step in which the aqueous-acidic reaction mixture is adjusted with aqueous base to a pH in the range of 5-8 and stirred either in the presence or in the absence of an organic solvent, and the use of this compound for preparing herbicides, for example 7-[(4,6-dimethoxy-pyrimidin-2-yl)thio]-3-methylphthalide.
摘要翻译：通过使四氯-2-（甲基氧基）-1,3-嘧啶在惰性有机溶剂中与碱金属甲醇盐反应制备4,6-二甲氧基-2-（甲基磺酰基）-1,3-嘧啶的方法，将将所得的4,6-二甲氧基-2-（甲硫基）-1,3-嘧啶转化为酸性介质，随后在催化剂存在下氧化该化合物，其中氧化后进行纯化步骤其中将水性 - 酸性反应混合物用碱水溶液调节至pH为5-8，并在有机溶剂存在或不存在下搅拌，并使用该化合物制备除草剂，例如 7 - [（4,6-二甲氧基 - 嘧啶-2-基）硫基] -3-甲基苯酞。

7. 发明授权

US06380422B1 3-amino-2-mercaptobenzoic acid derivatives and processes for their preparation 有权
标题翻译： 3-氨基-2-巯基苯甲酸衍生物及其制备方法
公开(公告)号：US06380422B1
公开(公告)日：2002-04-30
申请号：US09259897
申请日：1999-02-26
申请人： Walter Kunz , Beat Jau
发明人： Walter Kunz , Beat Jau
IPC分类号： C07C25550
CPC分类号： C07C335/22 , C07C319/02 , C07C319/12 , C07C323/63
摘要： Compounds of the formula I and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III In the compounds of the formulae I and III: X is halogen, n is 0, 1, 2 or 3; Z is CN, CO—A or CS—A, A is hydrogen, halogen, OR1, SR2 and N(R3)R4; R1 to R4 are hydrogen, a substituted or unsubstituted, open-chain, saturated or unsaturated hydrocarbon radical containing not more than 8 carbon atoms, a substituted or unsubstituted cyclic, saturated or unsaturated hydrocarbon radical containing not more than 10 carbon atoms, substituted or unsubstituted benzyl or phenethyl, a substituted or unsubstituted alkanoyl group containing not more than 8 carbon atoms, a substituted or unsubstituted benzoyl group or a substituted or unsubstituted heterocyclyl radical; or R3 and R4, together with the nitrogen atom to which they are bonded, are a 5- or 6-membered, substituted or unsubstituted heterocyclic radical having 1-3 heteroatoms O, S and/or N. Processes for the preparation of compounds of the formula I are described.
摘要翻译：式I及其二硫化物及其盐的化合物是制备具有式III的杀微生物和植物免疫作用的化合物的重要的中间产物。在式I和III的化合物中：X为卤素，n为0,1 ，2或3; Z是CN，CO-A或CS-A，A是氢，卤素，OR1，SR2和N（R3）R4; R1至R4是氢，取代或未取代的开链，饱和或含有不超过8个碳原子的不饱和烃基，取代或未取代的含有不超过10个碳原子的环状，饱和或不饱和烃基，取代或未取代的苄基或苯乙基，取代或未取代的含有不超过8个碳原子的烷酰基取代或未取代的苯甲酰基或取代或未取代的杂环基; 或R 3和R 4与它们所键合的氮原子一起是具有1-3个杂原子O，S和/或N的5或6元取代或未取代的杂环基。用于制备化合物的方法描述了公式I。

8. 发明授权

US08088960B2 Process for the production of substituted bromobenzenes 失效
标题翻译：制备取代溴苯的方法
公开(公告)号：US08088960B2
公开(公告)日：2012-01-03
申请号：US12446793
申请日：2007-10-08
申请人： Beat Jau , Colin Ellis , Linhua Wang
发明人： Beat Jau , Colin Ellis , Linhua Wang
IPC分类号： C07C17/00 , C07C22/00
CPC分类号： C07C25/02 , C07C17/093 , C07C25/13
摘要： The present invention relates to a process for the production of compounds of formula (I) wherein X is fluoro, chloro, bromo or iodo and n is 1, 2, 3 or 4, which process comprises reacting a compound of formula (II) wherein the substituents are as defined for formula (I), with inorganic nitrite in an acidic aqueous medium in the presence of bromide and a copper catalyst and wherein the process is carried out as a one-pot reaction.
摘要翻译：本发明涉及制备式（I）化合物的方法，其中X为氟，氯，溴或碘，n为1,2,3或4，该方法包括使式（II）化合物与取代基如式（I）所定义，无机亚硝酸盐在酸性水性介质中，在溴化物和铜催化剂存在下，其中该方法作为一锅反应进行。

9. 发明授权

US06002013A 3-amino-2-mercaptobenzoic acid derivatives and processes for their preparation 有权
标题翻译： 3-氨基-2-巯基苯甲酸衍生物及其制备方法
公开(公告)号：US06002013A
公开(公告)日：1999-12-14
申请号：US148276
申请日：1998-09-04
申请人： Walter Kunz , Beat Jau
发明人： Walter Kunz , Beat Jau
IPC分类号： C07C319/02 , C07C319/12 , C07C323/63 , C07C327/26 , C07C335/22 , C07D277/82 , C07D285/14 , C07D277/62 , C07C255/07 , C07C321/08
CPC分类号： C07D285/14 , C07C319/02 , C07C319/12 , C07C323/63 , C07C327/26 , C07C335/22 , C07D277/82
摘要： Compounds of the formula I ##STR1## and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III ##STR2## In the compounds of the formulae I and III: X is halogen,n is 0, 1, 2 or 3;Z is CN, CO--A or CS--A,A is hydrogen, halogen, OR.sub.1, SR.sub.2 and N(R.sub.3)R.sub.4 ;R.sub.1 to R.sub.4 are hydrogen, a substituted or unsubstituted, open-chain, saturated or unsaturated hydrocarbon radical containing not more than 8 carbon atoms, a substituted or unsubstituted cyclic, saturated or unsaturated hydrocarbon radical containing not more than 10 carbon atoms, substituted or unsubstituted benzyl or phenethyl, a substituted or unsubstituted alkanoyl group containing not more than 8 carbon atoms, a substituted or unsubstituted benzoyl group or a substituted or unsubstituted heterocyclyl radical; or R.sub.3 and R.sub.4, together with the nitrogen atom to which they are bonded, are a 5- or 6-membered, substituted or unsubstituted heterocyclic radical having 1-3 heteroatoms O, S and/or NProcesses for the preparation of compounds of the formula I are described.
摘要翻译：式I化合物及其二硫化物及其盐是制备具有式III的杀微生物和植物免疫作用的化合物的重要中间产物。在式I和III化合物中：X为卤素，n为0 ，1,2或3; Z是CN，CO-A或CS-A，A是氢，卤素，OR1，SR2和N（R3）R4; R 1至R 4为氢，取代或未取代的含有不超过8个碳原子的开链，饱和或不饱和烃基，取代或未取代的含有不多于10个碳原子的环状，饱和或不饱和烃基，取代或未取代的苄基或苯乙基，取代或未取代的不超过8个碳原子的烷酰基，取代或未取代的苯甲酰基或取代或未取代的杂环基; 或R 3和R 4与它们所键合的氮原子一起是具有1-3个杂原子O，S和/或N的5或6元取代或未取代的杂环基。描述了公式I。

10. 发明申请

US20110065968A1 PROCESS FOR THE PRODUCTION OF SUBSTITUTED BROMOBENZENES 失效
标题翻译：生产取代的溴代苯甲酸的方法
公开(公告)号：US20110065968A1
公开(公告)日：2011-03-17
申请号：US12446793
申请日：2007-10-08
申请人： Beat Jau , Colin Ellis , Linhua Wang
发明人： Beat Jau , Colin Ellis , Linhua Wang
IPC分类号： C07C17/093
CPC分类号： C07C25/02 , C07C17/093 , C07C25/13
摘要： The present invention relates to a process for the production of compounds of formula (I) wherein X is fluoro, chloro, bromo or iodo and n is 1, 2, 3 or 4, which process comprises reacting a compound of formula (II) wherein the substituents are as defined for formula (I), with inorganic nitrite in an acidic aqueous medium in the presence of bromide and a copper catalyst and wherein the process is carried out as a one-pot reaction.
摘要翻译：本发明涉及制备式（I）化合物的方法，其中X为氟，氯，溴或碘，n为1,2,3或4，该方法包括使式（II）化合物与取代基如式（I）所定义，无机亚硝酸盐在酸性水性介质中，在溴化物和铜催化剂存在下，其中该方法作为一锅反应进行。

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