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1. 发明授权

US07837728B2 Reduced length tissue shaping device 有权
标题翻译：缩短长度的组织成形装置
公开(公告)号：US07837728B2
公开(公告)日：2010-11-23
申请号：US10742519
申请日：2003-12-19
申请人： Gregory Nieminen , David Reuter , Nathan Aronson , Lucas Gordon , Garrett Beget
发明人： Gregory Nieminen , David Reuter , Nathan Aronson , Lucas Gordon , Garrett Beget
IPC分类号： A61F2/24
CPC分类号： A61F2/2451
摘要： One aspect of the invention is a method of treating mitral valve regurgitation in a patient. The method includes the steps of delivering a tissue shaping device to the patient's coronary sinus in an unexpanded configuration within a catheter having an outer diameter no more than nine or ten french, with the tissue shaping device including a connector disposed between a distal expandable anchor comprising flexible wire and a proximal expandable anchor comprising flexible wire, the device having a length of 60 mm or less; and deploying the device to reduce mitral valve regurgitation, such as by anchoring the distal expandable anchor by placing the distal expandable anchor flexible wire in contact with a wall of the coronary sinus, e.g., by permitting the distal expandable anchor to self-expand or by applying an actuating force to the distal expandable anchor and possibly locking the distal expandable anchor after performing the applying step. The invention also includes a device for performing the method.
摘要翻译：本发明的一个方面是治疗患者二尖瓣关闭不全的方法。该方法包括以下步骤：将组织成形装置以不超过9或10法兰的外径的导管内的未展开构造递送到患者的冠状窦，其中组织整形装置包括连接器，该连接器设置在包括柔性线和包括柔性线的近端可扩展锚，该装置具有60mm或更小的长度; 并且部署该装置以减少二尖瓣反流，例如通过将远端可扩张锚定柔性线与冠状窦的壁接触来锚定远端可扩张锚固体，例如通过允许远侧可扩张锚自体扩张或通过在远程可扩展锚固件施加致动力并且可能在执行施加步骤之后锁定远侧可扩展锚固件。本发明还包括用于执行该方法的装置。

2. 发明申请

US20050137685A1 Reduced length tissue shaping device 有权
标题翻译：缩短长度的组织成形装置
公开(公告)号：US20050137685A1
公开(公告)日：2005-06-23
申请号：US10742519
申请日：2003-12-19
申请人： Gregory Nieminen , David Reuter , Nathan Aronson , Lucas Gordon , Garrett Beget
发明人： Gregory Nieminen , David Reuter , Nathan Aronson , Lucas Gordon , Garrett Beget
IPC分类号： A61F2/24
CPC分类号： A61F2/2451
摘要： One aspect of the invention is a method of treating mitral valve regurgitation in a patient. The method includes the steps of delivering a tissue shaping device to the patient's coronary sinus in an unexpanded configuration within a catheter having an outer diameter no more than nine or ten french, with the tissue shaping device including a connector disposed between a distal expandable anchor comprising flexible wire and a proximal expandable anchor comprising flexible wire, the device having a length of 60 mm or less; and deploying the device to reduce mitral valve regurgitation, such as by anchoring the distal expandable anchor by placing the distal expandable anchor flexible wire in contact with a wall of the coronary sinus, e.g., by permitting the distal expandable anchor to self-expand or by applying an actuating force to the distal expandable anchor and possibly locking the distal expandable anchor after performing the applying step. The invention also includes a device for performing the method.
摘要翻译：本发明的一个方面是治疗患者二尖瓣关闭不全的方法。该方法包括以下步骤：将组织成形装置以不超过9或10法兰的外径的导管内的未展开构造递送到患者的冠状窦，其中组织整形装置包括连接器，该连接器设置在包括柔性线和包括柔性线的近端可扩展锚，该装置具有60mm或更小的长度; 并且部署该装置以减少二尖瓣反流，例如通过将远端可扩张锚定柔性线与冠状窦的壁接触来锚定远端可扩张锚固体，例如通过允许远侧可扩张锚自体扩张或通过在远程可扩展锚固件施加致动力并且可能在执行施加步骤之后锁定远侧可扩展锚固件。本发明还包括用于执行该方法的装置。

3. 发明申请

US20050027351A1 Mitral valve regurgitation treatment device and method 审中-公开
标题翻译：二尖瓣反流治疗装置及方法
公开(公告)号：US20050027351A1
公开(公告)日：2005-02-03
申请号：US10742747
申请日：2003-12-19
申请人： David Reuter , Gregory Nieminen , Nathan Aronson , Lucas Gordon , Garrett Beget , Clif Alferness , Mark Mathis
发明人： David Reuter , Gregory Nieminen , Nathan Aronson , Lucas Gordon , Garrett Beget , Clif Alferness , Mark Mathis
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , Y10S623/904
摘要： A method of treating regurgitation of a mitral valve in a patient's heart. The method includes the steps of: delivering a tissue shaping device to the coronary sinus; and deploying the tissue shaping device to reduce mitral valve regurgitation, the deploying step comprising applying a force through the coronary sinus wall toward the mitral valve solely proximal to a crossover point where a coronary artery passes between a coronary sinus and the mitral valve. The invention is also a set of devices for use in treating mitral valve regurgitation. The set includes a plurality of tissue shaping devices having different lengths, each of the tissue shaping devices being configured to be deliverable to a coronary sinus of a patient within a catheter having an outer diameter no greater than ten french.
摘要翻译：治疗患者心脏二尖瓣反流的方法。该方法包括以下步骤：将组织整形装置递送至冠状窦; 并且展开所述组织整形装置以减少二尖瓣反流，所述展开步骤包括仅通过冠状动脉穿过冠状窦和二尖瓣之间的交叉点向二尖瓣施加穿过冠状窦壁的力。本发明也是用于治疗二尖瓣反流的一组装置。该组包括具有不同长度的多个组织整形装置，每个组织整形装置构造成可输送到具有不超过十个法兰的外径的导管内的患者的冠状窦。

4. 发明申请

US20110106117A1 Device and Method for Modifying the Shape of a Body Organ 审中-公开
标题翻译：修饰身体器官形状的装置和方法
公开(公告)号：US20110106117A1
公开(公告)日：2011-05-05
申请号：US13004239
申请日：2011-01-11
申请人： Mark L. Mathis , David Reuter , Lucas Gordon , Cruz Beeson , Garrett Beget , Frederick Stewart
发明人： Mark L. Mathis , David Reuter , Lucas Gordon , Cruz Beeson , Garrett Beget , Frederick Stewart
IPC分类号： A61B17/08
CPC分类号： A61F2/2451 , A61B2017/00243
摘要： A tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen. In one embodiment the device includes first and second anchors; a connector disposed between the first and second anchors; and a focal deflector disposed between the first and second anchors and may be adapted to extend away from the lumen axis and toward the target tissue and/or away from the lumen axis and away from the target tissue when the device is deployed in the lumen. The invention is also a method of modifying target tissue shape. The method includes the steps of providing a tissue shaping device comprising proximal and distal anchors, a connector disposed between the proximal and distal anchors, and a focal deflector; placing the tissue shaping device in a lumen adjacent the target tissue; applying a shaping force from the focal deflector against a lumen wall to modify the shape of the target tissue; and expanding the proximal and distal anchors to anchor the device in the lumen.
摘要翻译：组织成形装置，其适于部署在内腔中以改变邻近内腔的靶组织的形状。在一个实施例中，该装置包括第一和第二锚固件; 连接器，设置在第一和第二锚固件之间; 以及设置在所述第一和第二锚固件之间的焦偏转器，并且可以适于在所述装置展开在所述内腔中时远离所述内腔轴线延伸并且朝向所述目标组织和/或远离所述内腔轴线延伸并远离所述目标组织。本发明也是改变目标组织形状的方法。该方法包括提供包括近端和远端锚固件的组织成形装置，设置在近端锚固件和远端锚固件之间的连接器以及焦点偏转器的步骤; 将组织成形装置放置在与目标组织相邻的内腔中; 将来自焦偏转器的成形力施加到管腔壁以改变靶组织的形状; 并且扩张近端和远端锚固件以将装置锚定在管腔中。

5. 发明申请

US20050010240A1 Device and method for modifying the shape of a body organ 有权
标题翻译：用于改变身体器官形状的装置和方法
公开(公告)号：US20050010240A1
公开(公告)日：2005-01-13
申请号：US10840188
申请日：2004-05-05
申请人： Mark Mathis , David Reuter , Lucas Gordon , Cruz Beeson , Garrett Beget , Frederick Stewart
发明人： Mark Mathis , David Reuter , Lucas Gordon , Cruz Beeson , Garrett Beget , Frederick Stewart
IPC分类号： A61B17/00 , A61F2/24 , A61B17/08
CPC分类号： A61F2/2451 , A61B2017/00243
摘要： A tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen. In one embodiment the device includes first and second anchors; a connector disposed between the first and second anchors; and a focal deflector disposed between the first and second anchors and may be adapted to extend away from the lumen axis and toward the target tissue and/or away from the lumen axis and away from the target tissue when the device is deployed in the lumen. The invention is also a method of modifying target tissue shape. The method includes the steps of providing a tissue shaping device comprising proximal and distal anchors, a connector disposed between the proximal and distal anchors, and a focal deflector; placing the tissue shaping device in a lumen adjacent the target tissue; applying a shaping force from the focal deflector against a lumen wall to modify the shape of the target tissue; and expanding the proximal and distal anchors to anchor the device in the lumen.
摘要翻译：组织成形装置，其适于部署在内腔中以改变邻近内腔的靶组织的形状。在一个实施例中，该装置包括第一和第二锚固件; 连接器，设置在第一和第二锚固件之间; 以及设置在所述第一和第二锚固件之间的焦偏转器，并且可以适于在所述装置展开在所述内腔中时远离所述内腔轴线延伸并且朝向所述目标组织和/或远离所述内腔轴线延伸并远离所述目标组织。本发明也是改变目标组织形状的方法。该方法包括提供包括近端和远端锚固件的组织成形装置，设置在近端锚固件和远端锚固件之间的连接器以及焦点偏转器的步骤; 将组织成形装置放置在与目标组织相邻的内腔中; 将来自焦偏转器的成形力施加到管腔壁以改变靶组织的形状; 并且扩张近端和远端锚固件以将装置锚定在管腔中。

6. 发明授权

US07887582B2 Device and method for modifying the shape of a body organ 有权
标题翻译：用于改变身体器官形状的装置和方法
公开(公告)号：US07887582B2
公开(公告)日：2011-02-15
申请号：US10840188
申请日：2004-05-05
申请人： Mark L. Mathis , David Reuter , Lucas Gordon , Cruz Beeson , Garrett Beget , Frederick Stewart
发明人： Mark L. Mathis , David Reuter , Lucas Gordon , Cruz Beeson , Garrett Beget , Frederick Stewart
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61B2017/00243
摘要： A tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen. In one embodiment the device includes first and second anchors; a connector disposed between the first and second anchors; and a focal deflector disposed between the first and second anchors and may be adapted to extend away from the lumen axis and toward the target tissue and/or away from the lumen axis and away from the target tissue when the device is deployed in the lumen. The invention is also a method of modifying target tissue shape. The method includes the steps of providing a tissue shaping device comprising proximal and distal anchors, a connector disposed between the proximal and distal anchors, and a focal deflector; placing the tissue shaping device in a lumen adjacent the target tissue; applying a shaping force from the focal deflector against a lumen wall to modify the shape of the target tissue; and expanding the proximal and distal anchors to anchor the device in the lumen.
摘要翻译：组织成形装置，其适于部署在内腔中以改变邻近内腔的靶组织的形状。在一个实施例中，该装置包括第一和第二锚固件; 连接器，设置在第一和第二锚固件之间; 以及设置在所述第一和第二锚固件之间的焦偏转器，并且可以适于在所述装置展开在所述内腔中时远离所述内腔轴线延伸并且朝向所述目标组织和/或远离所述内腔轴线延伸并远离所述目标组织。本发明也是改变目标组织形状的方法。该方法包括提供包括近端和远端锚固件的组织成形装置，设置在近端锚固件和远端锚固件之间的连接器以及焦点偏转器的步骤; 将组织成形装置放置在与目标组织相邻的内腔中; 将来自焦偏转器的成形力施加到管腔壁以改变靶组织的形状; 并且扩张近端和远端锚固件以将装置锚定在管腔中。

7. 发明申请

US20070066879A1 BODY LUMEN SHAPING DEVICE WITH CARDIAC LEADS 审中-公开
标题翻译：身体造型设备与心脏病领导
公开(公告)号：US20070066879A1
公开(公告)日：2007-03-22
申请号：US11550354
申请日：2006-10-17
申请人： Mark Mathis , Gregory Nieminen , David Reuter
发明人： Mark Mathis , Gregory Nieminen , David Reuter
IPC分类号： A61B5/042 , A61F2/24 , A61N1/05
CPC分类号： A61F2/2451 , A61B2017/00243 , A61N1/057 , A61N2001/0585
摘要： A shaping device and a cardiac lead, both adapted to be disposed in a coronary sinus of a patient's heart, are provided. In one method, a patient is treated by deploying in the patient's coronary sinus a shaping device and a cardiac lead and using the shaping device to modify mitral valve geometry.
摘要翻译：提供了适于设置在患者心脏的冠状窦中的成形装置和心脏引线。在一种方法中，通过在患者的冠状窦内展开成形装置和心脏引线并使用成形装置来修改二尖瓣几何形状来治疗患者。

8. 发明申请

US20050216077A1 Fixed length anchor and pull mitral valve device and method 审中-公开
标题翻译：固定长度锚和拉二尖瓣装置及方法
公开(公告)号：US20050216077A1
公开(公告)日：2005-09-29
申请号：US11132788
申请日：2005-05-18
申请人： Mark Mathis , Gregory Nieminen , David Reuter
发明人： Mark Mathis , Gregory Nieminen , David Reuter
IPC分类号： A61B17/00 , A61F2/24 , A61N1/05
CPC分类号： A61F2/2451 , A61B2017/00243 , A61F2/24 , A61F2/2442 , A61F2/2448 , A61F2/246 , A61F2/2466 , A61F2210/0014 , A61F2220/0008 , A61F2250/0012 , A61F2310/00017 , A61F2310/00023 , A61N1/057 , A61N2001/0585
摘要： A device affects the mitral valve annulus geometry of a heart. The device includes a first anchor configured to be positioned within and anchored to the coronary sinus of the heart adjacent the mitral valve annulus within the heart and a second anchor configured to be positioned within the coronary sinus of the heart proximal to the first anchor and adjacent the mitral valve annulus within the heart. The second anchor, when deployed, anchors against distal movement and is moveable in a proximal direction. The device further includes a connecting member having a fixed length permanently attached to the first and second anchors. As a result, when the first and second anchors are within the coronary sinus with the first anchor anchored in the coronary sinus, the second anchor may be displaced proximally to affect the geometry of the mitral valve annulus and released to maintain the effect on the mitral valve geometry.
摘要翻译：一个装置影响心脏的二尖瓣环几何形状。该装置包括第一锚定构件，其构造成定位在心脏内邻近心脏二尖瓣环的心脏的冠状窦内并且锚固在心脏周围的第二锚定件上，第二锚固件构造成定位在靠近第一锚固件的心脏的冠状窦内，心脏内的二尖瓣环。当第二锚固件被展开时，锚固件抵靠远端运动并且可沿近端方向移动。该装置还包括具有固定长度的连接构件，该固定长度永久地附接到第一和第二锚固件。结果，当第一和第二锚固件位于冠状窦内时，第一锚固件锚固在冠状窦中时，第二锚固件可以向近侧位移以影响二尖瓣环的几何形状并被释放以维持对二尖瓣的作用阀几何。

9. 发明申请

US20050209690A1 Body lumen shaping device with cardiac leads 审中-公开
标题翻译：带心脏导管的体腔整形装置
公开(公告)号：US20050209690A1
公开(公告)日：2005-09-22
申请号：US11132786
申请日：2005-05-18
申请人： Mark Mathis , Gregory Nieminen , David Reuter
发明人： Mark Mathis , Gregory Nieminen , David Reuter
IPC分类号： A61B17/00 , A61F2/24 , A61N1/05
CPC分类号： A61F2/2451 , A61B2017/00243 , A61N1/057 , A61N2001/0585
摘要： A shaping device and a cardiac lead, both adapted to be disposed in a coronary sinus of a patient's heart, are provided. In one method, a patient is treated by deploying in the patient's coronary sinus a shaping device and a cardiac lead and using the shaping device to modify mitral valve geometry.
摘要翻译：提供了适于设置在患者心脏的冠状窦中的成形装置和心脏引线。在一种方法中，通过在患者的冠状窦内展开成形装置和心脏引线并使用成形装置来修改二尖瓣几何形状来治疗患者。

10. 发明授权

US08439971B2 Adjustable height focal tissue deflector 有权
公开(公告)号：US08439971B2
公开(公告)日：2013-05-14
申请号：US12642525
申请日：2009-12-18
申请人： David Reuter , Mark Mathis , Greg Nieminen , Cruz Beeson
发明人： David Reuter , Mark Mathis , Greg Nieminen , Cruz Beeson
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61M25/1006
摘要： A tissue shaping device adapted to reshape target tissue adjacent to a lumen. In some embodiments, the device includes an expandable and contractable anchor, with the anchor having an adjustable height anchoring portion adapted to engage a wall of the lumen in at least first and second anchor heights, the anchoring portion being further adapted to be changed from the first anchor height to the second anchor height by a substantially proximally or a substantially distally directed actuation force. The invention is also a tissue shaping system including a tissue shaping device and a tool for adjusting the height of an anchor of the device. The invention also includes methods of using such tissue shaping devices and systems.

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