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1. 发明申请

US20110130386A1 DNA-PK INHIBITORS 审中-公开
标题翻译： DNA-PK抑制剂
公开(公告)号：US20110130386A1
公开(公告)日：2011-06-02
申请号：US12989510
申请日：2009-04-24
申请人： Mark Frigerio , Heather Mary Ellen Duggan , Marc Geoffrey Hummersone , Keith Allan Menear , Niall Morrison Barr Martin , Celine Cano , Roger John Griffin , Bernard Thomas Golding , Ian Robert Hardcastle
发明人： Mark Frigerio , Heather Mary Ellen Duggan , Marc Geoffrey Hummersone , Keith Allan Menear , Niall Morrison Barr Martin , Celine Cano , Roger John Griffin , Bernard Thomas Golding , Ian Robert Hardcastle
IPC分类号： A61K31/551 , C07D413/14 , C07D243/06 , C12N5/071 , A61K31/5355 , A61K31/55 , A61P35/00
CPC分类号： C07D413/14 , C07D417/14
摘要： A compound of formula (I) wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and RN1 and RN2 are selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms.
摘要翻译：式（I）的化合物，其中：R 1和R 2独立地选自氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5-20芳基，或者可以与氮原子一起形成与它们相连的任选取代的具有4至8个环原子的杂环; 并且RN1和RN2选自氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5-20芳基，或者可以与它们所连接的氮原子一起形成任选取代的具有4至8个环原子的杂环。

2. 发明授权

US07696203B2 DNA-PK inhibitors 失效
标题翻译： DNA-PK抑制剂
公开(公告)号：US07696203B2
公开(公告)日：2010-04-13
申请号：US11403606
申请日：2006-04-13
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Xiao-ling Cockcroft , Mark Frigerio , Roger John Griffin , Bernard Thomas Golding , Ian Robert Hardcastle , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Kappusamy Saravanan , Marine Desage-El Murr
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Xiao-ling Cockcroft , Mark Frigerio , Roger John Griffin , Bernard Thomas Golding , Ian Robert Hardcastle , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Kappusamy Saravanan , Marine Desage-El Murr
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D413/00 , C07D401/14 , C07D405/04 , C07D407/04 , C07D407/14 , C07D409/04 , C07D471/04
摘要： Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N; and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C(═O), CH2 and NH are disclosed for use in inhibiting DNA-PK.
摘要翻译：式I化合物：其中A，B和D分别选自：（i）CH，NH，C; （ii）CH，N，N; 和（iii）CH，O，C; 虚线表示适当位置的两个双键; 并且其中Z选自S，O，C（= O），CH 2和NH用于抑制DNA-PK。

3. 发明授权

US07402607B2 DNA-PK inhibitors 失效
标题翻译： DNA-PK抑制剂
公开(公告)号：US07402607B2
公开(公告)日：2008-07-22
申请号：US11231041
申请日：2005-09-20
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
IPC分类号： A61K31/381 , C07D333/76
CPC分类号： C07D413/14 , C07D409/04 , C07D409/14
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(═O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3, or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(═O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R6 and R7 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and if Q is —NH—C(═O)—, —Y—X may additionally be selected from C1-7 alkyl.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2独立地选自氢，任选地取代的C 1-7烷基，C 3-20杂环基或C 5-20-20芳基，或者可以一起形成与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; Q是-NH-C（-O） - 或-O-; Y是任选取代的C 1-5亚烷基; X选自SR 3或NR 4 R 5，其中R 3，R 3，R 3， 4和R 5独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基，或 C 3-20杂环基或R 4和R 5可以一起与它们所连接的氮原子一起形成一个具有4至8个环原子的任选取代的杂环; 如果Q是-O-，X另外选自-C（-O）-NR 6 R 7，其中R 6和R 独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基或C 3-20 或者R 6和R 7可以与它们所连接的氮原子一起形成任选取代的杂环，其具有4个至8个环原子; 并且如果Q是-NH-C（-O） - ，-Y-X可另外选自C 1-7烷基。

4. 发明授权

US07732483B2 DNA-PK inhibitors 失效
标题翻译： DNA-PK抑制剂
公开(公告)号：US07732483B2
公开(公告)日：2010-06-08
申请号：US12133837
申请日：2008-06-05
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
IPC分类号： A61K31/381 , C07D333/74 , C07D409/04
CPC分类号： C07D413/14 , C07D409/04 , C07D409/14
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(═O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3, or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(═O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R6 and R7 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and if Q is —NH—C(═O)—, —Y—X may additionally be selected from C1-7 alkyl.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2独立地选自氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5- 20芳基，或者可以与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; Q是-NH-C（= O） - 或-O-; Y是任选取代的C 1-5亚烷基; X选自SR 3或NR 4 R 5，其中，R 3或R 4和R 5独立地选自氢，任选取代的C 1-7烷基，C 5-20芳基或C 3-20杂环基，或者R 4和R 5可以一起形成与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; 如果Q是-O-，X另外选自-C（= O）-NR 6 R 7，其中R 6和R 7独立地选自氢，任选取代的C 1-7烷基，C 5-20芳基或C 3-20杂环基，或R6和R7可以与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; 并且如果Q是-NH-C（= O） - ，-Y-X可另外选自C 1-7烷基。

5. 发明申请

US20080242664A1 DNA-PK INHIBITORS 失效
标题翻译： DNA-PK抑制剂
公开(公告)号：US20080242664A1
公开(公告)日：2008-10-02
申请号：US12133837
申请日：2008-06-05
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
IPC分类号： A61K31/5377 , C07D409/10 , A61K31/381 , C07D409/14 , A61P35/04 , A61K31/496 , C07D413/14
CPC分类号： C07D413/14 , C07D409/04 , C07D409/14
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(═O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3, or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(═O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R6 and R7 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and if Q is —NH—C(═O)—, —Y—X may additionally be selected from C1-7 alkyl.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2独立地选自氢，任选地取代的C 1-7烷基，C 3-20杂环基或C 5-20-20芳基，或者可以一起形成与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; Q是-NH-C（-O） - 或-O-; Y是任选取代的C 1-5亚烷基; X选自SR 3或NR 4 R 5，其中R 3，R 3，R 3， 4和R 5独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基，或 C 3-20杂环基或R 4和R 5可以一起与它们所连接的氮原子一起形成一个具有4至8个环原子的任选取代的杂环; 如果Q是-O-，X另外选自-C（-O）-NR 6 R 7，其中R 6和R 独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基或C 3-20 或者R 6和R 7可以与它们所连接的氮原子一起形成任选取代的杂环，其具有4个至8个环原子; 并且如果Q是-NH-C（-O） - ，-Y-X可另外选自C 1-7烷基。

6. 发明申请

US20090042865A1 DNA-PK INHIBITORS 审中-公开
标题翻译： DNA-PK抑制剂
公开(公告)号：US20090042865A1
公开(公告)日：2009-02-12
申请号：US12175542
申请日：2008-07-18
申请人： Mark Frigerio , Marc Geoffrey Hummersone , Keith Allan Menear , Christine Sarah Bailey , Heather Mary Ellen Duggan , Sylvie Gomez , Niall Morrison Barr Martin
发明人： Mark Frigerio , Marc Geoffrey Hummersone , Keith Allan Menear , Christine Sarah Bailey , Heather Mary Ellen Duggan , Sylvie Gomez , Niall Morrison Barr Martin
IPC分类号： A61K31/5377 , C07D413/14 , A61K31/551 , A61P35/00 , C07D243/08
CPC分类号： C07D409/04 , C07D409/14
摘要： A compound of formula I: wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; X is CH or N; n is 1 or 2; RC1 and RC2 are independently selected from H and methyl; when X is N, RX is selected from the group consisting of H, and optionally substituted C1-7 alkyl, C3-20 heterocyclyl, C5-20 aryl, acyl, ester, amido and sulfonyl; and when X is CH, RX is selected from the group consisting of H, and optionally substituted C1-7 alkyl, C3-20 heterocyclyl, C5-20 aryl, acyl, ester, amido, sulfonyl, amino and ether.
摘要翻译：式I的化合物：其中：R 1和R 2独立地选自氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5-20芳基，或者可以一起与氮原子一起形成它们所连接的是具有4至8个环原子的任选取代的杂环; X是CH或N; n为1或2; RC1和RC2独立地选自H和甲基; 当X是N时，RX选自H和任选取代的C 1-7烷基，C 3-20杂环基，C 5-20芳基，酰基，酯，酰氨基和磺酰基; 当X是CH时，RX选自H和任选取代的C 1-7烷基，C 3-20杂环基，C 5-20芳基，酰基，酯，酰氨基，磺酰基，氨基和醚。

7. 发明申请

US20080194546A1 Pyrido-, Pyrazo- and Pyrimido-Pyrimidine Derivatives as mTOR Inhibitors 审中-公开
公开(公告)号：US20080194546A1
公开(公告)日：2008-08-14
申请号：US11842927
申请日：2007-08-21
申请人： Marc Geoffrey Hummersone , Gomez Sylvie , Keith Allan Menear , Graeme Cameron Murray Smith , Karine Malagu , Heather Mary Ellen Duggan , Niall Morrison Barr Martin , Frederic Georges Marie Leroux , Gesine Johanna Hermann , Xiao-Ling Fan Cockcroft
发明人： Marc Geoffrey Hummersone , Gomez Sylvie , Keith Allan Menear , Graeme Cameron Murray Smith , Karine Malagu , Heather Mary Ellen Duggan , Niall Morrison Barr Martin , Frederic Georges Marie Leroux , Gesine Johanna Hermann , Xiao-Ling Fan Cockcroft
IPC分类号： A61K31/5377 , C07D413/14 , A61K31/5513 , A61P35/00 , C07D243/14
CPC分类号： C07D475/08 , C07D475/06 , C07D487/04
摘要： There is provided a compound of formula I: wherein: one or two of X5, X6 and X8 is N, and the others are CH; R7 is selected from halo, ORO1, SRS1, NRN1RN2, NRN7aC(═O)RC1, NRN7bSO2RS2a, an optionally substituted C5-20 heteroaryl group, or an optionally substituted C5-20 aryl group, where RO1 and RS1 are selected from H, an optionally substituted C5-20 aryl group, an optionally substituted C5-20 heteroaryl group, or an optionally substituted C1-7 alkyl group; RN1 and RN2 are independently selected from H, an optionally substituted C1-7 alkyl group, an optionally substituted C5-20 heteroaryl group, an optionally substituted C5-20 aryl group or RN1 and RN2 together with the nitrogen to which they are bound form a heterocyclic ring containing between 3 and 8 ring atoms; RC1 is selected from H, an optionally substituted C5-20 aryl group, an optionally substituted C5-20 heteroaryl group, an optionally substituted C1-7 alkyl group or NRN8RN9, where RN8 and RN9 are independently selected from H, an optionally substituted C1-7 alkyl group, an optionally substituted C5-20 heteroaryl group, an optionally substituted C5-20 aryl group or RN8 and RN9 together with the nitrogen to which they are bound form a heterocyclic ring containing between 3 and 8 ring atoms; RS2a is selected from H, an optionally substituted C5-20 aryl group, an optionally substituted C5-20 heteroaryl group, or an optionally substituted C1-7 alkyl group; RN7a and RN7b are selected from H and a C1-4 alkyl group; RN3 and RN4, together with the nitrogen to which they are bound, form a heterocyclic ring containing between 3 and 8 ring atoms; R2 is selected from H, halo, ORO2, SRS2b, NRN5RN6, an optionally substituted C5-20 heteroaryl group, and an optionally substituted C5-20 aryl group, wherein RO2 and RS2b are selected from H, an optionally substituted C5-20 aryl group, an optionally substituted C5-20 heteroaryl group, or an optionally substituted C1-7 alkyl group; RN5 and RN6 are independently selected from H, an optionally substituted C1-7 alkyl group, an optionally substituted C5-20 heteroaryl group, and an optionally substituted C5-20 aryl group, or RN5 and RN6 together with the nitrogen to which they are bound form a heterocyclic ring containing between 3 and 8 ring atoms, or a pharmaceutically acceptable salt thereof, with the proviso that when R2 is unsubstituted morpholino. RN3 and RN4 together with the nitrogen atom to which they are attached form an unsubstituted morpholino and R7 is unsubstituted phenyl, and X5 is CH, then X6 is not N and X8 is not CH, or X6 is not CH and X8 is not N, and when R2 is unsubstituted piperidinyl, RN3 and RN4 together with the nitrogen atom to which they are attached form an unsubstituted piperidinyl and R7 is unsubstituted phenyl, and X5 is CH, then X6 is not CH and X is not N. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.

8. 发明授权

US07642254B2 ATM inhibitors 失效
标题翻译： ATM抑制剂
公开(公告)号：US07642254B2
公开(公告)日：2010-01-05
申请号：US11351052
申请日：2006-02-09
申请人： Marc Geoffrey Hummersone , Keith Allan Menear , Laurent Jean Martin Rigoreau , Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Roger John Griffin
发明人： Marc Geoffrey Hummersone , Keith Allan Menear , Laurent Jean Martin Rigoreau , Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Roger John Griffin
IPC分类号： A61K31/535 , A61K31/38 , A61K31/35 , C07D413/14 , C07D409/14 , C07D407/14
CPC分类号： C07D409/04 , C07D409/14
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 together form, along with the nitrogen atom to which they are attached, an optionally substituted nitrogen containing heterocyclic ring having from 4 to 8 ring atoms; and R3 is selected from hydroxy and —NRN1RN2, where RN1 and RN2 are independently selected from hydrogen, optionally substituted C1-7 alkyl groups, optionally substituted C3-20 heterocyclyl groups and optionally substituted C5-20 aryl groups, or together form, along with the nitrogen atom to which they are attached, an optionally substituted nitrogen containing heterocyclic ring having from 4 to 8 ring atoms, and its use in inhibiting ATM.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2一起与它们所连接的氮原子一起形成任选取代的含氮杂环，其具有4个至8个环原子; 并且R 3选自羟基和-NRN 1 R N 2，其中RN 1和RN 2独立地选自氢，任选取代的C 1-7烷基，任选取代的C 3-20杂环基和任选取代的C 5-20芳基，或一起形成，与它们相连的氮原子，具有4至8个环原子的任选取代的含氮杂环，以及其在抑制ATM中的用途。

9. 发明申请

US20090043091A1 ATM INHIBITORS 审中-公开
标题翻译： ATM抑制剂
公开(公告)号：US20090043091A1
公开(公告)日：2009-02-12
申请号：US12233736
申请日：2008-09-19
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Xiao-Ling Fan Cockcroft , Ian Timothy Williams Matthews , Keith Allan Menear , Laurent Jean Martin Rigoreau , Marc Geoffrey Hummersone , Roger John Griffin
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Xiao-Ling Fan Cockcroft , Ian Timothy Williams Matthews , Keith Allan Menear , Laurent Jean Martin Rigoreau , Marc Geoffrey Hummersone , Roger John Griffin
IPC分类号： C07D243/08 , C07D413/14 , C07D223/02 , C07D279/18
CPC分类号： C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D491/04 , C07D495/04
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and RN1 is selected from hydrogen, an optionally substituted C1-7 alkyl group, an optionally substituted C3-20 heterocyclyl group, an optionally substituted C5-20 aryl group, an acyl group, an ester group and an amido group, and its use as a pharmaceutical.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2一起与它们所连接的氮原子一起形成任选取代的具有4至8个的杂环环原子并且RN1选自氢，任选取代的C 1-7烷基，任选取代的C 3-20杂环基，任选取代的C 5-20芳基，酰基，酯基和酰胺基，其用作制药。

10. 发明授权

US07429660B2 ATM inhibitors 失效
标题翻译： ATM抑制剂
公开(公告)号：US07429660B2
公开(公告)日：2008-09-30
申请号：US10918180
申请日：2004-08-13
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Xiao-Ling Fan Cockcroft , Ian Timothy Williams Matthews , Keith Allan Menear , Laurent Jean Martin Rigoreau , Marc Geoffrey Hummersone , Roger John Griffin
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Xiao-Ling Fan Cockcroft , Ian Timothy Williams Matthews , Keith Allan Menear , Laurent Jean Martin Rigoreau , Marc Geoffrey Hummersone , Roger John Griffin
IPC分类号： A61K413/00
CPC分类号： C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D491/04 , C07D495/04
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and RN1 is selected from hydrogen, an optionally substituted C1-7 alkyl group, an optionally substituted C3-20 heterocyclyl group, an optionally substituted C5-20 aryl group, an acyl group, an ester group and an amido group, and its use as a pharmaceutical.
摘要翻译：式I化合物及其异构体，盐，溶剂化物，化学保护形式及其前药，其中：R 1和R 2一起与氮原子一起形成与它们相连的任选取代的具有4至8个环原子的杂环; 并且R“N1”选自氢，任选取代的C 1-7烷基，任选取代的C 3-20杂环基，任选取代的C 5-20芳基，酰基，酯基和酰胺基，以及其作为药物的用途。

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