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1. 发明申请

US20190350708A1 DEVICE AND METHOD FOR MODIFYING THE SHAPE OF A BODY ORGAN 审中-公开
公开(公告)号：US20190350708A1
公开(公告)日：2019-11-21
申请号：US16526843
申请日：2019-07-30
申请人： Mark L. MATHIS , Gregory D. NIEMINEN , Nathan ARONSON , Garrett R. BEGET
发明人： Mark L. MATHIS , Gregory D. NIEMINEN , Nathan ARONSON , Garrett R. BEGET
IPC分类号： A61F2/24
摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.

2. 发明申请

US20130096603A1 Lung Volume Reduction Devices, Methods, and Systems 有权
公开(公告)号：US20130096603A1
公开(公告)日：2013-04-18
申请号：US13618822
申请日：2012-09-14
申请人： Mark L. Mathis , David Thompson , Nathan Aronson , Patrick Wu
发明人： Mark L. Mathis , David Thompson , Nathan Aronson , Patrick Wu
IPC分类号： A61M16/20
CPC分类号： A61B17/12104 , A61B1/2676 , A61B17/12022 , A61B17/12031 , A61B17/12131 , A61B17/12145 , A61B17/12172 , A61B17/122 , A61B2017/00477 , A61B2017/00809 , A61B2017/1205 , A61B2017/12054 , A61F2/04 , A61F2002/043 , A61M16/04 , A61M16/0406 , A61M16/208 , A61M2205/0266
摘要： The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. A lung volume reduction system includes an implantable device having an elongate body that is sized and shaped for delivery via the airway system to a lung airway of a patient. The implant is inserted and positioned while the implant is in a delivery configuration, and is reconfigured to a deployed configuration so as to locally compress adjacent tissue of the lung, with portions of the elongate body generally moving laterally within the airway so as to laterally compress lung tissue. A plurality of such implants will often be used to treat a lung of a patient.

3. 发明申请

US20070239270A1 Mitral Valve Annuloplasty Device with Vena Cava Anchor 有权
标题翻译：二尖瓣瓣膜成形术与腔静脉栓塞
公开(公告)号：US20070239270A1
公开(公告)日：2007-10-11
申请号：US11279352
申请日：2006-04-11
申请人： Mark Mathis , Gregory Nieminen , Nathan Aronson , Garrett Beget
发明人： Mark Mathis , Gregory Nieminen , Nathan Aronson , Garrett Beget
IPC分类号： A61F2/24
CPC分类号： A61F2/2451
摘要： The present invention relates to a medical device and uses thereof that supports or changes the shape of tissue near a vessel in which the device is placed. The present invention is particularly useful in reducing mitral valve regurgitation by changing the shape of or supporting a mitral valve annulus. The device includes a support structure, a proximal anchor adapted to be positioned in a superior vena cava, and a distal anchor adapted to be positioned in a coronary sinus. The support structure engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed.
摘要翻译：本发明涉及一种医疗装置及其用途，其用于支撑或改变其中放置该装置的血管附近的组织的形状。本发明特别可用于通过改变二尖瓣环的形状或支撑二尖瓣环来减少二尖瓣反流。该装置包括支撑结构，适于定位在上腔静脉中的近端锚，以及适于定位在冠状窦中的远侧锚。支撑结构接合血管壁以改变邻近其中放置血管内支持物的血管的组织的形状。

4. 发明申请

US20120172909A1 Lung Volume Reduction Devices, Methods, and Systems 有权
标题翻译：肺减容装置，方法和系统
公开(公告)号：US20120172909A1
公开(公告)日：2012-07-05
申请号：US13418534
申请日：2012-03-13
申请人： Mark L. Mathis , David Thompson , Nathan Aronson , Patrick Wu
发明人： Mark L. Mathis , David Thompson , Nathan Aronson , Patrick Wu
IPC分类号： A61M29/00
CPC分类号： A61B17/12104 , A61B1/2676 , A61B17/12022 , A61B17/12031 , A61B17/12131 , A61B17/12145 , A61B17/12172 , A61B17/122 , A61B2017/00477 , A61B2017/00809 , A61B2017/1205 , A61B2017/12054 , A61F2/04 , A61F2002/043 , A61M16/04 , A61M16/0406 , A61M16/208 , A61M2205/0266
摘要： The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. A lung volume reduction system includes an implantable device having an elongate body that is sized and shaped for delivery via the airway system to a lung airway of a patient. The implant is inserted and positioned while the implant is in a delivery configuration, and is reconfigured to a deployed configuration so as to locally compress adjacent tissue of the lung, with portions of the elongate body generally moving laterally within the airway so as to laterally compress lung tissue. A plurality of such implants will often be used to treat a lung of a patient.
摘要翻译：本发明提供改进的医疗装置，治疗处理系统和用于治疗肺的治疗方法。肺容积减小系统包括可植入装置，其具有细长体，其尺寸和形状用于经由气道系统输送到患者的肺气道。植入物在植入物处于输送构型中时被插入和定位，并且被重新配置为展开构型，以便局部压缩肺的邻近组织，细长体的一部分通常在气道内侧向移动，以便横向压缩肺组织。多个这样的植入物将经常用于治疗患者的肺部。

5. 发明授权

US08157823B2 Lung volume reduction devices, methods, and systems 有权
标题翻译：肺减容装置，方法和系统
公开(公告)号：US08157823B2
公开(公告)日：2012-04-17
申请号：US12209662
申请日：2008-09-12
申请人： Nathan Aronson , Mark L. Mathis
发明人： Nathan Aronson , Mark L. Mathis
IPC分类号： A61B17/08
CPC分类号： A61M16/208 , A61B1/018 , A61B1/04 , A61B1/2676 , A61B5/06 , A61B6/032 , A61B6/12 , A61B6/485 , A61B17/00234 , A61B17/12022 , A61B17/12031 , A61B17/12104 , A61B17/12131 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B90/00 , A61B90/02 , A61B2017/00477 , A61B2017/00809 , A61B2017/00867 , A61B2017/12054 , A61F2/04 , A61F2002/043 , A61F2002/046 , A61M16/04 , A61M16/0406 , A61M16/0833 , A61M37/0069 , A61M2205/0266 , A61M2205/32
摘要： The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. A lung volume reduction system includes an implantable device having an elongate body that is sized and shaped for delivery via the airway system to a lung airway of a patient. The implant is inserted and positioned while the implant is in a delivery configuration, and is reconfigured to a deployed configuration so as to locally compress adjacent tissue of the lung, with portions of the elongate body generally moving laterally within the airway so as to laterally compress lung tissue. A plurality of such implants will often be used to treat a lung of a patient.
摘要翻译：本发明提供改进的医疗装置，治疗处理系统和用于治疗肺的治疗方法。肺容积减小系统包括可植入装置，其具有细长体，其尺寸和形状用于经由气道系统输送到患者的肺气道。植入物在植入物处于输送构型中时被插入和定位，并且被重新配置为展开构型，以便局部压缩肺的邻近组织，细长体的一部分通常在气道内侧向移动，以便横向压缩肺组织。多个这样的植入物将经常用于治疗患者的肺部。

6. 发明授权

US07837728B2 Reduced length tissue shaping device 有权
标题翻译：缩短长度的组织成形装置
公开(公告)号：US07837728B2
公开(公告)日：2010-11-23
申请号：US10742519
申请日：2003-12-19
申请人： Gregory Nieminen , David Reuter , Nathan Aronson , Lucas Gordon , Garrett Beget
发明人： Gregory Nieminen , David Reuter , Nathan Aronson , Lucas Gordon , Garrett Beget
IPC分类号： A61F2/24
CPC分类号： A61F2/2451
摘要： One aspect of the invention is a method of treating mitral valve regurgitation in a patient. The method includes the steps of delivering a tissue shaping device to the patient's coronary sinus in an unexpanded configuration within a catheter having an outer diameter no more than nine or ten french, with the tissue shaping device including a connector disposed between a distal expandable anchor comprising flexible wire and a proximal expandable anchor comprising flexible wire, the device having a length of 60 mm or less; and deploying the device to reduce mitral valve regurgitation, such as by anchoring the distal expandable anchor by placing the distal expandable anchor flexible wire in contact with a wall of the coronary sinus, e.g., by permitting the distal expandable anchor to self-expand or by applying an actuating force to the distal expandable anchor and possibly locking the distal expandable anchor after performing the applying step. The invention also includes a device for performing the method.
摘要翻译：本发明的一个方面是治疗患者二尖瓣关闭不全的方法。该方法包括以下步骤：将组织成形装置以不超过9或10法兰的外径的导管内的未展开构造递送到患者的冠状窦，其中组织整形装置包括连接器，该连接器设置在包括柔性线和包括柔性线的近端可扩展锚，该装置具有60mm或更小的长度; 并且部署该装置以减少二尖瓣反流，例如通过将远端可扩张锚定柔性线与冠状窦的壁接触来锚定远端可扩张锚固体，例如通过允许远侧可扩张锚自体扩张或通过在远程可扩展锚固件施加致动力并且可能在执行施加步骤之后锁定远侧可扩展锚固件。本发明还包括用于执行该方法的装置。

7. 发明授权

US07828842B2 Tissue shaping device 有权
标题翻译：组织整形装置
公开(公告)号：US07828842B2
公开(公告)日：2010-11-09
申请号：US12060781
申请日：2008-04-01
申请人： Gregory Nieminen , Nathan Aronson
发明人： Gregory Nieminen , Nathan Aronson
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61B2017/00243 , A61F2/24 , A61F2/2442 , A61F2/2466 , A61F2210/0014 , A61F2220/0008 , A61F2250/0012 , A61F2310/00017 , A61F2310/00023 , A61N1/057 , A61N2001/0585
摘要： In one embodiment, the present invention relates to a tissue shaping device adapted to be disposed in a vessel near a patient's heart to reshape the patient's heart. Such tissue shaping device can include an expandable proximal anchor; a proximal anchor lock adapted to lock the proximal anchor in an expanded configuration; an expandable distal anchor; a distal anchor lock adapted to lock the distal anchor in an expanded configuration; and a connector disposed between the proximal anchor and the distal anchor, the connector having a substantially non-circular cross-section.
摘要翻译：在一个实施例中，本发明涉及一种适于设置在患者心脏附近的容器中以重塑患者心脏的组织整形装置。这种组织成形装置可以包括可扩张的近端锚; 适于将近端锚固件以扩展构型锁定的近端锚固件; 可扩展的远端锚; 适于将远端锚固件以扩展构型锁定的远侧锚定锁; 以及设置在所述近端锚固件和远端锚固件之间的连接器，所述连接器具有基本上非圆形的横截面。

8. 发明授权

US07814635B2 Method of making a tissue shaping device 有权
标题翻译：制作组织整形装置的方法
公开(公告)号：US07814635B2
公开(公告)日：2010-10-19
申请号：US11383115
申请日：2006-05-12
申请人： Lucas Gordon , Mark L. Mathis , Nathan Aronson
发明人： Lucas Gordon , Mark L. Mathis , Nathan Aronson
IPC分类号： B23P11/00 , A61F2/24
CPC分类号： A61F2/2451 , Y10T29/49609 , Y10T29/49826 , Y10T29/49947 , Y10T29/49995
摘要： A tissue shaping device adapted to be deployed in a vessel to reshape tissue adjacent to the vessel. In some embodiments the device includes first and second anchors and a connector disposed between the first and second anchors, with the connector being integral with at least a portion of the first anchor. The invention is also a method of making a tissue shaping device including the steps of removing material from a blank to form a connector and an integral anchor portion; and attaching a non-integral anchor portion to the integral anchor portion.
摘要翻译：一种组织成形装置，其适于部署在容器中以重塑邻近容器的组织。在一些实施例中，该装置包括第一和第二锚定器以及设置在第一和第二锚固件之间的连接器，其中连接器与第一锚固件的至少一部分成一体。本发明还是一种制造组织成形装置的方法，包括以下步骤：从坯料上去除材料以形成连接器和一体的锚定部分; 以及将非整体锚定部分附接到所述整体锚定部分。

9. 发明申请

US20070221230A1 MINIMALLY INVASIVE LUNG VOLUME REDUCTION DEVICE AND METHOD 有权
标题翻译：最小的入侵体积减少装置和方法
公开(公告)号：US20070221230A1
公开(公告)日：2007-09-27
申请号：US11422047
申请日：2006-06-02
申请人： David Thompson , Nathan Aronson , Patrick Wu , David Lehrberg
发明人： David Thompson , Nathan Aronson , Patrick Wu , David Lehrberg
IPC分类号： A61F2/20 , A61M16/00
CPC分类号： A61M16/208 , A61B1/018 , A61B1/04 , A61B1/2676 , A61B5/06 , A61B6/032 , A61B6/12 , A61B6/485 , A61B17/00234 , A61B17/12022 , A61B17/12031 , A61B17/12104 , A61B17/12131 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B90/00 , A61B90/02 , A61B2017/00477 , A61B2017/00809 , A61B2017/00867 , A61B2017/12054 , A61F2/04 , A61F2002/043 , A61F2002/046 , A61M16/04 , A61M16/0406 , A61M16/0833 , A61M37/0069 , A61M2205/0266 , A61M2205/32
摘要： A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient comprising inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.
摘要翻译：公开了一种肺容积减小系统，其包括可植入装置，其适于以递送配置递送到患者的肺气道并且改变为展开的配置以弯曲肺气道。本发明还公开了一种弯曲患者的肺气道的方法，包括将装置以输送构造插入气道并将装置弯曲成展开构型，从而弯曲气道。

10. 发明申请

US20050137451A1 Tissue shaping device with integral connector and crimp 有权
标题翻译：具有整体式连接器和压接的组织整形装置
公开(公告)号：US20050137451A1
公开(公告)日：2005-06-23
申请号：US10742742
申请日：2003-12-19
申请人： Lucas Gordon , Mark Mathis , Nathan Aronson
发明人： Lucas Gordon , Mark Mathis , Nathan Aronson
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2451 , Y10T29/49609 , Y10T29/49826 , Y10T29/49947 , Y10T29/49995
摘要： A tissue shaping device adapted to be deployed in a vessel to reshape tissue adjacent to the vessel. In some embodiments the device includes first and second anchors and a connector disposed between the first and second anchors, with the connector being integral with at least a portion of the first anchor. The invention is also a method of making a tissue shaping device including the steps of removing material from a blank to form a connector and an integral anchor portion; and attaching a non-integral anchor portion to the integral anchor portion.
摘要翻译：一种组织成形装置，其适于部署在容器中以重塑邻近容器的组织。在一些实施例中，该装置包括第一和第二锚定器以及设置在第一和第二锚固件之间的连接器，其中连接器与第一锚固件的至少一部分成一体。本发明还是一种制造组织成形装置的方法，包括以下步骤：从坯料上去除材料以形成连接器和一体的锚定部分; 以及将非整体锚定部分附接到所述整体锚定部分。

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