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1. 发明申请

US20110106117A1 Device and Method for Modifying the Shape of a Body Organ 审中-公开
标题翻译：修饰身体器官形状的装置和方法
公开(公告)号：US20110106117A1
公开(公告)日：2011-05-05
申请号：US13004239
申请日：2011-01-11
申请人： Mark L. Mathis , David Reuter , Lucas Gordon , Cruz Beeson , Garrett Beget , Frederick Stewart
发明人： Mark L. Mathis , David Reuter , Lucas Gordon , Cruz Beeson , Garrett Beget , Frederick Stewart
IPC分类号： A61B17/08
CPC分类号： A61F2/2451 , A61B2017/00243
摘要： A tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen. In one embodiment the device includes first and second anchors; a connector disposed between the first and second anchors; and a focal deflector disposed between the first and second anchors and may be adapted to extend away from the lumen axis and toward the target tissue and/or away from the lumen axis and away from the target tissue when the device is deployed in the lumen. The invention is also a method of modifying target tissue shape. The method includes the steps of providing a tissue shaping device comprising proximal and distal anchors, a connector disposed between the proximal and distal anchors, and a focal deflector; placing the tissue shaping device in a lumen adjacent the target tissue; applying a shaping force from the focal deflector against a lumen wall to modify the shape of the target tissue; and expanding the proximal and distal anchors to anchor the device in the lumen.
摘要翻译：组织成形装置，其适于部署在内腔中以改变邻近内腔的靶组织的形状。在一个实施例中，该装置包括第一和第二锚固件; 连接器，设置在第一和第二锚固件之间; 以及设置在所述第一和第二锚固件之间的焦偏转器，并且可以适于在所述装置展开在所述内腔中时远离所述内腔轴线延伸并且朝向所述目标组织和/或远离所述内腔轴线延伸并远离所述目标组织。本发明也是改变目标组织形状的方法。该方法包括提供包括近端和远端锚固件的组织成形装置，设置在近端锚固件和远端锚固件之间的连接器以及焦点偏转器的步骤; 将组织成形装置放置在与目标组织相邻的内腔中; 将来自焦偏转器的成形力施加到管腔壁以改变靶组织的形状; 并且扩张近端和远端锚固件以将装置锚定在管腔中。

2. 发明授权

US07887582B2 Device and method for modifying the shape of a body organ 有权
标题翻译：用于改变身体器官形状的装置和方法
公开(公告)号：US07887582B2
公开(公告)日：2011-02-15
申请号：US10840188
申请日：2004-05-05
申请人： Mark L. Mathis , David Reuter , Lucas Gordon , Cruz Beeson , Garrett Beget , Frederick Stewart
发明人： Mark L. Mathis , David Reuter , Lucas Gordon , Cruz Beeson , Garrett Beget , Frederick Stewart
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61B2017/00243
摘要： A tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen. In one embodiment the device includes first and second anchors; a connector disposed between the first and second anchors; and a focal deflector disposed between the first and second anchors and may be adapted to extend away from the lumen axis and toward the target tissue and/or away from the lumen axis and away from the target tissue when the device is deployed in the lumen. The invention is also a method of modifying target tissue shape. The method includes the steps of providing a tissue shaping device comprising proximal and distal anchors, a connector disposed between the proximal and distal anchors, and a focal deflector; placing the tissue shaping device in a lumen adjacent the target tissue; applying a shaping force from the focal deflector against a lumen wall to modify the shape of the target tissue; and expanding the proximal and distal anchors to anchor the device in the lumen.
摘要翻译：组织成形装置，其适于部署在内腔中以改变邻近内腔的靶组织的形状。在一个实施例中，该装置包括第一和第二锚固件; 连接器，设置在第一和第二锚固件之间; 以及设置在所述第一和第二锚固件之间的焦偏转器，并且可以适于在所述装置展开在所述内腔中时远离所述内腔轴线延伸并且朝向所述目标组织和/或远离所述内腔轴线延伸并远离所述目标组织。本发明也是改变目标组织形状的方法。该方法包括提供包括近端和远端锚固件的组织成形装置，设置在近端锚固件和远端锚固件之间的连接器以及焦点偏转器的步骤; 将组织成形装置放置在与目标组织相邻的内腔中; 将来自焦偏转器的成形力施加到管腔壁以改变靶组织的形状; 并且扩张近端和远端锚固件以将装置锚定在管腔中。

3. 发明申请

US20050010240A1 Device and method for modifying the shape of a body organ 有权
标题翻译：用于改变身体器官形状的装置和方法
公开(公告)号：US20050010240A1
公开(公告)日：2005-01-13
申请号：US10840188
申请日：2004-05-05
申请人： Mark Mathis , David Reuter , Lucas Gordon , Cruz Beeson , Garrett Beget , Frederick Stewart
发明人： Mark Mathis , David Reuter , Lucas Gordon , Cruz Beeson , Garrett Beget , Frederick Stewart
IPC分类号： A61B17/00 , A61F2/24 , A61B17/08
CPC分类号： A61F2/2451 , A61B2017/00243
摘要： A tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen. In one embodiment the device includes first and second anchors; a connector disposed between the first and second anchors; and a focal deflector disposed between the first and second anchors and may be adapted to extend away from the lumen axis and toward the target tissue and/or away from the lumen axis and away from the target tissue when the device is deployed in the lumen. The invention is also a method of modifying target tissue shape. The method includes the steps of providing a tissue shaping device comprising proximal and distal anchors, a connector disposed between the proximal and distal anchors, and a focal deflector; placing the tissue shaping device in a lumen adjacent the target tissue; applying a shaping force from the focal deflector against a lumen wall to modify the shape of the target tissue; and expanding the proximal and distal anchors to anchor the device in the lumen.
摘要翻译：组织成形装置，其适于部署在内腔中以改变邻近内腔的靶组织的形状。在一个实施例中，该装置包括第一和第二锚固件; 连接器，设置在第一和第二锚固件之间; 以及设置在所述第一和第二锚固件之间的焦偏转器，并且可以适于在所述装置展开在所述内腔中时远离所述内腔轴线延伸并且朝向所述目标组织和/或远离所述内腔轴线延伸并远离所述目标组织。本发明也是改变目标组织形状的方法。该方法包括提供包括近端和远端锚固件的组织成形装置，设置在近端锚固件和远端锚固件之间的连接器以及焦点偏转器的步骤; 将组织成形装置放置在与目标组织相邻的内腔中; 将来自焦偏转器的成形力施加到管腔壁以改变靶组织的形状; 并且扩张近端和远端锚固件以将装置锚定在管腔中。

4. 发明申请

US20050137685A1 Reduced length tissue shaping device 有权
标题翻译：缩短长度的组织成形装置
公开(公告)号：US20050137685A1
公开(公告)日：2005-06-23
申请号：US10742519
申请日：2003-12-19
申请人： Gregory Nieminen , David Reuter , Nathan Aronson , Lucas Gordon , Garrett Beget
发明人： Gregory Nieminen , David Reuter , Nathan Aronson , Lucas Gordon , Garrett Beget
IPC分类号： A61F2/24
CPC分类号： A61F2/2451
摘要： One aspect of the invention is a method of treating mitral valve regurgitation in a patient. The method includes the steps of delivering a tissue shaping device to the patient's coronary sinus in an unexpanded configuration within a catheter having an outer diameter no more than nine or ten french, with the tissue shaping device including a connector disposed between a distal expandable anchor comprising flexible wire and a proximal expandable anchor comprising flexible wire, the device having a length of 60 mm or less; and deploying the device to reduce mitral valve regurgitation, such as by anchoring the distal expandable anchor by placing the distal expandable anchor flexible wire in contact with a wall of the coronary sinus, e.g., by permitting the distal expandable anchor to self-expand or by applying an actuating force to the distal expandable anchor and possibly locking the distal expandable anchor after performing the applying step. The invention also includes a device for performing the method.
摘要翻译：本发明的一个方面是治疗患者二尖瓣关闭不全的方法。该方法包括以下步骤：将组织成形装置以不超过9或10法兰的外径的导管内的未展开构造递送到患者的冠状窦，其中组织整形装置包括连接器，该连接器设置在包括柔性线和包括柔性线的近端可扩展锚，该装置具有60mm或更小的长度; 并且部署该装置以减少二尖瓣反流，例如通过将远端可扩张锚定柔性线与冠状窦的壁接触来锚定远端可扩张锚固体，例如通过允许远侧可扩张锚自体扩张或通过在远程可扩展锚固件施加致动力并且可能在执行施加步骤之后锁定远侧可扩展锚固件。本发明还包括用于执行该方法的装置。

5. 发明授权

US07837728B2 Reduced length tissue shaping device 有权
标题翻译：缩短长度的组织成形装置
公开(公告)号：US07837728B2
公开(公告)日：2010-11-23
申请号：US10742519
申请日：2003-12-19
申请人： Gregory Nieminen , David Reuter , Nathan Aronson , Lucas Gordon , Garrett Beget
发明人： Gregory Nieminen , David Reuter , Nathan Aronson , Lucas Gordon , Garrett Beget
IPC分类号： A61F2/24
CPC分类号： A61F2/2451
摘要： One aspect of the invention is a method of treating mitral valve regurgitation in a patient. The method includes the steps of delivering a tissue shaping device to the patient's coronary sinus in an unexpanded configuration within a catheter having an outer diameter no more than nine or ten french, with the tissue shaping device including a connector disposed between a distal expandable anchor comprising flexible wire and a proximal expandable anchor comprising flexible wire, the device having a length of 60 mm or less; and deploying the device to reduce mitral valve regurgitation, such as by anchoring the distal expandable anchor by placing the distal expandable anchor flexible wire in contact with a wall of the coronary sinus, e.g., by permitting the distal expandable anchor to self-expand or by applying an actuating force to the distal expandable anchor and possibly locking the distal expandable anchor after performing the applying step. The invention also includes a device for performing the method.
摘要翻译：本发明的一个方面是治疗患者二尖瓣关闭不全的方法。该方法包括以下步骤：将组织成形装置以不超过9或10法兰的外径的导管内的未展开构造递送到患者的冠状窦，其中组织整形装置包括连接器，该连接器设置在包括柔性线和包括柔性线的近端可扩展锚，该装置具有60mm或更小的长度; 并且部署该装置以减少二尖瓣反流，例如通过将远端可扩张锚定柔性线与冠状窦的壁接触来锚定远端可扩张锚固体，例如通过允许远侧可扩张锚自体扩张或通过在远程可扩展锚固件施加致动力并且可能在执行施加步骤之后锁定远侧可扩展锚固件。本发明还包括用于执行该方法的装置。

6. 发明申请

US20050027351A1 Mitral valve regurgitation treatment device and method 审中-公开
标题翻译：二尖瓣反流治疗装置及方法
公开(公告)号：US20050027351A1
公开(公告)日：2005-02-03
申请号：US10742747
申请日：2003-12-19
申请人： David Reuter , Gregory Nieminen , Nathan Aronson , Lucas Gordon , Garrett Beget , Clif Alferness , Mark Mathis
发明人： David Reuter , Gregory Nieminen , Nathan Aronson , Lucas Gordon , Garrett Beget , Clif Alferness , Mark Mathis
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , Y10S623/904
摘要： A method of treating regurgitation of a mitral valve in a patient's heart. The method includes the steps of: delivering a tissue shaping device to the coronary sinus; and deploying the tissue shaping device to reduce mitral valve regurgitation, the deploying step comprising applying a force through the coronary sinus wall toward the mitral valve solely proximal to a crossover point where a coronary artery passes between a coronary sinus and the mitral valve. The invention is also a set of devices for use in treating mitral valve regurgitation. The set includes a plurality of tissue shaping devices having different lengths, each of the tissue shaping devices being configured to be deliverable to a coronary sinus of a patient within a catheter having an outer diameter no greater than ten french.
摘要翻译：治疗患者心脏二尖瓣反流的方法。该方法包括以下步骤：将组织整形装置递送至冠状窦; 并且展开所述组织整形装置以减少二尖瓣反流，所述展开步骤包括仅通过冠状动脉穿过冠状窦和二尖瓣之间的交叉点向二尖瓣施加穿过冠状窦壁的力。本发明也是用于治疗二尖瓣反流的一组装置。该组包括具有不同长度的多个组织整形装置，每个组织整形装置构造成可输送到具有不超过十个法兰的外径的导管内的患者的冠状窦。

7. 发明申请

US20050137449A1 Tissue shaping device with self-expanding anchors 审中-公开
标题翻译：具有自膨胀锚的组织成形装置
公开(公告)号：US20050137449A1
公开(公告)日：2005-06-23
申请号：US10742585
申请日：2003-12-19
申请人： Gregory Nieminen , Garrett Beget , Nathan Aronson , Lucas Gordon
发明人： Gregory Nieminen , Garrett Beget , Nathan Aronson , Lucas Gordon
IPC分类号： A61F2/04 , A61F2/24
CPC分类号： A61F2/2451
摘要： A tissue shaping device adapted to be deployed in a vessel to reshape tissue adjacent to the vessel. In some embodiments the device includes a distal anchor having a flexible wire with at least one bending point and first and second arms extending from the bending point, the first and second arms being adapted to deform about the bending point; a proximal anchor having a flexible wire with at least one bending point and first and second arms extending from the bending point, the first and second arms being adapted to deform about the bending point; and a connector disposed between the distal anchor and the proximal anchor.
摘要翻译：一种组织成形装置，其适于部署在容器中以重塑邻近容器的组织。在一些实施例中，该装置包括具有柔性线的远端锚固件，其具有至少一个弯曲点，并且第一和第二臂从弯曲点延伸，第一和第二臂适于围绕弯曲点变形; 近端锚具有具有至少一个弯曲点的柔性线，并且从弯曲点延伸的第一和第二臂，第一和第二臂适于围绕弯曲点变形; 以及设置在远端锚固件和近端锚固件之间的连接器。

8. 发明授权

US07814635B2 Method of making a tissue shaping device 有权
标题翻译：制作组织整形装置的方法
公开(公告)号：US07814635B2
公开(公告)日：2010-10-19
申请号：US11383115
申请日：2006-05-12
申请人： Lucas Gordon , Mark L. Mathis , Nathan Aronson
发明人： Lucas Gordon , Mark L. Mathis , Nathan Aronson
IPC分类号： B23P11/00 , A61F2/24
CPC分类号： A61F2/2451 , Y10T29/49609 , Y10T29/49826 , Y10T29/49947 , Y10T29/49995
摘要： A tissue shaping device adapted to be deployed in a vessel to reshape tissue adjacent to the vessel. In some embodiments the device includes first and second anchors and a connector disposed between the first and second anchors, with the connector being integral with at least a portion of the first anchor. The invention is also a method of making a tissue shaping device including the steps of removing material from a blank to form a connector and an integral anchor portion; and attaching a non-integral anchor portion to the integral anchor portion.
摘要翻译：一种组织成形装置，其适于部署在容器中以重塑邻近容器的组织。在一些实施例中，该装置包括第一和第二锚定器以及设置在第一和第二锚固件之间的连接器，其中连接器与第一锚固件的至少一部分成一体。本发明还是一种制造组织成形装置的方法，包括以下步骤：从坯料上去除材料以形成连接器和一体的锚定部分; 以及将非整体锚定部分附接到所述整体锚定部分。

9. 发明授权

US07794496B2 Tissue shaping device with integral connector and crimp 有权
标题翻译：具有整体式连接器和压接的组织整形装置
公开(公告)号：US07794496B2
公开(公告)日：2010-09-14
申请号：US10742742
申请日：2003-12-19
申请人： Lucas Gordon , Mark L. Mathis , Nathan Aronson
发明人： Lucas Gordon , Mark L. Mathis , Nathan Aronson
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , Y10T29/49609 , Y10T29/49826 , Y10T29/49947 , Y10T29/49995
摘要： A tissue shaping device adapted to be deployed in a vessel to reshape tissue adjacent to the vessel. In some embodiments the device includes first and second anchors and a connector disposed between the first and second anchors, with the connector being integral with at least a portion of the first anchor. The invention is also a method of making a tissue shaping device including the steps of removing material from a blank to form a connector and an integral anchor portion; and attaching a non-integral anchor portion to the integral anchor portion.
摘要翻译：一种组织成形装置，其适于部署在容器中以重塑邻近容器的组织。在一些实施例中，该装置包括第一和第二锚定器以及设置在第一和第二锚固件之间的连接器，其中连接器与第一锚固件的至少一部分成一体。本发明还是一种制造组织成形装置的方法，包括以下步骤：从坯料上去除材料以形成连接器和一体的锚定部分; 以及将非整体锚定部分附接到所述整体锚定部分。

10. 发明申请

US20080109059A1 Medical Device Delivery System 有权
标题翻译：医疗器械输送系统
公开(公告)号：US20080109059A1
公开(公告)日：2008-05-08
申请号：US11971174
申请日：2008-01-08
申请人： Lucas Gordon , Mark Mathis , Greg Nieminen
发明人： Lucas Gordon , Mark Mathis , Greg Nieminen
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61B17/3468 , A61B2017/1205 , A61F2002/9511
摘要： A system for selectively deploying a medical device includes a cartridge that is engageable with a proximal end of a delivery catheter that is routed to a desired location in a patient's body. An advancement mechanism is provided for advancing the medical device out of the cartridge and into the delivery catheter for deploying the medical device at the desired location in the patient's body.
摘要翻译：用于选择性地部署医疗装置的系统包括可与输送导管的近端接合的药筒，所述输送导管被路由到患者体内的期望位置。提供了一种推进机构，用于将医疗装置推出药筒并进入输送导管，以将医疗装置展开在病人身体的所需位置。

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