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1. 发明授权

US06954668B1 Apparatus and method for intra-oral stimulation of the trigeminal nerve 有权
标题翻译：用于口内刺激三叉神经的装置和方法
公开(公告)号：US06954668B1
公开(公告)日：2005-10-11
申请号：US09975501
申请日：2001-10-11
申请人： John W. Cuozzo
发明人： John W. Cuozzo
IPC分类号： A61N1/36
CPC分类号： A61N1/36078 , A61N1/0548
摘要： An apparatus for intra-oral stimulation of the trigeminal nerve includes an energy source that imparts energy to a tooth to stimulate the trigeminal nerve and an attachment portion to secure the energy source in a mouth in proximity to the tooth. Stimulating the trigeminal nerve in this manner has been experimentally shown to induce and/or enhance relaxation and/or sleep without the adverse side effects associated with traditional drug therapies. In one embodiment, the apparatus can be realized as a “cap” having two legs that engage opposing sides of a tooth and a bridge portion spanning the occlusal surface of the tooth to link the legs.
摘要翻译：用于口内刺激三叉神经的装置包括向牙齿施加能量以刺激三叉神经的能量源和附接部分以将能源固定在靠近牙齿的口中。以这种方式刺激三叉神经已被实验性地显示出诱导和/或增强松弛和/或睡眠，而没有与传统药物疗法相关的不良副作用。在一个实施例中，该装置可以被实现为具有两个腿的“帽”，其接合牙齿的相对侧面和横跨牙齿的咬合面以跨接腿部的桥接部分。

2. 发明授权

US10865409B2 Methods for tagging DNA-encoded libraries 有权
公开(公告)号：US10865409B2
公开(公告)日：2020-12-15
申请号：US14343306
申请日：2012-09-07
申请人： Anthony D. Keefe , Richard W. Wagner , Alexander Litovchick , Matthew Clark , John W. Cuozzo , Ying Zhang , Paolo A. Centrella , Christopher D. Hupp
发明人： Anthony D. Keefe , Richard W. Wagner , Alexander Litovchick , Matthew Clark , John W. Cuozzo , Ying Zhang , Paolo A. Centrella , Christopher D. Hupp
IPC分类号： C12N15/10 , C40B50/16
CPC分类号： C12N15/1065 , C12N15/10 , C12N15/1068 , C12N15/1093 , C40B50/16 , C07B2200/11
摘要： The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2′-substituted nucleotides, such as 2′-O-methyl or 2′-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.

3. 发明申请

US20140315762A1 METHODS FOR TAGGING DNA-ENCODED LIBRARIES 审中-公开
标题翻译：标记DNA编码的图书馆的方法
公开(公告)号：US20140315762A1
公开(公告)日：2014-10-23
申请号：US14343306
申请日：2012-09-07
申请人： Anthony D. Keefe , Richard W. Wagner , Alexander Litovchick , Matthew Clark , John W. Cuozzo , Ying Zhang , Paolo A. Centrella , Christopher D. Hupp
发明人： Anthony D. Keefe , Richard W. Wagner , Alexander Litovchick , Matthew Clark , John W. Cuozzo , Ying Zhang , Paolo A. Centrella , Christopher D. Hupp
IPC分类号： C12N15/10
CPC分类号： C12N15/1065 , C07B2200/11 , C12N15/10 , C12N15/1068 , C12N15/1093 , C40B50/16
摘要： The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2′-substituted nucleotides, such as 2′-O-methyl or 2′-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.
摘要翻译：本发明涉及寡核苷酸编码的文库和标记这些文库的方法。特别地，所述方法和寡核苷酸可以包括一个或多个2'-取代的核苷酸，例如2'-O-甲基或2'-氟核苷酸，以及用于增强酶连接的一些或多种化学功能的其它条件或试剂，以支持化学结扎。

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