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1. 发明授权

US6001713A Methods for forming nitrogen-rich regions in a floating gate and interpoly dielectric layer in a non-volatile semiconductor memory device 有权
标题翻译：在非易失性半导体存储器件中的浮栅和互聚电介质层中形成富氮区的方法
公开(公告)号：US6001713A
公开(公告)日：1999-12-14
申请号：US154074
申请日：1998-09-16
申请人： Mark T. Ramsbey , Vei-Han Chan , Sameer Haddad , Chi Chang , Yu Sun , Raymond Yu
发明人： Mark T. Ramsbey , Vei-Han Chan , Sameer Haddad , Chi Chang , Yu Sun , Raymond Yu
IPC分类号： H01L21/28 , H01L21/265
CPC分类号： H01L21/28273
摘要： Methods are provided for significantly reducing electron trapping in semiconductor devices having a floating gate and an overlying dielectric layer. The methods form a nitrogen-rich region within the floating gate near the interface to an overlying dielectric layer. The methods include selectively introducing nitrogen into the floating gate prior to forming the overlying dielectric layer. This forms an initial nitrogen concentration profile within the floating gate. An initial portion of the overlying dielectric layer is then formed of a high temperature oxide (HTO). The temperature within the floating gate is purposely raised to an adequately high temperature to cause the initial nitrogen concentration profile to change due to the migration of the majority of the nitrogen towards the interface with the overlying dielectric layer and an interface with an underlying layer. Consequently, the floating gate is left with a first nitrogen-rich region near the interface to the overlying dielectric layer and a second nitrogen-rich region near the interface to the underlying layer. The first nitrogen-rich region has been found to reduce electron trapping within the floating gate, which could lead to false programming of the floating gate. Unlike a conventional thermally grown oxide film, the high temperature oxide film within the interpoly dielectric layer advantageously prevents the surface of the floating gate from becoming too granular. As such, the resulting interpoly dielectric layer, which typically includes several films, can be formed more evenly.
摘要翻译：提供了用于显着减少具有浮置栅极和上覆电介质层的半导体器件中的电子俘获的方法。该方法在与上覆电介质层的界面附近的浮栅内形成富氮区。所述方法包括在形成上覆电介质层之前将氮气选择性地引入浮栅。这在浮动栅极内形成初始氮浓度分布。然后由上覆电介质层的初始部分由高温氧化物（HTO）形成。浮置栅极内的温度有意地升高到足够高的温度，以使得初始氮浓度分布由于大部分氮向与上覆介质层的界面的迁移以及与下层的界面而改变。因此，浮置栅极在与上覆电介质层的界面附近的第一富氮区域和与下层的界面附近的第二富氮区域留下。已经发现第一个富氮区域减少了浮动栅极内的电子俘获，这可能导致浮动栅极的错误编程。与传统的热生长氧化膜不同，多聚电介质层内的高温氧化膜有利地防止浮栅的表面变得太细。因此，可以更均匀地形成通常包括几个膜的所得到的互间介电层。

2. 发明申请

US20140187602A1 Anti-Sense Oligonucleotides Targeted Against Exon 9 of IL-23R alpha Gene and Method of Using Same to Induce Exon Skipping and to Treat Inflammatory Bowel Diseases 有权
标题翻译：针对IL-23Rα基因的外显子9的抗感知寡核苷酸及其使用方法诱导外显子跳跃和治疗炎症性肠病
公开(公告)号：US20140187602A1
公开(公告)日：2014-07-03
申请号：US14088553
申请日：2013-11-25
申请人： Grant Gallagher , Raymond Yu , Jonathan Brazaitis
发明人： Grant Gallagher , Raymond Yu , Jonathan Brazaitis
IPC分类号： C12N15/113
CPC分类号： C07K14/7155 , A61K31/7088 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2320/33
摘要： The present invention relates to anti-sense oligonucleotides (AONs) used to induce exon 9 skipping in IL-23Rαgene. Exon 9 skipping of the IL23Rα gene ultimately causes specific induction of a novel soluble truncated IL-23Rα (Δ9) protein, characterized by a lack in a transmembrane domain and has a unique eight (8) amino acids (GLKEGSYC) at its C-terminus end as a result of frame-shift. The present invention provides a utility application of the use of AONs to induce production of a Δ9 protein which inhibits IL-23R-mediated cell signaling. More particularly, Δ9 protein blocks STAT3 formation as well as Th17 maturation. There is provided a therapeutic application of AONs in treating a mammal such as a human patient inflicted with Crohn's disease.
摘要翻译：本发明涉及用于诱导IL-23Rα基因中外显子9跳跃的反义寡核苷酸（AON）。 IL23Rα基因的外显子9跳跃最终导致新型可溶性截短的IL-23Rα（＆Dgr; 9）蛋白的特异性诱导，其特征在于缺乏跨膜结构域，并且在其C处具有独特的8（8）个氨基酸（GLKEGSYC）由于帧转移，终端结束。本发明提供了使用AON来诱导抑制IL-23R介导的细胞信号传导的“Dgr”9蛋白的生产应用。更具体地，＆Dgr; 9蛋白质阻断STAT3形成以及Th17成熟。提供了AON治疗哺乳动物如患有克罗恩病的人类患者的治疗应用。

3. 发明授权

US08717284B2 User interface device 有权
标题翻译：用户界面设备
公开(公告)号：US08717284B2
公开(公告)日：2014-05-06
申请号：US12323393
申请日：2008-11-25
申请人： Raymond Yu
发明人： Raymond Yu
IPC分类号： G09G5/00
CPC分类号： G06F3/0338 , G06F3/016
摘要： A device comprises a manipulandum moveable in at least two degrees of freedom including a first link rotatably moveable about a pivot axis and a second link rotatably moveable about a pivot axis. The first link and the second link are coupled to a ground member. A first actuator is configured to engage the first link and provide an output about a drive axis of the first actuator. A second actuator is configured to engage the second link and provide an output about a drive axis of the second actuator. The drive axis of the first actuator is substantially parallel to the drive axis of the second actuator. The first actuator and the second actuator are each configured to receive a signal associated with a force feedback. The force feedback being associated with the manipulandum.
摘要翻译：一种装置包括可在至少两个自由度中移动的操纵件，包括可围绕枢转轴线可旋转地移动的第一连杆和可围绕枢轴可旋转地移动的第二连杆。第一链路和第二链路耦合到接地部件。第一致动器构造成接合第一连杆并提供围绕第一致动器的驱动轴的输出。第二致动器构造成接合第二连杆并且提供围绕第二致动器的驱动轴线的输出。第一致动器的驱动轴基本上平行于第二致动器的驱动轴。第一致动器和第二致动器均被配置为接收与力反馈相关联的信号。力反馈与操纵有关。

4. 发明申请

US20130172272A1 Novel Polypeptides That Bound to IL-23 Receptor and Inhibit Binding of IL-23 and Cell Signaling Thereof 有权
标题翻译：与IL-23受体结合并抑制IL-23和细胞信号传导的结合的新型多肽
公开(公告)号：US20130172272A1
公开(公告)日：2013-07-04
申请号：US13771305
申请日：2013-02-20
申请人： Grant Gallagher , Raymond Yu , Jonathan Brazaitis
发明人： Grant Gallagher , Raymond Yu , Jonathan Brazaitis
IPC分类号： C07K7/08
CPC分类号： C07K7/08 , A61K38/20 , C07K14/001 , C07K14/54
摘要： The present invention relates to novel polypeptides that bind to IL-23 receptor and inhibit the binding of IL-23 to its corresponding receptor and cell signaling thereof. The novel polypeptides of the present invention has a core structure of WX1X2X3W,where W is tryptophan, and X1, X2 and X3 are amino acids, with the proviso that when one of X1, X2 or X3 is W, the remaining two of X1, X2 or X3 cannot be W. Preferred core structures include WVDYW or WQDYW. The present invention relates a composition containing the novel polypeptides, and use of same in treating IL-23 associated human diseases including, for example, inflammatory bowel diseases, psoriasis and Crohn's disease.
摘要翻译：本发明涉及结合IL-23受体并抑制IL-23与其相应受体和细胞信号传导的结合的新型多肽。本发明的新型多肽具有WX1X2X3W的核心结构，其中W是色氨酸，X 1，X 2和X 3是氨基酸，条件是当X 1，X 2或X 3中的一个为W时，X 1， X2或X3不能为W.优选的核心结构包括WVDYW或WQDYW。本发明涉及含有新多肽的组合物及其在治疗IL-23相关人类疾病中的应用，包括例如炎症性肠病，牛皮癣和克罗恩病。

5. 发明授权

US06281689B1 Means of correcting a measurement of a property of a material with a sensor that is affected by a second property of the material 有权
标题翻译：用受材料的第二特性影响的传感器校正材料性能的测量的方法
公开(公告)号：US06281689B1
公开(公告)日：2001-08-28
申请号：US09289066
申请日：1999-04-12
申请人： Lee Chase , John D. Goss , Claud Hagart-Alexander , Martin G. Clarke , Graham V. Walford , Raymond Yu
发明人： Lee Chase , John D. Goss , Claud Hagart-Alexander , Martin G. Clarke , Graham V. Walford , Raymond Yu
IPC分类号： G01N2702
CPC分类号： G01N33/343 , D21G9/0009
摘要： A sensor apparatus and electrode configuration within the sensor apparatus for measuring electrical characteristics of an aqueous fibrous composition. The electrode configuration includes an elongated ground electrode and at least one segmented electrode to form an array of measurement electrode cells. The electrode configuration further includes an array of reference electrode cells formed by a plurality of reference electrodes built into the array of measurement electrode cells. The measurement electrode cells and reference electrode cells have a different sensitivity to water weight of the aqueous fibrous composition and the same sensitivity to conductivity of the aqueous fibrous composition. The measurement apparatus obtains simultaneous resistive measurements from both measurement and reference cells and determines the ratio of the measurements such that the affects from conductivity is canceled out of the measurement ratio. The determined measurement ratio is used to obtain a measurement of the water weight of the aqueous fibrous composition by using previously determined characterization data of the water weight vs. a range of measurement ratios.
摘要翻译：用于测量水性纤维组合物的电特性的传感器装置内的传感器装置和电极结构。电极配置包括细长接地电极和至少一个分段电极，以形成测量电极单元阵列。电极结构还包括由内置在测量电极单元阵列中的多个参考电极形成的参考电极单元的阵列。测量电极单元和参考电极单元对水性纤维组合物的水重量具有不同的灵敏度，并且与水性纤维组合物的导电性相同。测量装置从测量和参考单元获得同时的电阻测量，并且确定测量值的比例，使得在测量比之外抵消来自电导率的影响。使用确定的测量比率通过使用预先确定的水重量的特征数据与测量比的范围来获得水性纤维组合物的水重量的测量。

6. 发明申请

US20160115218A1 Anti-Sense Oligonucleotides Targeted Against Exon 9 of IL-23R-alpha Gene and Method of Using Same to Induce Exon Skipping and to Treat Inflammatory Bowel Diseases 审中-公开
标题翻译：针对IL-23R-α基因外显子9的抗感知寡核苷酸及其使用方法诱导外显子跳跃和治疗炎症性肠病
公开(公告)号：US20160115218A1
公开(公告)日：2016-04-28
申请号：US14918657
申请日：2015-10-21
申请人： Grant Gallagher , Raymond Yu , Jonathan Brazaitis
发明人： Grant Gallagher , Raymond Yu , Jonathan Brazaitis
IPC分类号： C07K14/715 , C12N15/113
CPC分类号： C07K14/7155 , A61K31/7088 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2320/33
摘要： The present invention relates to anti-sense oligonucleotides (AONs) used to induce exon 9 skipping in IL-23Rα gene. Exon 9 skipping of the IL23Rα gene ultimately causes specific induction of a novel soluble truncated IL-23Rα (Δ9) protein, characterized by a lack in a transmembrane domain and has a unique eight (8) amino acids (GLKEGSYC) at its C-terminus end as a result of frame-shift. The present invention provides a utility application of the use of AONs to induce production of a Δ9 protein which inhibits IL-23R-mediated cell signaling. More particularly, Δ9 protein blocks STAT3 formation as well as Th17 maturation. There is provided a therapeutic application of AONs in treating a mammal such as a human patient inflicted with Crohn's disease.
摘要翻译：本发明涉及用于诱导IL-23Rα基因中外显子9跳跃的反义寡核苷酸（AON）。 IL23Rα基因的外显子9跳跃最终导致新型可溶性截短的IL-23Rα（＆Dgr; 9）蛋白的特异性诱导，其特征在于缺乏跨膜结构域，并且在其C处具有独特的8（8）个氨基酸（GLKEGSYC）由于帧转移，终端结束。本发明提供了使用AON来诱导抑制IL-23R介导的细胞信号传导的“Dgr”9蛋白的生产应用。更具体地，＆Dgr; 9蛋白质阻断STAT3形成以及Th17成熟。提供了AON治疗哺乳动物如患有克罗恩病的人类患者的治疗应用。

7. 发明申请

US20130183755A1 THERAPEUTIC APPLICATION OF ISOLATED NATURALLY-OCCURRING SOLUBLE TRUNCATED FORMS OF IL-23 RECEPTOR 审中-公开
标题翻译： IL-23受体分离自然可解交联形式的治疗应用
公开(公告)号：US20130183755A1
公开(公告)日：2013-07-18
申请号：US13748066
申请日：2013-01-23
申请人： Grant Gallagher , Raymond Yu , Jonathan Brazaitis
发明人： Grant Gallagher , Raymond Yu , Jonathan Brazaitis
IPC分类号： C12N5/071
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/7155 , C12N5/0602 , G01N33/6863 , G01N2333/705 , G01N2800/065 , G01N2800/368
摘要： The present invention relates to an isolated naturally-occurring soluble truncated IL-23Rα protein, which is a translated protein resulting from a mRNA splice variant of IL-23Rα. The soluble IL-23Rα proteins (e.g., Δ9 and Δ8,9) represents a novel soluble IL-23Rα protein, which is lacking a transmembrane domain and has a unique eight (8) amino acids (GLKEGSYC) at its C-terminus end (due to frame-shift). ELISA reveals that Δ9 is present in blood and can serve as a diagnostic tool for auto-immune diseases including Crohn's disease. There is also provided a method of recombinant production for this soluble truncated form of IL-23Rα protein. More importantly, the present invention provides an utility application of the Δ9 and Δ8,9 protein in inhibit IL-23R-mediated cell signaling. More particularly, Δ9 and Δ8,9 blocks STAT3 formation as well as Th17 maturation. There is provided a therapeutic application of Δ9 and Δ8,9 in treating a human patient inflicted with Crohn's disease.
摘要翻译：本发明涉及分离的天然存在的可溶性截短的IL-23Rα蛋白，其是由IL-23Rα的mRNA剪接变体产生的翻译蛋白。可溶性IL-23Rα蛋白（例如，Delta9和Delta8,9）代表一种新的可溶性IL-23Rα蛋白，其缺乏跨膜结构域，并且在其C末端具有独特的八（8）个氨基酸（GLKEGSYC）由于帧移）。 ELISA显示，Delta9存在于血液中，可用作包括克罗恩病在内的自身免疫疾病的诊断工具。还提供了这种可溶性截短形式的IL-23Rα蛋白的重组生产方法。更重要的是，本发明提供了Delta9和Delta8,9蛋白在抑制IL-23R介导的细胞信号传导中的应用。更具体地，Delta9和Delta8,9阻断STAT3形成以及Th17成熟。提供了Delta9和Delta8,9在治疗患有克罗恩病的人类患者中的治疗应用。

8. 发明申请

US20120171704A1 Elisa for a naturally-occurring soluble truncated form of IL-23 receptor 有权
标题翻译： Elisa用于天然存在的可溶性截短形式的IL-23受体
公开(公告)号：US20120171704A1
公开(公告)日：2012-07-05
申请号：US13065867
申请日：2011-03-31
申请人： Grant Gallagher , Raymond Yu , Joyce Eskdale , Jonathan Brazaitis
发明人： Grant Gallagher , Raymond Yu , Joyce Eskdale , Jonathan Brazaitis
IPC分类号： G01N33/577 , G01N33/566
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/7155 , C12N5/0602 , G01N33/6863 , G01N2333/705 , G01N2800/065 , G01N2800/368
摘要： A naturally-occurring soluble truncated IL-23Rα protein (i.e., Δ9 IL-23Rα) is shown to be present in a biological sample and can serve as a diagnostic tool for autoimmune diseases. There is provided an enzyme-linked immunosorbent assay (ELISA) and test kit for the serological detection of the soluble truncated form of IL-23Rα protein. More particularly, antibody-sandwich ELISA method and kits for Δ9 IL-23Rα as an antigen were developed to detect Δ9 IL-23Rα levels in biological samples from a mammal and a human patient and are used as a diagnostic index. The present disclosed ELISA has utility as a diagnostic tool to detect Crohn's disease in patients using EDTA-plasma.
摘要翻译：天然存在的可溶性截短的IL-23Rα蛋白（即，＆Dgr; 9 IL-23Rα）显示存在于生物学样品中，并可用作自身免疫性疾病的诊断工具。提供了用于血清学检测IL-23Rα蛋白的可溶性截短形式的酶联免疫吸附测定（ELISA）和测试试剂盒。更具体地，开发了抗体夹心ELISA方法和用于Dgr。9 IL-23Rα作为抗原的试剂盒，以检测来自哺乳动物和人类患者的生物样品中的Dgr。9 IL-23Rα水平，并用作诊断指标。本公开的ELISA可用作诊断工具，用于检测使用EDTA-血浆的患者的克罗恩病。

9. 发明申请

US20060049010A1 Device and method for providing resistive and vibrotactile effects 审中-公开
标题翻译：用于提供电阻和振动触觉效应的装置和方法
公开(公告)号：US20060049010A1
公开(公告)日：2006-03-09
申请号：US10934142
申请日：2004-09-03
申请人： Neil Olien , Alexander Jasso , George Anastas , Erik Shahoian , Raymond Yu
发明人： Neil Olien , Alexander Jasso , George Anastas , Erik Shahoian , Raymond Yu
IPC分类号： B60L7/00
CPC分类号： H01H3/02 , B60K37/06 , B60K2370/158 , H01H19/14 , H01H2003/008 , H01H2215/05
摘要： Systems and methods for providing resistive and vibrotactile feedback from a single actuator are described. One described system comprises a manipulandum, and a resistive haptic actuator configured to generate a resistive haptic force in order to generate a vibrotactile haptic effect.
摘要翻译：描述了用于从单个致动器提供电阻和振动触觉反馈的系统和方法。一种描述的系统包括操纵和电阻式触觉致动器，其被配置为产生阻力触觉力以便产生振动触觉触觉效果。

10. 发明申请

US20050007347A1 Systems and methods for providing a haptic manipulandum 有权
标题翻译：提供触觉操作的系统和方法
公开(公告)号：US20050007347A1
公开(公告)日：2005-01-13
申请号：US10859930
申请日：2004-06-03
申请人： George Anastas , David Bailey , Gregory Tashjian , Raymond Yu
发明人： George Anastas , David Bailey , Gregory Tashjian , Raymond Yu
IPC分类号： G06F3/00 , G06F3/01 , G06F3/033 , G09G5/08
CPC分类号： G06F3/016 , G06F3/03549
摘要： Systems and methods for providing a haptic manipulandum are described. In one described system, a lever arm is pivotably coupled to a housing, and configured to apply a processor-controlled force to a substantially-spherical manipulandum to provide a haptic effect. The described system may include a processor in communication with an actuator for providing the haptic effect.
摘要翻译：描述了提供触觉操作的系统和方法。在一个描述的系统中，杠杆臂可枢转地联接到壳体，并且构造成将处理器控制的力施加到基本上为球面的操纵以提供触觉效果。所描述的系统可以包括与用于提供触觉效果的致动器通信的处理器。

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