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1. 发明授权

US07790421B2 Peptide acceptor ligation methods 有权
标题翻译：肽受体结合方法
公开(公告)号：US07790421B2
公开(公告)日：2010-09-07
申请号：US11483495
申请日：2006-07-10
申请人： Markus Kurz , Peter Lohse , Richard W. Wagner
发明人： Markus Kurz , Peter Lohse , Richard W. Wagner
IPC分类号： C12P19/34
CPC分类号： C12P19/34 , C07K1/1077 , C07K17/02 , C12N15/1006 , C12N15/1062 , C12N15/1075 , C12N15/11
摘要： Described herein are methods and reagents for the ligation of a peptide acceptor to an RNA, as well as the RNA-peptide acceptor products.
摘要翻译：本文描述了用于将肽受体与RNA连接的方法和试剂，以及RNA-肽受体产物。

2. 发明授权

US10865409B2 Methods for tagging DNA-encoded libraries 有权
公开(公告)号：US10865409B2
公开(公告)日：2020-12-15
申请号：US14343306
申请日：2012-09-07
申请人： Anthony D. Keefe , Richard W. Wagner , Alexander Litovchick , Matthew Clark , John W. Cuozzo , Ying Zhang , Paolo A. Centrella , Christopher D. Hupp
发明人： Anthony D. Keefe , Richard W. Wagner , Alexander Litovchick , Matthew Clark , John W. Cuozzo , Ying Zhang , Paolo A. Centrella , Christopher D. Hupp
IPC分类号： C12N15/10 , C40B50/16
CPC分类号： C12N15/1065 , C12N15/10 , C12N15/1068 , C12N15/1093 , C40B50/16 , C07B2200/11
摘要： The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2′-substituted nucleotides, such as 2′-O-methyl or 2′-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.

3. 发明申请

US20140315762A1 METHODS FOR TAGGING DNA-ENCODED LIBRARIES 审中-公开
标题翻译：标记DNA编码的图书馆的方法
公开(公告)号：US20140315762A1
公开(公告)日：2014-10-23
申请号：US14343306
申请日：2012-09-07
申请人： Anthony D. Keefe , Richard W. Wagner , Alexander Litovchick , Matthew Clark , John W. Cuozzo , Ying Zhang , Paolo A. Centrella , Christopher D. Hupp
发明人： Anthony D. Keefe , Richard W. Wagner , Alexander Litovchick , Matthew Clark , John W. Cuozzo , Ying Zhang , Paolo A. Centrella , Christopher D. Hupp
IPC分类号： C12N15/10
CPC分类号： C12N15/1065 , C07B2200/11 , C12N15/10 , C12N15/1068 , C12N15/1093 , C40B50/16
摘要： The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2′-substituted nucleotides, such as 2′-O-methyl or 2′-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.
摘要翻译：本发明涉及寡核苷酸编码的文库和标记这些文库的方法。特别地，所述方法和寡核苷酸可以包括一个或多个2'-取代的核苷酸，例如2'-O-甲基或2'-氟核苷酸，以及用于增强酶连接的一些或多种化学功能的其它条件或试剂，以支持化学结扎。

4. 发明申请

US20140113831A1 ANTIBODY SCREENING METHODS 有权
标题翻译：抗体筛选方法
公开(公告)号：US20140113831A1
公开(公告)日：2014-04-24
申请号：US14005085
申请日：2012-03-14
申请人： Yan Chen , Tod M. Woolf , Richard W. Wagner
发明人： Yan Chen , Tod M. Woolf , Richard W. Wagner
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , C07K16/005 , C07K16/2863 , C07K2317/21 , C07K2317/56 , C07K2317/622 , C40B30/04 , G01N33/6854
摘要： Provided are methods and compositions for the production of novel antibodies that bind specifically to a target anti gen. These methods and compositions are particularly useful for producing antibodies having the antigen binding specificity of a reference antibody but with improved properties (e.g., binding affinity, immunogenicity, and thermodynamic stability) relative to the reference antibody.
摘要翻译：提供用于生产特异性结合靶抗原的新型抗体的方法和组合物。这些方法和组合物特别可用于产生具有参考抗体的抗原结合特异性但具有相对于参照抗体具有改善的性质（例如，结合亲和力，免疫原性和热力学稳定性）的抗体。

5. 发明授权

US07022479B2 Sensitive, multiplexed diagnostic assays for protein analysis 有权
公开(公告)号：US07022479B2
公开(公告)日：2006-04-04
申请号：US10212620
申请日：2002-08-05
申请人： Richard W. Wagner
发明人： Richard W. Wagner
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04 , C07K14/00
CPC分类号： C12Q1/6825 , C12N15/1051
摘要： Disclosed herein are methods for detecting multiple compounds in a sample, involving: (a) contacting the sample with a mixture of binding reagents, the binding reagents being nucleic acid-protein fusions, each having (i) a protein portion which is known to specifically bind to one of the compounds and (ii) a nucleic acid portion which encodes the protein portion and which includes a unique identification tag; (b) allowing the protein portions of the binding reagents and the compounds to form complexes; (c) capturing the binding reagent-compound complexes; (d) amplifying the nucleic acid portions of the complexed binding reagents; and (e) detecting the unique identification tag of each of the amplified nucleic acids, thereby detecting the corresponding compounds in the sample. Also disclosed herein are kits for carrying out such methods.

6. 发明授权

US06489116B2 Sensitive, multiplexed diagnostic assays for protein analysis 有权
标题翻译：用于蛋白质分析的敏感多重诊断测定
公开(公告)号：US06489116B2
公开(公告)日：2002-12-03
申请号：US09755663
申请日：2001-01-04
申请人： Richard W. Wagner
发明人： Richard W. Wagner
IPC分类号： C12Q168
CPC分类号： C12Q1/6825 , C12N15/1051 , C12N15/1065
摘要： Disclosed herein are methods for detecting multiple compounds in a sample, involving: (a) contacting the sample with a mixture of binding reagents, the binding reagents being nucleic acid-protein fusions, each having (i) a protein portion which is known to specifically bind to one of the compounds and (ii) a nucleic acid portion which encodes the protein portion and which includes a unique identification tag; (b) allowing the protein portions of the binding reagents and the compounds to form complexes; (c) capturing the binding reagent-compound complexes; (d) amplifying the nucleic acid portions of the complexed binding reagents; and (e) detecting the unique identification tag of each of the amplified nucleic acids, thereby detecting the corresponding compounds in the sample. Also disclosed herein are kits for carrying out such methods.
摘要翻译：本文公开了用于检测样品中多种化合物的方法，其包括：（a）使样品与结合试剂的混合物接触，所述结合试剂是核酸 - 蛋白质融合物，每种具有（i）特异性已知的蛋白质部分结合一种化合物和（ii）编码蛋白质部分并且包括唯一识别标签的核酸部分; （b）允许结合试剂和化合物的蛋白质部分形成复合物; （c）捕获结合试剂 - 复合物; （d）扩增复合结合试剂的核酸部分; 和（e）检测每个扩增的核酸的唯一识别标签，从而检测样品中相应的化合物。本文还公开了用于实施这些方法的试剂盒。

7. 发明申请

US20120107840A1 Methods for Label Free Testing of Cells 审中-公开
标题翻译：细胞标记免疫测试方法
公开(公告)号：US20120107840A1
公开(公告)日：2012-05-03
申请号：US13291741
申请日：2011-11-08
申请人： Richard W. Wagner , Kaan Certel , Steven Shamah , Alexander Yuzhakov , Lance G. Laing
发明人： Richard W. Wagner , Kaan Certel , Steven Shamah , Alexander Yuzhakov , Lance G. Laing
IPC分类号： G01N21/84
CPC分类号： G01N21/7743 , G01N33/5026 , G01N33/5029 , G01N33/5032 , G01N33/5052 , G01N33/53 , G01N33/54373 , G01N33/574 , G01N33/6854 , G01N33/86 , G01N2500/00
摘要： The invention provides methods of detecting activation of an immune cell, methods for detecting blocking or enhancing properties of a test reagent or stimuli on activation of one or more immune cells or platelets, methods for selecting hybridomas producing antibodies to an antigen for quality of strength of binding to the antigen, methods for determining if a subject has had an immune response to an immunogen, methods of isolating neutralizing antibodies for an immunogen, methods of classifying a B cell lymphoma, and methods for selecting activated B-cells expressing an antibody to one or more antigens.
摘要翻译：本发明提供了检测免疫细胞活化的方法，用于检测在一种或多种免疫细胞或血小板激活时检测试剂或刺激物质的阻断或增强的方法的方法，用于选择产生针对抗原的抗体的杂交瘤的方法，与抗原结合的方法，用于确定受试者是否具有对免疫原的免疫应答的方法，分离免疫原的中和抗体的方法，B细胞淋巴瘤分类方法和选择表达抗体的活化的B细胞的方法或更多的抗原。

8. 发明授权

US06818418B1 Protein scaffolds for antibody mimics and other binding proteins 有权
标题翻译：用于抗体模拟物和其他结合蛋白的蛋白质支架
公开(公告)号：US06818418B1
公开(公告)日：2004-11-16
申请号：US09515260
申请日：2000-02-29
申请人： Dasa Lipovsek , Richard W. Wagner , Robert G. Kuimelis
发明人： Dasa Lipovsek , Richard W. Wagner , Robert G. Kuimelis
IPC分类号： A61K3800
CPC分类号： C12N15/1037 , C07K14/78 , C07K16/241 , C07K2317/21 , C07K2318/20 , C07K2319/30 , C12N15/62 , C12Q1/00 , C40B40/02
摘要： Disclosed herein are proteins that include a fibronectin type III domain having at least one randomized loop. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.
摘要翻译：本文公开了包含具有至少一个随机化环的纤连蛋白III型结构域的蛋白质。本文还公开了编码这种蛋白质的核酸以及这些蛋白质在诊断方法中的应用和用于进化新型化合物结合物种及其配体的方法。

9. 发明授权

US5014742A Vacuum actuated tank vapor vent valve 失效
标题翻译：真空致动槽蒸气排放阀
公开(公告)号：US5014742A
公开(公告)日：1991-05-14
申请号：US504818
申请日：1990-04-05
申请人： Charles H. Covert , Kenneth W. Turner , Carl H. Sherwood , William E. Gifford , Richard W. Wagner
发明人： Charles H. Covert , Kenneth W. Turner , Carl H. Sherwood , William E. Gifford , Richard W. Wagner
IPC分类号： B60K15/035 , F02M25/08 , F16K24/04
CPC分类号： F16K24/04 , B60K15/03519 , F02M25/089 , Y10T137/86332
摘要： A tank vapor vent valve assembly mounted to the top of the tank wall has a piston actuated by a source of engine vacuum which maintains a fill vapor exit closed until the gas cap is removed to relieve the vacuum and allow the piston to open.
摘要翻译：安装到罐壁顶部的罐蒸气排放阀组件具有由发动机真空源致动的活塞，其保持填充蒸汽出口关闭，直到气帽被移除以减轻真空并允许活塞打开。

10. 发明申请

US20080139791A1 Pharmaceutically acceptable Fn3 Polypeptides for human treatments 审中-公开
标题翻译：用于人类治疗的药学上可接受的Fn3多肽
公开(公告)号：US20080139791A1
公开(公告)日：2008-06-12
申请号：US11894732
申请日：2007-08-20
申请人： Dasa Lipovsek , Richard W. Wagner , Robert G. Kuimelis
发明人： Dasa Lipovsek , Richard W. Wagner , Robert G. Kuimelis
IPC分类号： C07K16/00
CPC分类号： C07K14/47 , C07K14/525 , C07K14/78 , C07K16/00 , C07K16/241 , C07K2317/22 , C07K2318/20 , C07K2319/00 , C07K2319/30 , C12N15/1037 , C12Q1/00 , C40B40/02
摘要： Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.
摘要翻译：本文公开了包含免疫球蛋白折叠并且可以用作支架的蛋白质。本文还公开了编码这种蛋白质的核酸以及这些蛋白质在诊断方法中的应用和用于进化新型化合物结合物种及其配体的方法。

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